Nucleosome assembly protein Nap1 safeguards genome integrity by regulating chromatin dynamics and guiding nuclear division. Its deletion disrupts cellular processes, leading to structural aberrations and genomic instability.
Scientists successfully demonstrated reversible topological phase transitions in β-Ag2Te using out-of-plane gate voltages. This breakthrough enables the creation of functional electronic components with high current on-off ratios, overcoming previous hurdles in practical application.
Researchers from Sun Yat-sen University discover a novel mechanism by which tsRNA-Gly promotes hepatocyte regeneration in ACLF. The study reveals that tsRNA-Gly activates GRHL1 and upregulates CCND1, driving liver regeneration.
A novel operator learning framework tackles the ill-posedness in inverse thermal problems by employing two synergistic deep learning components. The framework accurately estimates spatial material properties and filters high-frequency noise to project the final-state thermal field back to its initial distribution.
Research finds that advanced maternal age reduces autophagy in embryos from aged female mice, leading to impaired embryonic development. Supplementation with Rapamycin improves early embryonic development by regulating metabolic pathways.
A population-based study found that radical nephroureterectomy was associated with better overall and cancer-specific survival compared to kidney-sparing surgery. Tumor stage, size, lymph node dissection status, and patient-specific factors play a crucial role in individualized surgical planning.
Researchers identify hormone-driven molecular cascade enhancing K⁺ uptake in cotton under low-K⁺ conditions, revealing synergy between jasmonic acid and ethylene pathways. Foliar application of MeJA or ACC improves leaf K⁺ concentration and photosynthetic performance, increasing seed cotton yield by 11.6%.
A new study investigated the effects of ornidazole, an antimicrobial drug, on male fertility. Ornidazole was found to reduce sperm count and motility, as well as disrupt seminiferous tubule structure, in both mouse and human models.
Astronomers have discovered a new millisecond pulsar named PSR J1810−0623, featuring an exceptionally circular orbit. This discovery provides valuable information about binary evolution processes and the Galactic magnetic field structure.
Researchers identify CLASS 3G subtype of EGFR mutation associated with limited response to targeted drugs. This structural subtype alters protein shape, reducing treatment efficacy and allowing for more effective combination therapy.
The review highlights advances in multi-scale bioelectrical interactions, analyzing challenges such as interface impedance and material-tissue compatibility. It emphasizes a shift towards application-driven design, integrating biological needs with material selection and device engineering.
Topological methods have become a robust testing ground in black hole physics, revealing distinctive topological attributes of diverse black hole solutions. The review summarizes recent work toward universal topological classifications of black holes, organizing them according to their global topological number and winding numbers.
Researchers create siRNA delivery system based on IVSA technology, which targets EGFR-positive tumors with high efficacy and low toxicity. The system enables precise targeting and overcomes drug resistance challenges.
A new study reveals that climate change will reshape the surface sunlight map, making polar regions dimmer and mid-latitude areas brighter. The redistribution of sunlight may impact energy balance, snow and ice processes, hydrological cycles, and solar energy resources.
Methanol-to-hydrocarbons reactions exhibit multiscale heterogeneity due to differences in molecular diffusion, crystal structure, particle composition, and reactor conditions. This nonuniformity affects catalyst performance and product selectivity.
Researchers developed a quantum sensing approach using superconducting qubits, combining non-equilibrium dynamics and quantum criticality to measure gradient field strengths with quantum-limit precision. The method avoids complex measurement setups, enabling highly precise estimates of gradient field strengths with limited samples.
Researchers discovered that exercise enhances oxygen delivery to arthritic joints through tiny vesicles released from red blood cells, relieving tissue hypoxia and promoting joint health. Physical activity drives the circulation of these EVs into the joint, where they deliver oxygen and maintain joint function.
The ESOT FiSensor combines electrical signals with light transmission, allowing simultaneous monitoring of vibration, pressure, temperature, and strain through a single fiber. Tests show exceptional performance with over 90% sensitivity retention after traveling 50 meters.
Researchers developed anisotropy-tunable mesoporous polydopamine nanomotors with POM-mediated assembly, which combine intrinsic antibacterial activity, self-propulsion, and high drug-loading capacity. These nanomotors demonstrate enhanced antibacterial efficiency and biofilm eradication against drug-resistant bacterial biofilms.
A nonvolatile phase-programmable spintronic terahertz emitter has been developed, allowing for ultrafast programming of terahertz wave phases. The device demonstrates reversible write-read-reset processes and spatial terahertz phase patterning with high signal-to-noise ratios.
Researchers found that Buyang Huanwu Decoction alleviates acute inflammation following spinal cord injury by regulating the complement and coagulation cascades. The treatment promotes neuroprotection and motor function recovery, suppressing microglia-mediated inflammation.
Researchers developed a lock-in thermography-based method to rapidly characterize structural imperfections in freestanding oxide membranes. The study found distinct thermal responses for different types of defects, including microcracks and wrinkles, enabling efficient defect screening and quality evaluation.
Researchers introduce a set of universal relations that connect spectrum shapes to wave behavior in one-dimensional disordered systems. The framework reveals a never-before-seen critical state where waves localize differently depending on direction, and shows how it can be tracked using a topological winding number.
Researchers created a detailed atlas of human brain-vessel morphology, revealing subtle changes linked to stroke prognosis and suggesting that small-vessel features may help explain worse recovery outcomes. The atlas, MARVAL, provides a standardized tool for measuring the vascular network in large populations.
Researchers developed CardioNVT, an AI platform for high-throughput cardiomyocyte ploidy assessment. The platform accurately recognizes and segments cardiomyocyte nuclei from DAPI-stained images, enabling the analysis of nuclear volume distribution and inferred ploidy.
A novel deep learning framework integrates high-resolution pathology images with spatial transcriptomics and proteomics to reveal complex intra-tumor heterogeneity in colorectal cancer. The approach identifies distinct molecular subtypes that correlate with immune cell infiltration patterns.
Mitochondrial damage fuels neuroinflammation in CNS diseases, but targeted nanomedicines can restore function and reduce inflammation. Intelligent nanomaterials designed to cross the blood-brain barrier have shown striking efficacy in preclinical models.
Researchers developed ultrathin CdS nanosheets decorated with Ru single atoms and S vacancies, enabling record-high performance for ethanol photoreforming. The catalyst achieved a hydrogen evolution rate 81.5 times higher than pristine CdS and 100% selectivity for valuable chemicals.
The global incidence of type 1 diabetes nearly tripled over the past three decades, while health inequalities worsened. Lower-income countries carry a disproportionately large share of T1DM-related deaths and years of life lost due to disparities in access to insulin treatment and healthcare resources.
Researchers optimize blue perovskite LEDs by introducing ordered dipolar PVDF, improving carrier transport and recombination. The breakthrough results in world-record device performance, exceeding 43.9 lm W−1 peak power efficiency.
Researchers recreated the maternal-embryo interface using a novel co-culture system and mapped lipid metabolic dynamics during early implantation. Arachidonic acid metabolism is essential for embryo attachment, endometrial receptivity, and trophoblast development.
UPL3 E3 ubiquitin ligase promotes light-induced seed germination by degrading PIF1. The study reveals a critical role for UPL3 in mediating PIF1 degradation through the 26S proteasome pathway.
Researchers successfully created a novel, stably inheritable grass carp germplasm without intermuscular bones using the runx2b gene. The absence of IBs did not affect the fish's quality or nutritional profile, but improved gel strength and resilience were observed.
Researchers summarize how AI is accelerating inorganic biomaterial development for various biomedical applications. AI-powered property prediction and inverse design tools are being used to discover effective materials with unique properties.
Researchers developed targeted platinum-antibody conjugates that effectively enhance tumor immunogenicity and promote anti-tumor immunity. The low-dose platinum delivery strategy showed strong synergy with anti-PD-1 therapy, achieving tumor suppression superior to monotherapy or simple combination treatment.
Researchers developed a Pt–CuOx interfacial catalyst that converts HMF to FDCA at significantly lower voltages, achieving 99.1% FDCA selectivity and 93.8% yield. The optimized catalyst demonstrated excellent durability, maintaining over 90% selectivity for more than 110 hours.
A novel therapeutic paradigm combines electroacupuncture with regenerative tissue engineering to enhance nerve regeneration and functional recovery in spinal cord injury. The study found that electroacupuncture stimulation improved neural signal transmission, suppressed neuroinflammation, and promoted myelin regeneration.
A novel thermal transport phenomenon is discovered in an actively controlled system, where heat continuously accumulates towards one boundary, forming a robust temperature localization profile. The phenomenon exhibits remarkable robustness against external disturbances and topological transitions.
A nationwide study found 65% of China's freshwater is stored in remote western lakes, creating a severe spatial imbalance between water and population distribution. The Tibetan Plateau holds significantly more freshwater than the densely populated eastern plains.
A global meta-analysis of 8509 field observations found that plant-based and animal-based carbon inputs significantly improve agroecosystem multifunctionality. Soil biota abundance was strongly linked to multifunctionality and showed more frequent win-win relationships with other functions than species richness.
Scientists have successfully decoded the polarization cipher of high-energy electrons, demonstrating a new pathway to creating highly polarized gamma-ray sources. The study's findings confirm key predictions of quantum electrodynamics and open up new design options for mid- to high-energy gamma-ray sources.
Researchers established the first complete, exactly solvable framework that unifies all seven fundamental localization phases in quasiperiodic systems. The framework also points to a concrete route for realizing predicted physics with ultracold atoms, offering new opportunities for experimental realization.
Researchers developed a universal compounding technology to integrate up to 59% of carbon nanotubes (CNTs) into polymer matrices, improving material performance. The resulting CNT superplastics exhibit excellent mechanical, electrical, and thermal properties.
A research team has successfully realized a non-Hermitian higher-order Weyl exceptional ring semimetal in a lossy acoustic metamaterial. The material hosts Weyl exceptional rings with dual topological charges, giving rise to Fermi arc surface states and surface-dependent skin effect.
Researchers developed a flexible electrochemical sensing platform that captures dynamic small-molecule chemical signals in the gut. The platform reveals a new mechanism underlying enhanced intestinal mechanosensation under microbe-related stimulation, enabling real-time monitoring of serotonin release.
Scientists propose a strategy to control π-electron delocalization in polycyclic aromatic hydrocarbons, enabling the synthesis of narrow-spectrum emission materials. This approach results in red emitters with high efficiency, narrow spectral width, and record-high performance in OLED devices.
Researchers identified OsSD7, an F-box protein that regulates seed dormancy and resistance to pre-harvest sprouting (PHS) in rice. The study found that natural variation in this gene provides valuable resources for breeding PHS resistance.
A research team has achieved a major breakthrough in characterizing altermagnets, a newly discovered class of magnetic materials. They successfully visualized magnetic domains in RuO2 using lock-in thermography and the spin-dependent Peltier effect, resolving long-standing challenges in this emerging field.
A novel copper-based MOF material reduces CO2 to carbon monoxide and subsequently produces higher-value compounds, such as N-formamides, under visible light irradiation. The system offers a simpler and potentially greener alternative to conventional routes that rely on precious-metal catalysts and high temperatures.
Lanthanide nanoprobes have improved signal-to-noise ratio, enabling ultrasensitive detection of cancer biomarkers and visual identification of cancer cells. The nanoparticles maintain stable luminescence across a wide pH range and in simulated human body fluids, ensuring reliable performance.