Researchers discovered that MEX3D acts as a key player in activating stored RNAs during sperm maturation. The MXL vesicle system is also hijacked by gastric cancer to enhance tumor growth. Targeting this machinery holds promise for developing selective and safe anti-cancer therapies.
Researchers explore the potential of black phosphorus for high-capacity alkali metal-ion batteries, overcoming stability and interfacial challenges through engineered architectures. Scalable synthesis, composite engineering, and interfacial regulation hold key to practical deployment.
A systematic review finds that a combination of aerobic and muscle-strengthening exercises significantly improves cardiovascular outcomes in healthy adults. The optimal exercise duration is found to be between 40-60 minutes per week, with evening aerobic exercise showing greater health benefits.
A new study reveals that soil carbon residence time governs riverine dissolved organic matter's age, with climate, hydrology, and soil processes controlling carbon cycling in rivers. The research provides a high-resolution global atlas of riverine DOC, showing that ancient carbon sources are locally important but modern terrestrial org...
Researchers developed a microfluidic spray drying technology to rapidly synthesize high-phase-purity HE-NVPF cathode materials. The new method allows for efficient and scalable energy storage solutions with superior performance.
A study of 1,152 people found that humans cooperate more with fair AI than with AI that is helpful or selfish. Fairness was the key to cooperation, not unconditional niceness. The researchers suggest that humans respond best to AI that can navigate social rules and expectations in a believable way.
Researchers developed a unified topological framework to characterize complex boundary states in Floquet crystals, predicting the existence and type of various topological boundary states. The framework uses three complementary one-dimensional winding numbers to unify the description of multiple boundary orders.
Researchers propose atomically dispersed U−O−Ti bimetallic active sites for high-efficiency PEC OER catalysis, achieving a 3.82-fold enhancement compared to pristine TiO2. The material exhibits excellent structural stability and operational safety.
Research reveals two dimensions of neuroticism: one linked to mental disorders and life well-being, the other to emotional reactivity and internal stability. High-ERIS individuals live longer due to healthier habits and risk avoidance.
Researchers recorded single-unit activity in bats' inferior colliculus while they were freely vocalizing. The study found that 95% of neurons responded differently to self-generated vocalizations than to playback of the same calls.
Scientists create a novel nano-delivery system that boosts NAD+ synthesis and reduces consumption, rapidly restoring energy metabolism in damaged kidneys. The approach halts disease progression and prevents chronic kidney disease, offering a promising drug development platform for AKI and other energy metabolism disorders.
Researchers have discovered a pattern in ultra-low temperature measurements of quantum Hall effect states, which can be explained by the composite fermion (CF) theory. The findings propose a connection between CFs and the observed states, providing a new understanding of fractional quantum Hall states.
Researchers found that hydrogen in LaH3 can tunnel through energy barriers rather than surmounting them, with quantum tunneling becoming dominant at approximately 71 K and increasing to 308 K for single-ion migration. This study clarifies why classical models fail to capture key aspects of the underlying physics.
Researchers successfully decoded the polarization cipher of light using high-energy electrons, confirming a key prediction of quantum electrodynamics. The study's findings offer a new pathway toward creating highly polarized, high-brightness gamma-ray sources.
Researchers developed a molecular engineering strategy to enhance PEMFC performance by tailoring the ionomer microenvironment. The addition of fullerenol improved oxygen transport and reduced platinum-sulfonate interactions, leading to increased peak power density and operational stability.
Researchers used LP-TEM to visualize the dynamic processes occurring during early stages of liquid-liquid phase separation (LLPS) in intrinsically disordered proteins/regions. The study provides compelling evidence supporting a non-classical nucleation mechanism and proposes a multi-step process for LLPS, which is common in IDPs/IDRs.
A research team from China has developed a material with high charge-to-spin conversion efficiency, achieving record-breaking performance in spintronic devices. The discovery utilizes nonsymmorphic symmetry to stabilize the material and enables ultra-low power magnetic switching.
The article presents a conceptual design for an in-situ energy station on Mars, which could alleviate power fluctuations and distribution issues. The system utilizes the Martian atmosphere as a working medium for power generation and storage, with potential to save over 20 tons of payload in future manned missions.
Researchers are close to building a 'virtual gut' capable of predicting responses to diet, drugs, and microbiome-based therapies. A new review outlines an analytical framework for host-microbiome multi-omics studies, covering preprocessing, feature selection, data integration, predictive modeling, and evaluation.
A study led by Chinese Academy of Sciences reveals climate change leads to unprecedented sensitivity of soil inorganic carbon pools. Climate-driven effects on SIC dynamics are quantified using a novel process-based model, showing significant losses of up to 307 Tg C in topsoil.
Researchers propose an electron-bridge interface using n-type Zn-Al layered double hydroxide (AZH) to address interface failure in zinc anodes. This design enables simultaneous deposition of zinc at the interface and surface, enhancing the anode's adaptability to volume changes.
A novel nickel-based Pickering emulsion catalyst enables gram-scale synthesis of high-purity benzaldehyde with co-produced hydrogen, offering a sustainable alternative to traditional fine chemical synthesis. The synergistic effect of photon-heteroatom jointly promoted redox cycling accelerates the dehydrogenation reaction.
Researchers developed pigs with knocked-down SLA-I/II molecules, showing reduced human complement-dependent cytotoxicity and stronger resistance to T-cell responses. The findings suggest a multi-pronged approach combining genetic modification and targeted immunosuppression for successful pig-to-human transplantation.
Scientists have developed a new material that dramatically improves the efficiency of producing clean hydrogen fuel from water using sunlight. The innovative system, which anchors platinum clusters onto a specially designed organic framework, accelerates the chemical reaction 109 times faster than before.
Researchers map the full phase evolution of IV-VI TMDs, achieving scalable fabrication of atomically thin sheets for flexible thermoelectric devices. Novel phase transition modes are discovered, providing a precise basis for phase regulation and enabling mass production of high-performance materials.
Researchers have achieved a record-breaking transition temperature of 63 K in ambient-pressure nickelate films, surpassing previous limits. This breakthrough utilizes the 'Gigantic-oxidative Atomic-layer-by-layer Epitaxy' method and showcases enhanced Meissner effect and zero-resistance temperatures.
A new cobalt-based dual-atom catalyst significantly enhances oxygen reduction reaction performance while avoiding precious metals. The catalyst achieves remarkable catalytic activity and retains durability, enabling outstanding energy performance in zinc-air batteries.
Researchers develop a nature-inspired hybrid material that produces high-quality therapeutic proteins with nearly tenfold higher efficiency than traditional methods. The material's unique design enables it to adapt to different environments, alleviating hypoxic stress and activating cellular functions.
A new class of electrolytes has been developed that overcomes the bottleneck of water activity in traditional aqueous batteries. The electrolytes work with commonly used zinc salts and achieve exceptional electrochemical performance, including a wide stability window and ultra-long cycling life.
A team of scientists has found that applying pressure to the heavy-fermion ferromagnet Ce5CoGe2 reveals superconductivity above a magnetic quantum critical point, defying typical expectations. The unusual phase diagram suggests that other ingredients beyond magnetic fluctuations may drive superconductivity in this material.
Advances in high-throughput proteomics and artificial intelligence are transforming biomarker discovery, disease prediction, and drug development. Proteomic technologies enable comprehensive snapshots of physiological and pathological states, driving breakthroughs in early diagnosis and personalized treatments.
Simulations suggest Greenland ice sheet changed in response to atmospheric CO2 scenarios and orbital forcing, with increased dynamical instability after expansion. The results imply that other factors, such as Antarctic ice changes and ocean processes, are needed to fully explain the persistence of certain climate cycles.
Researchers developed an ovarian follicle-based angiogenesis microphysiological system that forms complex 3D vascular networks without exogenous VEGF. The platform enables direct visualization and quantitative analysis of vascular remodeling, allowing for the rapid identification of anti-angiogenic compounds with meaningful in vivo act...
Tiny mechanical strain can reshape graphene's electronic landscape, opening a new route for controlling quantum states in two-dimensional materials. Researchers visualize electronic states of strained regions and identify domain walls as robust one-dimensional quantum channels.
Researchers developed a novel spatial-confinement strategy to stabilize high-efficiency perovskite solar cells. The new design creates a 'molecular lock' at the interface, improving durability and thermal cycle stability.
Researchers found that gut microbial communities in estuarine fish are driven by functional traits rather than evolutionary history. The study identified three distinct enterotypes associated with dietary habits and migratory behaviors, revealing specific metabolic adaptations tailored to each host's lifestyle.
Researchers discover that catalyst supports facilitate nitrogen activation by capturing and transferring active nitrogen species, bypassing metal particles. This mechanism boosts ammonia synthesis efficiency and provides new insights for catalyst design.
A novel oral nanoreactor targets isoamylamine, a gut-derived metabolite associated with age-related cognitive decline, by degrading it through monoamine oxidase. The treatment also reduces oxidative stress and improves spatial learning and recognition memory in aged mice.
A research team found that enhanced silicate weathering contributed to CO2 drawdown and the onset of the Late Paleozoic Ice Age, reducing atmospheric CO2 levels by approximately 800 ppm. This process also boosted marine nutrient supply and productivity, leading to the observed shifts in carbon isotopes.
Ovarian cancer cells induce adipose tissue dysfunction and ADSC senescence, creating favorable conditions for tumor metastasis. Targeting senescent ADSCs with dasatinib plus quercetin or resveratrol achieves remarkable efficacy in delaying tumor progression and reducing metastases.
Research reveals OH concentrations in China, Europe, and US are 300% higher than in clean regions, linked to increased NOx emissions. The study's observation-based approach provides a reliable characterization of long-term hydroxyl changes, shedding light on the impact of human activities on atmospheric oxidation capacity
This study reveals that lymphoma cells exhibit organotropism based on their germ-layer origin, with different mutations affecting migration patterns and survival. The research provides insights into the molecular basis of tumor invasion and metastasis, offering a new perspective for personalized cancer treatment.
A comprehensive framework optimizes electrolyte and interface designs to boost efficiency and stability in neutral zinc-air batteries. The multiscale approach addresses key performance issues, including oxygen reaction kinetics and electrode instability.
Scientists have developed a new system enabling unprecedented large-volume photocatalysis driven by low-energy sunlight with wavelengths beyond 1000 nm. The hybrid QDs/Th-DPP NIR-II photosensitizers achieved a record upconversion efficiency of 3.9%, overcoming spectral limitations of visible-light technologies.
Researchers have developed a room-temperature method to separate battery electrode materials from aluminum foil, preserving valuable cathode materials. The process produces clean hydrogen as a byproduct and can be repeated multiple times with high efficiency.
The study uses adaptive machine learning force fields to track sodium metal-electrolyte reactions, achieving a 71% speedup over ab initio molecular dynamics while retaining comparable accuracy. The approach identifies key components of the solid electrolyte interphase, including Na2O and NaOH, which influence its stability.
The study clarifies the typical characteristics and driving factors of Oxygen Minimum Zones (OMZ) in the global ocean, highlighting the role of temperature, ocean circulation, and other factors. The researchers also propose establishing OMZ gradient thresholds for better understanding and management.
Researchers propose a temporally developmental continual learning framework inspired by human brain development, enabling cross-domain learning across perception, motor control, and interaction tasks. The approach achieves stable and strong continual learning performance while reducing network size and mitigating catastrophic forgetting.
A comprehensive review highlights FAK's driving role in tumor progression, immune evasion, and resistance to modern cancer therapies. Emerging strategies targeting FAK's enzymatic and scaffold functions hold promise for overcoming resistance mechanisms.
A recent study elucidated the molecular mechanism by which Fd1 and FNR1 enhance rice thermotolerant yield stability. The research found that overexpression of these genes stabilizes photosynthesis, reduces ROS accumulation, and protects pollen viability.