Researchers at UCSD School of Medicine and Children's Hospital found rapid brain growth in infants with autism, linked to early diagnosis and improved outcomes. The study identified a window of abnormal brain development, predicting the severity of autism, and suggests earlier interventions could improve treatment.
A study found that applying a non-steroidal anti-inflammatory drug cream to the skin reduced muscle soreness by 37-45% in healthy males after exercise. This method avoids systemic side effects associated with oral NSAID use, which are common among patients.
Researchers at the University of California, San Diego, have developed a new technique using ultrafast lasers to obtain high-quality images of brain tissue. This technique enables scientists to automate and modernize histology, mapping neurotransmitter production and normal cell function.
Scientists have identified a new class of proteins that promote angiogenesis, the formation of new blood vessels. Del-1 protein, discovered four years ago, has been found to be stable and continually stimulate angiogenesis. The researchers hope to use this knowledge to develop therapies that can inhibit angiogenesis in cancer.
UCSD researchers define multiple steps initiated by COX-2 enzymes, including cyclic adenosine monophosphate and Inhibitors of Apoptosis, leading to suppressed cell killing and uncontrolled growth. The study also explains how aspirin and NSAIDs can reduce colon cancer incidence by inhibiting COX-2.
A study published in the Journal of the International Neuropsychological Society found that chronic cannabis use has a small impact on learning and forgetting, suggesting selective memory defects. The research team suggests that heavy marijuana users often abuse other drugs with potential long-term neurological effects.
Scientists have identified 400 'fragile regions' in the human genome that are more susceptible to genetic rearrangements, which could lead to a better understanding of cancer and other diseases. The study's findings contradict previous theories on genomic breakage, suggesting that these regions are like fault lines in the genome.
A mutation in the GRK3 gene, specifically in the promoter region, is linked to bipolar disorder in up to 10% of cases. The study suggests that this mutation causes individuals to become hypersensitive to dopamine, leading to mood extremes characteristic of the disease.
Researchers found that glutamate regulates the movement of bicarbonate and chloride into epithelial cells, controlling mucus transport and water flow. This discovery contributes to understanding how cystic fibrosis is controlled by gland cell membranes and may lead to future therapies for severe forms of the disease.
In a groundbreaking study, UCSD researchers discovered that the 14-3-3 epsilon protein is crucial for normal brain development and migration of neurons. Defects in this protein lead to severe brain disorders like Miller-Dieker syndrome, characterized by profound mental retardation and early death.
The UCSD Stroke Center will utilize a new ultrasound screening tool and provide remote consultations via wireless technology to increase the number of stroke patients receiving timely treatment. The grant also supports clinical trials using hypothermia as a method to extend the window of treatment effectiveness from three to six hours ...
Researchers at UC San Diego discovered that a protein essential for fruit fly embryonic development also plays a crucial role in mammalian wound healing. The study reveals that the loss of this protein causes skin cells to bunch up and stall, leading to slower wound healing rates.
The University of California, San Diego (UCSD) has received a $600,000 grant from the Technical Support Working Group (TSWG) to develop advanced video surveillance systems for public safety. The project aims to improve the ability to detect and track potential terrorists using 'smart' cameras that can adapt to various lighting conditions.
A recent study published in Personality and Social Psychology Review by Christine Harris questions the evolutionary theory of sex differences in jealousy. She finds that men and women view sexual and emotional jealousy in a similar light, with many studies failing to account for individual variability and cultural influences. Harris su...
Researchers at UCSD School of Medicine have demonstrated that pneumococcal vaccination can reduce the extent of atherosclerosis by 21 percent in laboratory mice. This breakthrough provides insight into the biological role of immune responses and offers potential therapeutic interventions for this complex disease.
A Scripps Institution of Oceanography professor and his colleague revisit the famous Miller experiment to recreate a prebiotic soup that may have been present on early Earth. The report traces the history of the experiment and highlights its significance in transforming the study of life's origin into a respectable field of inquiry.
Scientists in Japan and UCSD have discovered a novel regulatory role for pseudogenes, which stabilizes a protein-coding gene on another chromosome. The study found that disabling the pseudogene led to abnormal kidneys and bones in laboratory mice, while re-introducing it resulted in normal development.
UCSD researchers found that the Staph protein SpA triggers a pre-emptive attack on B cells, leading to their death and preventing them from developing memory cells. This process may explain why staph infections are common and recurring. The study's findings have potential applications in treating autoimmune diseases and cancers.
Researchers have developed a new brain imaging technique called Voxel-based Lesion-Symptom Mapping (VLSM), which pinpoint areas of the brain most crucial for normal functioning. The method uses structural MRI scans and compares them to functional brain imaging data, allowing for more accurate mapping of brain damage and behavior.
A new theory describes a fundamental pattern that unifies various ecological relationships, providing insight into species abundance and biodiversity. The theory also suggests a predictable relationship between the sizes of rock pieces and species populations.
A recent study published in JAMA found that obese children and their parents experience significantly impaired quality of life. The study used the Pediatric Quality of Life Inventory (PedsQL) to assess physical, emotional, social, and school functioning.
Researchers at UCSD have developed a way to transfer the optical properties of silicon sensors to plastic, creating flexible and biocompatible devices that can monitor drug delivery, joint strain, or healing. This technology could lead to non-invasive monitoring of implantable devices.
Researchers at University of California - San Diego develop new compound cidofovir analogs to treat poxvirus infections, showing effectiveness in preventing death and maintaining efficacy when given prior or after infection. The study found two compounds, HDP-CDV and ODE-CDV, to be most effective against lethal cowpox infection.
Scientists at UCSD discovered a protein, HIF-1, that enables white blood cells to function in low-oxygen environments, leading to inflammation. Inhibiting this protein blocks inflammatory responses in mice, offering new hope for treating arthritis and potentially improving cancer treatment.
A UCSD biologists' study links human impacts along the coast to size declines of marine snails, particularly among owl limpets and Gilded turban snails. The researchers found that human activity, not environmental change, has led to diminished size in gastropods on the southern California coast.
Researchers have discovered that Bt toxins can kill a range of parasitic nematode species, including those affecting humans, animals, and crops. The findings suggest the potential for developing an inexpensive and environmentally safe means of controlling parasitic roundworms.
Truong Nguyen will receive $120,000 funding to develop a video decoder that generates additional frames to produce smoother video sequences. The technology aims to enhance live video applications like videoconferencing and surveillance over wireless connections.
OptIPuter program to deploy DiamondWave all-optical switches, enabling fast and cost-effective network with high-speed data transmission. The platform will support scalable and flexible network infrastructure with minimal signal power loss and latency.
The Visualization Center at UCSD has made cutting-edge visualization technology available in the classroom, enabling students to interact with three-dimensional images and real-time data. This technology is particularly beneficial for underprivileged students who may not have access to such resources otherwise.
Researchers at UCSD identified a key gene pathway contributing to pulmonary hypertension, with potential molecular targets for new therapies. The study revealed that abnormal expression of angiopoietin-1 leads to muscle cell proliferation in lung vessels, causing disease progression.
The University of California, San Diego's IGCC will establish a six-year program for training Ph.D. students in nuclear threats and public policy issues. The program aims to address the scarcity of experts in these areas, particularly following the retirement of Cold War-era strategic thinkers.
Researchers have found a novel group of bacteria in tropical ocean sediments that produce molecules with potential in treating infectious diseases and cancer. The discovery has opened up a new source for drug discovery, with thousands of strains available.
A genetic defect in muscle growth and survival is linked to human heart failure, causing the heart muscle to lose its ability to adapt to stress. Researchers identified a specific gene mutation that disrupts normal stretch activity, leading to enlarged hearts with thin ventricular walls.
A recent study published in Health Psychology found that female bypass patients experience fewer complications when their spouses are informed of the recovery process. The study showed that male spouses who watched an optimistic video before discharge helped reduce complications and rehospitalization rates for their female partners.
Scripps Institution researchers have developed a new approach for designing marine reserves in the Gulf of California, using optimization algorithms and ecological data. The study, published in Science, provides a mapped series of reserves that meet conservation goals while minimizing societal conflicts with fishing interests.
Researchers at UCSD estimate that many evolutionary genome rearrangements accounted for differences between human and mouse genomes. The study found over 245 major and 3,170 micro-rearrangements, revealing significant evolutionary distance between the two species.
Paul Dayton, a renowned marine ecologist at Scripps Institution of Oceanography, has received the Diving Lifetime Achievement Award for his groundbreaking research on coastal and estuarine habitats. His work, including over 500 dives in Antarctica, has significantly advanced our understanding of Antarctic undersea ecology.
A study published in JAMA found that ICU patients treated with diuretics have a 68% increase in mortality and 77% non-recovery of kidney function. The researchers suggest reassessing diuretic use, particularly for those not responding to treatment, as delays can lead to adverse outcomes.
The study aims to understand the burden of neurological disease in people living with HIV and inform effective management strategies. A cross-sectional study will assess prevalence and features of neurocognitive-behavioral complications, while a subset of patients will be followed over time to monitor health status.
The OptIPuter project, led by Cal-(IT)2 researchers, partners with Chiaro to deploy Enstara routing platform for high-performance networking and data analysis. The platform's innovative technologies reduce infrastructure costs and enhance packet processing efficiency.
A six-week self-management program has been shown to enhance the quality of life and reduce depression in patients with age-related macular degeneration. The program, which includes group sessions and problem-solving skills, improved patients' confidence and ability to cope with their vision loss.
A new study by Scripps researchers reveals that phytoplankton capture and absorb solar radiation, contributing to a global warming of 0.1-0.6 degrees Fahrenheit. The findings challenge iron fertilization efforts aimed at reducing global warming, suggesting this approach may actually contribute to warming the ocean.
A recent clinical trial found that a combination of estrogen and micronized progesterone causes fewer days and less intense bleeding than commonly used hormone replacement therapies. The study suggests that estrogen plus micronized progesterone (MP) may be the form of HRT with the least bleeding and potentially lower health risks.
Nancy Bowers, a Scripps Institution of Oceanography doctoral student, has been awarded the 2002 Chrysalis Scholarship from the Association for Women Geoscientists. Her research focuses on analyzing high-frequency fluctuations in Earth's magnetic field as observed in oceanic crust data.
A nationwide brain imaging network will share data from patients with schizophrenia to expand understanding of the disease and develop new treatments. The project, led by Steven G. Potkin, aims to create a comprehensive database of brain images and advance research in brain disorders.
A team of UCSD researchers found that regular outbursts of ultraviolet radiation from massive stars may play a significant role in stirring up galaxies. The simulation study suggests that this radiation acts as an important regulation mechanism, inhibiting further star formation and regulating the galactic perturbations.
Researchers induce leukemia cells to change behavior and stimulate immune system, killing significant numbers of leukemia cells in a 3-step process. The approach has shown strong killing effect against AML cell lines but not other types of cancer, with potential for safe transfer back into patients.
A national clinical trial with 80 Parkinson's patients showed that high-dose coenzyme Q10 slowed functional decline by 44%, particularly in everyday activities. The therapy needs to be tested in a larger trial before it can be recommended.
A new UCSD study found that counseling services provided through state-funded quitlines significantly increase abstinence rates at 1, 3, 6 and 12 months. The research suggests that these programs can help a higher number of long-term quitters compared to those who do not use such services.
The National Science Foundation (NSF) has awarded UCSD a total of $22 million over five years to support research in information technology. The OptIPuter project, funded at $13.5 million, aims to develop a powerful distributed cyberinfrastructure for data-intensive scientific research and collaboration.