Articles tagged with Neuroblasts
Researchers found that removing the choroid plexus leads to a reduction of newly born immature neurons and fewer repairing damage caused by a stroke. The study suggests that the choroid plexus keeps regenerative cells ready to deploy to injured areas in animal models.
Researchers found that removing the choroid plexus led to a reduction in newly born immature neurons, which are essential for repairing damage caused by stroke. The study suggests that the choroid plexus may be necessary to retain these cells and facilitate brain repair after injury.
A study investigated the association between miR-492 rs2289030 G>C polymorphism and neuroblastoma susceptibility in Chinese children. The results showed no significant impact of the polymorphism on neuroblastoma risk, suggesting a need for further validation with larger samples.
The study reveals that non-coding regions near sloppy-paired genes are essential for temporal transcription factor expression and that Notch-signaling regulates the transition to subsequent TTFs. This mechanism couples temporal patterning with neuron generation, providing insights into brain diversity.
In a study published in Nature Communications, researchers uncovered the molecular players involved and how timing is controlled for creating neural diversity. Single-cell RNA sequencing technology revealed a temporal patterning gene network in Drosophila medulla neuroblasts, including nine new transcription factors.
A study by Makoto Sato and colleagues from Kanazawa University reveals that a gene called Dscam regulates the repulsion between neurons in fly brains, leading to the formation of columnar structures. This finding supports the radial unit hypothesis, which describes the development of the cerebral cortex in mammals.
Researchers at Baylor College of Medicine discovered that the Zika virus protein NS4A disrupts brain growth by hijacking a pathway that regulates the generation of new neurons. The study found that overexpression of Zika protein NS4A causes microcephaly in flies by inhibiting the function of ANKLE2, a cell cycle regulator.
Researchers have identified a novel mechanism for neuronal regeneration after stroke. By overproducing the protein Slit in neuroblasts, these cells can migrate past activated astrocytes and mature into functional neurons.
Research reveals that fruit flies' adult and larval nervous systems share similar structures and molecular signatures, contradicting the traditional view of metamorphosis as two separate stages. The study uses lineage tracing to identify neuroblast lineages and discover unique neuroblasts controlling leg motor neurons.
Two protocols from the Neurobiology of Drosophila course are now available in Cold Spring Harbor Protocols: a method for stimulating neurons in the brain and identifying neuroblasts via immunofluorescent staining. These methods provide insight into the giant fiber system and role of stem cells in development.
Researchers found that an enzyme called aurora-A is required to coordinate protein position within neural stem cells, and its absence leads to overproduction of new neuroblasts and tumors. In humans, this enzyme may prevent abnormal tumor growth by maintaining a steady population of stem cells.
Researchers found that neural stem cells migrate to injured brain areas in response to acute brain injuries, such as strokes. This self-repair mechanism could potentially lead to new treatments for brain-related disorders.