Dissimilatory iodate-reducing microorganisms (DIRMs) inhabit marine oxygen minimum zones (OMZs) where oxygen is depleted, contradicting theoretical predictions. DIRMs reduce nitrate (NO3⁻) before iodate (IO3⁻), allowing them to thrive in OMZs.
Research reveals UBE2M's critical regulatory link to inflammation and innate immune pathway in KrasG12D driven non-small cell lung cancer. Simultaneous UBE2M deletion and KrasG12D activation causes severe inflammatory TME, shortening life-span and promoting tumor growth.
Researchers created Eu-doped infinite-layer nickelates using high oxygen pressure, revealing robust high-Tc superconductivity and reentrant superconductivity in both underdoped and overdoped regions. Rare-earth substitution provided an additional control knob, strengthening the superconducting state and enhancing pairing.
Researchers discovered a mitochondrial protein called ROMO1 that protects motor neurons from ALS-like degeneration. ROMO1 helps maintain healthy mitochondria in motor neurons, suggesting that mitochondrial damage may trigger motor neuron degeneration.
Epigenetic regulation governs chromatin accessibility and transcriptional output, enabling cells to adopt distinct functional states. The review discusses the importance of epigenetic mechanisms in development, disease and therapy, highlighting their potential for clinical translation.
A new AI method called OMPO (Occupancy-Matching Policy Optimization) has been developed to help robots learn from past experiences without being trapped by changing conditions. OMPO uses a combination of historical data and recent interactions to stabilize reinforcement learning and adapt to policy and physical changes.
The study develops a new climate prediction method called SFA-based Climate Prediction (SCP) that extracts predictable signals from precipitation data. It demonstrates higher prediction skill than two dynamical models and a hybrid dynamical–statistical system, providing a new approach for regional seasonal precipitation prediction.
Researchers have developed a wide-field hyperspectral camera that captures real-time spectral changes from hundreds of nanoparticles simultaneously, revealing hidden heterogeneity in electrodeposition. The technique, called wide-field Fourier transform hyperspectral imaging, solves the throughput bottleneck in conventional dark-field s...
Researchers discovered a new kind of planar defect, called 'filling fault,' in half-Heusler compounds. This defect arises from the local filling of vacant sublattices and introduces stoichiometric deviations, affecting material properties.
Researchers discovered plant bundles from the Wuwangdun Tomb, containing rice, millets, and other cereals, wrapped in oak leaves, with similar structures to modern zongzi. The bundles were likely used as funerary offerings, distinguishing them from their modern counterparts.
Researchers developed a compact built-in prompt gamma-ray neutron activation analysis (PGNAA) system to measure uranium loading and ionic contaminants in hydrometallurgy processes. The system provides on-site trends to support decisions on resin switching and elution timing.
Numerical experiments show that parameterization of orographic gravity wave drag reduces rainfall intensity overestimation and improves forecast accuracy. The study suggests current OGWD parameterization schemes require further improvements to achieve greater forecasting accuracy.
A Peking University team developed a homogenized gridded climate dataset for China, removing non-climatic signals from traditional meteorological observations. The dataset helps detect and attribute climate change, overcoming difficulties in correcting gradual and abrupt inhomogeneities.
Researchers developed graded membranes to separate complex hydrocarbons mixtures into valuable products. The strategy demonstrated molecular-level fractionation of light naphtha, achieving a recovery rate of 85-90% and reducing energy consumption by 91% compared to conventional distillation.
A team of scientists has successfully synthesized four distinct topological architectures, including a molecular-tweezer-like compound and an 8<sub>18</sub> knot, through coordination-angle-controlled self-assembly. The research establishes a novel platform for developing functional materials with exceptional photothermal conversion pr...
The study found that structural connectome embeddedness reveals a dynamic organizing dimension of human brain activity, where whole-brain functional activity is constrained by global structural topology. Higher CoDE values indicate stronger brain activity patterns embedded in structural connectome topology.
Researchers developed cellulose metafibers with a maximum tensile strength of 3.29 GPa and a toughness of 349.5 MJ m–3, comparable to top-tier synthetic fibers and natural spider silk. The biodegradable fibers were used in lawn and vegetation maintenance, showing wear resistance and environmental benefits.
A new evaluation framework helps bridge the lab-to-manufacturing gap for battery prelithiation technologies. The framework assesses eight prelithiation strategies across eight dimensions, enabling informed industrial technology selection.
Researchers developed a covalently bridged interface engineering method to improve organic transistor stability, reducing leakage currents and increasing device performance. The design enables low-voltage operation and excellent charge-transport capability, making it suitable for flexible electronics applications.
Researchers developed a unified scaling framework to separate quantum geometry contributions from disorder in nonlinear Hall data. The framework identified quantum-metric and Berry-curvature signals in existing second-order Hall data, allowing for clearer understanding of quantum-metric and Berry-curvature signals.
Researchers propose a new AI framework, Generative Electrochemical Intelligence, to accelerate the discovery and development of electrochemical energy technologies. The framework combines generative AI with automated robotic experimentation to create a closed-loop system that can generate new ideas, test them, and learn from feedback.
A dual-functional single-crystalline layer improves OLED stability by serving as both a stable hole-transporting layer and an effective barrier layer, enhancing device performance and lifetime. The optimized layer demonstrates superior thermal, morphological, and electrochemical stability.
Researchers developed azaphenanthrene-fused non-fullerene acceptors with enhanced crystallinity and packing order, leading to high-efficiency devices. The N/halogen engineering strategy achieves a record 20.18% power conversion efficiency in binary organic solar cells.
Urban greenery provides substantial cooling benefits but also complicates ozone control by stabilizing the urban boundary layer and releasing ozone-polluting compounds. Locally tailored greening strategies are needed to maximize cooling benefits while minimizing air-quality trade-offs
The study found that regional deployment of marine cloud brightening could induce a global mean cooling of approximately 0.9°C, alleviating the global land drying trend. However, different regions exhibit varying responses, with some experiencing mitigated or overcompensated drought stress, while others face exacerbated conditions.
Researchers developed a solar-driven platform that converts desalination brine into a chemical resource for methane conversion, producing freshwater and value-added chemicals. The platform achieved 98.1% selectivity toward chloromethane production and maintained stable operation for 15 days.
Researchers examine bacterial persistence from multiple dimensions, highlighting its complex mechanisms and deep interactions with host-pathogen dynamics. Emerging strategies to eliminate persisters, such as phage-derived therapies and metabolic interventions, are also discussed.
Researchers have developed a mechanism for tunable Landau quantization using imaginary pseudo-electric and real pseudo-magnetic fields. This interplay enlarges Landau-level spacing and enhances mode localization, opening new avenues for exploring quantum-Hall-like phenomena.
A new material system has been developed to bypass limitations in spin-orbit torque magnetic random-access memory, enabling highly efficient orbital torque-driven magnetic tunnel junctions and solving critical yield bottlenecks.
A new strategy remodels the cell membrane to convert ordinary macrophages into pathogen-targeting immune cells. Engineered macrophages successfully overcame limitations of conventional antimicrobial therapies, demonstrating improved bacterial recognition and elimination.
A head-to-head comparison of nine blood tests for early Alzheimer's disease revealed noticeable variations in diagnostic accuracy. The CLEAR-AD study found that seven assays demonstrated strong accuracy, while two showed lower performance, highlighting the need for platform-specific calibration.
Researchers identify AGR2 as a prognostic marker for NF-PanNETs, while FOXM1 is found to promote malignancy and proliferation. AGR2-high cells exhibit malignant features, including increased proliferative activity and metastasis-like signatures.
Researchers argue that addressing climate change requires a new approach, one that considers the strong coupling between climate and society. The authors propose the 'Möbius-based Coupling Climate-Social System' framework, which identifies three principles: human-environment coupling, telecoupling, and strategic coupling.
Using TaS2 as a model system, researchers demonstrate that coordinated interlayer sliding and intralayer atomic reconstruction can reorganize layered crystals into adaptive hetero-phase superlattices. This enables the construction of superlattice architectures and controlling emergent quantum states in layered materials.
Researchers found that aged granulosa cells derived from iPSCs exhibit impaired germ cell differentiation due to age-related mitochondrial damage and nuclear ageing. However, inhibiting the ERK/MAPK pathway can partially rescue this defect, suggesting a promising strategy for improving germ cell regeneration.
Hankelformer improves forecasting of extreme weather events by capturing local spatiotemporal dynamics and enhancing feature invariance. It achieves state-of-the-art performance on multiple datasets, including energy, transportation, and extreme weather domains.
Researchers identify three water molecules as minimal unit for efficient catalytic dynamics in aqueous environments. The discovery reveals a unique 'structural switch' mechanism, enabling fast proton transport and resolving the long-standing question about the threshold required for collective catalysis.
Researchers identify H6PD as a novel causative gene for autosomal recessive Parkinson's disease, linked to disruption of ER-mitochondria connection. The study reveals that this genetic defect leads to energy failure and neuron death in dopaminergic neurons.
A single-cell atlas reveals that a balance between two macrophage states, with lipid-fueled immunesupressors, tracks clinical outcomes in gastric cancer patients. Tumors with a more permissive immune state respond better to immunotherapy and have longer progression-free survival.
The study targets microglia, brain immune cells involved in inflammation after sepsis. Evodiamine-loaded liposomes deliver anti-inflammatory treatment to the affected areas, reducing brain inflammatory signals and protecting hippocampal neurons.
Researchers discovered two families of non-Hermitian solitons, SMASs and NRDSs, differing in formation thresholds and underlying physical mechanisms. Skin-mode localization suppresses wave spreading, while band nonreciprocity enhances it, giving rise to distinct nonlinear localized states.
Researchers have discovered a new class of high-Tc superconductors among 5d transition-metal-oxides, with the highest Tc recorded at 17.8 K in ReO3. The discovery is attributed to the synergistic mechanism of pressure-enhanced orbital hybridization and oxygen-lattice-dominated electron-phonon coupling.
Researchers challenged the double water bulge model by analyzing tidal data from satellite observations. They found that only 56.84% of locations experienced low tides and 43.16% experienced high tides, contradicting the physical existence of two water bulges.
Climate change is altering the distribution of cropland nitrogen pollution in China, with emerging hotspots shifting from the south to the north. Nitrogen accumulation in soils and increased rainfall are key drivers of this shift.
Researchers discover that manipulating the chiral asymmetry factor of catalysts accelerates sulfur redox reactions, leading to higher capacities, superior rate capability, and remarkable long-term cycling stability in lithium-sulfur batteries.
A new study by Dr. Wu Yuan's team reveals that retinal AI can lose accuracy in high-altitude populations due to altitude-associated domain shift. MIXFound, a lightweight framework, offers a practical solution to improve robustness and correct for these differences.
Researchers found that eustress reduces CCL2 expression, alleviating cardiac damage and enhancing chemotherapy response. Eustress also remodels the tumor immune microenvironment, increasing cytotoxic CD8⁺ T cells and anti-tumor M1-type macrophages.
Researchers developed a deep-learning compiler to map user-designed illusion patterns to programmable metasurfaces, enabling rewritable and customizable electromagnetic illusions. The metasurface can create complex two-dimensional illusions that adapt to changing conditions.
Halide cathode materials, long overlooked due to dissolution in liquid electrolytes, now enable dramatically higher energy densities through a fundamental shift in battery chemistry. Key strategies include multi-electron reactions, protective coatings, and nanostructuring to address stability issues.
A new study identified functional noncoding variants in the TBX1 enhancer that contribute to tetralogy of Fallot. These variants reduce TBX1 expression, disrupt outflow tract vessel formation, and lead to reduced angiogenesis, vessel regression, and abnormal tight junction morphology.