Articles tagged with Epigenetic Reprogramming
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Dr. Maria Margarita Behrens' work deciphers the molecular signatures defining every human brain cell type, shedding light on neural development and psychiatric disorders. Her single-cell epigenomic atlases will enable researchers to target specific cell types with unprecedented precision.
Scientists at the Salk Institute have discovered a new mode of epigenetic targeting in plant cells, where specific DNA sequences guide DNA methylation patterns. This finding has major implications for understanding epigenetic regulation and could inform future strategies for epigenetic engineering.
Scientists at the University of Leicester discovered that jewel wasps can slow down their biological rate of ageing by undergoing a natural 'time-out' as larvae. This pause in development extends lifespan and decelerates the epigenetic clock, tracking chemical changes in DNA.
A recent study published in The EMBO Journal reveals that the Setd8 gene plays a critical role in the premature aging of the brain by controlling neural stem cell activity and proliferation. Artificially lowering Setd8 levels mimicked molecular signatures of aging, highlighting its potential as a biomarker for early aging.
Researchers discovered temperature influences plant cell fate by regulating epigenetic marks. Low ambient temperatures can rescue developmental defects by compensating for PRC2 loss, highlighting the importance of H3K27me3 in maintaining cellular identity.
Researchers at UC Santa Cruz engineered cellular models of embryos using CRISPR technology, allowing them to study early developmental stages without experimenting with actual embryos. The team found that 80% of stem cells organized into embryo-like structures, showcasing a remarkable collective behavior and molecular composition.
Peter A. Jones, Ph.D., D.Sc., receives a seven-year, nearly $7.9 million grant to study epigenetic errors driving cancer development and explore potential new treatments. The funding will support his research into the molecule DNMT3A, which is involved in brain development and cancer development.
Researchers developed a new biological age indicator, DNAmFitAge, that incorporates physical fitness parameters, showing a correlation with lower mortality risk, coronary heart disease risk reduction, and improved disease-free status in physically fit individuals.
Researchers from the ALFA Score Consortium explore how nutrition and physical exercise can positively impact the aging process by modifying epigenetic changes. They find that healthy aging is associated with more tightly condensed chromatin, fewer histone post-translational modifications, and greater regulation by non-coding RNAs.
Researchers found epigenetic changes in post-COVID patients, including genes associated with taste and smell, as well as cell metabolism. These findings may lead to the development of new diagnostic tools for this and similar diseases.
Exercise promotes a molecular profile consistent with expression of youthfulness-promoting Yamanaka factors, according to a recent study published in the Journal of Physiology. The researchers found that exercise induces Myc protein in muscle, which may serve as a naturally induced reprogramming stimulus.
A new diagnostic marker has been identified that predicts successful and efficient oocyte development. The study found that X-chromosome inactivation and reactivation are critical for normal germ cell differentiation.
Researchers at the University of Illinois Chicago found that gene editing can reverse epigenetic changes in the brain caused by adolescent binge drinking, leading to a decrease in anxiety and excessive drinking behavior. The study used CRISPR-dCas9 technology to manipulate histone acetylation and methylation processes at the Arc gene.
A study found that early exposure to estrogen or BPA increases the risk of precancerous lesions in the prostate. Researchers discovered that this leads to epigenetic reprogramming, altering gene expression patterns that promote prostate disease with aging.