Articles tagged with Dose Response Curve
A new study by Adelaide University researchers found that higher cumulative doses of clomiphene citrate increase the risk of miscarriage and twinning, but do not improve live birth rates. The study analysed over 21,000 embryo transfer cycles and found a dose-response relationship between cumulative doses and adverse pregnancy outcomes.
A case-control study found that amateur-level soccer heading is associated with increased blood biomarkers of neural damage, including dose-response relationships. The findings suggest that even low-impact heading may acutely affect neural integrity.
Researchers validated panels of antibodies targeting clinically relevant nucleic acid modifications to visualize antisense oligonucleotides in both in vitro and in vivo studies. The tools enable detection of modified nucleic acids irrespective of sequence, facilitating multiple clinical and pre-clinical workflows.
Researchers have identified a hidden molecular mechanism involving two proteins that allows tumors to resist treatment. A new gelatin-based nanoparticle has been developed to shut down both proteins simultaneously, showing promising results in early studies with mice.
A cohort study found that prenatal cannabis use was associated with several negative maternal health outcomes during pregnancy. The study emphasizes the need for further research on how different aspects of prenatal cannabis use may impact these associations.
A new tool, developed with a machine learning-based approach, can predict diuretic response in patients with ADHF. The BAN-ADHF score may lead to personalized strategies for effectively managing congestion in hospitalized patients.
A Mediterranean diet has been associated with a reduced risk of adverse pregnancy outcomes. The study found a dose-response relationship between the intake of Mediterranean diet and lower risk of such outcomes.
Researchers found that B-type procyanidins induce hormesis in hemodynamic and metabolic responses, with optimal doses triggering improved cognitive functions and stress resistance. The study suggests a link between B-type procyanidin intake and CNS neurotransmitter receptor activation.
A UC Davis Health study found that patients on stable opioid therapy who had their doses tapered had significantly higher rates of overdose and mental health crisis. The study suggests that patients undergoing tapering need significant support to safely reduce or discontinue their opioids.