Articles tagged with Dementia
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Middle-aged people exhibit reduced exploration when learning a novel maze environment compared to younger individuals. This difference is partially driven by changes in how they learn about the maze, including visiting more objects and pausing for longer periods.
Dr. Jeetain Mittal's NIH grant will support multiscale computational models investigating phase separation in biology, particularly heterochromatin formation and its role in neurodegenerative diseases. The research aims to elucidate the molecular origins of phase separation using innovative models and methods.
A novel study led by NUS linguists reveals that seniors with memory-related mild cognitive impairment exhibit distinct speech patterns, including reduced noun usage and increased abstract thinking. These findings hold promise for developing language-based interventions to address dementia symptoms.
Research finds that Huntington’s disease damages microscopic blood vessels in the brain, affecting coordination between neuronal activity and oxygenation. The study uses non-invasive measurement techniques to monitor disease progression and evaluate potential treatments.
Research suggests that using hearing aids can help mitigate the acceleration of brain metabolism decline in individuals with mild cognitive impairment. The study found significant annual metabolic decline in frontal cortical regions among those with untreated hearing loss, whereas those with treated hearing aids experienced no such dec...
Researchers developed a therapeutic approach to replace the missing protein in the brain, reducing symptoms of frontotemporal dementia. The approach uses modified viruses to produce progranulin, which is then released into the bloodstream and crosses the blood-brain barrier, rescuing pathologies in mouse models.
Researchers at Queen Mary University of London developed a predictive test using fMRI scans that detects changes in the brain's 'default mode network' to predict dementia. The test showed accurate predictions up to nine years before an official diagnosis, with greater than 80% accuracy and a two-year margin of error.
A new study from Wake Forest University School of Medicine suggests that vigorous physical activity can lower the risk of cognitive decline in high-risk patients with hypertension. People who engage in one or more sessions of vigorous exercise per week had lower rates of mild cognitive impairment and dementia.
A comprehensive, user-friendly repository has been created to help study Alzheimer's disease. The ssREAD database encompasses 277 integrated datasets from 67 scRNA-seq & snRNA-seq studies, totaling 7,332,202 cells, and includes interactive visualizations for comprehensive analysis interpretations.
A new study from Karolinska Institutet found that stress weakens the association between cognitive reserve and improved cognition in memory clinic patients. Cognitive reserve is built through experiences like higher education and social interactions, but high or persistent stress levels can impair these benefits.
A new study found that an easy, five-minute assessment paired with recommendations in the electronic medical record system led to a three-fold improvement in diagnosis and treatment for patients with dementia. The '5-Cog paradigm' was developed to address cultural differences and testing disparities.
A new AI-driven tool can accurately diagnose Lewy body dementia by analyzing changes in vocal emotional expressions. The study found that individuals with Lewy body dementia exhibited more negative and calmer emotional expressions compared to those with Alzheimer's disease and healthy controls.
A new study found that almost two-thirds of prescribed tricyclic antidepressants were above the safe dosage threshold, with Black patients more likely to receive these high-dose medications. The research highlights the need for routine evaluation of drug efficacy in clinical care environments.
A new study by Brigham and Women's Hospital found that patients with dementia who underwent surgery for hip fractures experienced lower odds of death compared to those treated non-surgically. The benefit was seen in patients with head and neck of the femur fractures, but not in other locations.
A recent study published in the Journal of Applied Gerontology found that a 9-week online stress management intervention program for family caregivers reduced caregiver burden scores by 15%. The program provided education and strategies to manage stress, including self-care techniques like breathing and meditation.
Researchers have developed an AI algorithm that can track protein clumping under the microscope in real-time, revolutionizing the study of neurodegenerative disorders. The tool helps identify key characteristics of clumped proteins, which can lead to new therapies.
A new study at the University of Copenhagen reveals that urolithin A, a naturally occurring substance in pomegranates, can alleviate memory problems and other consequences of dementia. The substance shows promise in improving brain function by removing damaged mitochondria.
A cohort study of Japanese older adults found that upward and downward socioeconomic status transitions were associated with an increased risk of dementia. The study also revealed a link between social mobility and the length of dementia-free periods throughout life.
A new study published in JAMA Network Open reveals that upward social mobility significantly lowers the risk of dementia. The research, led by Osaka University researchers, analyzed data from 9,186 participants aged 65 and over, finding that individuals who experienced upward transitions had a notably lower risk of dementia incidence c...
Research suggests that oxidative stress (OS) may trigger Alzheimer's disease and that enriching brain glutathione (GSH) could be a way forward. Clinical studies indicate GSH depletion in the hippocampus initiates early onset of AD prior to amyloid beta deposition and tau phosphorylation.
A Phase III randomized, placebo-controlled trial found that donepezil did not improve memory or other cognitive functions in breast cancer survivors. Despite this, researchers emphasize the need for further trials with different approaches to address cancer-related cognitive impairment.
A new study from the University of Copenhagen found that long-term exposure to air pollution accelerates cognitive decline and increases risk of dementia. The research, which followed a cohort of nurses for 27 years, also suggests that physical activity may mitigate the adverse effects of air pollution.
A study by Duke and Columbia Universities found that non-white older adults with mild cognitive impairment reside in areas with more environmental injustices than their white peers. The study suggests that location, race, and environmental factors may interact to impact brain health.
Judges and physicians hold vastly different opinions on appointing legal guardians for people with dementia. Cognitive and neuropsychiatric symptoms, such as memory impairment and impulsivity, are evaluated differently by medical and legal professionals. Research emphasizes the need for consistency in assessments to ensure equal treatm...
Researchers developed a new system to prevent dementia, which was tested on 30 volunteers with mild cognitive impairment. The system showed a significant reduction in cognitive impairments after six weeks of training.
Scientists have recruited over 20,000 volunteers to a resource aimed at accelerating dementia drug development. The cohort will enable healthy individuals with increased genetic risk to participate in clinical trials, allowing researchers to test new treatments before symptoms appear.
White and Hispanic people are most likely to be diagnosed with behavioral symptoms of dementia, but also receive potentially harmful drugs. The study found substantial racial disparities in dementia diagnosis and treatment, with non-white patients being underdiagnosed for treatable symptoms.
A recent study published in BJSM found that increased cardio fitness level can reduce the risk of death from any cause and heart disease by 11-17% and 18%, respectively. Regular aerobic exercise programs can achieve this, leading to a reduced risk of early death and chronic conditions.
Physicians in states with mandatory reporting laws are 50% more likely to underdiagnose dementia, according to a new USC Dornsife study. This may worsen health outcomes and increase healthcare costs due to patients withholding symptoms out of fear of losing their driving privileges.
A recent study published in JAMA Network Open found that understaffed nursing homes in disadvantaged neighborhoods are more likely to overmedicate residents with antipsychotics. The researchers suggest that increasing staffing levels could help reduce the use of these medications and address the root causes of behavioral issues.
A new study found that better heart health in middle-aged Black women is linked to reduced cognitive decline and preserved brain function. However, this benefit was not observed among white women. The study suggests that taking care of one's heart may have a positive impact on brain function and overall well-being.
A new study assesses cognitive impairment over time in adults with essential tremor, finding a cumulative prevalence of 26.6% for mild cognitive impairment (MCI) and 18.5% for dementia. Early detection is crucial to slow further cognitive decline and improve quality of life.
A global consortium has studied the connection between a specific gene variation and Pick's disease, a rare form of early-onset dementia. The research found that the MAPT H2 genetic variant is associated with an increased risk of Pick's disease in people of European descent.
Researchers used state-of-the-art imaging techniques to discover the metabolism driving Alzheimer's disease, suggesting new treatment strategies. Lipid droplet metabolism can malfunction in Alzheimer's, leading to a cycle of stress and inflammation that worsens the disease.
A new study finds that initiating antihypertensive medication in older long-term care residents increases fracture risk, particularly among those with dementia. The study advises caution when prescribing antihypertensives to this vulnerable population.
A new study found that people with cognitively stimulating occupations during midlife had a lower risk of mild cognitive impairment (MCI) and dementia after age 70. The researchers analyzed data from over 300 jobs and found that high occupational cognitive demands were related to lower risks of MCI and dementia.
Researchers found that individuals from certain racial and ethnic groups are less likely to be eligible for Alzheimer's disease clinical trials due to lower amyloid levels at early stages of the disease. Amyloid buildup in the brain varies across different populations, contributing to underrepresentation in clinical trials.
A study published by The BMJ found that antipsychotics for dementia are associated with a wide range of serious adverse outcomes, including stroke, blood clots, heart attack, and pneumonia. Risks are highest soon after starting the drugs, highlighting the need for increased caution in early treatment.
Researchers aim to understand mechanisms behind high ADRD rates among MENA immigrants, a growing demographic. The study will investigate daily living, stress, genetics, brain health, and cognitive ability, using MRI-based imaging and cognitive assessments.
Researchers at Van Andel Institute have identified a gene expression pattern, akin to a disease-related fingerprint, in brain cells with Lewy bodies. This finding sheds light on the molecular changes that occur in these cells, which are key pathological hallmarks of Parkinson's disease and some dementias.
A new hypothesis paper proposes that Parkinson's disease starts in either the brain's smell center or the body's intestinal tract, tied to environmental factors. The study suggests that exposure to pesticides, air pollution, and tainted food may predispose to the disease.
A recent Mayo Clinic study investigated lucid episodes in people living with later stages of dementia, revealing that 75% were reported to have Alzheimer's Disease. The researchers identified distinct patterns or types of lucid episodes, suggesting they may be related to the level of cognition and circumstances surrounding the episode....
The COVID-19 pandemic highlighted the need for high-quality dementia care in nursing homes, where residents face social isolation and staff challenges. Experts emphasize person-centered care, resident involvement, and community connections to improve outcomes.
A new study found a link between midlife racial discrimination and increased levels of Alzheimer's disease markers, including phosphorylated tau181 and neurofilament light, in older age. Researchers analyzed data from 255 Black Americans over 17 years, revealing that chronic stress from racism contributed to dementia risk.
A new study found that non-medical cannabis use is significantly associated with a 96% decrease in odds of subjective cognitive decline. However, medical and dual-use were not significant in reducing the risk of SCD. The study highlights the potential protective effects of cannabis on cognition, but more longitudinal research is needed...
A traumatic brain injury quadruples the risk of developing dementia and neurodegenerative diseases like ALS. USC scientists used lab-grown human brain structures called organoids to study TBI's effects. They identified a gene, KCNJ2, that helps protect nerve cells against injury.
The study reveals that smartphone-based cognitive assessments can provide reliable and valid results for diagnosing frontotemporal lobar degeneration. These findings suggest a scalable solution for remote evaluations, which may enhance early detection.
Researchers developed a smartphone cognitive testing app that detects early signs of FTD in gene carriers before symptoms appear. The app was found to be comparable to gold-standard methods and may enable greater participation in clinical trials.
Scientists at The Florey have developed an mRNA technology approach to target the toxic protein tau, which builds up in patients with Alzheimer’s disease and other dementias. This new method demonstrates that mRNA can serve purposes other than vaccine development, offering a promising alternative to conventional treatments.
Researchers investigated genetic and modifiable influences on vulnerable brain regions using brain scans of 40,000 UK Biobank participants. They found that diabetes, air pollution, and alcohol consumption are the most harmful risk factors for dementia.
A new study found that people experiencing homelessness have a higher prevalence of dementia, especially in younger age groups. The researchers suggest that unhoused individuals should be screened for dementia at younger ages due to the complexity of diagnosing the condition in this population.
Researchers have identified PDE4B as a potential target for treating Alzheimer's disease, where reducing its activity shows promise in improving memory and glucose metabolism. The study suggests that this approach may also protect against other forms of dementia, such as Huntington's disease.
Researchers discovered changes to blood vessels in the brain that can increase stroke and dementia risk are common in people with heart conditions. The study confirms heart disease as a main cause of these changes, highlighting the importance of imaging tests to guide safer treatment choices.
A study of 17,000 hospitalized adults found that inappropriate pneumonia diagnoses were common among older adults and those with dementia or altered mental status. Full-course antibiotic treatment for these patients may be detrimental to their health.
A new study found that human brains are getting larger, with participants born in the 1970s having 6.6% greater brain volume and almost 15% larger brain surface area than those born in the 1930s. This increased brain size may lead to a higher brain reserve, potentially reducing the overall risk of age-related dementias.
Rats consuming reheated sesame or sunflower oil showed increased oxidative stress and inflammation in the liver, leading to significant damage in the colon and changes in endotoxins. The study suggests that long-term deep-fried oil consumption may contribute to neurodegeneration and highlight the need for further research on this topic.
Researchers discovered a genetic mutation in humanin, a mitochondrial microprotein, that may help individuals with the APOE4 allele live longer and preserve cognitive function. The variant was found to reduce amyloid-beta buildup in the brains of mice engineered to express human APOE4.
Researchers found that a high-fat diet suppresses the expression of a key protein in the gut, leading to inflammation and increased risk of Alzheimer's. Managing diabetes may be key to preventing or slowing down dementia symptoms.
A new study published in Aging and Mental Health found that people with dementia can assist their spousal caregivers, providing mutual benefits. The research suggests that reciprocated care can reduce caregiver burden and slow the progression of dementia symptoms, improving overall health outcomes.
Medicare expenditures were higher for Black and Hispanic individuals compared to whites, with average total costs ranging from $136,326 to $165,730. The analysis attributed these differences to greater use of high-cost care during the last year of life.