Tiny mechanical strain can reshape graphene's electronic landscape, opening a new route for controlling quantum states in two-dimensional materials. Researchers visualize electronic states of strained regions and identify domain walls as robust one-dimensional quantum channels.
Researchers developed a novel spatial-confinement strategy to stabilize high-efficiency perovskite solar cells. The new design creates a 'molecular lock' at the interface, improving durability and thermal cycle stability.
Researchers found that gut microbial communities in estuarine fish are driven by functional traits rather than evolutionary history. The study identified three distinct enterotypes associated with dietary habits and migratory behaviors, revealing specific metabolic adaptations tailored to each host's lifestyle.
Researchers discover that catalyst supports facilitate nitrogen activation by capturing and transferring active nitrogen species, bypassing metal particles. This mechanism boosts ammonia synthesis efficiency and provides new insights for catalyst design.
A novel oral nanoreactor targets isoamylamine, a gut-derived metabolite associated with age-related cognitive decline, by degrading it through monoamine oxidase. The treatment also reduces oxidative stress and improves spatial learning and recognition memory in aged mice.
A research team found that enhanced silicate weathering contributed to CO2 drawdown and the onset of the Late Paleozoic Ice Age, reducing atmospheric CO2 levels by approximately 800 ppm. This process also boosted marine nutrient supply and productivity, leading to the observed shifts in carbon isotopes.
Ovarian cancer cells induce adipose tissue dysfunction and ADSC senescence, creating favorable conditions for tumor metastasis. Targeting senescent ADSCs with dasatinib plus quercetin or resveratrol achieves remarkable efficacy in delaying tumor progression and reducing metastases.
Research reveals OH concentrations in China, Europe, and US are 300% higher than in clean regions, linked to increased NOx emissions. The study's observation-based approach provides a reliable characterization of long-term hydroxyl changes, shedding light on the impact of human activities on atmospheric oxidation capacity
This study reveals that lymphoma cells exhibit organotropism based on their germ-layer origin, with different mutations affecting migration patterns and survival. The research provides insights into the molecular basis of tumor invasion and metastasis, offering a new perspective for personalized cancer treatment.
A comprehensive framework optimizes electrolyte and interface designs to boost efficiency and stability in neutral zinc-air batteries. The multiscale approach addresses key performance issues, including oxygen reaction kinetics and electrode instability.
Scientists have developed a new system enabling unprecedented large-volume photocatalysis driven by low-energy sunlight with wavelengths beyond 1000 nm. The hybrid QDs/Th-DPP NIR-II photosensitizers achieved a record upconversion efficiency of 3.9%, overcoming spectral limitations of visible-light technologies.
Researchers have developed a room-temperature method to separate battery electrode materials from aluminum foil, preserving valuable cathode materials. The process produces clean hydrogen as a byproduct and can be repeated multiple times with high efficiency.
The study uses adaptive machine learning force fields to track sodium metal-electrolyte reactions, achieving a 71% speedup over ab initio molecular dynamics while retaining comparable accuracy. The approach identifies key components of the solid electrolyte interphase, including Na2O and NaOH, which influence its stability.
The study clarifies the typical characteristics and driving factors of Oxygen Minimum Zones (OMZ) in the global ocean, highlighting the role of temperature, ocean circulation, and other factors. The researchers also propose establishing OMZ gradient thresholds for better understanding and management.
Researchers propose a temporally developmental continual learning framework inspired by human brain development, enabling cross-domain learning across perception, motor control, and interaction tasks. The approach achieves stable and strong continual learning performance while reducing network size and mitigating catastrophic forgetting.
A comprehensive review highlights FAK's driving role in tumor progression, immune evasion, and resistance to modern cancer therapies. Emerging strategies targeting FAK's enzymatic and scaffold functions hold promise for overcoming resistance mechanisms.
A recent study elucidated the molecular mechanism by which Fd1 and FNR1 enhance rice thermotolerant yield stability. The research found that overexpression of these genes stabilizes photosynthesis, reduces ROS accumulation, and protects pollen viability.
A randomized, open-label bridging clinical trial was conducted to evaluate the immunogenicity and safety of a 9-valent HPV vaccine in adolescents aged 9-17 years compared to young women. The study found non-inferior immune responses with seroconversion rates comparable to those in young women receiving three doses.
A new optical-coupled scanning probe microscope uses a remote liquefaction cryogen-free system to visualize individual atoms and probe electronic and chemical properties without freezing budget. The system achieves stable base temperature and low noise levels, making it ideal for continuous experiments and studies of slow processes.
Researchers engineered pak choi with a chimeric protein targeting glycolytic enzymes to flavonoids biosynthesis, resulting in intensified sweet flavors. This breakthrough offers a blueprint for sustainable flavor improvement through metabolic engineering.
A new study found that maintaining a healthy weight from early adulthood is associated with lower risks of premature death from various diseases. Excess weight at 25 years old has lasting effects on mortality risk, independent of subsequent weight changes.
Researchers have identified a natural compound called PGG as a MAT2A inhibitor that promotes protein degradation while inhibiting enzymatic activity, offering a promising new strategy for cancer immunotherapy.
Researchers found an ecological conflict zone at mid elevations where human pressure overlaps with biodiversity hotspots, despite low protected area coverage. This convergence requires differentiated management strategies across elevation zones to safeguard mountain ecosystems.
Researchers discovered that PCGF1 is essential for maintaining H3K27me3 homeostasis during early embryonic development. Its absence leads to dysregulation of pluripotency gene silencing, causing cells to remain in a stem cell-like state and fail to commit to specific lineages.
In vivo CAR-T therapy bypasses ex vivo manufacturing, preserving native T-cell function and improving accessibility. Recent clinical progress demonstrates encouraging results in hematologic malignancies and autoimmune diseases.
A new graphdiyne nano-iontronic device enables selective pH detection in single cells, showing fast and reversible responses to pH shifts. The device retains accurate proton sensing even in the presence of interferents, demonstrating its potential for real-time intracellular pH detection.
New class of moiré materials enables exploration of diverse quantum phases, including strongly correlated and topological phases. Researchers have observed various effects, such as integer and fractional quantum anomalous Hall effects, at zero external magnetic field.
Researchers developed micro-pillar patterned electrodes with ordered ionomer structures to improve proton conduction and oxygen delivery, enhancing fuel cell performance. The design enabled robust operation under dry conditions and maintained electrochemical surface area, outperforming conventional electrodes.
Chinese researchers developed an integrated oxygen redox and solid solution design to achieve high voltage stability for practical sodium ion battery cathodes. The innovative FMT material shows superior cycling stability, rate capability, and air stability, overcoming key bottlenecks hindering high-voltage O3-type layered oxides.
Therapy-related myeloid neoplasms (t-MN) pose a significant threat to female cancer survivors, with limited treatment options and high mortality rates. New therapies and diagnostic approaches, such as CAR-T and hypomethylating agents, offer hope for improved treatment outcomes and prevention.
Researchers propose adaptive protocol for GHZ states, combining short and long measurements to achieve high precision while maintaining dynamic range. This approach enables dual Heisenberg-limited scaling, surpassing older methods, and proves more resilient to noise and dephasing.
Researchers have developed a reconfigurable textile interface that supports flat touch, folded 3D manipulation, and shape-change commands. The 'one cloth, many states' framework reduces the need to swap props and recalibrate alignment, making it promising for constrained-space operation training and human-machine interaction scenarios.
Researchers integrated topological photonics with nanoimprint lithography (NIL) to create a stable nanolaser. The work demonstrated type-III corner states and robustness against fabrication defects.
Researchers identify a three-way link between mechanical stress, integrin signaling, and endocytosis in osteoarthritis. Integrin trafficking may help explain why the same pathways have different effects across disease stages and tissue contexts.
Scientists discover arachidonic acid (AA) mediates oxidative stress-induced intestinal injury. AA treatment inhibits organoid activity and stem cell differentiation, leading to reduced goblet and endocrine cells. Inhibiting AA production with a specific inhibitor improves organoid vitality.
Researchers developed a smart window that uses electromagnetic Weber beams to eliminate blind zones in in-vehicle communications. The system demonstrates significant improvements in 5G signal power, enabling real-time transmissions of high-fidelity images.
A new brain-computer interface (BCI) has been developed that records brain activity from the lateral ventricle, a cerebrospinal fluid-filled cavity deep within the brain. The BCI showed signal bandwidth comparable to standard electrodes, but with superior long-term stability and a reduced immune response.
Researchers have discovered a tumor biomarker that can predict which gastric cancer patients will benefit from immunotherapy before surgery. The biomarker, tsMHC-II expression, showed strong correlation with treatment response and was easily assessable using standard immunohistochemistry techniques.
A new model, Xi–αNET, explains how brain structure and signal conduction speed shape alpha waves and background activity. The study found that faster conduction speeds in younger individuals correspond to higher alpha frequencies, while slower conduction speeds in older adults lead to declining alpha frequencies.
A transcription factor phosphorylation switch, OsAHL23, dynamically balances immune responses and growth in rice. The switch is precisely controlled by the kinase OsMPK5 and phosphatase PP2A-A.
Scientists created a room-temperature, zero-power infrared sensor with high sensitivity and fast response time. The device uses a novel asymmetric electrode structure to separate generated electrical charges, enabling clear images without external power.
Researchers identified MIEL1 as an E3 ligase that cooperates with XBAT31 to regulate thermoresponsive growth in plants. MIEL1 blocks XBAT31's auto-ubiquitination and self-degradation, maintaining its protein stability.
Researchers found that three-dimensional velocity models can reasonably reproduce observed ground motion, outperforming one-dimensional models. Averaging predictions from multiple models reduces systematic bias and improves results.
New zircon U–Pb dates indicate that major oil-source rocks formed during three separate periods between the late Carboniferous and middle Permian. The study provides a refined timeline of geological events, shedding light on the region's tectonic evolution and informing energy exploration.
Researchers found that endometrial microbiota imbalances contribute to recurrent implantation failure, with dimethylglycine supplementation potentially reversing the effects. The study suggests a complex interplay between microbiota, metabolites, and Treg cells in regulating endometrial receptivity.
A genome-wide CRISPR/Cas9 knockout screen identified two critical host factors, SLC35A1 and LSM12, essential for BPIV3 replication. Knockout of these genes significantly inhibits viral infection, revealing novel antiviral strategies to combat Bovine Respiratory Disease Complex.
Research reveals DHEA's role in regulating sperm motility through the Gs–cAMP–PKA signaling pathway. It also modulates reproductive tract ion homeostasis by enhancing ADGRG2–CFTR functional coupling.
Researchers have developed programmable nanofluidic neuromorphic devices with adjustable electrical performance, achieved through tuning ionic concentration and species. The devices exhibit hysteresis behaviors due to distinct physical origins, enabling multifunctional responses.
Iron oxyhydroxide nanorods trigger cytotoxic hydroxyl and superoxide radicals in cancer cells through sono-tribocatalytic therapy. The treatment disrupts mitochondrial function and redox homeostasis, leading to PANoptosis in cancer cells.
Scientists create a pair of copper-based metal clusters that can be controlled to convert light into electricity. The clusters exhibit enhanced light-induced conversion efficiency due to adjustable core composition. This breakthrough enables the development of cluster-based solid-state nanomaterials with customizable photoresponse prop...