A team of researchers discovered that the gut microbiome plays a critical role in driving granulopoiesis, a process formation of granulocytes, in mice models. The study found that alterations in the gut microbiome composition induced by neutropenia stimulate reactive granulopoiesis via interleukin 17A secreted by T cells, promoting neu...
Researchers have identified immune signatures that can distinguish between mild and severe febrile neutropenia (FN) episodes in child cancer patients. This breakthrough could prevent thousands of low-risk cancer patients from undergoing unnecessary treatment.
The study found that standing orders significantly raised guideline adherence for patients on intermediate FN risk regimens but did not change the FN rate among patients on chemotherapy at any risk level. Prophylactic CSF use rates were substantially below guidelines for both high-risk and low-risk regimens.
Researchers at Cardiff University found that genetic neutropenia is a benign condition in people of African descent that can lead to lower neutrophil levels. This allows more individuals with treatment-resistant schizophrenia to receive the medication clozapine without risk of rare side effects.
Researchers use a novel database on the neutrophil proteome to make genetic diagnoses for two children with severe congenital neutropenia whom typical sequencing had failed. The technique combines proteomic and genomic screening, which shows huge potential for personalized medicine at low cost.
A phase III trial found that continuous REVLIMID (lenalidomide) with dexamethasone improved progression-free survival and reduced risk of disease progression compared to standard treatment. Patients treated with continuous REVLIMID plus dexamethasone showed a significant reduction in risk of progression or death.
A recent study found that adding capecitabine to a standard chemotherapy regimen for breast cancer improves recurrence-free survival, but at the cost of increased adverse events. The treatment was associated with more cases of diarrhea and hand-foot syndrome, while also causing more severe neutropenia.
Scientists have discovered a new syndrome associated with severe congenital neutropenia, linked to mutations in the G6PC3 gene. The study found that these mutations affect glucose levels, leading to cellular stress and immune system dysfunction, potentially relevant to other diseases.
Researchers at Columbia University's Mailman School of Public Health found a strong association between neutropenia, or low white blood count, and women of African descent. This association may affect disparities in disease treatment and outcomes for cancer therapy, particularly among those with breast and colon cancer.
Researchers identify specific H. pylori strains associated with precancerous gastric lesions, potentially underestimating the risk of gastric cancer. Meanwhile, a gene called OGR1 is found to suppress prostate cancer metastasis in mice, suggesting its potential as a novel metastasis suppressor gene.
Researchers at St. Jude Children's Research Hospital found no association between the UGT1A1*28 gene variation and neutropenia or diarrhea in children treated with low-dose irinotecan. This allows clinicians to begin treatment sooner and eliminate costly genetic testing.
A Phase III study suggests ALIMTA-carboplatin may deliver less toxicity than GEMZAR-carboplatin, offering comparable quality-of-life benefits and survival data. The combination also appears to benefit from a lower toxicity profile.
The study demonstrated a statistically significant benefit of FOLFIRI in patients with metastatic colorectal cancer, improving progression-free survival and overall survival. Adding bevacizumab to FOLFIRI also showed improved outcomes, with a higher percentage of patients alive after one year.
A study found that severe congenital neutropenia, a genetic disorder, was transmitted through sperm donation in five children conceived via IVF or donor insemination. The authors conclude that potential mothers should be properly counseled and informed about the risks of genetic disorders transmission.
Research finds that neutropenia, a type of hematological toxicity, is associated with increased overall survival in patients with advanced non-small cell lung cancer. Prospective trials are needed to assess whether drug dosing guided by toxic effects could improve chemotherapy efficacy.
A large community-based clinical trial showed a significant reduction in febrile neutropenia and chemotherapy dose reductions among older patients receiving Neulasta. The study found that Neulasta reduced the incidence of serious adverse events, including hospitalizations and pneumonia.
A study of 4,522 patients found that 48-53% received less than 85% of recommended chemotherapy doses due to treatment delays or dose reductions. Patients over age 60 had significantly higher risk of under-treatment. The study emphasizes the importance of timely and effective chemotherapy management.
Researchers identified frequent BRAF mutations in intermittent sun-exposed skin melanomas, but rare mutations in chronically sun-damaged or unseen skin. Additionally, bladder cancer cell lines showed defective checkpoint function, suggesting barriers to carcinogenesis. These findings may inform therapeutic strategies for these diseases.
A nationwide survey found that 56% of women with early stage breast cancer received less than 85% of their prescribed chemotherapy dose intensity. Treatment delays and dose reductions were common due to neutropenia, a shortage of infection-fighting white blood cells.