Articles tagged with Autism
Adults with autism exhibit differences in coordinated neural activity, suggesting inefficient communication between brain regions. Researchers found abnormal connectivity patterns in the left hemisphere and decreased connections between frontal lobes and rest of autistic brain.
Young children with autism struggle to categorize objects into abstract groups, particularly living and nonliving things. They have difficulty recognizing goals and motivations of others due to a fundamental deficit in distinguishing between animate and inanimate objects.
Brain researchers in Göttingen have created a genetic animal model for autism, showing that neuroligins ensure signal transmission between nerve cells. The study reveals that autistic patients often lack mature synapses due to mutations in the genes carrying building instructions for proteins in the neuroligin family.
The NIMH has launched three major clinical studies on autism spectrum disorders (ASD) to better define subtypes and explore possible new treatments. Researchers will compare children with regressive, non-regressive, and other developmental disorders to investigate environmental factors that may trigger symptoms of autism.
A new study by UC Berkeley vision scientists found that the human visual system is more effective at distinguishing a single person's actions when they are in sync with another individual. This ability is crucial for our social species, allowing us to interpret visual cues to determine emotions and intentions.
Research suggests that older fathers are more likely to have autistic children, with a significantly increased risk compared to younger fathers. The study, which analyzed data from over 318,000 individuals, found that advancing age among fathers was associated with an increased risk of autism spectrum disorder.
Scientists have identified special proteins that help repair and protect the brain after it has been damaged by a lack of oxygen. Dr Nicole Jones and her team found that these proteins increase during oxygen deprivation, regulating processes like red blood cell production and glucose flow to the brain.
A study published in Neurology found that children with autism have altered brain anatomy, including differences in gray matter and brain size compared to children with typical development. The researchers used MRI scans to measure the transverse relaxation of cortical gray and white matter in the brains of autistic children.
A recent study found that autism is a global disorder affecting how the brain processes information, particularly when it becomes complicated. The study discovered that individuals with autism perform well in basic functioning tasks but struggle with complex tasks involving sensory perception, movement, and memory.
Researchers found children with autism have abnormal blood vessel function and high levels of oxidative stress, which may contribute to the disorder's symptoms. The study suggests that targeting this imbalance could lead to new therapies for autism.
A new study by Newcastle University and the International University Bremen found that long nerve fibre connections are essential for brain function, contradicting a prevailing theory. The research used computer analysis of public databases to show that long fibres can send messages quickly over longer distances compared to short fibres.
Researchers have adapted a psychiatric test for monitoring mental abnormalities in mice, revealing a key skill impaired in humans with autism and similar illnesses. The study found that mice can learn to switch attention between tasks, shedding light on the cognitive deficits underlying human mental dysfunction.
Researchers discovered that different genes may be responsible for causing autism in boys than in girls, with varying degrees of severity. The study also found evidence for multiple genetic subtypes of autism, including male versus female and early versus late onset forms.
Researchers from the UC Davis M.I.N.D. Institute have found significantly fewer neurons in the amygdala of males with autism, a key brain region responsible for emotional responses and social learning. The study provides new insights into the neuroanatomical basis of autism, which may help advance research into this lifelong neurodevel...
Research suggests a significant increase in childhood autism prevalence in the UK, affecting approximately 1% of the child population. The study found that children with autism constitute 39 per 10,000 and 77 per 10,000 in South London, indicating a much higher prevalence than previously estimated.
Studies found that people with autism have reduced connections and coordination between brain areas, leading to difficulties in problem-solving and communication. The research provides evidence for a new theory that views autism as a failure of brain regions to communicate with each other.
Researchers found that people with autism have lower brain synchronization and rely heavily on visualization to process information. The studies suggest that these differences are related to the brain's cabling and connectivity problems.
A new brain model, iSTART, describes how imbalanced brain mechanisms underlie autistic behaviors. Individuals with autism exhibit hyperspecific learning, under-aroused emotional responses, and breakdowns in adaptive timing, leading to symptoms like reduced emotional expression and emotional outbursts.
A study by Dr. Eric Fombonne and colleagues found no link between MMR vaccinations and autism rates in Quebec children, contradicting previous concerns. The incidence of autism remained high despite reductions in thimerosal use.
Researchers have identified a potential biomarker for autism in placentas of children born with the condition, indicating that an unusual placental abnormality may be present from birth. This finding suggests that the ideal time for autism diagnosis could be at birth, prior to age one.
A study of 192 children found that most diagnosed with autism at age 2 were also diagnosed at age 9, with 76% receiving the same diagnosis. Parent interviews and clinicians' judgment also predicted future diagnoses.
Researchers found that developmental red flags, such as poor eye contact and language delay, can be identified at 14 months and worsen by 24 months. Early intervention could improve outcomes for children with autism.
Researchers have identified 33 structural changes in the cerebral cortex of individuals with Williams syndrome, including asymmetry between left and right sides. The study's findings may provide insights into developmental brain disorders like autism by enabling scientists to quantify brain structure trends.
A Hopkins study found that pediatricians rarely screen patients for Autism Spectrum Disorder (ASD), with 62% citing a lack of knowledge about screening tools. Screening for ASD is crucial to prevent poorer outcomes in children with developmental disorders, but current national efforts may not be effective.
Researchers found that mutant mice displayed major abnormalities in social interactions, including reduced interest in new mice and impaired nest-forming behavior. The mice also showed hyperactivity, anxiety-like behaviors, seizures, and decreased learning, all characteristic of autism spectrum disorder (ASD).
Researchers identified a gene mutation linked to autism, revealing physical abnormalities in the brain that mimic some cases of autism. The study found altered nerve cell structure and function, potentially leading to sensory overload.
A new study challenges the notion of an autism epidemic in the US, citing inconsistencies in special education data and diagnostic practices. Researchers argue that changes in how children are labeled as having special needs can lead to misleading trends and undermine efforts to accurately measure the scope of developmental disability.
A new childhood-onset epilepsy disorder, cortical dysplasia-focal epilepsy syndrome (CDFE), has been identified in a group of Old Order Amish children. The disorder is caused by a genetic mutation in the CASPR2 protein, which plays a crucial role in maintaining physical contacts between neurons and neighboring glial cells.
Research reveals that social perception plays a significant role in gaze-following behavior among executive monkeys. Low-ranking macaques exhibit faster reaction times to follow the gaze of other monkeys, while high-ranking individuals are more blasé.
A UC Davis study with mice found that even low levels of thimerosal can alter dendritic cell function and lead to abnormal immune responses. The study's findings suggest a link between thimerosal exposure and immune system dysfunction, potentially shedding light on the immunotoxic effects of this common preservative.
The 'imprinted brain hypothesis' proposes that competition between maternally and paternally expressed genes contributes to autism's development. This imbalance in the brain's development is supported by genomic imprinting components, which influence core behavioral features of autism.
Researchers at Binghamton University are using an innovative eye-tracking system to study the social interactions of children with and without autism. The system allows them to measure physiological anxiety, affect, performance, and behavior, providing valuable insights into the subtleties of social interaction.
The Autism Phenome Project is a large-scale, longitudinal study enrolling 1,800 children with autism, developmental delay, and typically developing children. The project aims to identify specific types of autism and develop a database of biomedical information to refine understanding and develop targeted treatments.
A panel of autism experts will assess widely held stereotypes about the developmental disability, including the notion that autistic individuals lack a theory of mind, vaccines cause autism, or are cognitively impaired. Experts aim to move beyond myths and misconceptions to set scientific reality straight.
Research reveals that autistic individuals' intelligence is often misjudged using Wechsler scales, which require oral language skills. However, Raven's Progressive Matrices (RPM) tests show that autistics can excel in high-level abstract reasoning and problem-solving, indicating a more accurate assessment of their intelligence.
Research shows that a unique brain region acts as an integrative centre, modifying pain sensations when people are thirsty. Elite athletes can push through normal thresholds of pain and thirst due to their ability to balance this 'priority switch',
A study by Utah researchers confirms that a specific region on chromosome 3 is linked to autism, with results showing strong similarities to Finnish studies. The researchers used genetic markers to analyze the DNA of 31 family members, seven of whom have autism or an autism-related disorder.
Dr Anthony Hannan from the Howard Florey Institute has won a $1 million Pfizer Australia Research Fellowship to study environmental factors that delay degenerative brain diseases. His recent work showed that mental and physical exercise can slow down HD progression in mice, challenging genetic determinism.
A brain imaging study has discovered that oxytocin quells the brain's fear hub, the amygdala, and its brainstem relay stations in response to fearful stimuli. This finding suggests a potentially powerful treatment approach toward socially relevant fear and may have therapeutic value in disorders characterized by social avoidance.
Researchers found significant brain volume enlargement in children with autism, particularly in white and gray matter, which affects the cerebral cortex responsible for thought, perception, and memory. The study suggests that this enlargement may begin as late as the first year of life, during the postnatal period.
A UCLA imaging study found that children with autism have a dysfunctional mirror neuron system, which may underlie their social deficits. The study used fMRI to measure brain activity in high-functioning children with autism while they imitated and observed emotions.
A Yale University study found that methylphenidate is an effective medication for children with autism and increased hyperactivity. However, the response rate was lower than expected compared to ADHD without co-occurring PDD.
Researchers found that individuals with autism and related disorders have difficulties distinguishing facial expressions from emotional states. The study suggests that these problems may be related to the processing of emotion rather than face perception.
A recent study published at the Society for Neuroscience Annual Meeting found that brain activity related to face processing is similar in individuals with and without autism. The researchers used functional magnetic resonance imaging (fMRI) to examine brain function in people with autism as they processed social cues, including faces.
A randomized, placebo-controlled trial found that methylphenidate significantly improved symptoms of hyperactivity and impulsiveness in children with pervasive developmental disorders. The study included 58 participants who showed a response rate of around 76 percent to the medication.
Research using fMRI technology found reduced activity in the caudate nucleus, a critical part of prefrontal brain circuits, in boys with autism. This impairment affects attention, problem-solving, and learning abilities. The study's findings may help develop better therapies for children with autism.
The National Institutes of Health (NIH) has joined forces with advocacy groups to fund research on autism susceptibility genes. The initiative aims to expand knowledge of the genetic factors involved in autism and develop targeted therapies.
Researchers at Rutgers University have made new findings linking genetic variants to susceptibility to autism and schizophrenia. The study suggests that a mutated form of the EN2 gene may contribute to up to 40% of autism cases, while another gene called CAPON has been implicated in schizophrenia.
Researchers identified a rare syndrome resulting from a HOXA1 gene mutation, affecting horizontal eye movement, hearing, motor skills, and cardiovascular development. The study provides new insights into the role of HOXA1 in human brain development and may lead to ongoing research directions in developmental biology.
Researchers at Rutgers University have identified the protein snapin as having therapy potential for autism by modulating dendrite patterning. Snapin's interaction with cypin regulates branching, and targeting this pathway could lead to new drugs.
The study found that complex gene-gene interactions are likely responsible for the development of autism. The GABA brain system is implicated in this process, with multiple genes working together to influence the disease.
Researchers analyzed home videotapes of 56 children to find that infants with autism who experience regression show more frequent word use and babble than normal infants at 12 months. Early onset ASD infants display the least frequency of language development.
Recent studies suggest that multiple rare mutations within a single gene may increase risk for autism. The SERT gene regulates brain levels of serotonin, which is involved in various biological processes and has been found to be elevated in about 25% of people with autism. SSRIs have improved some symptoms, leading scientists to propos...
Research by Larry Young on voles has shed light on the molecular mechanisms underlying social attachment, which may hold clues for understanding autism. The study suggests that oxytocin and vasopressin play a critical role in modulating social behavior and shaping normal adult social behavior.
A new classification tool developed by Dr. James Coplan may predict outcomes for children with autism and autistic spectrum disorders more accurately than existing methods. The study found that children in the normal range of intelligence show significant improvement in their ASD symptoms over time.
A multi-site study found Risperidone effective in decreasing aggression, repetitive behaviors, and increasing social interaction in children with autism. The medication showed limited side effects, supporting its use as an intermediate-term treatment option.
Researchers identify three reasons to be cautious about an autism epidemic, including a flawed California study and the lack of reporting category for autism in public schools. They propose that the increase in diagnoses may be due to broadened diagnostic criteria and increased public awareness.
Researchers have found that disruption of the Foxp2 gene affects the ability of infant rodents to emit ultrasonic vocalizations, which is crucial for social communication. The study suggests that Foxp2 subsumes communication across species, enabling researchers to learn about human speech and articulation.
A study by Emory University researchers has found that variations in microsatellite sequences of the vasopressin receptor gene can influence social behavior and parenting behaviors in voles. These findings suggest that junk DNA may play a role in shaping individual differences and social diversity.
Researchers identified a link between chromosomes 7 and 21 and autism susceptibility, with new evidence suggesting chromosome 21 plays a role in the condition. This finding may help explain the increased prevalence of autism among children with Down syndrome.