A randomized, open-label bridging clinical trial was conducted to evaluate the immunogenicity and safety of a 9-valent HPV vaccine in adolescents aged 9-17 years compared to young women. The study found non-inferior immune responses with seroconversion rates comparable to those in young women receiving three doses.
A new optical-coupled scanning probe microscope uses a remote liquefaction cryogen-free system to visualize individual atoms and probe electronic and chemical properties without freezing budget. The system achieves stable base temperature and low noise levels, making it ideal for continuous experiments and studies of slow processes.
Researchers engineered pak choi with a chimeric protein targeting glycolytic enzymes to flavonoids biosynthesis, resulting in intensified sweet flavors. This breakthrough offers a blueprint for sustainable flavor improvement through metabolic engineering.
A new study found that maintaining a healthy weight from early adulthood is associated with lower risks of premature death from various diseases. Excess weight at 25 years old has lasting effects on mortality risk, independent of subsequent weight changes.
Researchers have identified a natural compound called PGG as a MAT2A inhibitor that promotes protein degradation while inhibiting enzymatic activity, offering a promising new strategy for cancer immunotherapy.
Researchers found an ecological conflict zone at mid elevations where human pressure overlaps with biodiversity hotspots, despite low protected area coverage. This convergence requires differentiated management strategies across elevation zones to safeguard mountain ecosystems.
Researchers discovered that PCGF1 is essential for maintaining H3K27me3 homeostasis during early embryonic development. Its absence leads to dysregulation of pluripotency gene silencing, causing cells to remain in a stem cell-like state and fail to commit to specific lineages.
In vivo CAR-T therapy bypasses ex vivo manufacturing, preserving native T-cell function and improving accessibility. Recent clinical progress demonstrates encouraging results in hematologic malignancies and autoimmune diseases.
A new graphdiyne nano-iontronic device enables selective pH detection in single cells, showing fast and reversible responses to pH shifts. The device retains accurate proton sensing even in the presence of interferents, demonstrating its potential for real-time intracellular pH detection.
New class of moiré materials enables exploration of diverse quantum phases, including strongly correlated and topological phases. Researchers have observed various effects, such as integer and fractional quantum anomalous Hall effects, at zero external magnetic field.
Researchers developed micro-pillar patterned electrodes with ordered ionomer structures to improve proton conduction and oxygen delivery, enhancing fuel cell performance. The design enabled robust operation under dry conditions and maintained electrochemical surface area, outperforming conventional electrodes.
Chinese researchers developed an integrated oxygen redox and solid solution design to achieve high voltage stability for practical sodium ion battery cathodes. The innovative FMT material shows superior cycling stability, rate capability, and air stability, overcoming key bottlenecks hindering high-voltage O3-type layered oxides.
Therapy-related myeloid neoplasms (t-MN) pose a significant threat to female cancer survivors, with limited treatment options and high mortality rates. New therapies and diagnostic approaches, such as CAR-T and hypomethylating agents, offer hope for improved treatment outcomes and prevention.
Researchers propose adaptive protocol for GHZ states, combining short and long measurements to achieve high precision while maintaining dynamic range. This approach enables dual Heisenberg-limited scaling, surpassing older methods, and proves more resilient to noise and dephasing.
Researchers have developed a reconfigurable textile interface that supports flat touch, folded 3D manipulation, and shape-change commands. The 'one cloth, many states' framework reduces the need to swap props and recalibrate alignment, making it promising for constrained-space operation training and human-machine interaction scenarios.
Researchers integrated topological photonics with nanoimprint lithography (NIL) to create a stable nanolaser. The work demonstrated type-III corner states and robustness against fabrication defects.
Researchers identify a three-way link between mechanical stress, integrin signaling, and endocytosis in osteoarthritis. Integrin trafficking may help explain why the same pathways have different effects across disease stages and tissue contexts.
Scientists discover arachidonic acid (AA) mediates oxidative stress-induced intestinal injury. AA treatment inhibits organoid activity and stem cell differentiation, leading to reduced goblet and endocrine cells. Inhibiting AA production with a specific inhibitor improves organoid vitality.
Researchers developed a smart window that uses electromagnetic Weber beams to eliminate blind zones in in-vehicle communications. The system demonstrates significant improvements in 5G signal power, enabling real-time transmissions of high-fidelity images.
A new brain-computer interface (BCI) has been developed that records brain activity from the lateral ventricle, a cerebrospinal fluid-filled cavity deep within the brain. The BCI showed signal bandwidth comparable to standard electrodes, but with superior long-term stability and a reduced immune response.
Researchers have discovered a tumor biomarker that can predict which gastric cancer patients will benefit from immunotherapy before surgery. The biomarker, tsMHC-II expression, showed strong correlation with treatment response and was easily assessable using standard immunohistochemistry techniques.
A new model, Xi–αNET, explains how brain structure and signal conduction speed shape alpha waves and background activity. The study found that faster conduction speeds in younger individuals correspond to higher alpha frequencies, while slower conduction speeds in older adults lead to declining alpha frequencies.
A transcription factor phosphorylation switch, OsAHL23, dynamically balances immune responses and growth in rice. The switch is precisely controlled by the kinase OsMPK5 and phosphatase PP2A-A.
Scientists created a room-temperature, zero-power infrared sensor with high sensitivity and fast response time. The device uses a novel asymmetric electrode structure to separate generated electrical charges, enabling clear images without external power.
Researchers identified MIEL1 as an E3 ligase that cooperates with XBAT31 to regulate thermoresponsive growth in plants. MIEL1 blocks XBAT31's auto-ubiquitination and self-degradation, maintaining its protein stability.
Researchers found that three-dimensional velocity models can reasonably reproduce observed ground motion, outperforming one-dimensional models. Averaging predictions from multiple models reduces systematic bias and improves results.
New zircon U–Pb dates indicate that major oil-source rocks formed during three separate periods between the late Carboniferous and middle Permian. The study provides a refined timeline of geological events, shedding light on the region's tectonic evolution and informing energy exploration.
Researchers found that endometrial microbiota imbalances contribute to recurrent implantation failure, with dimethylglycine supplementation potentially reversing the effects. The study suggests a complex interplay between microbiota, metabolites, and Treg cells in regulating endometrial receptivity.
A genome-wide CRISPR/Cas9 knockout screen identified two critical host factors, SLC35A1 and LSM12, essential for BPIV3 replication. Knockout of these genes significantly inhibits viral infection, revealing novel antiviral strategies to combat Bovine Respiratory Disease Complex.
Research reveals DHEA's role in regulating sperm motility through the Gs–cAMP–PKA signaling pathway. It also modulates reproductive tract ion homeostasis by enhancing ADGRG2–CFTR functional coupling.
Researchers have developed programmable nanofluidic neuromorphic devices with adjustable electrical performance, achieved through tuning ionic concentration and species. The devices exhibit hysteresis behaviors due to distinct physical origins, enabling multifunctional responses.
Iron oxyhydroxide nanorods trigger cytotoxic hydroxyl and superoxide radicals in cancer cells through sono-tribocatalytic therapy. The treatment disrupts mitochondrial function and redox homeostasis, leading to PANoptosis in cancer cells.
Scientists create a pair of copper-based metal clusters that can be controlled to convert light into electricity. The clusters exhibit enhanced light-induced conversion efficiency due to adjustable core composition. This breakthrough enables the development of cluster-based solid-state nanomaterials with customizable photoresponse prop...
Researchers discovered a new organic molecule that can boost the efficiency of non-doped blue OLEDs. By manipulating the exciton mechanism, they created a record-breaking device with an external quantum efficiency of 20.3%, outperforming existing emitters.
The study found that complex terrain, particularly orographic gravity wave drag, significantly affects the location and intensity of extreme precipitation. Without this effect, the low-level mesoscale vortex moves westward, leading to decreased rainfall intensity and a northwestward shift of the rainfall center.
A research team found that sweet osmanthus flowers use their intense fragrance to repel honeybees and other pollen feeders, while attracting tiny pollinators like thrips. This 'push–pull' strategy helps the plant filter out unwanted visitors and maintain reproductive success.
A comprehensive phylogenomic tree of ciliates has been reconstructed, providing a new framework for the phylum Ciliophora. The study establishes three main lineages and a divergence timeline linking key splits to major Earth history events. This robust phylogenetic framework enables precise tracing of key evolutionary innovations.
The journal focuses on advancing scientific understanding and expanding engineering horizons through rigorous peer-reviewed, open-access research. ASI aims to be the preeminent hub for pioneering next-generation scientific tools and fostering global collaboration.
Recent scientific review highlights Ga-LMs' natural fluidity, high electrical conductivity, and biocompatibility, making them suitable for wearable health monitoring systems, soft robots, and implantable medical devices. Advanced patterning techniques enable precise fabrication of Ga-LM-based circuits for high-performance HMIs.
Researchers have achieved first-ever in-situ polarization control in high-field infrared spectroscopy, overcoming a decades-old technical bottleneck. The newly developed collimated magneto-infrared spectroscopy system enables continuous modulation of polarization states under high magnetic fields and cryogenic temperatures.
Chinese researchers develop novel post-dual OPA technique to amplify weak SFG signals, enabling detection of molecular signals at surfaces. The breakthrough opens possibilities for studying transient species in chemical reactions and other systems where surface molecular structure determines function.
Researchers integrated transient optical spectroscopy with ultrafast electron microscopy to capture both electronic and structural dynamics simultaneously. This enables the study of heterogeneous materials, phase transitions, and light-driven functional responses with implications for solar cells, quantum computing, and next-generation...
The study reveals that bonding heterogeneity, rather than geometric similarity, governs relaxation dynamics in glasses. By incorporating electronic structure and chemical interactions, researchers establish a new physical framework for understanding structure-relaxation coupling in glasses.
Researchers reveal that coronaviruses hijack specific cellular protein to build large compartments for viral assembly, leading to reduced viral production in cells lacking the HGS protein. The discovery opens new avenues for antiviral therapy by targeting the interaction between HGS and viral proteins.
Researchers developed a new eDNA sampling membrane that captures DNA fragments with high efficiency, detecting multiple tropical coral reef fish species. The membrane, coated with molybdenum disulfide nanosheets, enables preferential interactions with DNA bases, improving the capture of trace eDNA from large volumes of seawater.
Researchers have developed bioengineered extracellular vesicles with enhanced therapeutic functionality, which can precisely target injured cardiac tissue and deliver therapeutic cargos. These bioengineered EVs have shown promising results in preclinical models of myocardial infarction, heart failure, and pulmonary arterial hypertension.
Researchers have developed an 'ECI patch' that reads brain signals and controls cars with 93.5% accuracy. The patch, powered by ultra-thin sheets called MXene, detects fatigue and mental states without causing skin irritation.
A research team has pioneered a novel optical neural network that physically 'learns' through associative light exposure, eliminating the need for traditional computing algorithms. The system successfully recognized letters and demonstrated capability in handwritten digit recognition.
Microbial community shifts from biotic to abiotic drivers under drought, with legacy effects persisting upon rehydration. Soil properties dominate recovery stages, highlighting dual focus on biology and abiotic factors for ecosystem resilience.
A novel soft biosensor with printable responsive hydrogel interfaces was developed for precise detection and differentiation of blood circulation complications in postoperative free flaps. The biosensor achieved high adhesion and high-fidelity signal acquisition while exhibiting low adhesion after monitoring to avoid wound damage.