Articles tagged with Cancer Genome Sequencing
Scientists at St. Jude Children's Research Hospital have developed a new algorithm called CREST to identify chromosomal aberrations in tumors, which are likely to advance our understanding of cancer. Using CREST, researchers found 89 new structural differences in cancer genomes and 50 new variations in melanoma cells.
A study of roundworm chromosomes may provide insight into large-scale genome duplications that occur in developing tumors. The research found that chromosome ends erode and fuse, creating genome rearrangements that contribute to tumor development.
Two studies highlight the power of sequencing cancer patients' genomes, identifying novel genetic mutations that guide treatment. Researchers used genome sequencing to diagnose a patient with acute myeloid leukemia and breast cancer, changing her course from stem cell transplant to targeted chemotherapy.
Researchers discuss recent developments in DNA replication, recombination, and repair, highlighting their importance in cancer development and gene therapy. The thematic program brings together experts to present discoveries on aberrant DNA repair, site-specific recombination, and genomic instability.
Researchers sequenced whole genomes of tumors from 50 breast cancer patients and compared them to healthy cells, finding over 1,700 unique mutations. The study highlights the complexity of cancer genomes and offers new insights into personalized medicine.
Researchers sequenced whole genomes of tumors from 50 breast cancer patients and compared them to healthy cells, finding over 1,700 unique mutations. The study identified three significant mutations that may be common in ER-positive breast cancers, offering new avenues for personalized treatment.
Researchers sequenced the genome of multiple myeloma in a landmark study, identifying mutations in genes involved in protein translation, blood coagulation, and histone methylation. The findings provide new insights into the disease's development and offer potential directions for targeted therapies.
Researchers sequenced a mouse cancer genome to find mutations driving human cancer. They identified genetic changes in three genes, including a mutation that also occurs in human patients with leukemia.
Researchers discover that chromosomal crisis is common in cancer development, causing hundreds of genome fragments and multiple mutations. The phenomenon is particularly common in bone cancers, where the ravaged genome can lead to increased cancer development.
Researchers have discovered that cancer can arise rapidly after a single catastrophic event involving tens to hundreds of genomic rearrangements. This phenomenon, known as chromothripsis, is seen in at least two percent of all cancers and up to 25 percent of bone cancers.
A team of researchers has sequenced the genome of an ancient sponge, revealing insights into the evolution of the first animals and cancer. The study found that sponges share many genes with humans, but also have significant differences, including missing components involved in cell division and development.
The Genomic SQueeZ (G-SQZ) compression technique developed by TGen can compress genomic sequencing data by up to 80 percent, reducing storage needs and costs. This technology allows for selective content access and maintaining the relative order of the data.
Complete Genomics sequenced a patient's lung tumor and normal tissue to detect somatic mutations and structural variations. The study found over 50,000 high-confidence single nucleotide variations, revealing an estimated genome-wide somatic mutation rate of 17.7 per Mb.
Researchers at Washington University School of Medicine sequenced a patient's genome and that of her breast tumor and brain metastasis, identifying 20 genetic changes linked to the deadly spread. The study suggests that sequencing entire genomes can reveal clues to tumor progression and metastasis, paving the way for new drug targets.
A study published in Genome Research has identified 11 novel gene fusions and 12 cases of chimeric transcripts in melanoma tumors. These genomic alterations, including rearrangements of genes and altered protein function, may play a role in the disease.
Researchers at Johns Hopkins have developed a new approach to detect cancer using whole genome sequencing, identifying rearrangements of DNA that can be found in tumor cells. This approach, called Personalized Analysis of Rearranged Ends (PARE), may help clinicians tailor treatments and monitor tumor levels after therapy.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have performed the first complete genomic sequencing of a brain cancer cell line, revealing a unique biological signature that may lead to new therapies. The study also holds promise for developing patient-specific diagnostics to monitor for cancer recurrence.
Research teams analyzed cancer genomes, uncovering over 30,000 mutations in lung cancer and 33,000 in melanoma, which carried records of when and how they occurred. The studies revealed the impact of environmental mutagens, such as cigarette smoke and sunlight, on DNA.
The Johns Hopkins Center for the Epigenetics of Common Human Disease has been awarded a $16.8 million NIH grant to advance genomics research. The team will focus on studying epigenetics' role in diseases such as bipolar disorder, aging, and autism.
Researchers at UBC have developed a new genome sequencing technique that could boost the fight against mountain pine beetles and improve cancer research. The method uses cutting-edge hardware with novel software to compile genome sequences at a fraction of the cost of previous methods.
Researchers sequenced a second leukemia patient's genome, discovering genetic changes also found in gliomas and AML-linked mutations. The study highlights the potential of genome sequencing to unravel cancer's genetic basis, paving the way for more effective treatments.
Scientists have identified three previously unknown genes in E. coli that are essential for the survival of the bacteria and one out of the three could be implicated in cancer or developmental abnormalities in humans. These genes are also found in numerous other creatures, suggesting a vital role for them across many species.
Researchers at Cold Spring Harbor Laboratory have devised 'DNA Sudoku,' a strategy that allows for the simultaneous sequencing of tens of thousands of DNA samples. This approach combines concepts from cryptology and combinatorial number placement rules, reducing costs dramatically compared to conventional methods.
A recent study published in Genome Research has mapped genomic translocations to base pair resolution, revealing a heavily rearranged genetic blueprint in breast cancer cells. The research highlights the importance of DNA repair machinery and identifies potential prognostic markers and therapeutic targets.
Researchers at Washington University sequenced a cancer patient's genome to discover 10 unique genetic mutations relevant to her acute myelogenous leukemia. The study sets the stage for using comprehensive genome-wide approaches to diagnose and treat cancer.
A study of 188 patients revealed 26 genes involved in the development of lung adenocarcinoma and its sub-types, including those in non-smokers. The findings could lead to improved diagnosis and treatment options for this deadliest form of lung cancer.
A large genetic study in mice has identified hundreds of genes involved in the development of cancer by examining the DNA of more than 500 lymphomas. The study found almost 10,000 mutations that together implicate around 350 gene regions in cancer formation.
The study provides a comprehensive view of the altered genetic background of lung adenocarcinoma, revealing new insights into its biology. The identification of the NKX2-1 gene highlights the importance of understanding the molecular properties of tumors to develop effective cancer diagnosis and therapy strategies.
The study reveals that driver mutations are fewer than previously thought, but still outnumber passenger mutations. The researchers identified possible driver mutations in 120 genes, most of which had not been seen before.
The Genome Sequencing Center will use DNA sequencing to unlock cancer secrets and improve diagnosis. The four-year grant focuses on disease genes, particularly those involved in cancer.
The National Human Genome Research Institute has awarded funding to three large-scale sequencing centers, which will focus on unlocking genomic secrets of human diseases. The centers will utilize existing technology to sequence important targets and pursue new technologies to increase speed and reduce costs.
The Berkeley Cancer Genome Center will use genome analysis to identify genetic changes involved in cancer. The center aims to analyze messenger RNA populations and exon-specific expression to understand cancer development.
The NHGRI has announced new sequencing targets, including the Northern white-cheeked gibbon genome, to gain insights into human health and disease. The gibbon genome is unique due to its high number of chromosome rearrangements and segmental duplications.
The study used 454 Sequencing to analyze EGFR gene mutations in lung cancer tumors, detecting genetic variations that can predict patient responsiveness to treatment with EGFR inhibitors. The technology enables accurate molecular diagnosis and may facilitate targeted therapies.
Researchers identified common properties among genes implicated in cancer development through a bioinformatic study. The study suggests that random breakage is a key mechanism in tumor formation, with a database of genome regions revealing characteristics of these breaks.
The NIH has launched a three-year, $100 million pilot project to explore cancer genomics through The Cancer Genome Atlas (TCGA) Pilot Project. This initiative aims to create a systematic framework for identifying and characterizing genetic mutations and genomic changes associated with cancer.
The published dog genome sequence offers insights into genetic factors contributing to human health and disease. The analysis revealed that dogs share common genetic elements with humans and mice, highlighting the importance of understanding the evolution of genomes.
The NYU team's algorithm detects genetic differences between normal and cancer cells, revealing excess or missing DNA segments associated with various cancers. The software will be made available online in mid-December.
The DOE has successfully sequenced the poplar tree's genome, providing a critical resource for developing faster-growing trees and increasing biomass conversion. Researchers aim to engineer trees that can sequester more carbon from the atmosphere, potentially helping mitigate global warming.