Research on dementia and cognitive decline. Covers Alzheimer's screening, brain injury recovery, attention training, and gaps in diagnosis and care.
Researchers at UCalgary have discovered a protein called CD2AP that may hold the key to reducing Alzheimer's disease risk. Levels of this protein are lower in patients with AD, and its absence affects memory function, particularly in males. The study suggests a sex-dependent link between vascular system health and brain function.
Researchers in New Zealand are shedding light on the prevalence of dementia in multicultural communities, revealing up to half of those affected are unaware they have the condition. Early diagnosis can be life-changing, providing access to social support and improving quality of life for both individuals and caregivers.
A new Electronic Frailty Index 2 (eFI2) system will improve the accuracy of identifying older people's frailty by integrating data on 36 health problems. This will enable GPs to provide personalized treatments to prevent costly loss of independence and falls in older age.
Researchers developed a blood test that accurately diagnoses Alzheimer's disease and measures its progression. The test correlates with the amount of tau aggregates in the brain, distinguishing between early- and late-stage diseases.
Research shows that atrial fibrillation (AF) is linked to a higher risk of dementia, with a 21% increased risk at any age and a 36% increased risk for early-onset dementia. The association was strongest in younger adults and lost statistical significance in older adults over 70.
Researchers develop a powerful model to study TDP-43 pathology, which accumulates in the cytoplasm and depletes from the nucleus, leading to neuronal death. The 'seeded' protein aggregates recapitulate key features of ALS and frontotemporal dementia.
A recent expert review highlights the strong link between hypertension and atrial fibrillation, which can lead to thousands of strokes. Controlling high blood pressure could significantly reduce the likelihood of developing atrial fibrillation.
A UniSA-led study is trialing medication safety rounds in aged care homes to identify and address potential problems with medication use. The project aims to reduce medication-induced harm and improve residents' health and wellbeing through pharmacist-led safety rounds, adapting an existing palliative care need rounds model.
A new study from the University of Bath argues that digital technology and AI can help employees with dementia continue in employment. The research suggests that simple adjustments to the working environment and the use of AI can alleviate many problems faced by those with dementia, such as finding words and organizing text.
A study published in Neurology found that people living in disadvantaged neighborhoods may be more likely to develop dementia. Researchers analyzed data from four communities in Chicago and found that those in the most disadvantageous tracts were over twice as likely to develop dementia as those in the least disadvantageous.
A new open-source model of brain metabolism has shown how altering key chemicals can restore aged cells to their youthful activity and resilience. The detailed simulation provides a glimpse into the impact of aging on brain metabolism and highlights potential drug targets.
Adults with ADHD have higher levels of brain iron and neurofilaments, associated with increased risk of dementia. The study provides first evidence for a neurological mechanism possibly involved in the link between ADHD and dementia.
A study confirms plasma p-tau217 as a blood-based biomarker for early Alzheimer's detection in Asian populations. Higher levels correlate with faster cognitive decline, suggesting its potential role as both diagnostic and predictor tool.
The study found that the 'About Me' Care Card helps clinicians identify patient concerns earlier, creating personalized care conversations. However, some patients with advanced cognitive challenges required assistance, highlighting the need for further development and refinement of the tool.
Researchers at WashU Medicine have found that rejuvenating the network of vessels outside the brain can improve memory in old mice. The study lays the groundwork for developing therapies to overcome the challenges faced by conventional medications, which struggle to reach the brain due to the blood-brain barrier.
A recent study published by the American Academy of Neurology found that increased daytime sleepiness in older women is associated with a double risk of developing dementia. The study tracked 733 female participants over five years and observed significant changes in sleep patterns, including declining nighttime sleep and increasing sl...
A clinical trial shows that removing amyloid plaques from the brain can delay Alzheimer's symptoms, supporting the amyloid hypothesis. The treatment reduced the risk of developing dementia in people destined to develop early-onset Alzheimer's disease.
A recent study by the University of Eastern Finland reveals that linguistic barriers, lack of digital skills, and cultural differences hinder older immigrants' access to social and medical services. Family members and communities play a crucial role in facilitating access, but NGOs require state support to overcome resource limitations.
A study of 733 older female participants found that those with increasing sleepiness had double the risk of stable sleepers. Poor sleep quality in midlife and delayed dream phase are also linked to a higher risk of dementia. The study adds to recent research on the relationship between sleep patterns and dementia.
A new stem cell therapy trial at UTHealth Houston aims to reduce neuroinflammation in patients with presymptomatic Alzheimer's disease. The study, which is sponsored by Weston Brain Institute, will enroll 12 patients and use PET imaging to determine whether stem cells reduce brain inflammation before symptoms develop.
Researchers developed a portable system using AI to spot cognitive impairment by measuring subtle differences in motor function. The device accurately identified 83% of participants with mild cognitive impairment (MCI), offering potential for early intervention and improved outcomes.
The American Heart Association emphasizes the importance of brain health, citing a growing burden of dementia and neurological conditions worldwide. By adopting healthy behaviors and addressing modifiable risk factors, individuals can improve their cognitive function and reduce the risk of age-related decline.
Researchers have revamped a symptom assessment instrument to address pain, anxiety, and other symptoms of nursing home residents who are cognitively impaired. The new tool reliably captures physical and emotional distress, well-being, and end-of-life symptoms, providing guidance for expanding palliative care services in nursing homes.
A new study by NYU researchers found that adults living with HIV in Malawi are more than twice as likely to also have dementia compared to those without HIV. The study sheds light on the significant burden of dementia among people living with HIV in resource-poor settings.
Researchers have discovered a blood test that can identify patients with a sleep disorder who are most likely to develop Dementia with Lewy Bodies. The blood test analyzes two proteins in the blood associated with Alzheimer's disease and predicted dementia risk in almost 90% of patients, four years before symptoms appeared.
A new study analyzing global data from 1990 to 2021 found significant cross-country disparities in Alzheimer's disease and other dementias, with approximately two-thirds of individuals living in low- and middle-income countries. The study highlights the need for targeted prevention and control strategies in different countries.
A meta-analysis from the University of Georgia's College of Public Health found that factors like air pollution and access to green spaces can significantly raise or lower dementia risk. Living near major roadways was associated with a 10% higher risk, while exposure to fine particulate matter increased risk by 9%.
A new Cochrane review has found evidence that music-based therapy may benefit people living with dementia, particularly by improving symptoms of depression. The review suggests that music therapy probably improves depressive symptoms and may improve overall behavioural problems by the end of treatment.
A new study led by researchers at UCL has found that online brain speed tests can provide valuable insights into cognitive function and potentially shed light on dementia development. The tests, which measure reaction times, were designed to be easy and convenient for women in their 40s and older to participate from home.
A study of nearly 900 postmenopausal women found an association between perimenopausal symptom burden and later cognitive function and behavioral impairment. Women with higher menopausal symptom burdens were more likely to experience poorer cognitive function and mild behavioral impairments, both markers of dementia.
Researchers at USC Stem Cell discovered a gene called KCTD20 that suppresses glutamate toxicity, leading to enhanced tau protein clearance. This approach offers a promising therapeutic strategy for patients with tau-related neurodegenerative diseases, including Alzheimer's disease.
A large prospective study found that long-term use of non-steroidal anti-inflammatory (NSAID) medications may help prevent dementia due to their anti-inflammatory effects. The study showed a 12% reduced risk of developing dementia among participants who used NSAIDs for an extended period.
A new study has found that widely used consumer-grade digital devices like smartphones and smartwatches can be effective in assessing cognitive health. This allows for early education and detection of cognitive changes, enabling individuals to enact lifestyle modifications and slow or prevent decline.
Researchers have discovered alarming levels of microplastics in human brain tissue, with concentrations 3-5 times higher in individuals with dementia diagnoses. The study highlights the need for large-scale human studies to determine dose-response relationships between microplastic exposure and chronic health outcomes.
A unique case study reveals an unexpected discrepancy between Alzheimer's pathology and cognitive function in a woman with Down syndrome. The study highlights the need to expand inclusion criteria for therapeutic drug trials and uncover genetic or lifestyle factors that contribute to cognitive preservation.
The project aims to uncover mechanisms bridging MCI and CVD, developing an integrated approach to promote resilience and improve overall health in the ageing population. It will use real-world data, AI, and clinical variables to enable risk stratification and personalised treatment.
A team of scientists at Indiana University School of Medicine has identified a potential link between retinal changes and Alzheimer's disease. The study found that the APOE4 gene variant impairs retinal function in mice, suggesting a direct link to visual processing deficits associated with Alzheimer's disease.
A study by Washington University in St. Louis researchers has found a critical role for the physical interfaces of amyloid beta peptides in determining their chemical dynamics, leading to neurodegeneration. The research identified small molecules capable of breaking the toxic feedback loop, providing evidence that proper nutrition may ...
A 30-year study analyzing Catholic nuns' aging patterns has clarified key factors influencing dementia risk and protection. The research found that early-life linguistic ability and grammatical complexity correlated with a lower risk of impairment in later life.
Researchers from Cleveland Clinic’s Genome Center linked human herpesviruses to Alzheimer's disease via transposable elements. They identified TEs activated in HSV-1 infected brains and found that commercially available drugs can reverse this pathway.
A new study found that people from minority ethnic groups are more likely to report non-cognitive symptoms, such as pain and dizziness, before receiving a dementia diagnosis. This can lead to delays in diagnosis and impact health inequalities. The research aims to improve culturally fair recognition of possible dementia in primary care.
A new observational study suggests that antidepressants can accelerate cognitive decline in people with dementia, while certain medications appear to be less harmful. Researchers analyzed data from 18,740 patients and found that selective serotonin reuptake inhibitors (SSRIs) were associated with the fastest cognitive decline.
A new University of Cincinnati trial is comparing two types of omega-3 supplements, LPC-DHA and TAG-DHA, to slow or prevent dementia progression in elderly adults. Researchers aim to investigate whether LPC-DHA supplementation increases CSF DHA levels and improves cognitive function.
Researchers at New Jersey Institute of Technology are working on assistive technology that allows people with mild dementia to customize tools and objects to provide assistance. The project aims to explore the use of smart objects as assistive technologies to support individuals in their daily lives.
Only about 1 in 5 older Americans have undergone cognitive screening in the past year, highlighting a persistent barrier to diagnosis and treatment. Researchers emphasize the importance of early conversations about cognitive health to prevent progression and improve outcomes.
A new study found that engaging in as little as 35 minutes of moderate to vigorous physical activity per week significantly lowers the risk of developing dementia. Even frail older adults can benefit from low-dose exercise, with the risk decreasing by up to 69%.
A new study published in Annals of Neurology found that lower concentrations of vitamin B12 in healthy, older adults led to signs of neurological and cognitive deficiency. These individuals showed slower processing speeds, brain lesions, and delayed responses to visual stimuli compared to those with higher B12 levels.
Researchers explore the connection between Alzheimer's and metabolic syndrome, finding links between insulin regulation, high blood pressure, and obesity. The study suggests that maintaining healthy blood fat levels may be crucial for brain health, paving way for potential therapeutic developments.
A new remotely-delivered support programme, NIDUS-Family, has been shown to improve the lives of people with dementia while reducing healthcare costs. The programme uses goal setting and personalized care to help individuals live well at home for longer, resulting in cost savings of £8934 per person over one year.
A new blood test has shown promise in improving the accuracy of Alzheimer's Disease diagnosis, with results comparable to established CSF biomarkers. The study found that measuring plasma p-tau217 was over 90% accurate, potentially replacing invasive diagnostic methods for up to half of patients.
Researchers found that intracranial hemorrhages double the risk of dementia in people. The study analyzed Medicare claims and observed a two-fold increase in dementia diagnoses within 5.6 years after a hemorrhage.
Researchers at WashU Medicine found that new Alzheimer's therapies can add up to 10 months of independent living with lecanemab and 8 months with donanemab. The study provides a more meaningful measure of treatment benefits, focusing on day-to-day impacts on patients' lives.
Researchers at the University of Sydney recommend adopting a primarily plant-centric fibre-rich diet to enhance overall health and longevity. The plan involves incorporating more plant-based meals into one's diet, starting with two days a week and increasing to five days as recommended by Professor Luigi Fontana.
A study at Lund University found that brain trauma triggers Alzheimer's disease through vascular changes, challenging existing paradigms. The research team identified increased aggregation of amyloid-beta and vascular alterations in patients with traumatic brain injury.
A study by University of Queensland researchers found nearly 70% of suspected frontotemporal dementia patients did not have the disease. Misinterpretation of brain scans and cognitive tests led to many incorrect diagnoses, highlighting the need for careful interpretation.
A Michigan Medicine-led study suggests that living in disadvantaged communities may decrease the length of time a person can survive with amyotrophic lateral sclerosis (ALS) by up to 37%. The study found that patients from more resourced areas tended to live longer, possibly due to better access to care and reduced caregiver burnout. T...
A study of older adults found that decline in body mass index, waist circumference, and high-density lipoprotein (HDL) occurred up to a decade before dementia diagnosis. These cardiometabolic changes may provide insights into the potential for early monitoring and intervention.
Certain mouth bacteria may support better memory and attention, while others increase the risk of Alzheimer's disease. The study found that an imbalance between beneficial and harmful bacteria can reduce nitric oxide production, crucial for brain communication.
Scientists from DZNE found that preventing brain inflammation may help treat Alzheimer's disease. The study, published in Immunity, suggests that inhibiting the NLRP3 inflammasome can reduce neuroinflammation and help microglia clear harmful amyloid-beta deposits.
The AI-powered tool, ReCOGnAIze, uses neuroscientific games to identify early signs of cognitive impairment in just 15 minutes, achieving nearly 90% accuracy. This scalable and cost-effective solution aims to improve quality of life for individuals with mild cognitive impairment.