Articles tagged with Neurological Disorders
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DNA recombinations of specific genomic sequences are found in both normal and diseased states, challenging the idea of a single genetic code. The study identified millions of mutations caused by recombination of repeated sequences Alu and L1, which may contribute to cancer and other genetic disorders.
Researchers found that transcranial brain stimulation can improve accuracy and speed in older adults, facilitating the emergence of efficient motor chunks. The study suggests that this non-invasive technique may restore motor skill acquisition in individuals with diminished learning mechanisms.
A new study from Regenstrief Institute reveals that two-thirds of stroke patients screening positive for depression received no mental health treatment. The gap persists despite changing attitudes toward mental health treatment, with disparities seen in older patients, men, and minority groups.
A review of over 200 publications suggests that fish perceive quantities using similar brain regions as mammals and birds. This finding could lead to the development of new treatments for human diseases affecting math skills, such as developmental dyscalculia.
Researchers from Rice University, Duke University, Brown University and Baylor College of Medicine developed a magnetic technology to wirelessly control neural circuits in fruit flies. They used genetic engineering to express heat-sensitive ion channels in neurons that control the behavior, and iron nanoparticles to activate the channels.
Researchers have created a new mouse model that mimics brain damage caused by severe RVFV infection, enabling the study of disease mechanisms and high-throughput testing of next-generation drugs. This breakthrough has significant implications for developing therapies and vaccines for this devastating virus.
Inhibitory and excitatory neuronal circuits develop through different processes, with inhibitory neurons requiring visual experience to form mature functional maps. This discovery sheds light on the importance of continued study of inhibitory neural development and its connection to neurodevelopmental disorders.
Researchers at Hokkaido University have discovered a molecular pathway by which stress affects lupus, revealing a potential target for treatment. The study found that sleep deprivation caused the activation of microglial cells in the brain, leading to increased levels of IL12 and IL23, a diagnostic marker for neuropsychiatric SLE.
New research models how post-viral fatigue syndromes like ME/CFS and Long COVID become life-changing diseases due to neuroinflammation. The study proposes a brain-body connection sustained through chronic neuroinflammation, leading to relapse recovery cycles.
In a new study, researchers found that microglia cells are responsible for neuronal death in a mitochondrial disease mouse model. Suppressing these cells with the drug Pexidartinib increased life expectancy and reduced motor problems. Further research is needed to understand the specific process by which microglia attack neurons.
Researchers propose a theory on how SARS-CoV-2 infects the body, leading to hyperactivation of the immune system and post-COVID syndromes. The hypothesis suggests that molecular motifs on the spike protein interact with immune cells, causing an overreaction and mistakenly attacking organs.
Researchers found altered cell-mediated immune function in ALS patients and a novel treatment approach using bone marrow transplants. The study suggests that abnormal CD8 T-cell response contributes to motor neuron degeneration.
A new study by University of Missouri found that Black nursing home residents and those under 65 are significantly more likely to experience repeat hospital transfers. This phenomenon can be attributed to various factors including 'full-code' status regarding end-of-life care, comorbidities, and inadequate staffing. The study suggests ...
Researchers discovered that blocking certain acetylcholine receptors in the lateral habenula balances reward and aversion, making it harder to resist seeking cocaine. This finding identifies a new role for these receptors as a potential target for treating cocaine use disorder.
A new genetic disease has been identified that causes abnormal brain development in children, resulting in severe learning difficulties. Researchers have discovered the underlying cause of the condition by analyzing changes in a protein coding gene called GRIA1, which helps move electrical signals around the brain.
Studies by UC Davis MIND Institute found predictive protein patterns in expecting mothers' blood and links between maternal autoantibodies and higher autistic traits. MAR ASD patterns were associated with autism before birth, with certain patterns predicting autism in previously diagnosed children.
Despite lower hospitalizations for strokes and mini-strokes during the pandemic, patients with stroke experienced no decline in overall quality of care and outcomes. Missing blood pressure checks were associated with higher short-term and long-term mortality rates.
A new study by an international group of researchers has found substantial reductions in grey matter in people with anorexia nervosa, a condition characterized by severe food restriction and low body weight. Early intervention and treatment can help the brain repair itself, according to the research team led by Dr. Paul M. Thompson.
A world-first study from the University of South Australia found a direct link between vitamin D deficiency and increased risk of dementia and stroke. The study analyzed data from 294,514 participants and found that up to 17% of dementia cases might have been avoided by boosting vitamin D levels.
Researchers at Colorado State University have found a way to alter the type of synapses between brain cells using enzymes. This breakthrough could lead to new treatments for brain disorders caused by faulty synaptic information processing and exchange.
A Rutgers study analyzing brain stem cells of autism patients found irregularities in early brain development, supporting the concept that ASD arises from poor control of brain cell proliferation. The study discovered that some patients had NPCs producing too many brain cells while others had underproduced cells.
A survey study examined sociodemographic factors influencing the association between neurodevelopmental disorders and bullying. The study found that certain factors, such as socioeconomic status and parental education, may modify this association.
Babies born to mothers infected with COVID-19 show differences in motor function and relaxation, especially when held. Preliminary analysis suggests increased risk of neurodevelopmental changes compared to uninfected babies.
A recent study of 7,600 adults found that higher levels of light- and moderate-to-vigorous intensity physical activity were associated with a reduced risk of stroke. Conversely, greater sedentary time was linked to an increased risk of stroke.
A meta-analysis published in The Lancet Oncology suggests that targeted radiation therapy, which spares healthy brain tissue, is equitable to whole brain radiation therapy for patients with small cell lung cancer and brain metastases. This approach may improve their care experience with fewer negative cognitive consequences.
Infants diagnosed with autism spectrum disorder at 24 months had differences in visual processing areas of the brain apparent at 6 months old. These early changes could affect further brain development and play a role in ASD symptoms.
A groundbreaking study found that infantile spasm patients and animal models have reduced IGF-1 levels in their brains, leading to treatment breakthroughs. The administration of an IGF-1 analog successfully eliminated spasms and abnormal brain activity in IS animal models.
Two preclinical studies have identified potential new therapies for patients with Allan-Herndon-Dudley syndrome (AHDS), a brain development disorder that causes severe intellectual disability and movement problems. A gene therapy approach has shown promise in improving cognitive and motor functions, while repurposing a common drug may ...
A recent cohort study found that previous cardiovascular conditions, including heart surgery and heart failure, were associated with increased COVID-19 severity in US pediatric patients. The study highlights the importance of pre-existing medical conditions in determining COVID-19 outcomes in children.
A new study by McGill University researchers has shed light on the complex relationships between concussion symptoms and brain damage in children. The findings suggest that certain combinations of brain injury can lead to specific symptoms, such as attention difficulties and sleep problems.
Researchers suggest a novel neuroimaging technique can unveil Alzheimer's disease secrets and predict symptom risk. The 'neuromelanin-sensitive MRI' method provides insights into the brain's noradrenergic system, linked to aggressive behavior and cognitive decline.
Scientists at Cedars-Sinai Medical Center used advanced brain imaging techniques to study the impact of prenatal opioid exposure on infant brain development. The study found that treatment with medications like buprenorphine and methadone can minimize brain abnormalities in newborns exposed to opioids prenatally.
The international consensus on diagnosing and treating opsoclonus-myoclonus syndrome has been published, providing support for families and clinicians. The guidance outlines the condition's characteristics, causes, and management options, aiming to improve care for affected children.
Researchers discovered a link between traumatic brain injuries and changes in the gut microbiome, suggesting a potential diagnostic tool for concussions. The study found two bacterial species that dropped significantly after concussions, indicating a correlation with traumatic brain injury-linked proteins in the blood.
A new type of RNA structure targeting tool has been developed to specifically recognise unusual four-strand RNA structures associated with diseases such as cancer and neurological disorders. The L-RNA aptamer-based rG4 targeting approach shows promise for developing new therapeutic tools.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
A new study found that extended space flight increases perivascular spaces in the brains of first-time astronauts, but not those who previously served in space. No neurological deficits were detected despite the changes.
Researchers found a correlation between Parkinson's gene alpha-synuclein and vocal production in zebra finches. The study suggests that this link could lead to earlier diagnoses and treatments for Parkinson's patients.
Severe COVID-19 causes cognitive impairment similar to 50-70 year age range, equivalent to losing 10 IQ points. Cognitive symptoms persist six months after acute illness and show gradual recovery.
A new study from Mayo Clinic suggests that AI-enabled electrocardiograms (ECGs) can predict atrial fibrillation, a cardiac rhythm abnormality linked to one-third of ischemic strokes. The algorithm also detects other cardiac disease markers and correlates with small vessel cerebrovascular disease and cognitive decline.
Researchers used gene therapy to recover the TCF4 gene's function in human brain tissue, rescuing neural structure and function in brain organoids. The study offers promising insights into treating neurological disorders like autism spectrum disorders and schizophrenia.
A study led by Kobe University researchers found that idiopathic autism is caused by epigenetic abnormalities in hematopoietic cells, leading to immune dysregulation and brain-gut axis disorders. The study used BTBR mice as a model and identified histone deacetylase HDAC1 as a common mechanism underlying these pathologies.
Researchers at UC San Diego have developed a smartphone app that uses near-infrared camera technology to track pupil size changes, which can indicate cognitive conditions. The app is designed to be user-friendly for older adults and has shown comparable results to traditional pupillometry devices.
Researchers at Johns Hopkins Medicine developed an AI training strategy to capture images of mouse brain cells in action, allowing scientists to understand how the brain functions and is affected by disease. The technology combines ultra-small microscopes with AI to enhance image resolution up to 52 frames per second.
The University of Texas at El Paso has received a $5M NIH grant to build an imaging and behavioral neuroscience facility focused on addressing Hispanic health disparities. The new facility will enable researchers to study the mechanisms contributing to cancer and neurological disorders in Hispanic populations.
A new AI-based method distinguishes between stable and progressive cognitive impairment, enabling accurate diagnosis with an accuracy rate of 85%. This technique overcomes the complexity of subtle structural changes in mild cognitive impairment, contributing to achieving Sustainable Development Goal 3.
A new study found a bi-directional relationship between gastrointestinal issues and internalized symptoms in children with autism, highlighting the importance of the gut-brain axis. The research aims to develop personalized treatments for individuals with autism experiencing gastrointestinal problems.
A preclinical study suggests that astrocyte abnormalities may contribute to repetitive behaviors and memory deficits in autism spectrum disorders. Researchers grew human astrocytes from patients with ASD and transplanted them into healthy mice, which developed repetitive behaviors but not social deficits.
A study of 447 former college football players found an association between playing football and increased rates of cognitive and neurological disorders, as well as higher mortality rates. The findings suggest that football players may face unique health challenges beyond their playing careers.
Scientists have created a searchable atlas of distinct cell populations in the ventral tegmental area, a key brain region involved in reward-directed behavior and substance use disorders. The study identified 16 cell populations, including classic dopaminergic neurons, glutamatergic neurons, and GABAergic neurons.
Research in mice suggests that neutrophil extracellular traps (NETs) can cause further damage to the brain after a stroke by trapping other cells and reducing blood flow. Blocking NETs with a compound called nNIF may protect the brain from this harm, leading to better outcomes for patients.
A new study by researchers at the University of Birmingham has identified two distinct brain structure patterns associated with poor outcomes in patients with recent onset psychosis and depression. The study used MRI scans to analyze grey matter volume and found that lower volumes were linked to poorer outcomes, while higher volumes we...
A Johns Hopkins Medicine-led study found that COVID-19-induced loss of smell is linked to inflammation-caused nerve damage, weakening odor signals to the brain. The researchers discovered more severe vascular injury and fewer axons in the olfactory bulb of patients with diminished or complete loss of smell.
Researchers have discovered that rhesus monkeys can sense their heartbeats, which may help understand interoception and its link to mental health conditions. This finding provides an important model for future psychiatric research.
A new study shows that the telestroke program prevents unnecessary hospital transfers for stroke patients, decreasing rural healthcare disparities. The program increases care efficiency and cost-effectiveness, while optimizing care for patients.
Australian researchers have discovered a new neurodevelopmental disorder linked to the tumor suppressor gene FBXW7. The condition causes mild to severe developmental delay, intellectual disability, and other symptoms, with genetic variations in this gene found in 28 individuals from 32 families worldwide.
A retrospective study confirms coffee's potential as a first-line treatment for ADCY5-related dyskinesia, improving symptoms in 87% of patients. Coffee's efficacy is attributed to its ability to bind to adenosine receptors and modify the function of the dysfonctional protein ADCY5.
Researchers developed new method to visualize CNS fibroblasts and their intercellular interactions in the CNS. The technique provides a detailed picture of CNS fibroblasts, including their location, size, morphology, and gene/protein expression patterns.
Researchers analyzed prenatal MRI scans of children later diagnosed with autism and found significant differences in brain structures at 25 weeks' gestation. These differences may be a strong biomarker for predicting ASD emergence, with the insular lobe showing increased volume.
Scientists at ISTA used brain organoids to study the effects of CHD8 mutations on brain development. The study found that mutant organoids produced larger amounts of neurons, leading to brain overgrowth and macrocephaly similar to patient symptoms.