Articles tagged with Alanine
This study found a significant association between urinary arsenic levels and the prevalence of metabolic dysfunction-associated steatotic liver disease. Higher arsenic exposure was linked to an increased risk of MASLD, particularly in females and individuals with higher incomes.
This study found a significant association between arsenic exposure and MASLD in humans, with higher urinary arsenic levels increasing the risk ofMASLD. The analysis also showed that arsenic exposure persisted across key subgroups, suggesting its contribution to hepatic steatosis even at moderate exposure levels.
Researchers from Osaka University have discovered a link between the rare D-form of the amino acid alanine and the circadian clock's influence on glucose metabolism in the kidney. The study found that D-alanine regulates gluconeogenesis, a process that creates new glucose to maintain energy levels, and is mediated by the protein Cry2.
Scientists develop a method to construct crystalline artificial steric zippers in peptide β-sheets, paving the way for novel therapeutic strategies and materials. The research utilizes metal ions to prevent aggregation and form needle-shaped crystals with specific structural characteristics.
Researchers found that a mutation in RPL3L, expressed only in heart and skeletal muscle, leads to impaired cardiac contractility by causing ribosomal collisions and protein folding abnormalities. The study aims to develop new treatments for cardiomyopathy and atrial fibrillation.
Researchers developed an efficient microbial cell factory producing β-alanine from fatty acid feedstocks with the highest reported metrics. This innovative approach leverages the glyoxylate-TCA cycle for high-yield and balanced product synthesis, offering insights into novel bioproduction routes.
A rise in severe acute hepatitis of unknown causes (SAHUC) in children has been reported worldwide, with symptoms including jaundice, vomiting, and diarrhea. Diagnostic tests such as liver enzymes and biopsy reports can help identify the disease, but its etiology remains unclear.
A new study systematically reviews data on PFAS exposure and liver damage, linking three commonly detected PFAS to elevated levels of a liver enzyme, ALT. The research suggests a potential link between PFAS and non-alcoholic fatty liver disease (NAFLD), a growing public health crisis affecting 25% of adults worldwide.
Scientists at Tokyo University of Science discovered a primitive protein synthesis system in Nanoarchaeum equitans, which may have inspired the development of modern aminoacyl-tRNA synthetases. The study found that an ancient enzyme can add alanine to tRNA and minihelix regions independently of a specific base pair.
A study by Joslin Diabetes Center shows that alanine can activate AMPK, increasing energy production and lowering glucose levels. This finding suggests a new potential way to modify glucose metabolism in the body.
A team of researchers discovered a protein called Rqc2 that specifies which amino acids are added to stalled proteins, blurring the lines of what we thought proteins could do. The study suggests potential implications for neurodegenerative diseases such as Alzheimer's, ALS, or Huntington's.
New research reveals that chiral metal surfaces can control chiral chemistry, offering a novel approach to pharmaceutical drug synthesis. The study finds that certain surface orientations form stable structures with one molecular enantiomer but not the other, promoting enantiospecific effects.
Researchers unveil unprecedented detail on how transporter proteins modulate neurotransmitter transfer and recycling. The study reveals the molecular workings of transporter proteins, essential for signaling in neurons, and sheds light on how they respond to binding molecules.
Researchers at Scripps Research Institute have discovered the chemical basis for why cells develop extra checkpoints to correct errors during protein production. The study reveals that the active site of a key enzyme, AlaRS, is flexible and can bind both larger and smaller amino acids, explaining the 'serine paradox'.