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Scientists pinpoint new drug target for RSV

Scientists at Trinity College Dublin have identified a key biological pathway, the JAK/STAT pathway, that RSV suppresses and prevents immune system igniters from activating. This discovery provides a promising new target for therapeutic immune restoration and could lead to significant impact in treating RSV infections.

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Ready and vigilant: immune cells on standby

A team of researchers found that immune cells maintain their alertness through the JAK-STAT signalling pathway when there is no immediate threat. This discovery could lead to new approaches for enhancing the immune system's attention and preventing autoimmune diseases.

Apple iPhone 17 Pro

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Researchers create mosquito resistant to dengue virus

Researchers genetically modified mosquitoes to resist infection from dengue virus, boosting their natural ability to fight the disease. The findings could be a prelude to developing a strategy to eliminate the threat of dengue.

Apple iPad Pro 11-inch (M4)

Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.

Why age reduces our stem cells' ability to repair muscle

Researchers found that age-related decline in skeletal muscle stem cell function is caused by increased activation of the JAK/STAT signalling pathway. Inhibiting this pathway with specific drugs restores muscle stem cell function and promotes tissue repair.

Molecular path from internal clock to cells controlling rest and activity

A new study found that a microRNA named miR-279 acts through the JAK/STAT pathway to regulate locomotor activity rhythms, maintaining normal patterns of wakefulness and sleep. The researchers identified a protein called Upd as a target of miR-279, which displays daily oscillations in its secretion.

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Scientists uncover a genetic switch that turns immune responses on and off

Researchers identified a novel negative regulator called eye transformer that controls the flow of information from chemical signals to genes in the cell nucleus. When this regulator is turned off, the JAK/STAT pathway hyper-activates, leading to conditions such as cancer, severe immune deficiencies, and autoimmune diseases.

Mutations point the way to new leukemia drugs

Researchers discovered a mutation in the MPL gene that activates the JAK-STAT pathway, leading to uncontrolled cell growth and leukemia. The new finding offers potential targets for drugs targeting the JAK-STAT pathway, which may be effective against leukemias caused by either the MPL or JAK2 mutations.

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Insight into JAK/STAT

The JAK/STAT signaling pathway is a crucial regulator of cell growth and survival in various organisms. Research at the Cold Spring Harbor Laboratory has shed light on the molecular mechanisms underlying this pathway.