Articles tagged with Golgi Apparatus
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Two key proteins, Oxr1 and Ncoa7, regulate V-ATPase to maintain optimal luminal pH for glycosylation within the Golgi apparatus and trans-Golgi network. This discovery provides new insight into congenital disorders of glycosylation and their cellular mechanisms.
Researchers found that treating the Golgi apparatus with hydrogen sulfide creates T-cells that can take more stress, leading to a better chance of controlling tumors. The study suggests sorting T-cells into high and low Golgi groups could be a new therapeutic target.
Researchers at Osaka Metropolitan University have discovered a key protein involved in transporting boron into plant cells. The protein complex, containing KNS3 and its homologs, facilitates the movement of boric acid channels from endoplasmic reticulum to plasma membrane.
Live imaging techniques reveal that the secretory pathway plays a crucial role in de novo membrane formation, with Gip1 identified as a key molecule affecting this process. In Gip1-deficient cells, abnormal spore plasma membranes are formed due to defects in regenerating ER exit sites.
Researchers report that Golgi ribbons are present in non-vertebrates like mollusks and earthworms, suggesting a fundamental function beyond vertebrate specificity. The team's findings indicate that Golgi ribbons might play a role in cell differentiation during embryogenesis.
Researchers at UC Riverside have identified a crucial protein that controls plant responses to stress and aging. The discovery reveals the importance of Golgi bodies in maintaining cellular health and highlights their potential role in human aging.
A team at Tohoku University has used cryo-electron microscopy to study a crucial protein involved in zinc ion transport. The study reveals new insights into the mechanisms governing zinc transport, which play a vital role in enzyme catalysis, DNA binding, and gene regulation.
Researchers at Tohoku University used cryo-electron microscopy to determine the high-resolution 3D structure of human SPCA1a, a protein pump involved in calcium and manganese ion transport. The study provided insights into how the protein works and how mutations can cause Hailey-Hailey disease and other neurodegenerative disorders.
The study found that the interaction between two organelles in the cell, the endoplasmic reticulum and Golgi apparatus, controls the transfer of cholesterol to the plasma membrane. This process is crucial for maintaining proper lipid composition at the cell surface.
A new study challenges a popular scenario explaining the origin of eukaryotes, suggesting that cells can grow to considerable volume without acquiring mitochondria. Researchers explore energy requirements and genome arrangement in prokaryotes and eukaryotes, revealing overlap between cell types rather than a hard boundary line.
Researchers at the University of Warwick have identified a novel cellular process called Golgiphagy that helps regulate the degradation of the Golgi complex in cells. This discovery opens new avenues for understanding the underlying mechanisms of diseases such as cancer, Alzheimer's, and Parkinson's.
Researchers have discovered that palmitoylation can occur at the plasma membrane, paving the way for innovative drug discovery strategies. A novel tool, SwissKASH, allows for dynamic observation of this process, enabling precise targeting of oncogenic proteins in cancer therapy.
Scientists have identified the cause of Saul-Wilson syndrome, a rare type of dwarfism characterized by short stature and developmental delays. A single spontaneous gene change alters protein packaging in the cell's Golgi complex, affecting protein function and stability.
Researchers describe how Oropouche virus replicates in human cells by hijacking the Golgi complex, a process that could lead to novel targets for preventing infection. The study provides new insights into the replication mechanisms of emerging viruses.
A recent study found that disabling the Golgi apparatus, a protein regulation part in brain cells, causes developmental delay, severe ataxia, and postnatal death in mice. This suggests a potential link to neurodegenerative diseases such as Alzheimer's and Parkinson's.
Researchers at Hiroshima University discovered a new role for the gene Rab6 in cell polarity, which directs proteins to specific sides of cells. The study found that Rab6 distinguishes between proteins destined for different parts of the cell, shedding light on how cells maintain their orientation.
Researchers have developed a powerful new tool to identify and characterize nucleotide sugar transporters, critical components in the biosynthesis of plant cell walls. The assay enabled the characterization of six novel transporters in Arabidopsis, revealing their bispecific nature and regulation by substrate availability.
Researchers found platelet Golgi apparatus undergoes changes after acute cerebral infarction, influencing CD40L expression and platelet function. This discovery may lead to new therapeutic targets for treating cerebral infarctions.
Researchers have discovered a domino effect in protein complexes that contribute to neurodegenerative diseases. The study, led by Dr. Aitor Hierro, reveals reduced levels of mutated protein Vps54 disrupt the GARP complex, leading to motorneurodegeneration.
Cells use a simple principle to control protein localization, ensuring high order and avoiding chaos. By adding a lipid anchor to proteins, cells direct them to specific destinations, and then remove the anchor to prevent misdirection.
Researchers at UC San Diego discover that a protein interaction generates force that shapes the Golgi apparatus, revealing a link between form and function. The discovery sheds light on the mechanism of the Golgi apparatus, a processing center for protein export.
Researchers developed a lab-on-a-chip device mimicking the natural Golgi apparatus, producing heparin quickly and efficiently in an assembly-line fashion. The artificial Golgi has strong clot-fighting potential, potentially leading to faster and safer heparin production methods.
Research finds stalled microtubules in cells with faulty dynamin 2 protein, leading to reduced nerve impulse strength and slowed movement. The stable microtubules disrupt normal cellular processes, including the formation of the Golgi complex.
Researchers at Yale have identified a new cellular structure, Centrin2, involved in duplicating the Golgi apparatus as cells prepare to divide. This process is crucial for distributing newly-made proteins to different membranes in the cell.
A recent study published in the Journal of Clinical Investigation has identified a potential detour for stalled intracellular lipid traffic. This novel approach could lead to the development of new treatments for various diseases, including those related to lipid metabolism.
Researchers at Virginia Tech found that proteins making up the Golgi apparatus are constantly being renewed, allowing potential new medical applications such as targeted medicine delivery. The discovery also suggests a method to modify cells to produce compounds for pharmaceuticals.
Researchers at Yale have discovered that the Golgi apparatus is an independent organelle that exists independently of the endoplasmic reticulum. This finding gives researchers a better understanding of cell division and uncontrolled cell division in cancer.
Golgi lipids play a crucial role in regulating protein trafficking, disrupting the organization of the Golgi apparatus and blocking certain proteins from being trafficked. The study found that PLA2 overexpression causes the fragmentation of the Golgi apparatus, similar to changes during mitosis.
Researchers at Johns Hopkins University have made a surprising discovery about the movement of proteins within the Golgi apparatus. The enzymes, which are crucial for various cellular processes, were found to be mysteriously retained in the organelle despite their rapid movement, contradicting long-held assumptions about their function.