A novel chiral Brønsted acid-catalyzed PED reaction provides an efficient route to access chiral benzannulated carbocyclic frameworks. The method enables the synthesis of azaarene-containing adducts with good yields and excellent enantioselectivity.
This review synthesizes recent progress in rice grain size and nutritional quality, identifying key signaling pathways and regulatory mechanisms. Strategic approaches, including genome editing and precision design, can improve yield while enhancing nutritional value for human health.
Researchers propose a unifying framework to rebuild brain–spinal communication in SCI patients, enabling closed-loop neurotechnology to support stable or adaptive function. The study introduces three technological routes to address communication loss, state mismatch, and learning failure.
A Chinese endoscopy-screened cohort study found that genetic risk and lifestyle factors independently contribute to upper gastrointestinal cancer risk. Integrating genetic risk with lifestyle information may improve risk stratification and identify individuals most likely to benefit from screening and prevention.
Researchers mapped CHD variant landscape in Asian population, identifying 11 overlapping candidate genes and 25 novel genes associated with abnormal cardiovascular phenotypes. The study highlights the importance of genetic testing and counseling for birth defects in Chinese populations.
CeCrGe₃ exhibits giant anomalous Hall and Nernst effects, originating from Kondo-driven topological flat bands. These remarkable responses are significantly larger than those observed in LaCrGe₃ and hold promise for future applications in electronic devices and thermoelectric energy conversion.
Scientists have developed a new type of semiconductor material that can both stretch like rubber and heal itself, breaking the long-standing trade-off between these properties. The material uses hierarchical hydrogen bonds to achieve this balance.
Researchers create tandem catalytic strategy to efficiently upcycle polyethylene into aromatic chemicals without precious metals or external hydrogen acceptors. The process achieves high aromatics yield and demonstrates excellent stability, offering a promising solution for managing plastic pollution and reducing fossil resource reliance.
Recent advances in noninvasive neural decoding, deep learning, and shared autonomy are bringing BCI-controlled robots closer to real-world use. These systems can decode complex brain signals related to movement intention, allowing for more flexible and higher-dimensional robotic behaviors.
Researchers create conjugated polymer with bipyridine units that enhances water oxidation kinetics and charge separation, leading to high efficiency in H2O2 production. The strategy offers a promising route for sustainable chemical synthesis driven by solar energy.
Research highlights the interplay between circadian disruption and cardiovascular comorbidities, including cardio-cerebral, cardio-hepatic, and cardio-renal interactions. Chronotherapies show promise in re-entraining circadian rhythms, with potential applications for personalized treatment.
A new grayscale lithography technique called PG-LDW is introduced, achieving sub-nanometer resolution in 3D structures. This process enables precise control over the depth profile of photoresists, opening opportunities for next-generation micro/nano-integrated devices.
Researchers have developed a microfluidic spray drying technology to rapidly synthesize high-phase-purity HE-NVPF cathode materials, outperforming traditional batch methods. The new method enables scalable energy storage solutions with ultra-fast charging speeds and high energy density.
Researchers introduce a novel approach to enhance solar thermal energy storage efficiency by anchoring the phase-change front, preventing its accumulation at the source. The continuous-flow system delivers a charging power of 0.54 kW and a solar thermal storage efficiency of 49.7%, outperforming conventional diffusion-limited approaches.
A recent study reveals how orbital effects shape the high-field phase diagram of Ising superconductors, providing a theoretical basis for understanding vortex phase transitions at high magnetic fields. The research also demonstrates that finite-momentum pairing configurations can form under in-plane magnetic fields, leading to a new ty...
Researchers found ancient Chinese water buffalo feather decorations contained multiple bird species, including hoopoe, black-headed grosbeak, and yellow-bellied whistler. They also identified the adhesive as water buffalo glue, providing insights into cultural connections and species origins.
A new review highlights the escalating global burden of MASLD, which can progress to liver cancer, emphasizing the need for early detection and multifaceted treatment. Non-invasive biomarkers are being developed to improve diagnostic precision, including multi-omic panels and molecular markers that outperform traditional tests.
Researchers discovered that MEX3D acts as a key player in activating stored RNAs during sperm maturation. The MXL vesicle system is also hijacked by gastric cancer to enhance tumor growth. Targeting this machinery holds promise for developing selective and safe anti-cancer therapies.
Researchers explore the potential of black phosphorus for high-capacity alkali metal-ion batteries, overcoming stability and interfacial challenges through engineered architectures. Scalable synthesis, composite engineering, and interfacial regulation hold key to practical deployment.
A systematic review finds that a combination of aerobic and muscle-strengthening exercises significantly improves cardiovascular outcomes in healthy adults. The optimal exercise duration is found to be between 40-60 minutes per week, with evening aerobic exercise showing greater health benefits.
A new study reveals that soil carbon residence time governs riverine dissolved organic matter's age, with climate, hydrology, and soil processes controlling carbon cycling in rivers. The research provides a high-resolution global atlas of riverine DOC, showing that ancient carbon sources are locally important but modern terrestrial org...
Researchers developed a microfluidic spray drying technology to rapidly synthesize high-phase-purity HE-NVPF cathode materials. The new method allows for efficient and scalable energy storage solutions with superior performance.
A study of 1,152 people found that humans cooperate more with fair AI than with AI that is helpful or selfish. Fairness was the key to cooperation, not unconditional niceness. The researchers suggest that humans respond best to AI that can navigate social rules and expectations in a believable way.
Researchers developed a unified topological framework to characterize complex boundary states in Floquet crystals, predicting the existence and type of various topological boundary states. The framework uses three complementary one-dimensional winding numbers to unify the description of multiple boundary orders.
Researchers propose atomically dispersed U−O−Ti bimetallic active sites for high-efficiency PEC OER catalysis, achieving a 3.82-fold enhancement compared to pristine TiO2. The material exhibits excellent structural stability and operational safety.
Research reveals two dimensions of neuroticism: one linked to mental disorders and life well-being, the other to emotional reactivity and internal stability. High-ERIS individuals live longer due to healthier habits and risk avoidance.
Researchers recorded single-unit activity in bats' inferior colliculus while they were freely vocalizing. The study found that 95% of neurons responded differently to self-generated vocalizations than to playback of the same calls.
Scientists create a novel nano-delivery system that boosts NAD+ synthesis and reduces consumption, rapidly restoring energy metabolism in damaged kidneys. The approach halts disease progression and prevents chronic kidney disease, offering a promising drug development platform for AKI and other energy metabolism disorders.
Researchers have discovered a pattern in ultra-low temperature measurements of quantum Hall effect states, which can be explained by the composite fermion (CF) theory. The findings propose a connection between CFs and the observed states, providing a new understanding of fractional quantum Hall states.
Researchers found that hydrogen in LaH3 can tunnel through energy barriers rather than surmounting them, with quantum tunneling becoming dominant at approximately 71 K and increasing to 308 K for single-ion migration. This study clarifies why classical models fail to capture key aspects of the underlying physics.
Researchers successfully decoded the polarization cipher of light using high-energy electrons, confirming a key prediction of quantum electrodynamics. The study's findings offer a new pathway toward creating highly polarized, high-brightness gamma-ray sources.
Researchers developed a molecular engineering strategy to enhance PEMFC performance by tailoring the ionomer microenvironment. The addition of fullerenol improved oxygen transport and reduced platinum-sulfonate interactions, leading to increased peak power density and operational stability.
Researchers used LP-TEM to visualize the dynamic processes occurring during early stages of liquid-liquid phase separation (LLPS) in intrinsically disordered proteins/regions. The study provides compelling evidence supporting a non-classical nucleation mechanism and proposes a multi-step process for LLPS, which is common in IDPs/IDRs.
A research team from China has developed a material with high charge-to-spin conversion efficiency, achieving record-breaking performance in spintronic devices. The discovery utilizes nonsymmorphic symmetry to stabilize the material and enables ultra-low power magnetic switching.
The article presents a conceptual design for an in-situ energy station on Mars, which could alleviate power fluctuations and distribution issues. The system utilizes the Martian atmosphere as a working medium for power generation and storage, with potential to save over 20 tons of payload in future manned missions.
Researchers are close to building a 'virtual gut' capable of predicting responses to diet, drugs, and microbiome-based therapies. A new review outlines an analytical framework for host-microbiome multi-omics studies, covering preprocessing, feature selection, data integration, predictive modeling, and evaluation.
A study led by Chinese Academy of Sciences reveals climate change leads to unprecedented sensitivity of soil inorganic carbon pools. Climate-driven effects on SIC dynamics are quantified using a novel process-based model, showing significant losses of up to 307 Tg C in topsoil.
Researchers propose an electron-bridge interface using n-type Zn-Al layered double hydroxide (AZH) to address interface failure in zinc anodes. This design enables simultaneous deposition of zinc at the interface and surface, enhancing the anode's adaptability to volume changes.
A novel nickel-based Pickering emulsion catalyst enables gram-scale synthesis of high-purity benzaldehyde with co-produced hydrogen, offering a sustainable alternative to traditional fine chemical synthesis. The synergistic effect of photon-heteroatom jointly promoted redox cycling accelerates the dehydrogenation reaction.
Researchers developed pigs with knocked-down SLA-I/II molecules, showing reduced human complement-dependent cytotoxicity and stronger resistance to T-cell responses. The findings suggest a multi-pronged approach combining genetic modification and targeted immunosuppression for successful pig-to-human transplantation.
Scientists have developed a new material that dramatically improves the efficiency of producing clean hydrogen fuel from water using sunlight. The innovative system, which anchors platinum clusters onto a specially designed organic framework, accelerates the chemical reaction 109 times faster than before.
Researchers map the full phase evolution of IV-VI TMDs, achieving scalable fabrication of atomically thin sheets for flexible thermoelectric devices. Novel phase transition modes are discovered, providing a precise basis for phase regulation and enabling mass production of high-performance materials.
Researchers have achieved a record-breaking transition temperature of 63 K in ambient-pressure nickelate films, surpassing previous limits. This breakthrough utilizes the 'Gigantic-oxidative Atomic-layer-by-layer Epitaxy' method and showcases enhanced Meissner effect and zero-resistance temperatures.
A new cobalt-based dual-atom catalyst significantly enhances oxygen reduction reaction performance while avoiding precious metals. The catalyst achieves remarkable catalytic activity and retains durability, enabling outstanding energy performance in zinc-air batteries.
Researchers develop a nature-inspired hybrid material that produces high-quality therapeutic proteins with nearly tenfold higher efficiency than traditional methods. The material's unique design enables it to adapt to different environments, alleviating hypoxic stress and activating cellular functions.
A new class of electrolytes has been developed that overcomes the bottleneck of water activity in traditional aqueous batteries. The electrolytes work with commonly used zinc salts and achieve exceptional electrochemical performance, including a wide stability window and ultra-long cycling life.
A team of scientists has found that applying pressure to the heavy-fermion ferromagnet Ce5CoGe2 reveals superconductivity above a magnetic quantum critical point, defying typical expectations. The unusual phase diagram suggests that other ingredients beyond magnetic fluctuations may drive superconductivity in this material.
Advances in high-throughput proteomics and artificial intelligence are transforming biomarker discovery, disease prediction, and drug development. Proteomic technologies enable comprehensive snapshots of physiological and pathological states, driving breakthroughs in early diagnosis and personalized treatments.
Simulations suggest Greenland ice sheet changed in response to atmospheric CO2 scenarios and orbital forcing, with increased dynamical instability after expansion. The results imply that other factors, such as Antarctic ice changes and ocean processes, are needed to fully explain the persistence of certain climate cycles.
Researchers developed an ovarian follicle-based angiogenesis microphysiological system that forms complex 3D vascular networks without exogenous VEGF. The platform enables direct visualization and quantitative analysis of vascular remodeling, allowing for the rapid identification of anti-angiogenic compounds with meaningful in vivo act...