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Experts urge strongest isolation for new drug-resistant tuberculosis cases appearing in South Africa

A deadly, highly-contagious and drug-resistant mutant strain of tuberculosis is spreading rapidly in South Africa. The World Health Organization warns that the situation poses a potentially explosive international health crisis due to its contagious nature and the presence of millions of migrant laborers.

Penn critical-care physicians recommend strategies when facing requests to end supplemental oxygen

As technology improves life expectancy and oxygen therapy becomes more accessible at home, critical care physicians face a new challenge: honoring patient requests to discontinue supplemental oxygen. The commentary offers a four-step approach to help physicians overcome concerns and ensure patients' wishes are respected.

Paying physicians to recruit patients into trials: The ethical concerns

Recruitment incentives have grown due to competition among research sponsors, offering substantial finder's fees. This raises concerns about physician judgment, patient safety, and public trust in clinical research. The issues cannot be resolved by sanctioning individuals, but rather require broader institutional and regulatory reform.

SourcePLOS·JournalPLOS Medicine·DateJul 31, 2006

For-profit research ethics committees: How are they performing?

Research ethics committees run for profit face criticism for prioritizing sponsors' interests over study safety. Examples show that well-performing for-profit IRBs exist, but critics argue that the financial stakes create a conflict of interest. Huge profits from clinical trials can lead to delays in approval and impact patient care.

SourcePLOS·JournalPLOS Medicine·DateJul 24, 2006

Potentially 1000s of 'brain drain' scientists would help home countries if system to do so created

A study of 60 life science researchers and entrepreneurs from developing countries found a lack of communication and coordination between diaspora members and their home countries. The researchers call for the establishment of mechanisms such as Diaspora Business Initiatives and National Science Corps to facilitate partnerships and col...

Ethical decision-making at bioscience companies

A study published in PLoS Medicine reveals that bioscience companies are formalizing systematic approaches to ethical decision-making, including Ethical leadership, External expertise, and Ethics evaluation and reporting mechanisms. The research shows that these approaches are becoming an integral part of day-to-day decision-making.

SourcePLOS·JournalPLOS Medicine·DateApr 3, 2006

Amid growing public concerns, bioscience firms begin formalizing ethical decision-making practices

Research by the University of Toronto Joint Center for Bioethics reveals five interrelated approaches used by 13 bioscience firms to address ethical issues, including strong leadership, external expertise, and internal mechanisms. The study provides a constructive starting point for the industry to build upon.

Legal and ethical questions about stem cell research

The article highlights the need for researchers to navigate intricate legal, ethical, and political issues surrounding human embryonic stem cell research. The author, Henry T. Greely, emphasizes that these concerns will significantly impact researchers, institutions, and science as a whole.

SourcePLOS·JournalPLOS Medicine·DateFeb 27, 2006

Medical research must put public interests before commercial decisions, warns pharmaceutical faculty

A recent study by the Faculty of Pharmaceutical Medicine emphasizes the need for doctors to prioritize public interests in medical research, advising against withholding negative results from clinical trials. The organization's guiding ethical principles recommend agreeing publication with sponsors before trial initiation.

SourceBlackwell Publishing Ltd.·JournalInternational Journal of Clinical Practice·DateFeb 8, 2006

Penn researchers provide recommendations for artificial nutrition and hydration

The study recommends five fundamental principles for clinicians to follow in making decisions about artificial nutrition and hydration (ANH), including consistency with medical condition, prognosis, and patient goals. The authors argue that ANH is a medical therapy with substantial risks and burdens, requiring technical procedures and ...

SourceUniversity of Pennsylvania School of Medicine·JournalNew England Journal of Medicine·DateDec 15, 2005