Articles tagged with Primordial Germ Cells
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study published in Science Advances has discovered that the RAD21L protein plays a crucial role in regulating DNA structure and gene expression in sperm precursor cells. The absence of this protein leads to defects in chromosome pairing, genetic recombination, and spermatogenesis, resulting in male infertility.
Researchers at Wyss Institute develop in vitro method to induce meiosis in human cells, enabling replication of critical step in egg and sperm cell development. The breakthrough could lead to modeling defects and creating healthy gametes for individuals with infertility.
Researchers developed tiny human ovary organoids using stem cells to understand gonad development and disease. The models replicate key aspects of ovarian follicles, offering a powerful platform for studying gene function in a controlled environment.
Researchers at Kyoto University's Institute for the Advanced Study of Human Biology have identified a crucial signaling molecule that drives epigenetic reprogramming and differentiation in human germ cells. This breakthrough has significant implications for the development of human IVG research, which aims to treat all forms of inferti...
Scientists have successfully created primordial germ cell-like cells (PGCLSs) from induced pluripotent stem cells of the northern white rhino Nabire, paving the way to produce artificial gametes. This breakthrough aims to prevent the extinction of the northern white rhinoceros and increase genetic diversity.
Researchers at the Max Delbrück Center have successfully generated primordial germ cells from stem cells, a world's first for a large mammalian species. This milestone aims to save the northern white rhino subspecies from extinction through lab-grown egg and sperm cells.
A research team analyzed germ cells in chickens using RNA-sequencing to predict the mechanism that determines sex. The study reveals a mix of cell-autonomous and somatic-cell regulation, with sex determination occurring earlier in females than males.
Scientists have developed a method to maintain human primordial germ cells in culture for at least five months, allowing for the study of their function and development. This breakthrough enables researchers to investigate how exposure to chemicals affects human reproduction and testicular cancer.
Researchers at the University of Tsukuba discovered a male-biased protein expression in primordial germ cells of fruit flies. The study used the Gal4-UAS system to induce gene expression and found that male cells had more protein synthesis occurring, with stronger GFP expression.
Scientists from the University of Tsukuba have developed a new technique to preserve Drosophila primordial germ cells, which can be used to produce new offspring. The cryopreserved PGCs were found to be effective after up to 400 days of long-term storage.
Researchers recreated ovarian follicle structures using mouse embryonic stem cells and successfully matured primordial germ cells into fully functional oocytes. The study provides a model system for studying later events of oogenesis and has implications for assisted reproductive technologies.
A team of biologists and mathematicians developed a new software tool to analyze cell migration processes in zebrafish embryos. The study identified physical barriers that influence cell migration and found a tissue-specific expression of green fluorescent protein, which serves as a reference structure for image registration.
Researchers at UT Southwestern Medical Center have derived a new intermediate embryonic stem cell type that can contribute to chimeras and create precursors to sperm and eggs in culture. This discovery could lead to advances in basic biology, regenerative medicine, and reproductive technology.
Researchers successfully used CRISPR/Cas9 gene editing to delete a specific protein necessary for avian leukosis virus subgroup J infection in chickens. The edited cells were then bred to create resistant chickens, addressing a major concern for the poultry industry.
Researchers at the University of Cologne have found that somatic niche cells surrounding primordial germ cells (PGCs) control their response to DNA damage. This discovery sheds new light on how PGCs maintain genome integrity, potentially improving understanding of inheritance and infertility.
Researchers developed a method to generate primordial germ cell 'lookalike' cells, enabling the study of early stages of specification and regulation of developmental timings. This breakthrough opens up new avenues for understanding transgenerational epigenetic inheritance in humans.
A study published in Cell has described the comprehensive erasure of epigenetic information in early primordial germ cells prior to egg and sperm formation. However, researchers found that around 5% of DNA remains resistant to reprogramming, potentially contributing to conditions such as schizophrenia and obesity.
Scientists at Weizmann Institute and Cambridge University successfully created human primordial germ cells, the earliest precursors of sperm and ova, in a lab. The breakthrough method could help address fertility issues and potentially enable new reproductive technologies.
Researchers at the University of Cambridge successfully created primordial germ cells from human embryonic stem cells, a crucial step in early mammalian development. The study identified a critical gene, SOX17, involved in directing human stem cells to become these cells, and showed that PGCs can be made from reprogrammed adult cells.
Researchers at NYU Langone Health have unraveled the signals governing ovarian development, revealing a feedback loop that ensures sufficient primordial germ cells in the ovary. This discovery has implications for understanding organ growth, regeneration, and disease treatment using stem cells.
Researchers found a potential link between testicular cancer and male infertility, suggesting that genetic mutations during fetal development may play a role. The study provides insights into the origins of human testicular cancer, which is a leading cause of cancer in men between 15-39 years old.
A recent study has identified Wunen2 as a crucial guidance molecule in Drosophila germ cell migration, requiring maternal activity to sustain pole cells during migration. The research suggests a new paradigm for explaining the function of lipid phosphate phosphatases in developmental processes.