Articles tagged with Crohn Disease
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Recent studies have found that biologic therapies, such as adalimumab and certolizumab pegol, can effectively maintain clinical remission and response in patients with moderately to severely active Crohn's disease. These treatments have shown fewer side effects compared to traditional medications.
A new study reviews the therapeutic benefits of lubiprostone for c-IBS patients, showing improvements in abdominal discomfort and bowel movements. Teduglutide is also found to be effective in inducing remission and response in patients with moderate or severe Crohn's disease.
The FDA has granted a priority review of REMICADE for the treatment of children with moderately to severely active Crohn's disease. In the REACH trial, nearly 90% of pediatric patients achieved clinical response at week 10 and over half were in clinical remission at one year.
The Crohn's & Colitis Foundation of America has partnered with John Wiley & Sons, Inc. to publish the peer-reviewed journal Inflammatory Bowel Diseases. The journal will provide a platform for researchers and clinicians to share advances in the treatment and mechanisms of Crohn's disease and ulcerative colitis.
Researchers found that Crohn's disease patients produce lower quantities of neutrophils and inflammatory mediators in response to trauma, leading to delayed blood flow and persistence of bacteria. Treatment with Viagra corrected abnormally low blood flow, suggesting a potential role for the drug in treating the disease.
A recent study published in American Journal of Roentgenology found that CT enteroclysis can detect complications like fistulas, abscesses, and tumors superior to conventional enteroclysis. This imaging method also detects minimal mucosal changes, a sign of early stage Crohn's disease, with no disadvantages.
The Voices of UC survey highlights the extensive impact of ulcerative colitis on patients' lives, including work, family, and social activities. The study found that nearly half of patients believe their condition is underestimated and misunderstood by others.
The PRECiSE 2 study found that patients treated with CIMZIA achieved a higher clinical response and remission rate compared to those receiving placebo. The study demonstrated the efficacy of CIMZIA in maintaining clinical response after induction therapy, with a significant proportion of patients able to achieve remission by week 26.
A team of scientists at Sanford Burnham Prebys found that an antibody produced in reaction to a naturally-occurring sugar chain curbs intestinal inflammation induced in mice, reversing early symptoms and halting disease progression. The research holds promise for treating Crohn's disease and other inflammatory disorders.
Research confirms that patients with inflammatory bowel disease (IBD) are more likely to develop conditions such as asthma, multiple sclerosis, and other demyelinating disorders. The studies found a nearly two-fold increased risk of multiple sclerosis in IBD patients, highlighting the need for closer monitoring.
A comprehensive analysis of gene expression revealed that 650 genes differ between normal individuals and patients with ulcerative colitis or Crohn disease. Down-regulation, rather than up-regulation, was the prevailing pattern found in both diseases.
Researchers found that GM-CSF treatment alleviated symptoms of Crohn's disease and improved patients' quality of life, with significantly less inflammation in the mucosal linings. The study showed a 40% remission rate for those receiving the drug compared to 19% of placebo recipients.
Researchers found that GM-CSF treatment significantly improved Crohn's disease symptoms in patients, suggesting a defect in innate immune system is the underlying cause. The study supports a new understanding of Crohn's and offers hope for a new treatment option.
Researchers found that rifaximin significantly improved disease activity in patients with Crohn's disease. The analysis of 8 patients showed a mean decrease in Harvey Bradshaw index of 7.1, indicating potential effectiveness as a treatment.
Recent clinical trials have shown promising results for biologic therapies in treating Crohn's disease, with Alequel achieving high clinical remission rates. Additionally, a study on adalimumab has demonstrated increased efficacy over time, while maintaining a strong safety profile.
A study published in Science identified interleukin-1Beta (IL-1â) as a major cause of severe inflammation in mouse models of Crohn's disease, which is a chronic inflammatory bowel disease affecting over 500,000 Americans. High levels of IL-1â were found in mice with mutant NOD2, a genetic defect linked to 50% of Crohn's cases.
Researchers at the University of Alberta found that adding calcium and vitamin D therapy alone provides significant benefit for patients with Crohn's disease who suffer from osteoporosis or osteopenia. The study concluded that physicians should consider BMD testing and drug therapy only for high-risk patients, not those with mild Crohn...
The IBDchip is an open tool that includes polymorphisms associated with the disease, predisposition, and evolution. Progenika has developed similar products, including the Lipochip for hypercholesterolemia diagnosis and the Bloodchip for genotyping blood donors.
Research reveals NOD2 activation leads to modification of NEMO, a central component of the NF-kB signaling pathway controlling inflammatory responses. This discovery suggests a potential pharmacological target for Crohn's Disease treatment.
Researchers challenge traditional hypotheses on Crohn's disease, suggesting a more complex role for cytokines in the immune response. This could lead to new treatment strategies involving the blockade of multiple cytokines.
A new antibody treatment has shown promise in slowing or halting Crohn's disease by blocking the production of inflammatory proteins. The treatment was safe and effective in reducing symptoms in patients with active Crohn's disease.
A study finds that 50% of patients with Crohn's disease have viable MAP in their blood, suggesting a systemic infection. The findings raise questions about the role of MAP in IBD and highlight the need for further research to clarify its significance.
Researchers found that growth hormone reduces STAT3 activation, modulates cellular apoptosis and proliferation, and improves weight gain in mice with colitis. The study suggests using growth hormone as a new therapeutic approach to improve growth and intestinal healing in IBD.
Researchers have found that adding butyrate to an intravenous nutrition solution can cause the intestine to grow back and become more functional. This breakthrough offers hope for preterm infants and patients with Crohn's disease who rely on IV feeding due to surgically removed intestines.
Researchers have found that natalizumab and adalimumab can help maintain clinical response and remission in patients with Crohn's disease. A trial also investigated the use of helminth ova as a potential treatment, showing significant improvements in clinical response and remission.
Researchers found that among patients with confirmed Crohn's disease, clinical decisions based on capsule endoscopy findings improved outcomes in 95% of patients. Capsule endoscopy was also 100 percent effective in excluding a diagnosis of Crohn's disease.
A Phase III maintenance trial of natalizumab found sustained clinical response and remission rates among patients with Crohn's disease. The study also showed that a majority of patients on corticosteroids were able to withdraw from the medication without losing their response.
U of T researchers identify gene responsible for protein malfunction in Crohn's patients, enabling diagnostic test and potential new treatments. The findings provide valuable insights into chronic inflammation and its impact on the disease.
A study published in Inflammatory Bowel Diseases found that gadolinium-enhanced MRI (G-MRI) was highly accurate in diagnosing inflammatory bowel disease (IBD) in children, with 92% accuracy for ulcerative colitis and 96% accuracy for Crohn's disease. This non-invasive diagnostic tool could replace conventional tests like colonoscopy.
A study led by Massachusetts General Hospital found that infliximab can heal and reduce the recurrence of fistulas in Crohn's disease patients. The treatment, which targets tumor necrosis factor, showed significant benefits in closing fistulas and improving quality of life.
Researchers discover a variant of the NFKB1 gene associated with ulcerative colitis, a condition characterized by intestinal inflammation. Additionally, a second study links the MDR1 gene to Crohn's disease and possibly ulcerative colitis.
The cold-chain hypothesis proposes that psychrotrophic bacteria in refrigerated foods contribute to Crohn's disease. These bacteria have been identified in disease lesions and may trigger excessive host responses.
Researchers identified TL1A, a cytokine that regulates immune response, as a potential target for treating IBD. The protein's expression correlated with inflammation severity in Crohn's disease, but not ulcerative colitis.
Researchers at Temple University have identified a genetic mutation responsible for inflammation in Crohn's disease. The study found that a specific protein, kininogen, plays a key role in the development of the disease.
Researchers found that intestinal bacteria in the terminal ileum activate p40 expression, leading to chronic inflammation and predisposing this region to Crohn's disease. The study provides a molecular explanation for why Crohn's disease often affects the small intestine.
A new multi-center study confirms the effectiveness and safety of infliximab in treating pediatric Crohn's disease, leading to significant short-term medical benefits and a reduced need for steroids. The study shows improved symptoms such as pain, growth rates, and bowel movements, with no adverse reactions at infusion sites.
In the Phase II study, natalizumab demonstrated higher rates of clinical remission compared to placebo at multiple time points. The highest rate of remission was observed in the dual 3 mg/kg dose group, with a maximal response of 71%.
Researchers found that patients with moderate to severe Crohn's disease improved significantly after receiving GM-CSF, with 12 out of 15 patients in clinical remission. The treatment targets the innate immune response and has shown promise as an alternative approach to traditional therapies.
A study of 355 patients with severe Crohn's disease found that infliximab treatment every two months significantly increased remission rates compared to placebo. Infliximab also allowed patients to taper off steroids and maintain clinical remissions.
A multi-center research team found that infliximab prolonged remissions in moderate to severe Crohn's disease patients by twice as long at bi-monthly infusions compared to every eight weeks. The drug also helped patients reduce steroid use and improve quality of life.
Researchers at Whitehead Institute identify a new gene, IBD5, on chromosome 5 that increases susceptibility to Crohn's disease. The study provides a strong case for building a haplotype map of the human genome, which could make finding disease-causing genes faster and cheaper.
A UK-based study of over 17,000 people found left handers more than twice as likely to be affected by Crohn's disease and ulcerative colitis. The research suggests later birth may play a role in the increased risk, but the exact cause remains unknown.
New research published in Gut journal found no evidence that measles virus is associated with Crohn's disease. The study isolated particles from the gut tissue of patients and compared them to healthy tissue samples, but found high levels of related cells in all types of samples.
A study of 14 patients with refractory Crohn's disease found that all participants responded to thalidomide treatment, with significant improvements in disease activity and fistula closure. The median daily steroid dose fell by over 70%, indicating a potential steroid-sparing effect.
Scientists at Boston University's School of Dental Medicine have discovered a new gene involved in common inflammatory diseases, including Crohn's disease. The researchers identified the gene that controls production of Tumor Necrosis Factor alpha (TNF), a molecule implicated in various inflammatory conditions.
Researchers found that Thalomid significantly improved symptoms for two-thirds of patients with chronic, steroid-dependent or unresponsive Crohn's disease. Common side effects included drowsiness and peripheral neuropathy. The study suggests a Phase III trial using Thalomid to treat Crohn's disease should be conducted.
Patients with long-standing Crohn disease in remission showed significant nutritional and functional deficiencies, especially in males with high prednisone doses. This study highlights the importance of comprehensive nutritional assessment over single-dimensional assessments.
Recent studies from Johns Hopkins Medicine have identified genetic links to Crohn's disease, a condition affecting 400,000 US citizens. The research suggests multiple genes contribute to the disease, with earlier onset in families with a history of the condition.