A national study of approximately 3,500 women found that those with a history of stroke are more likely to believe they won't receive adequate emergency care due to their gender and race. This perception may lead to delays in treatment for stroke patients, highlighting the need for improved healthcare equity.
SourceMichigan Medicine - University of Michigan·JournalStroke·TypeData/statistical analysis·DateNov 6, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A $5 million NIH grant is expanding the University of Illinois Chicago's neurology tissue bank into a citywide effort to study epilepsy and brain cancer. The project will create a powerful new resource combining brain tissue data with clinical, functional, genetic, and 3D imaging information.
New experiments by Bar-Ilan University researchers suggest dendritic trees, not neuronal somas, are responsible for many brain features. This reevaluation could impact research on degenerative diseases and the origin of sleep and awake states.
SourceBar-Ilan University·JournalPhysica A Statistical Mechanics and its Applications·DateNov 6, 2023
A recent study found that people living in areas with high levels of fine particulate matter have a 56% greater risk of developing Parkinson's disease. The Mississippi-Ohio River Valley and parts of Texas, Kansas, and eastern Michigan were identified as regions with higher rates of the disease.
SourceDignity Health Arizona·JournalJournal of Neurology·DateOct 30, 2023
Researchers have discovered axonal dysregulation in the prenatal brain as a mediator of genetic risk for schizophrenia. The study used induced pluripotent stem cells and three-dimensional brain organoids to identify key genes involved, including CYFIP1, which is highly expressed in microglia.
SourceElsevier·JournalBiological Psychiatry·TypeExperimental study·DateOct 24, 2023
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers at the University of Texas Health Science Center discovered a gene therapy approach that can restore motor functions in mice with Contactin-Associated Protein 1 (Cntnap1) mutations. The study found that turning on the normal gene earlier improves the rescue outcome, and the next phase is to test this approach in humans.
SourceUniversity of Texas Health Science Center at San Antonio·JournalCell Reports·TypeExperimental study·DateOct 20, 2023
The WVU School of Medicine and Benjamin M. Statler College of Engineering and Mineral Resources will support clinical trials and engineering technology development. The project aims to improve care and rehabilitation for people with neurological disorders through novel physician-engineer programs and human research.
A new national study finds that lesbian, gay, and bisexual adolescents in the US are more than twice as likely to report binge eating than their heterosexual peers. Stressors like discrimination and stigma can lead to poor self-esteem and disordered eating.
SourceUniversity of Toronto·JournalEating Disorders·DateOct 18, 2023
Researchers found that hierarchical cortical organization is impaired in people with schizophrenia, leading to disruptions in processing stimuli from the external world. This disruption affects secondary processing of sensorimotor-visual gradients, explaining behavioral and clinical symptoms of the disease.
SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateOct 17, 2023
Researchers have developed a lab-grown human skin model that effectively replicates mpox virus infections, providing insights into the virus's mechanisms of attack on skin cells. The study reveals how the virus causes disease and identifies potential therapeutic targets, including an antiviral drug called tecovirimat.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalNature Microbiology·DateOct 16, 2023
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Two parallel projects publish detailed cell atlases of the adult human brain and brain development, revealing over 3,000 cell types, including new insights into brain diseases and potential therapeutic targets. The freely available brain atlases will enable researchers to compare healthy brains with diseased ones.
SourceKarolinska Institutet·JournalScience·TypeExperimental study·DateOct 12, 2023
Brain inflammation in early childhood may prevent specific neurons from maturing fully, leading to conditions like autism spectrum disorders and schizophrenia. Researchers studied post-mortem brain tissue from children with inflammatory conditions or accidents and found that two types of cerebellar neurons were most vulnerable.
SourceUniversity of Maryland School of Medicine·JournalScience Translational Medicine·TypeExperimental study·DateOct 12, 2023
Researchers have created detailed cell maps of the human brain and nonhuman primate brain, paving the way for new generation of treatments for mental disorders. The study reveals a comprehensive inventory of brain cells, their organization, and gene regulation, setting the stage for developing targeted therapies.
SourceNIH/National Institute of Mental Health·JournalScience·DateOct 12, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers discovered the STAT3 signaling pathway as a potential target for treating H3K27M-mutant diffuse midline gliomas (DMGs), a uniformly lethal central nervous system malignancy. The current standard of care, including palliative radiation and chemotherapy, remains ineffective in this disease.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateOct 10, 2023
A study by researchers at the University of California - Riverside found that certain aspects of video game play can stimulate dopamine release and potentially aid in treating Parkinson's disease symptoms. The research suggests a promising new approach for managing the condition.
The number of people who die from stroke globally is projected to increase by 50% to 9.7 million deaths per year by 2050, mainly affecting Low-Middle Income Countries (LMICs). The annual costs are estimated to reach up to US$2.3 trillion, with a disproportionate impact on LMICs.
SourceThe Lancet·JournalThe Lancet Neurology·TypeSystematic review·DateOct 9, 2023
Researchers discuss lurbinectedin as a method to treat neuroendocrine tumors (NETs), with encouraging results from phase II basket studies demonstrating activity in platinum-sensitive relapsed SCLC and other malignancies. Lurbinectedin's mechanism of action involves inhibiting oncogenic transcription, promoting apoptosis and cell death.
SourceImpact Journals LLC·JournalOncoscience·TypeCommentary/editorial·DateOct 6, 2023
A Phase IIIb study published in the New England Journal of Medicine found that esketamine nasal spray achieved higher remission rates (27.1%) compared to quetiapine extended-release (17.6%) in patients with treatment-resistant depression, indicating its potential as a targeted therapy for this population.
SourceGoethe University Frankfurt·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateOct 5, 2023
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Brazilian researchers screened 160 existing drugs and identified six compounds effective against Toxoplasma gondii. Almitrine, a COPD treatment, showed significant reduction in brain parasite load. Further studies are needed to repurpose these drugs for toxoplasmosis treatment.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalPLOS ONE·DateOct 4, 2023
A new CRISPR-based gene therapy platform will be developed to target genetic brain diseases like Angelman syndrome and H1-4 syndrome. The platform utilizes a novel delivery technology called STEP (Stimuli-responsive Traceless Engineering Platform), which has the capacity to revolutionize genome-editing therapy.
Researchers at the Technion have made a breakthrough in understanding sporadic Alzheimer's disease by identifying the mechanism behind protein accumulation. The study found that damage to the ubiquitin system leads to the accumulation of toxic proteins, even in healthy tissue, mimicking typical Alzheimer's pathology.
SourceTechnion-Israel Institute of Technology·JournalNature Communications·TypeExperimental study·DateOct 3, 2023
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers discovered that a mutation in the gene ACTA2 causes moyamoya disease and strokes in young children. The mutation leads to dysfunctional smooth muscle cells in arteries, resulting in blockages and increased risk of stroke. Understanding this mechanism could lead to new treatments for moyamoya disease.
SourceUniversity of Texas Health Science Center at Houston·JournalNature Cardiovascular Research·DateSep 28, 2023
A recent study published in Radiology: Artificial Intelligence found significant racial and sex-related biases in an AI chest X-ray foundation model, affecting its performance across patient subgroups. The researchers highlighted the need for comprehensive bias analysis to ensure diversity and representativeness in dataset collection.
SourceRadiological Society of North America·JournalRadiology Artificial Intelligence·DateSep 27, 2023
The University of Minnesota Medical School has received a $16 million grant from the NIH BRAIN Initiative to create detailed maps of brain connections. This project aims to better understand how complex neural pathways generate human behaviors and develop treatments for brain disorders.
SourceUniversity of Minnesota Medical School·DateSep 26, 2023
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
A team of scientists has discovered a second toxin produced by the cyanobacterium Aetokthonos hydrillicola, which is highly toxic and similar to substances used in cancer treatment. The findings could lead to the development of new anti-cancer drugs.
SourceMartin-Luther-Universität Halle-Wittenberg·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateSep 26, 2023
Researchers have developed an integrated sensor capable of capturing and enhancing bio-signals, paving the way for potential treatments of brain disorders. The innovative technology uses inkjet printing to create a flexible substrate with a custom-made sensor.
SourcePohang University of Science & Technology (POSTECH)·JournalAdvanced Materials·DateSep 21, 2023
Researchers launch EU-funded initiative to uncover EBV's role in MS, aiming to find underlying mechanism and develop antiviral treatments. The project seeks to improve disease course or stop progression, with potential for preventive strategies like vaccination.
The new guidelines provide a framework for genetic testing and counseling, recommending comprehensive testing and gene-targeted therapies for all persons with ALS. The guidelines aim to improve access and standardize practice among neurologists and genetic counselors.
SourceOhio State University Wexner Medical Center·JournalAnnals of Clinical and Translational Neurology·TypeMeta-analysis·DateSep 18, 2023
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A UMass Amherst neuroscientist is mapping the brain of a sea slug to study how neurons are added to functional neural circuits, shedding light on how this process contributes to neurological conditions. The project aims to provide an unprecedented look at brain development and potentially inform human brain development.
A study published in Sleep Medicine found that arousal disorders, including sexsomnia and sleep eating, often go untreated due to a lack of consensus on best treatments. Cognitive behavioral therapy and sleep hygiene have shown effectiveness in managing these conditions, which can result in injuries or weight gain.
SourceNorthwestern University·JournalSleep Medicine·TypeSystematic review·DateSep 14, 2023
York University researchers found that maternal care significantly impacts the development, microbiome, and health of wild carpenter bees. Without proper care, pathogen loads increase, leading to reduced microbiomes, increased disease susceptibility, and poor overall health.
SourceYork University·JournalCommunications Biology·TypeExperimental study·DateSep 14, 2023
Experts convened at the Stroke Treatment Academic Industry Roundtable XII meeting to address key issues hindering enrollment in acute stroke trials. Broadening emergency consent procedures and adopting efficient trial designs are recommended to enhance participant recruitment.
SourceUniversity of Cincinnati·JournalStroke·TypeCommentary/editorial·DateSep 14, 2023
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers developed a technique called CHOOSE that allows them to test the effect of multiple mutations in parallel and at a single-cell level within human brain organoids. The study identified critical transcriptional changes regulated through common networks, or GRNs, and found that some cell types are more susceptible to autism mu...
SourceIMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences·JournalNature·TypeExperimental study·DateSep 13, 2023
A new study suggests that transcranial ultrasound stimulation can be used to change specific types of activity within the brain, paving the way for targeted treatments of mental health conditions. The research found that TUS induced significant changes in GABA concentration and altered communication between brain regions.
SourceUniversity of Plymouth·JournalNature Communications·TypeExperimental study·DateSep 12, 2023
A new study uses brain imaging to explore the neural underpinnings of uncertainty processing in OCD, finding that patients struggle with certainty and decision-making, particularly when outcomes are more certain. This understanding may offer new hope for developing therapies targeting uncertainty processing in OCD.
SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateSep 12, 2023
A study published in NPJ Aging reveals that COVID-19 exacerbates production of auto-antibodies associated with blood clotting disorders and aging. Researchers found that severe COVID-19 cases display a significant age-related increase in auto-antibodies, which can lead to tissue injury and organ damage.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·Journalnpj Aging·DateSep 12, 2023
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers are developing a new treatment for ischemic stroke by targeting the prostaglandin receptor EP2, which could have a wider therapeutic window and improve behavioral outcomes. The potential new treatment has the potential to reduce inflammation and provide protection for neurons after an ischemic stroke.
SourceUniversity of Tennessee Health Science Center·DateSep 7, 2023
Researchers developed a new model of hereditary Alzheimer's disease in marmosets by introducing mutations into the PSEN1 gene, which causes early-onset disease in humans. The study aims to characterize and validate genetic, molecular, functional, and cognitive features of aging and Alzheimer's disease in these animals.
SourceUniversity of Pittsburgh·JournalAlzheimer s & Dementia Translational Research & Clinical Interventions·DateSep 6, 2023
This review summarizes six common RNA modifications, including m6A, m5C, m1A, m7G, Ψ, and A-to-I editing, which play crucial roles in various human diseases. The authors discuss the mechanisms of these modifications and their targeting by small molecule inhibitors.
SourceBeijing Zhongke Journal Publising Co. Ltd.·JournalMolecular Biomedicine·DateSep 6, 2023
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A new NYU Langone Health program trains neurology residents to diagnose neurological ailments using simulated virtual exams. The curriculum includes 'actor-patients' and self-testing, improving residents' comfort levels and interest in teleneurology, a crucial skill for the future of healthcare.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalNeurology Education·DateSep 6, 2023
A groundbreaking review paper reveals the importance of GABA tone, the amount of GABA that regulates continuous signaling in the brain. The study identifies key mechanisms and functions, including astrocytes' role in regulating GABA tone and its impact on cognitive processes.
SourceInstitute for Basic Science·JournalNature Reviews Neuroscience·TypeSystematic review·DateSep 5, 2023
Researchers at UC Davis have developed SparkMaster2, an open-source software that analyzes normal and abnormal calcium activity in human cells. The tool can identify calcium sparks associated with irregular heartbeats, or arrhythmia, enabling better understanding of the underlying biology.
SourceUniversity of California - Davis Health·JournalCirculation Research·TypeData/statistical analysis·DateSep 1, 2023
Research reveals that T-cell infiltration into the brain is the primary cause of pulmonary dysfunction in Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS). The study provides new insights into the condition and potential treatment pathways.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalNature Communications·TypeExperimental study·DateAug 30, 2023
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A new study found that people who received free produce prescriptions experienced increased fruit and vegetable consumption, leading to improved body mass index, blood sugar, and blood pressure levels. This research suggests that produce prescription programs may be an effective way to address food insecurity and promote health.
SourceAmerican Heart Association·JournalCirculation·DateAug 29, 2023
A new MU study highlights the protective role of innate lymphoid cells and interferons in reducing neurological effects of Brucellosis. The findings could lead to improved diagnostics and therapies for neurobrucellosis, a condition that can cause long-term neurological complications.
SourceUniversity of Missouri-Columbia·JournalAmerican Journal Of Pathology·TypeExperimental study·DateAug 29, 2023
Researchers at Purdue University have developed a 'mini-brain' that tracks the effects of concussive force on brain cells, revealing a link between head trauma and Alzheimer's disease. The study found that even hours after a hit, acrolein production leads to misfolded amyloid beta protein aggregation.
SourcePurdue University·JournalLab on a Chip·TypeExperimental study·DateAug 29, 2023
Researchers found novel autoantibodies implicated in hypertensive disorders of pregnancy, fetal growth restriction, and recurrent pregnancy loss. These autoantibodies are also associated with infertility and endometriosis-associated infertility.
SourceKobe University·JournalInternational Journal of Molecular Sciences·TypeObservational study·DateAug 28, 2023
Patients with severe long COVID often struggle with fatigue and exertion intolerance, with recovery rates varying depending on the initial infection's severity. A recent study found that those with ME/CFS experience little to no improvement in symptoms, while some patients in a second group show gradual improvement over time.
SourceCharité - Universitätsmedizin Berlin·JournalEClinicalMedicine·TypeObservational study·DateAug 28, 2023
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers at the University of Sydney have developed a nanoscale optical technique to monitor protein aggregates forming in cells, which can lead to neurodegenerative diseases such as Alzheimer's and ALS. The study provides a new window into the transition of proteins from liquid to solid phase.
SourceUniversity of Sydney·JournalProceedings of the National Academy of Sciences·TypeObservational study·DateAug 23, 2023
Researchers at Stanford Medicine have developed a brain-computer interface that can decode the intended words of a speech-disabled person and display them on a computer screen. The technology has shown promise in restoring communication for individuals with amyotrophic lateral sclerosis (ALS) who are unable to speak.
SourceStanford Medicine·JournalNature·TypeCase study·DateAug 23, 2023
Researchers have successfully transplanted human microglia cells into mouse retina, creating a model for studying treatments for diabetic retinopathy, glaucoma, and age-related macular degeneration. The study demonstrates the potential of microglial replacement therapy to treat retinal and central nervous system diseases.
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers at the University of Minnesota Medical School have made a breakthrough in treating Hurler syndrome using gene therapy. The new approach produced normal enzymes from the liver that were able to sustain normal connections within specific neural networks, restoring brain connectivity.
SourceUniversity of Minnesota Medical School·JournalScientific Reports·TypeExperimental study·DateAug 21, 2023
Researchers found that endogenous retroviruses, naturally present in the human genome, can influence the spread of tau aggregates between cells. This suggests that viral proteins could be potential targets for therapies to stop or slow neurodegeneration.
SourceDZNE - German Center for Neurodegenerative Diseases·JournalNature Communications·TypeExperimental study·DateAug 21, 2023
A Penn State-led research team discovered that somatostatin signaling acts to dampen communication among cell types in the prefrontal cortex, promoting exploratory and risk-taking-like behavior. The findings suggest that somatostatin fine-tunes circuits to promote certain behaviors, including decision making.
SourcePenn State·JournalCell Reports·TypeExperimental study·DateAug 17, 2023
A new study found that high-stress caregivers had higher klotho levels and longer telomeres in specific immune cells, which may provide protection against aging. In contrast, low-stress caregivers showed no significant associations between klotho levels and telomere length.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateAug 17, 2023
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers developed a new mathematical model to study circadian rhythm resilience and develop ways to improve it in individuals with weak internal clocks. Sustained disruptions can lead to disorders like diabetes and memory loss.
SourceUniversity of Waterloo·JournalSIAM Journal on Applied Dynamical Systems·DateAug 17, 2023
A study of nearly 1,300 individuals diagnosed with six types of mental illness reveals diverse brain changes, with no more than 7% showing similar deviations in the same area. The research identifies potential treatment targets for individualized therapy.
SourceMonash University·JournalNature Neuroscience·TypeExperimental study·DateAug 14, 2023
A first-in-human trial of deep brain stimulation (DBS) for post-stroke rehabilitation patients has shown that DBS to target the dentate nucleus improves motor impairment and function, with gains nearly tripling initial scores. The study also found significant improvements in quality of life.
SourceCleveland Clinic·JournalNature Medicine·DateAug 14, 2023
Researchers found an abnormal imbalance of excitatory cortical neurons in people with autism spectrum disorder, depending on their head size. The study used human 'mini-brain' models called organoids to recreate the brain development alteration that occurred in patients during fetal development.
SourceMayo Clinic·JournalNature Neuroscience·DateAug 10, 2023
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers have created a novel animal model to study the pathogenesis of neurobrucellosis, a severe complication of brucellosis. The model reveals that innate lymphoid cells and interferons play a crucial role in limiting brain damage during Brucella infection.
SourceElsevier·JournalAmerican Journal Of Pathology·TypeExperimental study·DateAug 10, 2023