Using TaS2 as a model system, researchers demonstrate that coordinated interlayer sliding and intralayer atomic reconstruction can reorganize layered crystals into adaptive hetero-phase superlattices. This enables the construction of superlattice architectures and controlling emergent quantum states in layered materials.
Researchers found that aged granulosa cells derived from iPSCs exhibit impaired germ cell differentiation due to age-related mitochondrial damage and nuclear ageing. However, inhibiting the ERK/MAPK pathway can partially rescue this defect, suggesting a promising strategy for improving germ cell regeneration.
Hankelformer improves forecasting of extreme weather events by capturing local spatiotemporal dynamics and enhancing feature invariance. It achieves state-of-the-art performance on multiple datasets, including energy, transportation, and extreme weather domains.
Researchers identify three water molecules as minimal unit for efficient catalytic dynamics in aqueous environments. The discovery reveals a unique 'structural switch' mechanism, enabling fast proton transport and resolving the long-standing question about the threshold required for collective catalysis.
Researchers identify H6PD as a novel causative gene for autosomal recessive Parkinson's disease, linked to disruption of ER-mitochondria connection. The study reveals that this genetic defect leads to energy failure and neuron death in dopaminergic neurons.
A single-cell atlas reveals that a balance between two macrophage states, with lipid-fueled immunesupressors, tracks clinical outcomes in gastric cancer patients. Tumors with a more permissive immune state respond better to immunotherapy and have longer progression-free survival.
The study targets microglia, brain immune cells involved in inflammation after sepsis. Evodiamine-loaded liposomes deliver anti-inflammatory treatment to the affected areas, reducing brain inflammatory signals and protecting hippocampal neurons.
Researchers discovered two families of non-Hermitian solitons, SMASs and NRDSs, differing in formation thresholds and underlying physical mechanisms. Skin-mode localization suppresses wave spreading, while band nonreciprocity enhances it, giving rise to distinct nonlinear localized states.
Researchers have discovered a new class of high-Tc superconductors among 5d transition-metal-oxides, with the highest Tc recorded at 17.8 K in ReO3. The discovery is attributed to the synergistic mechanism of pressure-enhanced orbital hybridization and oxygen-lattice-dominated electron-phonon coupling.
Researchers challenged the double water bulge model by analyzing tidal data from satellite observations. They found that only 56.84% of locations experienced low tides and 43.16% experienced high tides, contradicting the physical existence of two water bulges.
Climate change is altering the distribution of cropland nitrogen pollution in China, with emerging hotspots shifting from the south to the north. Nitrogen accumulation in soils and increased rainfall are key drivers of this shift.
Researchers discover that manipulating the chiral asymmetry factor of catalysts accelerates sulfur redox reactions, leading to higher capacities, superior rate capability, and remarkable long-term cycling stability in lithium-sulfur batteries.
A new study by Dr. Wu Yuan's team reveals that retinal AI can lose accuracy in high-altitude populations due to altitude-associated domain shift. MIXFound, a lightweight framework, offers a practical solution to improve robustness and correct for these differences.
Researchers found that eustress reduces CCL2 expression, alleviating cardiac damage and enhancing chemotherapy response. Eustress also remodels the tumor immune microenvironment, increasing cytotoxic CD8⁺ T cells and anti-tumor M1-type macrophages.
Researchers developed a deep-learning compiler to map user-designed illusion patterns to programmable metasurfaces, enabling rewritable and customizable electromagnetic illusions. The metasurface can create complex two-dimensional illusions that adapt to changing conditions.
Halide cathode materials, long overlooked due to dissolution in liquid electrolytes, now enable dramatically higher energy densities through a fundamental shift in battery chemistry. Key strategies include multi-electron reactions, protective coatings, and nanostructuring to address stability issues.
A new study identified functional noncoding variants in the TBX1 enhancer that contribute to tetralogy of Fallot. These variants reduce TBX1 expression, disrupt outflow tract vessel formation, and lead to reduced angiogenesis, vessel regression, and abnormal tight junction morphology.
Ancient populations across six regions in the central-eastern Eurasian Steppe shifted their diets in near-perfect synchrony over 4,000 years. The study suggests that climate, mobility, and advances in milling technology drove these dietary transitions.
The discovery of Ganiopteris, a 360-million-year-old seed plant from China, provides clear evidence of the earliest-known leaf-borne ovules. This finding marks a major evolutionary milestone and sheds new light on the origin of Permian glossopterids.
Researchers have developed a directly synthesized p-type PbS QD ink to overcome the bottleneck of large-area film uniformity. The approach enabled broad spectral tunability and dense, crack-free films with reduced thickness variation, leading to improved imaging performance.
Researchers have discovered novel quantum phenomena in twisted graphene, including orbital magnetism, quantum anomalous Hall effect, and unconventional superconductivity. The review highlights the flatband electronic structure of magic-angle bilayer graphene, driving complex behaviors like correlated insulators and topological states.
A comprehensive genomic analysis of idiopathic male infertility has identified specific gene defects tied to assisted reproductive technology (ART) outcomes. The study offers actionable insights for infertile men, guiding testicular sperm retrieval, donor sperm use, or ICSI prognosis.
A recent study reveals that tumor cells undergo profound cellular identity reshaping during metastasis in head and neck squamous cell carcinoma (HNSCC), characterized by 'identity rewriting'. WDR54 is identified as a key epigenetic regulator driving this process, promoting tumor-cell lineage plasticity and metastatic progression.
Researchers developed a skin-worn Janus bioelectrode that uses gradient impedance to suppress electromagnetic interference and maintain signal quality. The electrode achieved high recognition accuracy for human motion states when combined with electromyography and electrocardiography signals.
Researchers found that tumor cells use DDB1 to ubiquitinate PD-L1, allowing it to enter the nucleus and drive immune suppression. A new compound, thalidomide, disrupts this process, restoring sensitivity to immunotherapy in preclinical breast cancer models.
Scientists created thresholdless corner vortex solitons that unify topological corner states and vortex light, enabling stable high-speed data transmission. The new solitons resist signal damage and maintain performance across a broad input power window.
Researchers developed a wearable optoelectronic clip that turns exhaled breath into a clear optical switching signal, enabling touch-free interaction and respiratory health monitoring. The device showed high accuracy in multi-user tests, suggesting its potential for practical applications.
A team identified GABPA as the missing link recruiting Integrator complex to target specific genes. Biochemical and structural analyses confirmed direct interaction between GABPA and Integrator's endonuclease module.
Researchers developed a flexible, battery-free hydrogel bioelectronic patch that wirelessly monitors periodontal inflammation and delivers localized miRNA therapy. The system successfully distinguished MMP-9 levels between healthy volunteers and patients with periodontal disease.
A new study reveals that plants with similar volatile organic compound (VOC) profiles can detect and respond to defense signals from neighboring plants more effectively. This finding offers a potential roadmap for designing more pest-resilient agricultural systems by strategically pairing plant species based on their VOC profiles.
High-resolution Solar Orbiter data detected abundant high-frequency magnetohydrodynamic waves in coronal plumes, with energy contributions similar to those of transverse Alfvénic waves. The findings provide crucial evidence for the role of these waves in coronal heating and solar wind acceleration.
The article highlights the need for AI tools to provide interpretable and reportable results, with a focus on improving turnaround time, diagnostic consistency, and clinical decision-making. While AI is unlikely to replace pathologists, it can help convert tissue morphology into actionable evidence for better patient care
Co-transcriptional splicing plays a critical role in regulating chromatin structure, mRNA maturation, and protein diversity. The review identifies key detection methods, regulatory mechanisms, and therapeutic applications for this process.
Researchers found that smaller crumpled sheets exhibit higher load-bearing capacity than larger ones, with denser internal ridge networks playing a key role. The team identified a universal evolution pathway governing the formation of ridges and junctions under compression.
A novel LFIA based on selenium nanoparticles reveals long-term dynamics of neutralizing antibodies against SARS-CoV-2, showing accelerated antibody decline in patients with neurological and hematological diseases. The detection platform enables automated result readout and scalable monitoring for large populations.
Researchers have discovered that tumor-educated pericytes drive alternative angiogenic pathways, bypassing VEGF inhibition and making them a major contributor to drug resistance. A novel therapeutic strategy targeting both endothelial cells and pericytes has shown superior anti-angiogenic effects in multiple cancer models.
A global assessment found that only 63.3% of lakes worldwide meet good water quality standards, exposing nearly half of the world's population to potential health risks associated with freshwater security. Strong regional disparities were observed, with Europe and North America faring better than Asia, South America, and Africa.
Researchers propose a four-stage pathway to evaluate AI for intracranial aneurysm detection, including lesion-level testing, reader performance evaluation, and surveillance after deployment. The framework aims to assess the tool's net clinical benefit in specific care settings.
A new review proposes a paradigm-shifting framework to address the growing threat of Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). The framework highlights the importance of considering virulence phenotype over co-detection of resistance genes and virulence markers.
A 16-week personalized exercise intervention improved glycemic regulation, physical fitness and reduced abdominal fat while increasing skeletal muscle mass. Cognitive impairment also showed significant improvements in working memory, perceptual speed and executive function.
A research team has developed a dual-side electrosynthesis strategy to convert plastic and biowaste into succinic acid, a versatile four-carbon platform chemical. The new system achieved an apparent succinic acid yield of 169.1%, exceeding the theoretical limit of conventional single-electrode processes.
A new study reveals that USP22 regulates B-cell activation and differentiation through the CHD4-CD19 axis. Inhibiting USP22 partially reversed B-cell hyperactivation in Kawasaki disease patients.
Researchers at Xi'an Jiaotong University create single-molecule magnetostrictor with temperature-dependent response to magnetic fields. The discovery could broaden applications of single-molecule magnets and enable new technologies.
Researchers found that specific bacterial genera on litchi peel act as a 'freshness clock' predicting fruit freshness with high accuracy. They also isolated a strain that inhibits postharvest pathogens, providing a safe alternative to synthetic fungicides.
A study analyzing Chinese and global soil metagenomes found substantial declines in antimicrobial resistance genes after China implemented its AMR control plan. The research suggests a close association between soil resistomes and antimicrobial use patterns across human and animal sectors.
The discovery of Cygnus X-3 reveals it as the most powerful particle accelerator known to date, producing photons with energies up to 30 PeV. The precise temporal variability and high gamma-ray energies measured by LHAASO confirm its status as a source of cosmic rays.
A comprehensive study maps the global CSDH trial landscape, identifying research hotspots, evidence gaps, and future priorities. The study highlights persistent geographic imbalance, recurrence as a core challenge, and the need for standardized anticoagulation management and MMAE guidelines.
Researchers developed a lean-lithium oxychloride solid electrolyte with high ionic conductivity and tunable properties. The interfacial percolation strategy enabled the creation of a continuous transport network throughout the electrolyte, allowing for efficient lithium-ion migration.
Researchers developed an elastic bevel thermal lamination method that removes interlayer impurities, producing clean interfaces and high-performance 2D device arrays. The method significantly reduces bubbles and wrinkles while maintaining structural integrity.
Researchers have designed a tough, fatigue-resistant, and multifunctional biogel for next-gen wearable electronics. The biogel enables self-powered devices for gesture recognition and robotic hand control with high precision.