Articles tagged with Signaling Cascades
Scripps Research Institute scientists have identified key triggers of an important cancer-blocking mechanism in cells, known as oncogene-induced senescence. The study reveals a cascading interaction of three enzymes necessary to initiate this response.
Scientists investigated why ethylene causes tomatoes to mature after picking but not peppers. They found that genes involved in breaking down the cell wall and carotenoid biosynthesis were produced in greater quantities in both tomatoes and peppers, suggesting a different ripening mechanism for non-climacteric fruits like peppers.
Researchers at Goethe University Frankfurt have elucidated a new signaling pathway in the immune system that regulates inflammation and chronic dermatitis. The discovery provides new avenues for therapeutic intervention and potential targeted therapy for patients with unclear origin.
Researchers at Duke University Medical Center have found a cascade of signaling molecules that allow brief signals to last for tens of minutes, forming stronger connections in the brain. This discovery could lead to new insights into diseases like Alzheimer's and autism.
Researchers at the University of Washington analyze PLC signal transmission process using fluorescence technology, extending kinetic model to cover entire signaling cascade. The studies reveal steps linking changes in PtdIns(4,5)P2 to potassium channel activity regulation.
Researchers at MDC Berlin-Buch have identified a protein, CNP, that triggers the splitting of sensory axon growth cones. This discovery sheds light on neuronal branching and its role in transmitting sensations such as touch, pain, and temperature.
Researchers at the University of California, San Diego, discovered a protein compass that helps amoebas find bacteria by scent. This molecular switch is also shared with human immune cells to locate infection sites.
Researchers at Imperial College London have discovered a bacteria cell's 'stressosome', a large molecule that responds to external stress and danger. The stressosomes trigger a cascade of signals within the cell, producing over 150 proteins that enable the cell to adapt and survive.
Researchers discovered a pathway plants use to defend against pathogens, involving a signaling cascade that triggers the production of anti-microbial compounds. This understanding could lead to improved crop disease resistance.
Researchers discovered a new 'helper' compound, dasatinib, that effectively treats some leukemias by targeting both BCR-ABL and SRC kinases. The findings suggest addressing both pathways is crucial for optimal treatment outcomes.
Researchers identified a protein, Smk-1, that regulates longevity in Caenorhabditis elegans without affecting other insulin signaling pathway functions. This finding raises the prospect of medically tweaking this pathway to slow aging and improve quality of life.
Researchers found that sera from lupus patients contain antibodies that bind to T cells and suppress IL-2 production through CaMKIV. This deficiency in IL-2 contributes to the autoantibody production seen in lupus, highlighting a new understanding of how microenvironment influences defective T cell function.
Researchers have discovered a new inhibitor called hSef, which regulates the Ras/ERK MAP kinase cascade by limiting ERK activity to specific regions of the cell. This discovery provides insights into how cellular signals are localized and controlled within the cell.
Researchers at the Salk Institute discovered a complex chain of events leading to Notch activation, which is crucial for proper left-right asymmetry. The study used mathematical modeling to pinpoint factors regulating Notch activity, revealing extracellular calcium as a key trigger.
The HOME scientists used various instruments and equipment to track ocean energy and turbulence, finding that the Hawaiian Ridge is a site with vastly increased ocean mixing. They documented undersea internal wave energy enhanced 10 times at the ridge compared to normal open ocean areas.
Two new faculty members at UC Davis have been awarded Sloan Fellowships for their groundbreaking research. Marie Burns studies the G-protein cascade in light-sensitive cells, while Alexander Soshnikov explores the applications of random matrix theory in pure statistics and mathematical physics.
Researchers have found evidence of recent earthquakes in a deep-sea core, suggesting the Cascadia subduction zone was active as recently as 300 years ago. The discovery provides new insights into earthquake cycles and helps establish methods to trace the history of earth's active crust.