Articles tagged with Dementia
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Medicare expenditures were higher for Black and Hispanic individuals compared to whites, with average total costs ranging from $136,326 to $165,730. The analysis attributed these differences to greater use of high-cost care during the last year of life.
A Johns Hopkins Medicine-led team has developed a fluid biomarker that can detect the early stages of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The biomarker, HDGFL2, is associated with TDP-43 function loss and can be detected in blood or cerebrospinal fluid samples.
People with dementia experience declines in social well-being as their disease progresses, while caregivers become isolated due to caregiving responsibilities. Experts recommend screening for loneliness and finding ways to keep individuals socially connected to improve quality of life and reduce health outcomes.
A Duke University-led study suggests that targeting disadvantaged neighborhoods for dementia prevention programs could help lower dementia risk. People living in poorer neighborhoods show early signs of cognitive decline and have measurably poorer brain health as early as age 45, regardless of their own personal income or education.
The study reveals that neurological conditions are the leading cause of ill health and disability globally, with 3.4 billion people affected in 2021. The analysis shows a significant increase in disability-adjusted life years (DALYs) caused by these conditions over the past three decades.
A healthy diet has been shown to slow the pace of biological aging and reduce the risk of dementia. The study, published in Annals of Neurology, found that adherence to the Mediterranean-Dash Intervention for Neurodegenerative Delay diet slowed the pace of aging as measured by an epigenetic clock.
Researchers used single-cell RNA sequencing to analyze the effects of APC treatment on AD transgenic mice, revealing alterations in glial cells and upregulated genes associated with AD progression. APC treatment downregulates inflammatory processes and recovers nervous system functions.
The Hastings Center's new special report reviews options for supporting better lives of people facing dementia. The report analyzes care inequities and recommends policy changes to reduce financial hardships and social isolation associated with the diagnosis. It also explores emerging topics in health law and healthcare practice.
The Federation of European Neuroscience Societies is open to media registration for its 2024 event. Journalists can access the latest research discoveries in neuroscience fields such as dementia, addiction and depression.
A study published by the University of Florida suggests a connection between elevated amyloid blood levels and subtle brain microstructural changes in individuals without dementia. Researchers used diffusion MRI to detect free-water in the brain, revealing associations with structural abnormalities even when PET scans were negative.
A study found that people with essential tremor are at a heightened risk of developing dementia, with rates 3 times higher than in the general population. Researchers also found a significant increase in mild cognitive impairment among those with essential tremor.
Research suggests that magnetite particles, found in air pollution, can induce signs and symptoms of Alzheimer's disease. The study exposed mice to fine particles of iron, magnetite, and diesel hydrocarbons, finding that magnetite induced Alzheimer's disease pathologies, including neuronal cell loss and amyloid plaque formation.
Researchers found that individuals with mild cognitive impairment (aMCI) struggle with ambiguous sentences, indicating a key deficit in processing complex language. This deficit is independent of memory loss and may serve as an additional 'cognitive biomarker' for early detection.
A study published in BMC Geriatrics uses in-vehicle sensors to detect anomalous driving behavior indicative of cognitive impairment in older adults. The system analyzes driving patterns, facial expressions, and eye movement to identify early signs of dementia.
Researchers used machine learning to identify key predictors of mortality in dementia patients across various types. The study found neuropsychological test results were a better predictor of mortality risk than age-related factors, highlighting the potential for personalized care and more effective interventions.
Medical University of South Carolina researchers report that worsened anxiety and depression can predict the risk of developing Alzheimer's disease. The study found that patients with more severe neuropsychiatric symptoms were more likely to progress from mild cognitive impairment to full-blown Alzheimer's disease.
A UCLA Health study suggests Kundalini yoga can improve cognitive function, memory and brain health for postmenopausal women. The study found that yoga prevented brain matter decline, reversed aging and inflammation-associated biomarkers – improvements not seen in a group who received standard memory training exercises.
A new study by Baycrest and the University of Toronto suggests that talking speed is a more important indicator of brain health than difficulty finding words. Changes in general talking speed may reflect changes in the brain, indicating its importance in detecting cognitive decline faster.
Scientists developed an innovative neural cell culture model that replicates the aberrant behavior of TDP-43 in neurons. The model identified NPTX2 as a toxic protein that accumulates in cells containing abnormal TDP-43, leading to neurodegeneration in ALS and FTD.
Scientists have developed a single-dose genetic medicine that halts the progression of both ALS and frontotemporal dementia in mice. The treatment targets pathological TDP-43 build-ups in brain cells, which may also treat common forms of dementia like Alzheimer's disease.
The D-CARE Study successfully enrolled 2,176 racially/ethnically diverse persons with Alzheimer's disease or related dementias and their caregivers, highlighting the importance of adaptable recruitment strategies. The study provides valuable insights into how to better support patients with dementia and their caregivers.
A new study suggests that caregivers can establish a safe and workable mealtime routine for people with dementia living at home by reducing distractions, clearing away clutter, and leveraging community-based nutrition programs. The strategies aim to address the complex factors surrounding mealtime in the home, including cognitive impai...
A new study from Uppsala University found that people who have had herpes virus are twice as likely to develop dementia as those who have never been infected. The researchers studied 1,000 70-year-olds over 15 years and confirmed previous research on the potential link between herpes and dementia.
A team at Texas A&M University's School of Public Health has received funding to design a mobile app to help older Chinese American and Korean American adults prevent dementia. The app will focus on cognitive function and quality of life, with culturally appropriate content and multiple language options.
Dr. Jean Chen receives grant to investigate cognitive behaviour therapy's effect on caregiver brain health, reducing dementia risk and improving overall wellbeing. The research aims to optimize CBT use for Canadians living with depression.
Researchers discovered that aggregates prevent silencing of stress response in brain cells, leading to cell death. A new treatment involves administering a drug to turn off the stress response and keeping SIFI turned on to clean up protein aggregates.
A Rutgers Health-led study found that South Asian and East Asian older adults are less likely to believe in the benefits of participating in health research studies without direct personal gain. This hesitation may lead to a lack of representation in research, affecting the development of dementia treatments.
Researchers found that bariatric surgery led to improved cognition and overall well-being two years after the procedure. The study revealed changes in blood vessel efficiency and cortical thickness of the temporal cortex, offering new treatment options for patients with obesity and dementia.
Researchers found that immigrants with dementia were more likely to exhibit agitation and aggression, while non-immigrants were more likely to experience hallucinations and delusions. Language barriers and cultural considerations played a significant role in these findings.
New research from Flinders University found that regular exercise and a personalized falls prevention plan based on individual needs can reduce the likelihood of falls. The studies also highlighted the importance of having an individual falls risk assessment and modifying strategies according to specific circumstances, such as dementia.
A healthy lifestyle can help maintain cognitive abilities in older adults with common neuropathologies of dementia. The study found that a balanced lifestyle provides cognitive reserve, protecting against cognitive decline.
A new therapy called NIDUS-Family has shown promising results in improving the lives of people with dementia and their family carers. The study found that those who received the intervention were more likely to achieve their personal goals, such as increasing social engagement or improving caregiver support.
Researchers identified 180,940 people who had suffered a recent stroke and matched them to control groups to evaluate dementia risk after stroke. The study found that the rate of post-stroke dementia was higher than the rate of recurrent stroke over the same time period.
A systematic review and meta-analysis of 104 studies with 341,000 participants found that physical activity was associated with better late-life cognition, although the association was weak. The findings suggest that even a weak link between physical activity and cognitive decline is still important from a population health perspective.
A new analysis of ancient Greek and Roman medical texts suggests that severe memory loss was extremely rare 2,000 to 2,500 years ago. The study bolsters the idea that Alzheimer's disease and related dementias are diseases of modern environments and lifestyles.
A study from VCU School of Medicine and Richmond VA Medical Center found that up to 10.3% of veterans with dementia have high FIB-4 scores, indicating a likelihood of cirrhosis. Early detection and targeted interventions can reverse cognitive decline in these patients.
A study at Lake Okeechobee found that a faith-based approach increased ADRD diagnoses from 0.9% to 24.3%, with 55.3% of participants receiving referrals for further testing and treatment.
Researchers have identified five cases of Alzheimer's disease acquired through exposure to contaminated cadaver-derived human growth hormone (c-hGH) used in medical treatment between 1959 and 1985. Biomarker analyses and autopsy results confirmed the diagnoses, highlighting a rare but significant risk of transmission via this route.
A new study published by experts at the University of Exeter found that playing a musical instrument is associated with improved memory and executive function in older adults. Continuing to play into later life provides even greater benefit, suggesting that music could be a way to harness cognitive reserve.
Researchers have identified a network of lymphatic vessels at the back of the nose as a major hub for CSF outflow to deep cervical lymph nodes. This discovery has significant implications for understanding and treating conditions related to impaired CSF drainage, such as Alzheimer's disease.
Researchers at UTA developed a novel learning-based framework to predict Alzheimer’s disease progression. The DETree strategy can pinpoint clinical status within the disease spectrum, allowing for more accurate planning and potential applications in other diseases with multiple stages of development.
A new study reveals significant disparities in dementia care among minoritized racial and ethnic populations, including delayed diagnoses and inadequate treatment. The researchers highlight the importance of granular data collection to address these disparities and promote health equity.
Researchers found a correlation between cortical gray matter thickness and dementia risk, with thinner ribbons indicating higher risk. The study suggests that this biomarker could be used to identify people at high risk of dementia, potentially allowing for early intervention.
A recent meta-analysis of 20,000 patients with Alzheimer's disease found no clinically significant improvement in cognitive or functional abilities from monoclonal antibody treatment. The studies also revealed a high risk of serious harms, including cerebral edema and death, associated with the use of these expensive medications.
The Study of Healthy Aging in African Americans (STAR) will continue for five years to investigate behaviors, lifestyle, and brain health in Black adults. Researchers hope to identify risk factors and protective measures to reduce disparities in Alzheimer's disease diagnosis among Black Americans.
A recent study found that controllable risk factors for dementia vary by race and ethnicity. For example, the percentage of cases attributed to these risk factors was higher among Black people (24%) and Native Hawaiians (14%) compared to white people (22%). The most prevalent risk factors also differed across racial and ethnic groups.
A commonly used cognitive screening tool, MoCA, is found to be inaccurately assessing cognitive impairment in ethnically and linguistically diverse older adults. The study's findings underscore the importance of considering cultural factors when evaluating cognitive performance in traditionally underserved communities.
Researchers at UMass Amherst have received an NIH grant to create predictive models for Alzheimer's disease using brain MRIs and clinical data. The goal is to enable earlier detection of the condition, ideally two years before onset of symptoms.
Scientists at the University of Bath have found that the gene Angiogenin plays an important role in the development of nerve cells. In its mutated form, it causes stem cells to persist in their original state longer than they should, resulting in neurodevelopmental defects.
A UC Irvine-led study finds that increased staffing improves outcomes for all patients, but disparities persist between high- and low-dementia facilities. Specialized training and a secure environment are critical to meeting the unique challenges of dementia care.
A major new study has found a significant link between hearing loss and the development of dementia. People with severe hearing loss are at a higher risk, with a 20% increased likelihood of developing dementia compared to those with normal hearing.
A large study of over 573,000 people found that hearing loss is associated with a higher risk of dementia, particularly among those not using hearing aids. The study suggests that hearing aid use may help prevent or delay the onset and progression of dementia.
A study of 8,000 participants found that negative wealth shock was associated with accelerated cognitive decline and elevated risks of dementia among middle-aged and older U.S. adults. The findings suggest a potential link between financial hardship and cognitive aging.
A recent study published in JAMA Neurology identified 15 risk factors for young-onset dementia, including genetic predispositions, lifestyle factors, and health issues. By targeting these modifiable risk factors, it may be possible to reduce the risk of young-onset dementia.
Researchers found that baseline amyloid burden and brain health are stronger predictors of Alzheimer's progression than age alone. The study also showed that individuals with higher amyloid levels developed dementia two years earlier than those without.
A study by McGill University researchers found that people with symptomatic H. pylori infection have an 11% higher risk of developing Alzheimer's disease. The findings suggest a potential role for the bacterium in the development of the disease, opening avenues for future research and possible prevention strategies.
A pilot pragmatic clinical trial found daily-delivered meals lowered nursing home placement risk among people with self-reported dementia. Although not statistically significant, the feasibility of this intervention warrants further exploration in a larger trial.
A digital training program improved the lives of people with dementia in UK care homes, reducing sedative medication and increasing social interactions. The iWHELD programme delivered personalized care and encouraged meaningful connections, even amidst the COVID-19 pandemic.
Researchers at the University of Virginia Health System discovered that tau proteins damage brain cells by warping their nuclei, altering gene function and increasing tau production. This finding could lead to new treatments for Alzheimer's disease and other tauopathies.
A new study found that people with Alzheimer's dementia who were treated with lipid-lowering statins showed slower cognitive decline compared to those not treated. The researchers emphasize caution due to the observational nature of the study and initial concerns about statins' effects on patients with dementia.