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New study led by Brown researchers sheds light on incidental findings in lung cancer screening

A new study by Brown researchers found that 33.8% of patients with low-dose computed tomography (LDCT) screening had significant incidental findings, many of which were clinically important. The study suggests that standardizing reporting of these findings could improve patient care and reduce unnecessary medical interventions.

SourceBrown University·JournalJAMA Internal Medicine·TypeCase study·DateMay 9, 2023

Nuclear medicine bone scan study identifies prevalence and outcomes of cardiac amyloidosis

A new study found that approximately three percent of all bone scan patients have markers of cardiac amyloidosis, which can lead to heart failure and increased mortality. The research highlights the importance of early diagnosis and treatment, as well as potential automated detection methods using machine-learning algorithms.

SourceSociety of Nuclear Medicine and Molecular Imaging·JournalJournal of Nuclear Medicine·DateJan 3, 2023

Liquid biopsies can detect which cancer patients may be at higher risk of developing additional blood cancers

Researchers found that liquid biopsies can detect clonal haematopoiesis, a condition placing patients at higher risk of developing myelodysplastic syndrome or acute myeloid leukaemia. The study suggests that these patients should be referred for further evaluation to uncover actual risk and identify potential diagnostic pathways.

JMD publishes article on laboratory perspective of incidental findings reporting

The Journal of Molecular Diagnostics published a Special Article on laboratory perspective of incidental findings reporting, highlighting the need for increased understanding and transparency of complex genomic testing. The AMP Incidental Findings Working Group recommends laboratories establish clear policies for delivering ancillary i...

SourceAssociation for Molecular Pathology·JournalJournal of Molecular Diagnostics·DateFeb 12, 2015

Ethicists provide framework supporting new recommendations on reporting incidental findings in gene sequencing

A group of experts developed a framework for reporting incidental findings in clinical exome and genome sequencing, following the American College of Medical Genetics and Genomics recommendations. The framework justifies reporting clinically beneficial incidental findings as ethically compatible with respect for patient autonomy.

SourceBaylor College of Medicine·JournalScience·DateMay 16, 2013

Patients should have right to control genomic health information

Bioethicists argue that patients should not be forced to receive genomic information about future health risks without their consent. The ACMG recommendations on reporting incidental findings in clinical genome sequencing are seen as problematic due to concerns over patient autonomy and cost implications.

SourceCell Press·JournalTrends in Biotechnology·DateMay 9, 2013

ACMG releases report on incidental findings in clinical exome and genome sequencing

The American College of Medical Genetics and Genomics has released a report on incidental findings in clinical exome and genome sequencing. The report provides guidelines for laboratories to return incidental genetic findings to doctors ordering the tests, who will then manage the information with patients. This is expected to benefit ...

SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·DateMar 21, 2013

Unexpected findings at multi-detector CT scans: Less reason to worry

A recent study from Rhode Island Hospital found that nearly seven percent of urologic multi-detector CT scans for hematuria resulted in clinically important incidental findings. The most common findings were lung nodules, aneurysms, and ovarian cysts, with only a small percentage requiring immediate medical attention.

SourceLifespan·JournalAmerican Journal of Roentgenology·DateAug 27, 2012

Incidental findings at MRI-enterography

In a study published in World Journal of Gastroenterology, researchers found that MRI-enterography revealed incidental findings outside the small intestine in 25% of patients with suspected or known Crohn's disease. These extra-intestinal manifestations were rare and did not necessarily require additional examinations.

SourceWorld Journal of Gastroenterology·JournalWorld Journal of Gastroenterology·DateJan 14, 2010