Articles tagged with Oncology
A Swedish study of 1,275 women with breast cancer found no increased risk of disease recurrence or death after fertility preservation procedures. The research provides new hope for women who want to preserve their fertility after cancer treatment.
Researchers at Karolinska Institutet have developed a potential curative treatment for neuroblastoma, using DHODH blockers in combination with chemotherapy to cure mice with the disease. The treatment has shown promising results and could improve survival rates for children with neuroblastoma.
Researchers at Texas Biomed have developed a modified tuberculosis vaccine that can treat non-muscle invasive bladder cancer without strong side effects. The delipidated vaccine triggers well-regulated immune responses and reduces inflammation, making it more effective than traditional treatments.
A 3-dose Moderna COVID-19 vaccination schedule significantly improved SARS-CoV-2 antibody concentrations in immunocompromised patients. This improvement was comparable to those obtained by healthy individuals after the standard two-dose Moderna vaccination schedule.
The August issue of the CHEST journal features 47 articles on clinically relevant topics such as asthma, COPD, and pulmonary vascular disease. A highlighted article examines barriers to palliative care in interstitial lung disease.
A University of Michigan-led analysis found that training patients to voice their concerns and advocate for themselves can reduce the impact of physicians' racial biases on care. The study showed that 'patient activation' creates more equitable interactions between patients and physicians.
A study found that a majority of online pharmacies selling imatinib, a chronic myeloid leukemia therapy, are uncertified and operate unsafely. Patients may face risks of nonadherence, treatment failures, and adverse events if they use these pharmacies.
A study of 3,028 patients with COVID-19 reveals that race, ethnicity, and severity of infection are key factors contributing to delayed cancer treatment. Researchers found that these patient demographic factors are strongly associated with delays in receiving timely medical care.
A multi-national study found that over half of clinical trials leading to FDA-approved anticancer medicines are not available for independent scrutiny. The lack of transparency hinders the use of data for further research into the safety and efficacy of medicines.
A recent study published in Blood Advances found a significant disparity in the representation of women among medical educators, with women comprising just 37.7% of speakers at hematology and medical oncology board review lectures. The study also highlights the importance of increasing diversity in educational opportunities to promote ...
A large cohort study found that hormone replacement therapy for breast cancer survivors is not associated with an increased risk of recurrence. The study included over 8,400 Danish postmenopausal women and found no link between vaginal estrogen or menopausal hormone therapy and breast cancer reoccurrence.
Occupational exposure to firefighting has been linked to increased cancer risk, including mesothelioma and bladder cancer. The new classification aims to reduce firefighter exposures and prevent cancer through interventions and research collaborations.
The July issue of CHEST journal features 62 articles on clinically relevant topics, including asthma and COPD. The journal has received an Impact Factor of 10.262, an increase from 2020's Impact Factor of 9.410.
Researchers at Osaka University identified Src as a key molecule in the process of epithelial cells becoming invasive and cancerous. The study found that CDCP1 forms a molecular scaffold that activates Src, promoting cancer cell invasion.
Researchers from University Hospitals developed a transfusion appropriateness algorithm to analyze blood transfusions for adult patients. The algorithm led to a decrease in transfusions and an increase in appropriate use, resulting in cost savings of $2.5 million over 12 months.
A recent survey revealed significant gaps in cancer screening among women aged 50-64, with rates as low as 50% for colorectal cancer and 46.5% for both cancers. The study found that patient-centered approaches to screening can facilitate timely testing and management of abnormal results.
A new study found that transitioning from in-person to virtual conferences significantly reduces travel-related carbon dioxide emissions, with an estimated 80% reduction during the COVID-19 pandemic. The researchers estimated CO2 emissions associated with conference attendance before and during the pandemic.
This volume of Oncotarget features groundbreaking research on various cancers, including breast, lung, colorectal, and neuroblastoma, as well as novel drug targets for bladder cancer. The studies also delve into the role of BRCA in breast and colorectal cancers.
A study of 45,000 women found significant racial and ethnic disparities in the time it takes to receive a biopsy after an abnormal screening mammogram result. Factors such as individual characteristics, neighborhood socioeconomic status, and healthcare access were also associated with delays in biopsies.
A population-based study found that patients with estrogen receptor-positive breast cancer who experienced hot flashes while on adjuvant hormone therapy had worse outcomes and a higher risk of early treatment discontinuation. The study suggests that managing side effects may not be enough to prevent treatment discontinuation, highlight...
A study by Washington State University researchers found that Native Americans have to travel up to 103 miles farther than non-Hispanic whites to reach the nearest radiation therapy facility. This significant burden can lead to delayed or foregone treatment, resulting in poorer cancer outcomes.
The American College of Chest Physicians' flagship journal CHEST published its June issue featuring 58 articles on various chest medicine topics, including asthma and COPD. The journal is set to expand with two new open-access journals, CHEST Pulmonary and CHEST Critical Care.
A recent study identified 34 novel genes that contribute to endocrine resistance in breast cancer using dynamic gene expression analysis. The researchers found that these genes are differentially expressed in both estrogen receptor-positive and triple-negative breast cancers, suggesting shared genetic mechanisms underlying resistance d...
A single-center study found lower pneumonia frequency and severity in fully vaccinated patients compared to unvaccinated patients. The study included 467 patients who underwent chest CT during hospitalization for symptomatic COVID-19, with significant reductions in pneumonia frequency and severity observed in those fully vaccinated.
A meta-analysis published in The Lancet Oncology suggests that targeted radiation therapy, which spares healthy brain tissue, is equitable to whole brain radiation therapy for patients with small cell lung cancer and brain metastases. This approach may improve their care experience with fewer negative cognitive consequences.
Researchers developed CancerOmicsNet, a graph neural network model that integrates multiple heterogeneous data to predict cancer cell growth rate after drug treatment. The model achieved significantly higher cross-validated accuracy than other approaches on the same data.
The article proposes a new framework for understanding the hallmarks of cancer and aging, highlighting their shared underlying principles. Dr. Blagosklonny's hyperfunction theory arranges these hallmarks in a hierarchical structure, revealing common signaling pathways involved in both aging and cancer.
A nationwide study of 100 million hospitalizations found that percutaneous coronary intervention is safe and increasing among cancer patients. The study suggests that PCI can nearly double from 2016 to 2018 among patients with thrombocytopenia, without significantly increasing mortality.
A recent study found that 70% of adults with stage 3 or 4 cancer were at risk of drug-drug interactions, highlighting the importance of deprescribing medications to avoid harm. The study's results emphasize the need for education and problem-solving to address polypharmacy in older adults with cancer.
The American Journal of Roentgenology has published best practices for managing an iodinated contrast media (ICM) shortage in radiology practices. To mitigate the shortage, practice leaders should prioritize examination findings and reduce overall ICM usage.
Researchers are developing a novel MRI nanotechnology that targets specific markers in solid tumours, including high-grade brain cancers. The new imaging technology has shown promising preclinical results and is set to be tested in a first-in-human clinical trial.
A new study published in the Journal of the National Comprehensive Cancer Network (JNCCN) found that incorporating the Electronic Health Record-Enabled Evidence-Based Smoking Cessation Treatment (ELEVATE) program into electronic health records can significantly improve smoking cessation rates among cancer patients. The research demonst...
The new ASTRO guideline provides guidance on radiation therapy for brain metastases, including evidence-based recommendations for multidisciplinary planning and delivery of advanced techniques to manage intact and resected brain tumors. The guideline aims to improve quality of life and outcomes for patients with brain metastases.
Dr. Gary J. Whitman, MD of the University of Texas MD Anderson Cancer Center, has been appointed as the 122nd President of the American Roentgen Ray Society (ARRS). He succeeds Jonathan Kruskal, MD, PhD, and will serve for the next year.
The University at Buffalo is developing new treatments for ovarian cancer by targeting the apelin receptor. Ovarian cancer cells rely on lipids for energy and survival, making this a promising therapeutic target.
A study published by Wiley found that women with low vitamin D levels are more likely to develop breast cancer, particularly among Hispanic/Latina women. The research suggests that sufficient vitamin D may protect against breast cancer, with a 21% lower risk observed in women with adequate levels.
Researchers at Texas A&M University developed a low-cost, minimally invasive wireless device that uses photodynamic therapy to kill cancer cells. The device enables precise and safe treatment options during surgery, potentially reducing the need for additional treatments like chemotherapy.
Patients with mild to moderate kidney disease and kidney transplant recipients had a higher risk of cancer. They also faced a higher risk of dying from cancer, particularly from cancers such as bladder, kidney, and multiple myeloma, compared to those with normal kidney function.
Researchers found a steady decline in annual mammography use by breast cancer survivors between 2009 and 2016, with the largest decrease seen among younger patients. The study highlights the importance of reinforcing the significance of annual mammograms for breast cancer survivors.
The NCCN Annual Conference focuses on the cancer patient journey, featuring state-of-the-art practice algorithms, updates to clinical guidelines, and new therapies. Leading experts present treatment recommendations for various cancer types, including breast, colorectal, and lung cancer.
A study published in JAMA Network Open found that half of all women will experience at least one false positive mammogram over a decade of annual breast cancer screening with 3D mammography. The risk of false positives is lower for women screened every other year, and non-dense breasts also show a lower false positive risk.
A recent study found that mutant clones expand in the normal endometrium through a rhizome structure, which arises from a common ancestral clone. This expansion increases the risk of developing endometriosis and endometrial cancer. The study proposes a new model of clonal expansion in the normal endometrium.
A retrospective study found that positive oral CT contrast material improves detection of malignant deposits, particularly with adequate bowel filling. The NPV for detection was 65.8% for positive oral contrast material with adequate bowel filling.
Two clinical trials will report groundbreaking data on adjuvant olaparib for germline BRCA1/2 associated breast cancer and pembrolizumab for early-stage non-small cell lung cancer. These treatments aim to improve survival rates and reduce recurrence.
Research found a significant drop in new cancer diagnoses during the COVID-19 pandemic, particularly for screening cancers like breast, cervical, and colorectal cancer. The study estimates around 12,600 cancers went undetected between March 2020 and September 2020.
Researchers will compare proton, carbon and electron radiotherapy to protect normal tissues from harm while controlling solid tumors of the gastrointestinal tract, lungs, soft tissues throughout the body, and bones. The goal is to develop a more effective treatment with shorter duration and frequency.
Researchers have developed a low-cost, easy-to-use focused ultrasound device that can precisely target the mouse brain. The $80 device, created using a 3D printer, has been shown to achieve sub-millimeter targeting accuracy and improve drug delivery outcome.
A recent study found that gene therapy delivery vectors were unlikely to cause the blood malignancies reported in trials; however, the exact cause remains a mystery. The study's results suggest that cancer risk in sickle cell disease may be more complex than initially thought, warranting further investigation.
A new symptom management approach, WRITE Symptoms, guides patients to reflect on their symptoms and develop strategies for addressing target symptoms. Both nurse-led and self-directed versions of the tool improved women's sense of control over their symptoms after eight weeks.
A culturally tailored patient navigation program improved the rate of colorectal cancer screening among Hispanic adults, reducing historical gender disparities. The program's colonoscopy completion rate was 85%, with no difference between males and females.
A single genetic test using RNA sequencing has been used for all children with cancer in the Netherlands since 2018, improving diagnosis and treatment in seven cases. The technique picked up 78 fusion genes, 23 of which led to a more accurate diagnosis or possible treatment.
A new bilateral tumor model was demonstrated to be useful for investigating the relationship between T-cell repertoire and cancer immunotherapy's therapeutic effects. The study found that T-cell profiles of both tumors were almost identical, indicating a similar anti-tumor response in a single mouse.
Scientists at the University of Missouri discovered that bisphenol A (BPA) exposure during pregnancy can negatively impact fetal brain development. MicroRNAs in the placenta play a key role in regulating cellular functions, including neural development. Researchers believe that microRNA packages could reach the brain through the placen...
Research finds that psychological distress among AYA cancer survivors is associated with higher annual medical expenses and greater health care use, including more office visits and prescription medications. The study suggests screening for psychological distress can help mitigate these effects.
The Society of Nuclear Medicine and Molecular Imaging has published appropriate use criteria (AUC) for prostate-specific membrane antigen (PSMA) PET imaging. The guidelines provide a framework for healthcare providers to determine the most effective use of PSMA PET scans in patients with suspected or known prostate cancer.
Pediatric clinicians play a crucial role in ensuring access to critical resources for children with chronic medical conditions or special education needs. Clinicians should address school-related challenges and provide support to help these patients keep up academically with their peers.
A study found that one in five cancer survivors mistakenly believed taking vitamins could reduce the risk of cancer return. Those who thought supplements reduced recurrence were three times more likely to take them. Healthcare professionals must advise patients on safe dietary supplement use.
Researchers simulated an attack that falsified mammogram images, fooling both AI breast cancer diagnosis models and human radiologist experts. The study highlights the need to develop ways to make AI models more robust to adversarial attacks, which could lead to incorrect cancer diagnoses.
A recent study found that despite some progress, the US academic workforce in radiation and medical oncology remains underrepresented compared to the broader US cancer population. The study emphasizes the need for continued efforts to recruit and retain diverse faculty members.
The COVID-19 pandemic caused a decline in diagnostic procedures for cancer and other conditions, leading to delayed new diagnoses. Colonoscopies decreased by 45% compared to annual averages, while new cancer diagnoses dropped by 13-23%, depending on the type.