Articles tagged with Dementia
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Zarbio and Georgia State University scientists propose a framework for understanding Alzheimer's disease, linking molecular mechanisms, beta-amyloid biomarkers, and diagnosis. The Amyloid Degradation Toxicity Hypothesis resolves long-standing paradoxes in AD research.
The study aims to refine and validate a set of remote-testing methods called R-CARE Toolbox to assess older adults with dementia in diverse populations. Participants will undergo comprehensive assessments both in-person and remotely, followed by follow-up assessments at 18 and 36 months.
A new study published in Neurology found that people with very irregular sleep patterns may have a higher risk of developing dementia. Researchers analyzed data from over 88,000 participants and found that those with the most irregular sleep were 53% more likely to develop dementia than those with regular sleep.
A study found that saliva biomarkers sTNFR2 and sIgA can effectively detect pain in people with dementia, providing an alternative to invasive methods. The researchers discovered a decrease in sTNFR2 levels and an increase in sIgA in patients with dementia compared to a control group.
A recent study published in Biological Psychiatry: Global Open Science found that smoking causes brain shrinkage and increases the risk of age-related cognitive decline and Alzheimer's disease. Quitting smoking can prevent further loss of brain tissue, but stopping does not restore the brain to its original size.
Researchers found that a rare genetic mutation in the APOE gene, known as the Christchurch mutation, may prevent Alzheimer's dementia by severing the link between amyloid and tau accumulation. This discovery offers new hope for preventing the disease.
A protein called TAF15 forms amyloid filaments in brain cells, affecting frontal and temporal lobes. This discovery identifies a potential target for diagnostic and therapeutic strategies for frontotemporal dementia.
Researchers have identified a new protein, TAF15, associated with frontotemporal dementia, a rare and debilitating condition. The discovery provides a potential therapeutic target for diagnostic tests and treatments, offering hope for patients and families affected by the disease.
A recent study published in the Journal of the American Geriatrics Society found that Veterans experiencing housing instability are 53% more likely to receive an Alzheimer's disease or dementia diagnosis. The study included over 44,000 participants and tracked their health outcomes from 2011 to 2019.
A new study by University of Arizona psychologists investigated the possible scenarios leading to waning memory in older people. The researchers found that the hippocampus contributes to the difficulty in learning new environments and locations in some older adults.
A meta-analysis of 15 randomized controlled trials found significant improvements in sleep efficiency and psycho-behavioral symptoms in patients with Alzheimer's disease. Light therapy also alleviated depression and reduced patient agitation and caregiver burden.
Researchers found that misfolded prion proteins can trigger the clumping of TDP-43 in nerve cells, leading to reduced splicing activity and altered protein expression. This study reveals a new mechanism of how disease-associated prion proteins affect physiological signaling pathways through cross-seeding.
A new paper reveals that media coverage of Bruce Willis' condition was inaccurate, with journalists misrepresenting the relationship between aphasia and frontotemporal degeneration. The disease was often described as if it were a separate disorder from aphasia, when in fact aphasia is a symptom of frontotemporal degeneration.
A study will examine the cognitive function of older adults who were exposed to measles during childhood, shedding light on potential long-term benefits of routine childhood vaccinations. The research aims to better understand how childhood experiences shape health and well-being across the life course.
A new study found that very high levels of HDL-C, known as 'good cholesterol', are associated with an increased risk of dementia in older adults. Researchers observed a 27% higher risk of dementia among participants with very high HDL-C levels compared to those with optimal levels.
Research found a significant linear relationship between age of coronary heart disease onset and dementia, highlighting the detrimental influence of premature cardiovascular events on brain health. Adults diagnosed with coronary heart disease at a young age may be at increased risk of developing dementia, Alzheimer's disease, and vascu...
Research reveals that people with high conscientiousness and extraversion traits are less likely to receive a dementia diagnosis, unlike those with neuroticism and negative affect. The study analyzed data from over 44,000 individuals and found no link between personality traits and actual brain pathology.
A two-year study found that participants who received personalized coaching experienced a modest boost in cognitive testing, measuring a 74% improvement over the non-intervention group. Additionally, improvements were noted between the two groups in measurements of risk factors and quality of life.
Researchers have discovered a bidirectional interaction between amyloid-beta protein and sulfatides that may play a key role in the development of Alzheimer
A recent study found that older adults with dementia who are transferred to another hospital are less likely to receive intensive care or medical procedures within the first two days of transfer. This highlights the need for closer patient and family involvement in determining whether transfer provides optimal care.
Researchers at UCSF and Kaiser Permanente Washington found that participants who received personalized coaching experienced a 74% improvement in cognitive testing compared to non-intervention participants. The study also showed improvements in risk factors and quality of life, with modest but significant increases in cognitive function.
A study found that Black patients undergo medical imaging for cognitive impairment years later than white and Hispanic patients, with significantly lower rates of MRI testing. This delay can lead to earlier stages of disease diagnosis and reduced treatment options.
A recent study of 7,000 older US residents found that food insecurity was associated with a higher risk of dementia, as well as poorer memory function and accelerated memory decline. The researchers suggest that addressing food insecurity may have benefits for brain health.
A new study reveals that COVID-19 can leave a lasting impact on older adults living in nursing homes, causing them to need more help with daily activities and experience a decline in brain function. The study found that those who tested positive for COVID had effects that lasted up to nine months.
Researchers linked hearing loss to microstructural differences in auditory areas of the temporal lobe and frontal cortex. The study suggests that compensatory brain changes may lead to increased dementia risk, and interventions like subtitles or speech-to-text apps could protect against this.
Cambridge scientists have grown small blood vessel models in the lab and identified a drug target to prevent vascular dementia and stroke. The study found that disrupting the scaffolding that supports these vessels can cause them to leak, leading to conditions such as SVD.
A UTHealth Houston researcher is leading a large-scale implementation trial to address disparities in palliative care for Parkinson's disease and related dementia patients. The study aims to reduce low-value and unequal care, improve end-of-life care, and promote health equity.
A four-year blood-pressure intervention significantly reduced the risk of developing dementia among adults with high blood pressure, compared to those who received usual care. The study found that lowering systolic blood pressure to less than 130 mm Hg and diastolic blood pressure to less than 80 mm Hg reduced dementia risk.
Dr. Sabine Krabbe is investigating the function of the brain's emotion center in neurodegenerative diseases like Alzheimer's and Parkinson's, which often co-occur with depression and anxiety. Her research aims to find common mechanisms that could lead to better treatments for patients.
Earlier onset of atrial fibrillation is associated with an elevated risk of subsequent all-cause dementia, Alzheimer's disease, and vascular dementia. Monitoring cognitive function among patients with atrial fibrillation, especially those younger than 65 years at diagnosis, is crucial.
Researchers have identified a crucial biological trigger of Huntington's disease, finding that methylation converts an important protein into waste. By targeting this process, they may develop effective therapies for other neurodegenerative diseases.
A Berlin researcher is investigating biophysical phenomena relevant to brain diseases through a €1.5M European Research Council grant. The goal is to understand the behavior of aberrant protein inclusions in neurodegenerative diseases.
Yabing Chen has received two NIH grants totaling over $5 million to investigate vascular diseases and their link to dementia. Her research focuses on Runx2, a master transcription factor involved in both bone formation and calcification of arteries.
A recent study published in Nutrients found that daily strawberry consumption can improve cognitive performance and reduce depressive symptoms in middle-aged adults. The research, led by Professor Robert Krikorian, suggests that strawberries contain antioxidants and micronutrients that may help mitigate the risk of dementia.
Researchers found that cognitive decline quickened by 50% in the first year of the pandemic, with factors like loneliness, depression, and decreased exercise contributing to the impact. The study suggests that lockdowns had a lasting effect on brain health in people aged 50+, raising concerns about increased risk of dementia.
A study published in JAMA Neurology found that a 1% reduction in deep sleep per year for people over 60 increases dementia risk by 27%. The research suggests that maintaining or enhancing deep sleep could stave off dementia.
A 32-year study of 820 adults found high blood pressure variability in late life increased dementia risk, but had little effect on midlife risk. The results suggest blood pressure variability may be a key indicator of dementia risk in older age.
A new study finds that dementia incidence started to increase in England and Wales after 2008, leading to a projected increase of 40% by 2040. The number of people with dementia may reach 1.7 million, twice the current estimate of one million.
Researchers found that higher triglyceride levels were associated with a lower risk of developing dementia, with every doubling of levels reducing the risk by 18%. Higher triglycerides also linked to slower cognitive decline over time.
Terminating metformin treatment was associated with higher risk of developing dementia in a large cohort of adults. The study of 41,000 participants found that early metformin cessation was linked to increased dementia incidence compared to continued use.
A new study reveals that living near major roads is associated with a higher incidence of dementia and alterations in brain structure due to air pollution. The research, conducted in China and the UK, analyzed data from 460,901 participants over 12.8 years.
Two new studies suggest that of the 8 million Americans who have MCI, more than 90% don’t know it. Early diagnosis is key to delaying onset of dementia and Alzheimer’s disease. Researchers found that detection of MCI was poorer in those with cardiovascular disease, diabetes, hypertension, and other health issues.
A Cornell University-led study has separated the role of the hippocampus in two functions of memory, which are crucial for associating time, place, and past experiences with future actions. The breakthrough has significant implications for treating memory and learning issues found in Alzheimer's disease and dementia.
A new study published in The American Journal of Clinical Nutrition found that consuming more red meat is associated with a higher risk of developing type 2 diabetes. Replacing red meat with plant-based protein sources like nuts and legumes may reduce this risk.
A Rutgers University study of over 100,000 older adults found that adults with ADHD are at a significantly higher risk of developing dementia. The research suggests that ADHD treatment may help mitigate this risk, particularly with psychostimulant medications.
A new method using deep learning can provide as much information from brain images taken with CT as images captured with MRI, enhancing diagnostic support for conditions like dementia and other brain disorders. The software has been trained on 1,117 people and shows promise in diagnosing normal pressure hydrocephalus.
A large cohort study found a significant association between adult attention-deficit/hyperactivity disorder (ADHD) and the risk of dementia. The study followed 109,000 individuals born between 1933 and 1952 and found that ADHD was associated with an increased risk of dementia.
A new study by Boston University School of Public Health finds that adults with Down syndrome are more consistently enrolled in Medicaid and utilize more healthcare services than people without developmental disabilities. However, racial disparities exist, with White individuals having greater access to care.
The study reveals that dementia significantly affects an older adult's long-term care and financial status, with incremental changes being substantial. Family care availability should be considered in assessing the effects of dementia on caregivers' lives.
A new study finds that short and long-term blood pressure fluctuations increase the risk of dementia and vascular problems in older people. Higher systolic BP variations are also linked with stiffening of the arteries, a key factor in heart disease.
People with dementia experience a rapid rise in unpaid and paid home care, and major erosion of net worth. Family members face significant demands, providing an average of 45 hours of care per month.
A new trial combining an Alzheimer's medication with two other drugs may amplify its effects and arrest disease progression. The trial, funded by a $150M grant, will recruit 900 participants with early-onset Alzheimer's.
The UK Biobank study found that racial minority status increased dementia risk by 24%, with socio-economic status attenuating this effect. Lifestyle factors such as diet, smoking, physical activity, and sleep were identified as crucial in reducing racial and socio-economic disparities in dementia.
A clinical trial led by Western Sydney University's NICM Health Research Institute has revealed that Sailuotong, a novel herbal extract, shows promise as a potential treatment for mild cognitive impairment. The study found improvements in memory and executive function in participants taking SLT compared to those on a placebo.
A study using virtual reality led by UCL researchers found people with early Alzheimer's consistently overestimated turns and showed increased variability in sense of direction. These specific impairments were not observed in healthy older participants or those with mild cognitive impairment.
A new study found that people with subjective memory decline who also exhibit minor test deficits are more likely to progress to mild cognitive impairment. Participants who showed no signs of problems on standard tests had a lower risk of developing the condition.
A new study analyzing English primary care records found that hypertension, obesity, diabetes, and low HDL cholesterol confer a higher risk of dementia in South Asian and Black people compared to White individuals. The results suggest tailored dementia prevention efforts should be targeted towards minority ethnic groups.
A University of Minnesota Medical School professor is receiving a $4.39 million grant to study atrial myopathy, a heart condition associated with increased risk of dementia and vascular brain injury. The project aims to characterize the progression of atrial myopathy and its relationship to dementia and mild cognitive impairment.
A new study has identified two main pathways involved in Alzheimer's disease, with one acting through amyloid and tau proteins and the other based on immune system reactions. The research also found that certain genes have opposite effects in men and women, suggesting a need for further investigation.
Researchers discovered a non-invasive eye exam that can detect early signs of cognitive decline and cerebral small vessel disease, a major contributor to vascular dementia. The study found connections between altered retinal blood flow and changes in brain structure associated with the condition.