Research on containing and managing disease. Covers critical-illness theory, zoonotic disease, immunotherapy trials, and historical epidemics.
Researchers found a two- or three-dose schedule may be as effective as the traditional four-dose schedule in preventing pneumococcal disease in young children. The vaccine showed high effectiveness against seven strains of Streptococcus pneumoniae, with 96% efficacy in healthy children and 81% in those at risk.
A recent study from Brown Medical School and Harvard Medical School found significant racial disparities in Medicare managed care plans, even among high-performing plans. Blacks were more likely to have poor control of cholesterol, blood pressure, and blood sugar levels compared to whites.
Researchers have identified a key mechanism by which Filoviruses, including Ebola and Marburg, cause immunosuppression. By targeting specific amino acid sequences, new drugs may be developed to disrupt the virus's ability to shut down the immune system.
Research found that Parkinson's disease patients developing impulse control disorders show increased rates of depression, appetite changes, and irritability compared to those without the disorder. The study identified nine patients with impulse control disorders, including pathological gambling, hypersexuality, and excessive shopping.
Two new blood tests, T-SPOT.TB and QuantiFERON-TB Gold, have improved the detection of latent tuberculosis (TB) infection. These tests offer more accurate results, faster turnaround times, and no return visits compared to traditional tuberculin skin tests.
Rural India sees a shift from infectious to chronic diseases as the leading cause of death. Cardiovascular disease and injuries now account for over 50% of deaths in rural areas.
A Florida State University study found that parental notification laws and consent requirements significantly reduced risky sexual behavior among teens, with a 20% decrease in gonorrhea rates among Hispanic girls. However, the results were not statistically significant for black girls.
Schistosomiasis, a widespread parasitic disease, can be controlled through wide-scale drug treatment and socio-economic progress. Establishing strong health systems is crucial for integrating sustainable control measures and caring for patients.
A new supplement provides essential information on preconception care, emphasizing the importance of women's health before pregnancy. The supplement covers topics such as folic acid supplements, vaccinations, and screening for HIV, as well as measures to avoid harmful substances like alcohol and anti-epileptic drugs.
A recent study published in PLOS Genetics has identified two distinct genetic profiles among modern Europeans, which can be used to control for ancestry in genetic studies. The findings have significant implications for understanding the distribution of genetic variation in European populations and their impact on disease research.
A new study found that removing deer from small areas can lead to increased tick populations and higher rates of tick-borne diseases. In contrast to previous studies, researchers discovered that smaller deer-free zones tend to harbor more ticks, making them potential disease hotspots.
A global health expert argues that up to seven neglected tropical diseases, including river blindness and trachoma, can be brought under control with increased coverage of existing programs. This could lead to the elimination of infections in some cases and improved health outcomes for millions of people in Africa.
The study found a significant decrease in the age-adjusted HSV-2 seroprevalence from 17.0% in 1999-2004 to 21.0% in 1988-1994, with decreases especially concentrated among persons aged 14 to 19 years. The prevalence of genital herpes caused by HSV-1 may be increasing.
A recent outbreak of corneal infection Fusarium keratitis is associated with the use of a specific contact lens solution, ReNu with MoistureLoc. The study found that users of this product were 20 times more likely to develop the infection compared to non-users.
New research reveals squirrel poxvirus is wiping out red squirrels in northern England at a rate 17-25 times higher than areas unaffected by the virus. Targeted grey squirrel control at narrow entry points is recommended to save the species.
MRSA is the most common cause of skin and soft-tissue infections among patients presenting in emergency rooms across the country, according to a UCLA study. The infection was found to be resistant to commonly used antibiotics, emphasizing the need for clinicians to culture infections and prescribe effective medications.
A new study shows that anakinra, a rare arthritis drug, brings marked improvement to children and young adults with the devastating inflammatory disease NOMID. The treatment reduces inflammation, improves symptoms, and has a significant impact on the central nervous system.
A trachoma control programme using the SAFE strategy, which combines surgery, antibiotics, facial cleanliness, and environmental change, significantly reduced active trachoma prevalence by 92% in two districts. The study highlights the potential for this approach to also benefit other communicable diseases like diarrhoea and pneumonia.
Research found that SNCA gene variability is associated with an increased risk of Parkinson disease, explaining approximately 3% of the population's susceptibility. The study also suggests that this variation may be a common factor in the development of the disease.
A low-fat vegan diet has been shown to treat type 2 diabetes more effectively than a standard diabetes diet, with significant improvements in blood sugar control and weight loss. The diet also appears to have favorable effects on cholesterol levels and kidney function.
A new study finds that diabetes disease-management programs lead to higher rates of recommended examinations, such as eye and foot exams, and cholesterol checks. However, these strategies had no impact on controlling key factors associated with diabetes complications, like blood pressure, cholesterol, or blood sugar levels.
Prevention strategies for Noma include information campaigns, eradication of poverty, and improved living conditions. The disease is often linked to malnutrition, poor sanitation, and unsafe drinking water.
The Human Variome Project aims to catalog human mutations, providing valuable information for people in developing countries. The project has already yielded significant results, including identifying genetic variants that make people resistant to asthma drugs and those predisposed to schizophrenia.
A study found that education and retraining programs reduced serious bloodstream infections associated with central venous catheters by 21%. The intervention, which included updating ICU policies and training modules for clinicians, also prevented 131 serious bloodstream infections and avoided over 250 additional hospital days.
A long-term study of DCCT participants found no cognitive impairment from severe hypoglycemic reactions, supporting the safety of intensive diabetes therapy. Higher A1C readings were associated with a decline in motor speed and psychomotor efficiency, but not other cognitive domains.
Researchers found that a new 'disease control rate' measure was associated with survival, suggesting it could enhance efficacy assessment and improve clinical trials for advanced NSCLC. The study pooled data from 984 patients with advanced NSCLC who participated in three randomized trials of platinum-based chemotherapy regimens.
Researchers found that mice lacking MHC Class I molecules can still mount an effective CD8 T cell response against chronic herpes virus infections. This suggests the presence of a backup immune system component that can recognize and fight viral proteins without relying on MHC Class I.
The NIH panel advocates for expanded regulation of vitamins and minerals, calling for changes in FDA's authority to ensure quality production and consumer reporting of adverse events. The panel also recommends rigorous randomized trials and new MVM databases to test efficacy and safety.
Researchers will test 400,000 SNPs in 552 patients to clarify the role of genes in sporadic ALS. The study's results could strongly shape the search for a cure if it finds gene associations or suggests an environmental cause.
The DCPP identifies four major health challenges: cardiovascular diseases, HIV/AIDS, influenza, and malaria. The authors recommend adopting cost-effective interventions on a wider scale to tackle these threats.
A group of experts allege that the World Bank has neglected malaria treatment for years, concealing its expenditures and downscaling its staff. In response, the World Bank defends its efforts, citing research on the challenges of linking funding to health outcomes.
A recent study published in Archives of Surgery found that tightly controlled blood sugar levels before surgery can significantly reduce the risk of postoperative infections in diabetic patients. The research involved 490 diabetic patients who underwent major noncardiac surgery between 2000 and 2003, with 197 having good glycemic control.
Researchers found that a high-caloric ketogenic diet slowed ALS progression in mice by promoting mitochondrial energy production and membrane stabilization. The study suggests that dietary interventions may offer new therapeutic options for ALS patients.
Researchers found that both self-monitoring of blood glucose and precise physician testing of hemoglobin A1c can help diabetics manage their disease. Consistent communication between patients and healthcare professionals is also crucial.
Diabetic patients undergoing periodontal therapy show improved metabolic control, with a 20% reduction in HbA1c levels. The study suggests that periodontal treatment may help diabetic patients move from the 'at-risk' category to a healthy range.
Between 1998 and 2002, risky food consumption decreased significantly, from 31% to 21%. Runny eggs were the most frequently consumed risky food. Targeted outreach is needed for high-risk groups.
Researchers found that feeding animals, touching them, and failing to wash hands after visiting petting zoos are strongly linked to E. coli O157:H7 infections. Simple handwashing was shown to be an effective preventive measure against infection.
Patients with asthma often view their condition as a temporary health problem, leading to inadequate treatment and poor disease control. A study found that nearly half of hospitalised asthma patients believed they only had asthma when symptoms appeared.
Researchers and academics explored ways to reduce oral health disparities and increase health literacy. Progress toward achieving Healthy People 2010 objectives was highlighted, with future directions for national surveillance also discussed.
Researchers found that Resolvin E1 provided remarkable protection against soft tissue and bone loss associated with gum disease. The study supports the concept that inflammation is a good therapeutic target in the treatment of periodontal disease.
The COMDIS programme aims to improve healthcare quality and coverage for the poor and vulnerable by developing practical and affordable interventions. Effective healthcare systems are crucial in preventing the spread of disease, and the project focuses on addressing bottlenecks and operational constraints to achieve this goal.
A male-specific gene, SRY, has been found to be linked to the control of physical movement and may contribute to the higher incidence of Parkinson's disease in men. The protein, which determines male gender, was discovered in British scientists in 1990.
The Global Youth Tobacco Survey found nearly 9% of students aged 13-15 were current smokers, with high exposure to secondhand smoke and non-cigarette tobacco use among young girls. Reduction efforts require preventing initiation and promoting cessation, with strong smoke-free policies necessary to combat the growing toll of tobacco use.
The Yale Center will assess and improve public health workforce training, develop new continuing education curricula, and collaborate with other CDC-funded centers to increase preparedness resources.
A study analyzing 487 primary studies found that medical test accuracy is often overestimated, particularly in detecting mild or early disease. The researchers emphasize the importance of knowing test accuracy in real clinical settings and the accuracy of gold standard tests to ensure accurate diagnoses.
A study by Joslin's Asian-American Diabetes Initiative found that Chinese-speaking immigrants with type 2 diabetes had less knowledge of disease management and poor blood glucose control compared to English-speaking immigrants. Bilingual education improved their understanding and led to better blood glucose control in laboratory tests.
A study of middle-age and older adults found that about a third had cholesterol disorders requiring drug treatment, but only 54% received it. Cholesterol control was lowest in those at highest risk of heart vessel disease, highlighting the need for improved treatment and control.
A $5.4 million grant will fund research on the epidemiological and immunological aspects of cutaneous leishmaniasis in Colombia. The study aims to develop effective treatments for children, who comprise a high percentage of cases and have a poor response to current therapies.
Researchers have discovered a functional interaction between the genes MECP2 and BDNF, which could lead to new therapeutic opportunities for Rett syndrome patients. By modulating BDNF expression, it may be possible to delay or reverse disease progression.
A recent study suggests that controlling neglected tropical diseases like leprosy and sleeping sickness may help combat the global fight against HIV/AIDS, tuberculosis, and malaria. Integrating these efforts could provide a cost-effective solution to control or eliminate seven neglected tropical diseases for just $200 million annually.
A recent study published in the Canadian Medical Association Journal found that over 63,000 Ontario patients with diabetes had inadequate blood sugar control, with testing rates decreasing among younger adults. The research highlights concerns about unequal access to care and its impact on health outcomes for this vulnerable population.
A Hopkins investigation found that a newly introduced catheter valve was linked to a spike in bloodstream infections in the pediatric intensive care unit. The team identified mechanical issues with the device as the likely source of infection, highlighting the need for closer monitoring of technology's safety.
Research shows that tight glucose control significantly reduces heart disease and damage to the eyes, nerves, and kidneys in people with type 1 diabetes. The study found a 42% lower risk of cardiovascular events and a 58% lower risk of serious events like heart attacks or strokes.
A 12-year-old girl from rural Hunan, China died of acute respiratory distress syndrome after developing fever and cough. Her 9-year-old brother recovered after treatment with antiviral medication. The investigation highlights the need for improved infection control measures in backyard farming settings.
Evidence-based research and innovative initiatives can safeguard sex workers' lives. Peer education, condom-negotiating skills training, and occupational health guidelines are proven interventions that can benefit sex workers.
Golimumab, a fully-human anti-TNF-alpha monoclonal antibody, achieves primary endpoint and shows significant improvement in signs and symptoms of moderately to severely active rheumatoid arthritis. Patients receiving golimumab plus MTX achieved higher ACR response rates compared to placebo.
Researchers at The University of Manchester and The University of Maryland School of Medicine have made a breakthrough in understanding what makes a substance taste sweet. They found that sugar interacts with two types of taste receptors on the tongue, while some synthetic sweeteners only interact with one receptor. This discovery has ...
Three finalists, Pingxi Xu, Justin Blau, Paul Frankland, and Johanna Montgomery, have made significant contributions to understanding insect behavior through pheromone signaling. Their research has the potential to develop sustainable methods of pest control and improve human health by preventing disease.
A new focus for asthmatics aims to control the condition, rather than letting it control them. Asthma treatment should be individualized and tailored to achieve target symptom control, with regular visits to doctors for reassessment and medication adjustment.
A rapid impact package of four anti-parasitic drugs could bring tangible benefits to Africa's poorest communities by controlling seven neglected diseases. The cost of the package would be negligible, ranging from $0.07 to $0.40 per person per year.