Articles tagged with Neurological Disorders
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Researchers found white matter differences in post-treatment Lyme patients using advanced imaging scans, correlating with cognitive difficulties and immune response. Axonal leakage in white matter was associated with better outcomes but also indicative of changed physiology.
A global study of over 28,000 people found that lowering blood pressure can significantly reduce the risk of dementia. The researchers analyzed five double-blind placebo-controlled trials and discovered a broad linear relationship between blood pressure reduction and lower dementia risk.
Dr. Ted Price is leading a $11.3 million NIH multicenter project to elucidate the origins of pain, focusing on human nociceptor and spinal cord molecular signatures. Researchers will study DRG tissue from organ donors to understand how neurons communicate signals along the human pain pathway.
A Cornell University researcher is using optical microscopy and other tools to map the brain's neural response to psychedelics. The study aims to develop fast-acting antidepressants and treatments for substance-use disorders and cluster headaches.
A new study has identified a specialized and distinctive type of microglia with enhanced antioxidant function in the ischemia/reperfusion injured brain, linked to stroke. The presence of Peroxiredoxin-1 protects against acute I/R injury, reducing microglial cell death and inflammatory responses.
Researchers at the University of Copenhagen have made a breakthrough in understanding schizophrenia by analyzing individual brain cells. The study identified specific neurons and networks affected by the disease, suggesting that targeting these areas could lead to new treatment options.
The platform enhances neurosurgical procedures by delivering precise treatment and diagnosis in deep brain tissue. Researchers successfully implanted the catheter in live sheep without damage or infection, paving the way for potential human trials within four years.
Researchers found lower serum TDP-43 levels in patients with C9orf72 repeat expansion or motoneuron disease, distinguishing them from other FTD subtypes. This study suggests TDP-43 as a potential biomarker for diagnosing specific FTD subtypes, enabling patient-specific interventions.
Researchers at Scripps Research Institute have developed a new tool to measure proteins in brain cells, revealing how brain activity remodels the physical structure of neurons. The study found that certain proteins related to DNA packaging play a key role in gene expression changes after neural activity.
A recent study analyzed the records of over 33,000 dementia patients in Wales and found that those closest to their diagnosis were taking an average of three or more medications. This suggests a possible link between polypharmacy and the development of dementia.
Research in Zambia suggests children infected with HIV are more likely to struggle with cognitive and mental health issues despite well-controlled disease. Early intervention through better nutrition and antiretroviral therapies may improve neurological function.
Researchers at UCSF discovered a small molecule called ISRIB that can reverse the neural and cognitive effects of concussion in mice, weeks after an injury occurred. The drug blocks the integrated stress response, which became chronically activated in damaged neurons, restoring normal spine dynamics and cognitive function.
A new study has discovered two distinct cell populations in Alzheimer's Disease: disease-associated microglia and disease inflammatory macrophages. The former exhibits beneficial functions, while the latter displays pro-inflammatory features.
Scientists have developed a new method to study human brain development by growing millimetre-sized three-dimensional tissues called organoids from pluripotent stem cells. The researchers characterized the cells in molecular-genetic terms, creating a kind of map showing the molecular fingerprint of each cell within the organoid.
A systematic review and meta-analysis found that psychotic disorders like schizophrenia are associated with a higher risk of developing dementia. People with psychotic disorders are 2.5 times more likely to develop dementia than those without a psychotic disorder, according to the review.
Researchers at USF Health successfully tested a protein that activates a unique pathway in cells to increase survival and protect endothelial cells from toxic substances. The study reveals the potential of apolipoprotein A1 as a novel therapeutic for ALS patients, with the goal of slowing disease progression and alleviating symptoms.
The CMU Array, a new microelectrode array, offers customized treatments for neurological disorders by allowing for three-dimensional sampling and ultra-high-density configurations. This technology has the potential to transform how doctors treat conditions like epilepsy and limb function loss.
Researchers investigate how motor proteins transport vital proteins and RNAs to the right location within cells, where they can cause or prevent genetic neurological diseases. By understanding these highly regulated transport systems, scientists hope to develop new treatments for conditions like spinal muscular atrophy and Charcot-Mari...
A Rutgers-led study statistically evaluated government data to determine if COVID-19 vaccination increases the incidence of Guillain-Barré syndrome. The results show no significant association between any COVID-19 vaccinations and the disease.
The National Institutes of Health has awarded a $10.7 million grant to Cleveland Clinic to expand a national research consortium focused on improving diagnosis and treatments for Dementia with Lewy Bodies. The consortium, which includes multiple clinical sites, aims to identify biomarkers for disease and develop new therapies.
A study from UniSA researchers found associations between metabolic profiles and adverse brain findings, including lower hippocampal and grey matter volumes. People with metabolic profiles linked to obesity were more likely to have higher accumulation of iron in the brain.
A study at Michigan Medicine found multiple lipid biomarkers linked to diabetic neuropathy in patients with type 2 diabetes. High scores for neuropathy were associated with changes in lipids reflecting impaired energy metabolism, suggesting a potential target for testing and managing the condition.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
A study found that aberrant expression of MAO-B causes both peripheral and neuroinflammation in RA patients, leading to joint pain and cognitive impairment. Administering an MAO-B inhibitor called KDS2010 improved both joint inflammation and cognitive function in a RA animal model.
A University at Buffalo-led study suggests the huntingtin protein is involved in neuronal injury and regeneration. The research found that HTT moves from the injury site to the cell body, carrying components necessary for survival.
A new study found that certain pre-existing conditions have a more significant impact on COVID-19 outcomes than previously thought. Researchers developed a novel prediction model, PDeathDx, which outperformed conventional models and identified degenerative neurological diseases, dementia, and severe disabilities as major risk factors.
A new research model allows scientists to study hereditary spastic paraplegias (HSPs) and test potential therapeutics. HSPs cause increased muscle tone in infants and young children, leading to wheelchair-bound individuals who lose motor function.
Researchers have identified a small molecule drug, SHP656, that can target the circadian clock proteins responsible for glioblastoma's recurrence and spread. The drug has shown promise in reducing cancer stem cell growth without harming normal stem cells.
A novel fluorescent sensor has been developed to visualize the release of oxytocin, also known as the 'happy hormone', in living animals. The sensor, called MTRIA OT, allows for real-time measurement of extracellular oxytocin dynamics in the brain, revealing variability in OT levels dependent on behavioral and physical conditions.
Researchers at UCLA and UCSF will map gene regulatory regions to understand how genetic variants affect brain development. They aim to build a comprehensive catalog of cell types in the developing brain and identify specific cell types and genomic regions that mediate the risk of brain diseases.
A new study reveals key differences in dopamine disposal machinery between male and female mice with a rare human genetic variant found in boys with ADHD or ASD. Females exhibit unique behavioral changes, such as increased anxiety and novelty recognition issues, while males display reduced social behavior and perseverative traits.
Women with a history of gestational diabetes are at substantially higher risk of cardiovascular and cerebrovascular diseases, including coronary artery disease, heart attack, and stroke. Continuous monitoring is crucial to mitigate these risks.
A pooled data analysis found that deep brain stimulation reduced OCD symptoms by 47% and improved substantial outcomes in two-thirds of participants. This treatment approach showed promising results in addressing severe OCD with substantial improvement in approximately half of the patients.
Tel Aviv University researchers discovered that skin cancer cells interact with astrocytes in the brain, promoting metastasis. By inhibiting this interaction using existing treatments, they delayed the spread of melanoma to the brain by 60-80%. This breakthrough has implications for treating advanced-stage melanoma.
Researchers developed a mathematical model to analyze cognitive changes and impairment in the brain, applicable to multiple sclerosis and other neurodegenerative diseases. The model uses multilayer networks for comprehensive analysis of CT scans, X-rays, ultrasound, and magnetic resonance imaging data.
Adults with ADHD are more than twice as likely to develop at least one cardiovascular disease compared to those without the condition. The study found that ADHD is an independent risk factor for a wide range of cardiovascular diseases, including cardiac arrest and peripheral vascular diseases.
The University of Ottawa-led team aims to bridge the gap between heart and brain health by developing new diagnostic tools and treatments. They will focus on improving patient outcomes for disorders linked to both organs.
The NEUROCOV project seeks to understand the interplay between SARS-CoV-2 infection and the nervous system, with a focus on immune response and neuronal functions. The research aims to predict risk for neurological symptoms and develop effective treatments.
A new study identified distinct metabolic profiles in women with Idiopathic Intercranial Hypertension (IIH), a condition characterized by raised brain pressure. Weight loss programs showed positive effects on results, suggesting that metabolism plays a role in disease development.
Researchers used data from over 400,000 individuals to model genetic and environmental factors influencing common neuropsychiatric disorders. Gene-environment interactions accounted for a significant proportion of variability in some disorders, while others showed more substantial contributions.
Researchers at Tel Aviv University develop a groundbreaking method to eradicate glioblastoma brain tumors by targeting astrocytes and starving them of energy. The study found that in the absence of these brain cells, tumor cells die and are eliminated, offering a promising basis for developing effective medications.
Researchers identified critical period plasticity in the amygdala that can be treated with therapeutic intervention at key developmental time points. Early pharmacological intervention was shown effective in reducing fear-learning in the mouse model.
Researchers at CSU found that a gene called MSH1 helps keep plant mitochondrial genomes mutation-free, allowing for quick sorting of normal and diseased DNA. This process is more efficient in plants than in humans, where mutations are passed down through generations.
A team of researchers from Ritsumeikan University in Japan has elucidated the mechanism behind the liquid-solid phase transition of FUS protein that leads to ALS. They discovered a new therapeutic target, arginine, which suppresses FUS aggregation and could delay ALS progression.
Research reveals that 32 species of animals, including prawns, crabs, and lizards, can act as carriers of the rat lungworm parasite, which can cause serious illness and death. The study aims to raise awareness about paratenic hosts and prevent infection by avoiding eating raw or infected animals.
Researchers at Washington University School of Medicine have discovered a new pathway that could help prevent Alzheimer's dementia. Increasing the clearance of waste products in the brain by ramping up a genetic quirk known as readthrough may be effective for other neurodegenerative diseases, such as Parkinson's disease.
A study has found that pheasant meat can contain small fragments of toxic lead, which can be absorbed by the body and cause long-term harm. Researchers detected up to 10mg of tiny lead shards per pheasant, widely distributed within the bird's tissues.
A study investigated the frequency and characteristics of non-motor symptoms in ALS patients, finding over 90% experienced symptoms such as fatigue, pain, and sleep disorders. These symptoms reduced QoL even when motor symptoms were mild, highlighting their importance to consider.
Researchers at Cedars-Sinai Medical Center have developed a new method to identify which human gut microbes contribute to inflammatory diseases. By analyzing protein levels in blood serum, the team discovered specific bacteria that trigger immune activation and inflammation.
Olga Boukrina's five-year grant funds research on neurobehavioral reading intervention with potential to promote post-stroke plasticity. The study aims to develop an fMRI neurofeedback-based approach to improve reading recovery in stroke survivors.
Researchers developed nanometric photodiodes that can bind to nerve cell surfaces and activate them with infrared light, allowing for selective stimulation of individual neurons. This technology has the potential to study the nervous system in-depth and develop targeted therapies for neurological diseases.
Researchers tested a core-strengthening program using the AllCore360º to improve trunk function, balance, and mobility after stroke. The study showed promising effects on functional outcomes, including improved lateral control of posture and standardized treatment dosage.
A new study published in Nature reveals that microglia cells change their molecular state to match neighboring neurons, influencing neural circuit function. The researchers found that different types of cortical neurons recruit specific numbers of microglia, which then adapt to the neuron's environment.
A new study found that neuronal cilia play a crucial role in ensuring proper signaling of dopamine receptors, which regulate motivated behavior and movement. Mice lacking functional cilia on dopamine receptor 1-expressing neurons became obese and sedentary, highlighting the importance of cilia in dopamine-dependent neural signaling.
Researchers at Okayama University discovered EPA's molecular target, which blocks purinergic chemical transmission and reduces pain perception. The study suggests EPA can be used as a therapeutic strategy for managing chronic pain with fewer side effects.
Researchers at KAIST developed a novel fusion protein drug, αAβ-Gas6, which efficiently eliminates amyloid beta (Aβ) without causing inflammatory side effects. The study showed that αAβ-Gas6 promoted the robust uptake of Aβ without inflammation and neurotoxicity.
Newborn neurons in Rett syndrome organoids migrate slowly and erratically compared to non-mutated cells. The study provides new insight into how MECP2 mutations affect brain development, revealing larger ventricles and thinner neural zones.
A new AI-based dynamic brain imaging technology has been introduced by Carnegie Mellon University, which can map out rapidly changing electrical activity in the brain with high precision and speed. The technology uses deep learning approaches to translate scalp EEG signals back to neural circuit activity without human intervention.
Scientists have identified two areas of the auditory cortex specialized to recognize human voice sounds without linguistic meaning. These regions help react to sound cues allowing people to identify characteristics of the person speaking, such as gender, age, and height. This discovery sheds light on neurological disorders affecting vo...
A new study found that HIV-1 Tat expression accelerates age-related diseases in male mice by disrupting neuroendocrine function. Researchers discovered that Tat alters steroid hormone levels, leading to anxiety-like behavior, cognitive errors, and reduced grip strength.