Rebeca Wong has been awarded a $3.03 million NIH grant to continue her longitudinal aging study in Mexico, collecting data on thousands of participants across various topics. The Mexican Health and Aging Study aims to compare health outcomes with other national surveys globally.
Researchers found that high iron and copper levels can block brain-cell DNA repair mechanisms, leading to accumulation of genetic damage associated with neurodegenerative diseases. The study suggests a potential therapeutic target in curcumin, a common spice with beneficial health effects.
Researchers have uncovered the detailed dynamics of the Epac2 protein switch, which plays a critical role in cAMP-mediated cell signaling. This finding holds promise for developing new therapeutic strategies specifically targeting this pathway to combat diseases like diabetes and cancer.
Scientists have identified a single amino acid change in the chikungunya virus' exterior protein that enables it to infect Aedes albopictus mosquitoes, allowing for rapid spread across India and Southeast Asia. The discovery sheds light on why outbreaks occurred despite previous strains being present in the region.
Bhavnani's research uses advanced visual analytical methods to classify asthma patients, enabling targeted diagnosis and treatments. The study builds on molecular data from multiple institutions, demonstrating the potential of translational bioinformatics.
Researchers have identified a new virus as the cause of deadly outbreaks in six Chinese provinces, with a mortality rate of 12%. The virus, known as Severe Fever with Thrombocytopenia Syndrome virus, is transmitted through tick bites and affects humans without causing human-to-human transmission.
Researchers discovered a critical link between respiratory syncytial virus and oxidative stress, which causes lung inflammation and damage in children. The study found that the virus blocks the activity of Nrf2, a protein needed for antioxidant enzymes, leading to increased reactive oxygen species and cell killing.
Researchers have identified a single 'master switch' enzyme, aldose reductase, as crucial in producing excess mucous that clogs airways of people with asthma and COPD. The discovery could lead to improved therapies for the 510 million people worldwide suffering from these diseases.
A study by UTMB researchers reveals a significant increase in hypertension prevalence among older Mexican-Americans, with higher rates among those with diabetes and obesity. The study highlights the need for targeted interventions to address these factors and improve hypertension management in this growing population.
A recent study from the University of Texas Medical Branch at Galveston found that aggressively marketed drugs tend to offer less benefit and more harm to most patients. The 'inverse benefit law' highlights the need for physicians to critically evaluate commercial marketing and prioritize patient safety.
Researchers have discovered the molecular mechanism of measles virus infection, which could lead to a targeted cancer therapy. The study found that modifying the attachment protein is crucial for infectivity, and this discovery brings the dream of using measles virus as a cancer weapon closer to reality.
A recent study from the University of Texas Medical Branch (UTMB Health) has found that women using injectable or oral contraception, including DMPA and desogestrel, do not experience adverse effects on glucose and insulin levels. The research, conducted over three years, provides reassuring news for non-diabetic women using hormonal c...
A comprehensive medical education reform significantly improves failure rates of the Step 1 licensing exam and increases graduation rates among underrepresented minority medical students. The integrated curriculum shows a nearly 70% decrease in failure rates and a 94% decrease in failure rates for African American students.
A new study by the University of Texas Medical Branch at Galveston found that hospitalized elderly patients who take even short walks around their unit tend to leave the hospital sooner than those who are less mobile. This correlation was observed after adjusting for varying severities of illness, suggesting a potential 'standard of ca...
New research finds nearly 25% of overweight and 16% of normal-weight reproductive-age women misperceive their body weight, leading to unhealthy weight loss behaviors. Clinicians are recommended to calculate BMI, screen for misperceptions, and counsel patients to address this issue.
Researchers conclude that caring for prisoners' mental and physical health directly impacts public health, with a significant burden of chronic and infectious disease among incarcerated individuals. The authors recommend targeted healthcare resources in prisons to prevent disease transmission and ensure effective treatment upon release.
A team of scientists will investigate how spaceflight affects the immune system, particularly in response to viruses like RSV, which can cause severe respiratory illness. The study aims to protect astronauts and vulnerable populations on Earth from increased infection susceptibility.
Researchers have sequenced the genome of Culex quinquefasciatus, a mosquito species that transmits West Nile virus. The study provides insights into disease transmission and offers a platform for comparative studies to investigate interactions between viruses and mosquitoes.
Researchers from the University of Texas Medical Branch at Galveston advocate for reclassifying traumatic brain injury as a chronic disease to ensure proper care and funding for research. The study highlights the long-term effects of brain trauma on cognitive function, physiological processes, and quality of life.
Researchers at the University of Texas Medical Branch at Galveston have discovered a way to use widely available blood pressure drugs to combat age-related muscle loss. By dilating blood vessels, these medications can increase amino acid delivery to muscles, restoring normal growth and potentially reducing frailty.
Researchers at the University of Texas Medical Branch have developed new techniques to identify specific asthma subtypes using protein patterns in airway lining fluid. This allows for targeted medication and potentially improved treatment outcomes. The study aims to reduce trial and error in asthma diagnosis and treatment.
Obesity rates among seniors in Latin America and the Caribbean have surged, leading to a significant increase in disability among elderly populations. Current trends suggest that unchecked obesity will result in larger numbers of people vulnerable to chronic medical conditions, straining healthcare resources in poorer countries.
Researchers from the University of Texas Medical Branch at Galveston have successfully grown new lung tissue using embryonic stem cells and decellularized rat lungs. The breakthrough, published in Tissue Engineering Part A, paves the way for potential applications in treating severe lung disorders such as cystic fibrosis.
Research at the University of Texas Medical Branch found that elderly people's muscles don't respond to insulin by expanding their blood vessels like younger people do. This response is necessary for muscle protein synthesis and growth, with implications for improving strength and health in older adults.
Researchers at UTMB found that restricting blood flow during low-intensity resistance exercise increases protein synthesis and stimulates muscle growth in older men. The study offers hope for patients who need to regain muscle mass after surgery or due to conditions like arthritis.
The current BMI standards misclassify many reproductive-age women as 'not obese', particularly whites and Hispanics. The study recommends ethnic-specific BMI cutoff values to produce proper diagnosis of obesity, especially for Hispanic women.
Researchers found that 16% of 6-month-olds were obese, highlighting the need for early detection and prevention strategies. Exclusive breastfeeding and adequate fiber intake can help prevent obesity in infants.
Researchers have developed an experimental vaccine for chikungunya virus, which has already infected millions of people in Asia, Africa, and Europe. The vaccine, composed of virus-like particles, successfully protected monkeys from infection.
Researchers at the University of Texas Medical Branch found that offspring of female mice exposed to BPA developed significant signs of asthma. The study suggests a link between maternal BPA exposure and childhood asthma, highlighting the need for further human epidemiological studies.
Researchers have developed a broad-spectrum antiviral compound that can stop a wide range of highly dangerous viruses, including those causing HIV, Ebola, and hepatitis C. The compound works by altering the lipid envelope of enveloped viruses, making them unable to fuse with host cells.
Researchers found that inflammation is critical in aortic dissection and interleukin-6 plays key role. Studies using mice and human samples validate findings, providing new insights into underlying mechanisms.
Researchers at the University of Texas Medical Branch (UTMB) have identified a viral protein called nsp1 as a major contributor to SARS virus virulence. The protein interferes with host cell defenses by targeting ribosomes, which are responsible for producing proteins crucial for immune defense.
A recent study found that consuming moderate amounts of protein per meal, around 30 grams, is most effective for building muscle. Eating larger portions does not necessarily lead to greater muscle synthesis. Shifting extra protein from dinner to lunch and breakfast may help optimize daily intake and reduce muscle loss in the elderly.
Researchers at University of Texas Medical Branch at Galveston have found that increasing insulin levels can restore impaired muscle-building processes in elderly individuals. This breakthrough suggests a novel approach to addressing age-related muscle loss and has implications for developing new treatments.
Scientists discovered that endocannabinoids in the human body can disable brakes on pain signals, leading to prolonged chronic pain. In contrast, THC from cannabis may worsen toothaches, but could alleviate neuropathic pain.
Researchers have found that blocking a key enzyme, aldose reductase, can significantly reduce asthma symptoms. The discovery opens the way for human trials of a new treatment, which could provide a badly needed alternative to existing therapies.
Researchers identified 'early gainers' who averaged 24 pounds of weight gain over three years, linked to increased abdominal fat and metabolic syndrome. The study recommends physicians tailor counseling based on women's risk factors and suggest alternative contraception methods for those who gain significant weight.
Researchers used a NASA centrifuge to simulate artificial gravity and found that just one hour a day was enough to maintain thigh muscle protein synthesis. The study suggests that this could be a potential countermeasure for preventing muscle loss in space, with implications for human health on Earth as well.
Scientists discovered two critical biochemical pathways for Ebola virus entry into cells and developed inhibitors to block them. The UTMB team prevented Ebola infection in cell culture experiments, a crucial step towards developing the first therapy for the deadly disease.
Researchers discovered benfotiamene, a fat-soluble form of vitamin B1, strongly suppresses uveitis by shutting down NF-kappa B activation. This treatment has great potential due to its low cost and rapid absorption, with existing clinical trials showing improved diabetic polyneuropathy outcomes.
According to a UTMB study, Medicare patients experienced significant lapses in continuity of care between 1996 and 2006. The decline was attributed partly to the increased use of hospitalists, who specialize in hospitalized patient care. The researchers recommended further study on the impact of reduced continuity on patient outcomes.
A recent UTMB study found a dramatic increase in the number of hospitalists, from 5.9% to 19% of internal medicine physicians between 1995 and 2006. Hospitalist care has grown substantially across different diagnoses and hospital sizes, with regional variations also observed.
Researchers at UTMB discovered that DMPA users gained an average of 11 pounds and increased their body fat by 3.4 percent over three years. Nonhormonal contraception reversed this weight gain, with women losing nearly four pounds over two years.
A study of over 2,000 HIV-infected prisoners found that 80% experienced significant interruptions in antiretroviral therapy after release. This can lead to poor clinical outcomes and the creation of drug-resistant HIV reservoirs in the community.
Researchers at the University of Texas Medical Branch discovered a major virulence factor for Rift Valley fever virus that has a dual mechanism. The protein NSs promotes viral replication by attacking a host cell protein, preventing interferon beta production and allowing the virus to replicate unchecked.
Researchers Higgs and Gould examine climate's impact on West Nile, Chikungunya, Rift Valley fever, and Bluetongue viruses' spread. Climate change is linked to the northward expansion of Culex imicola midge species, facilitating Bluetongue virus dispersal.
University of Texas Medical Branch researchers have identified a promising new target for colon cancer therapy by mapping the biochemical pathway critical to the spread of tumors. High levels of the enzyme Akt2 are found in association with other cancers, and its inhibition shows promise in stopping colon cancer's spread.
Researchers at the University of Texas Medical Branch have discovered a key biochemical link in the process by which Ebola Zaire virus infects cells. By activating the PI3 kinase pathway, Ebola tricks the cell into drawing it into an endosome, where it can reproduce itself.
Researchers at UTMB have tested a new universal vaccine effective against multiple influenza strains, with promising results in a Phase I clinical trial. The vaccine candidate, VaxInnate's M2e, could provide a safe and highly effective solution to prevent seasonal and pandemic influenza A.
Researchers at the University of Texas Medical Branch have found that shutting down gastrin-releasing peptide receptors can dramatically suppress neuroblastoma tumor formation and slow its spread. This breakthrough could lead to the development of new therapies for this devastating disease.