Researchers at Trinity College Dublin made a breakthrough in treating AMD by finding that IL-18 suppresses abnormal blood vessel growth behind the retina. Low doses of IL-18 have shown no adverse effects on the retina, offering a promising non-invasive treatment option.
Research by Trinity College Dublin scientists establishes a clear link between nanoparticles and autoimmune diseases like rheumatoid arthritis. Exposure to nanoparticles can trigger the transformation of amino acids, leading to inflammation and tissue damage.
Researchers at Trinity College Dublin developed a patented technology to reduce cerebral oedema by safely manipulating blood vessels in the brain. The technique, 'Neuronal Barrier Modulation,' has shown promising results in animal models and is planned for Phase I clinical trials.
Salmonella causes food poisoning, killing around 400,000 people worldwide every year. Researchers have discovered multiple gene switches that control the bacteria's weapon systems, offering new ways to curb human infection. The discovery could lead to the development of antibiotics to reduce disease caused by Salmonella.
Scientists at Trinity College Dublin have found that controlling IL-18 levels could prevent the development of wet AMD, a form of blindness. Drs. Sarah Doyle and Matthew Campbell discovered that drusen accumulating in the macula lead to IL-18 production, which acts as an anti-angiogenic factor.
Researchers at Trinity College Dublin have discovered a protein, TMED7, that can shut down part of the immune system after an infection has been cleared. This finding could lead to new ways to prevent over-activation of the immune system in diseases.
Researchers identify RORalpha as critical for nuocyte development and allergic-like inflammation, offering new therapeutic strategy targets. The discovery has the potential to treat asthma and other allergic diseases, addressing growing global prevalence.
Researchers at Trinity College Dublin have developed a new vaccine to treat cancer by manipulating the immune response. The vaccine, which has shown high effectiveness in pre-clinical trials, overcomes obstacles that have hindered previous cancer vaccines.
Soil microbes release more methane and nitrous oxide when atmospheric carbon dioxide increases, counteracting the cooling effects of plant growth. This feedback loop suggests that nature is not as efficient in slowing global warming as previously thought.
A €6m European Commission grant will fund clinical trials of NILVADIPINE, a medication already used to treat high blood pressure, in treating Alzheimer's disease. The trials aim to improve memory and slow the progression of Alzheimer's disease.
Researchers at Trinity College Dublin have discovered how autophagy, a process of 'self-eating', safeguards against cancer development. The discovery highlights an unexpected role for Noxa in triggering the self-destructive process that kills fledgling tumour cells.
Researchers discovered a rare gene mutation strongly linked to schizophrenia, which could be a new target for effective treatment. The mutation affects the VIPR2 gene, leading to increased signaling in the Vasoactive Intestinal Peptide pathway.
Researchers have discovered a versatile method for creating atom-thin nanosheets from various materials, which could enable novel electronic and energy storage technologies. These nanosheets have the potential to generate electricity from waste heat and improve efficiency in thermoelectric devices.
Research using MRI reveals that childhood stress and abuse can lead to permanent brain structure changes, making individuals more susceptible to developing depression. The study's findings have significant implications for early intervention and prevention strategies.
Researchers at Trinity College Dublin have made significant discoveries about Type 2 diabetes in young adults, shedding light on muscle cell mechanisms that contribute to severe insulin resistance. The study's findings may lead to the development of more targeted treatments for young people with Type 2 diabetes.
A new study conducted by an Irish-led research team found no link between folic acid-related auto-antibodies and the risk of having a child with spina bifida. The study, which involved over 140 mothers of affected children, confirms previous findings that maternal folate status can prevent neural tube defects.
Patients given an omega-3 enriched supplement maintained all aspects of their body composition after surgery, while those without it suffered clinically severe weight loss. The study suggests that omega-3 fatty acids may reduce the risk of post-surgical complications by suppressing inflammation.
Trinity College Dublin scientists have developed a more efficient system for detecting viruses, which uses micro-sized cantilevers to directly detect viruses binding to membrane proteins. This technology has the potential to enable portable diagnostic devices and specific blood tests.