Researchers at UB used a fluorescent probe to track the uptake of AN-152, a cancer drug linked to a peptide hormone carrier, by human breast-cancer cells. The study provides evidence that AN-152 directly enters cancer cells, accumulates in the nucleus and associates with chromosomes.
The University of Michigan School of Public Health is leading a $12.5 million project to improve the quality of life for children with asthma. The initiative aims to establish local coalitions that implement programs reducing hospital stays, emergency room visits, and enhancing asthma management. Faculty from U-M's asthma research team...
A Cornell University study of over 1,700 six- and seven-year-olds found that single mothers' education levels were more important than family income for their children's math, reading, and vocabulary scores. Strong links between a mother's ability level and her child's academic performance were seen in white, black, and Hispanic families.
New research from UCSF reveals that HIV patients with high CD4+ counts are still at risk of opportunistic infections such as CMV retinitis. The studies found a relationship between the effectiveness of anti-CMV therapy and HAART, highlighting the need for careful consideration in treatment strategies.
The Microbe-Mineral Group at Virginia Tech aims to discover conditions under which microbes release nutrients or contaminants from mineral surfaces. Researchers hope to advance bioremediation and control unwanted releases of phosphorus and other minerals.
The Max Planck Institute for Gravitational Physics has released the public beta of the Cactus Computational Toolkit 4.0, a collaborative environment for solving partial differential equations in physics and engineering. The toolkit allows individual scientists to plug their own computing applications into a modular framework, enabling ...
A study suggests that frequent dental visits can eliminate gingival overgrowth recurrence in patients taking nifedipine for high blood pressure. This regimen significantly reduces gum swelling and associated health risks.
Researchers found that increasing humus content can increase quinoline's movement to groundwater, but mineral interactions play a key role. The study suggests that strongly bound pollutants may still be broken down by microorganisms.
The University of Wisconsin-Madison has launched a Center for the Study of Mind-Body Interaction to investigate how emotions affect physical health. The center will focus on five projects, including examining resilience in older women and the impact of meditation on brain activity.
A recent study published in Nature Medicine has found that gamma/delta T cells are essential for regulating airway hyperresponsiveness, which is characterized by an exaggerated response to stimuli. The research suggests that these cells have a suppressive effect on airway constriction and may be a key target for future treatments.
Researchers have identified 15 M. tuberculosis genes expressed only when the bacteria are growing in macrophages, key disease-fighting cells. These genes play important roles in pathogen metabolism, propagation and self-protection, potentially leading to new drug targets or vaccines.
Researchers have identified 109 mariner elements in the human genome, which may contribute to genetic disorders such as Charcot-Marie-Tooth disease and hereditary neuropathy. The study's findings suggest that mariner transposons could be a hotspot for genetic change and error.
Researchers at University of Washington found that couples who later divorced displayed significantly more negative emotions and words in their initial discussions compared to those who stayed married. The study suggests that learning how to soften one's approach and improve emotional connectedness can help prevent divorce.
Recent studies have found that high cortisol levels might be a cause of depression, potentially leading to new antidepressant drug strategies. Cortisol-lowering drugs have shown promise in reducing depressive symptoms, especially in patients with high cortisol levels.
Outbreaks of toxic Pfiesteria microorganisms in recreational waterways can have significant impacts on summer tourism and seafood sales. According to a survey of 3,500 coastal residents, a Pfiesteria outbreak could reduce tourism by at least 40% and lead to nearly two-thirds of respondents eating less locally harvested seafood. Consume...
The University of Maryland School of Medicine will receive $24 million over six years from Novartis Pharma AG to discover new treatments for schizophrenia. The partnership aims to find ways to treat patients with 'negative' symptoms, which are limited in emotional expression and social functioning.
The consortium aims to collect medical information and genetic material from 400 families nationwide with AS to identify additional genes associated with its pathogenesis. Researchers will conduct genome-wide searches and map genes linked to AS outside of the MHC.
Scientists have found that the gene order in Arabidopsis, a model eudicot, is not preserved in rice, a model monocot. This discovery reveals an evolutionary divide between dicots and monocots, cautioning against using Arabidopsis genome for understanding cereal crops like rice and wheat.
Researchers at Michigan Technological University found that metal contaminants in Lake Superior sediments primarily come from native ore deposits, not atmospheric sources. High concentrations of mercury were detected, associated with copper and silver deposits.
Researchers have successfully sequenced human chromosome 17 using a microdevice fabricated from glass wafers, demonstrating a bright future for convenient and low-cost sequencing machines. The device holds 500 sequencing machines on a single chip, making it a significant breakthrough in DNA sequencing technology.
A study found that despite comprehensive treatment, four patients became infected with HIV at least six months after initial exposure due to ongoing contact with infected partners. Counseling strategies targeting misconceptions about transmission are crucial to preventing future infections.
Researchers at Yale University have found that healthy bullfrog tadpoles can distinguish the odors given off by infected animals and keep their distance. This ability may be widespread among animals, enabling them to avoid diseases and reducing the spread of infection.
A new method enables cheap and simple manufacture of customized DNA chips, revolutionizing genetic analysis and research. This technology can help diagnose genetic diseases and accelerate drug discovery, while reducing production costs.
Armstrong's groundbreaking work elucidated the physical processes underlying electrical signaling in and between cells. His research has contributed significantly to our understanding of ion channels and their role in transmitting nerve impulses, with implications for drug development and treatment of various diseases.
Scientists at Millennium and the Whitehead Institute discovered a novel protein FATP4 that plays a role in transporting fatty acid molecules from the intestine into the body. Inhibiting its function may provide new approaches to treating obesity.
A study by OHSU researchers found improved quality of care to be the major factor behind declining hospital mortality rates for heart failure patients in Oregon. The study analyzed data from 1991-1995 and concluded that better treatment and care were key contributors to the lower death rate.
Researchers aim to uncover principles of coordinated group motion and apply them to designing autonomous underwater or airborne robots. They will create a database recording fish school movements and test robotic versions of biological models.
A Cornell University research team led by Paulette Clancy is developing novel semiconducting materials using polymers, which could lead to cheaper and more portable 'throwaway electronics.' The project aims to create new materials for light-emitting diode displays and flexible laptop screens.
Researchers found that atovaquone was 100% effective in keeping volunteers bitten by mosquitoes carrying Plasmodium falciparum from developing the disease. Pairing atovaquone with proguanil, an older malaria-fighting drug, provides protection while avoiding drug resistance.
Scientists at OHSU have discovered a mechanism in the brain that controls weight, named the adipostat, which acts as a fat thermostat. The discovery could lead to medications that help regulate patient weight and prevent excessive caloric intake.
Scientists are working on developing new technologies to store, access, and search large volumes of data. The team aims to improve data management for next-generation science projects like the Sloan Digital Sky Survey, which will produce 40 terabytes of data.
Researchers are developing tiny, chip-based laboratories to speed up the search for new medicines by analyzing thousands of compounds simultaneously. This microscale analysis will enable faster, more cost-effective discovery in the fields of materials science and chemistry.
A team of researchers has produced high-resolution images of a complete ribosome complex using the Advanced Light Source (ALS), revealing more about its structure than previous observations. The new crystallographic images provide insights into how transfer RNA interacts with the ribosome and the molecular mechanisms of protein synthesis.
Research suggests that maternal depression may alter frontal brain activity associated with positive emotions in infants. The study found that infants of depressed mothers exhibited less left frontal EEG activity compared to right frontal EEG activity, indicating a potential impact on emotional processing.
Researchers will compare surgical and nonsurgical treatments for herniated discs, spinal stenosis, and degenerative spondylolisthesis in a 5-year study. The study aims to determine the relative effectiveness of these treatment approaches in improving health-related quality of life and reducing resource use.
A study of 1,037 inner-city boys found that those with behavioral problems in kindergarten became better adjusted as they grew older. High levels of hyperactive behavior were not linked to increased risk of juvenile delinquency.
Researchers at UCSF have identified a protein enzyme that plays a key role in pain signaling, suggesting a possible target for broad-based pain therapy. The finding applies to inflammatory pain syndromes, such as arthritis and colitis, and has potential implications for post-operative pain relief.
Millions of patients mix prescription medicines with alternative therapies without informing their doctors, raising concerns about herb-drug interactions. Studies have shown that herbs like St. John's wort and ginkgo can be effective in treating depression, anxiety, and memory problems, but may also cause side effects.
Researchers found a gene crucial for roundworm mating strongly resembles a gene involved in human polycystic kidney disease. The study uses Caenorhabditis elegans to understand the role of genes controlling reproductive behaviors, potentially shedding light on PKD1's function and its connection to kidney disease.
Researchers found that consuming water-rich foods instead of drinking water before meals can curb appetite and reduce calorie consumption. Foods high in water content, such as vegetables and soups, provide a sense of fullness while reducing energy density.
Research reveals striking increase in CD8 memory cells among HIV-positive teens, highlighting differences between male and female populations. The study provides a foundation for understanding adolescent immunity during HIV infection.
Researchers at UCSC have obtained detailed images of the complete structure of the ribosome, a tiny molecular machine responsible for translating genetic code and synthesizing proteins. The new images show how different parts of the ribosome interact with each other and with molecules involved in protein synthesis.
Researchers found that losing function of one copy of the PTEN tumor suppressor gene can lead to chronic fatal conditions, including cancer and autoimmune diseases. The study showed that this disruption allows white blood cells to accumulate unchecked and attack their own organs.
Researchers at UT Southwestern Medical Center have identified casein kinase I (CKI) as a novel component of the Wnt-signaling cascade, essential for proper animal development. The discovery may lead to new approaches for influencing developmental processes and developing cancer treatments.
Researchers found that girls with close relationships with their fathers tend to develop later, while those with cold or distant relationships develop earlier. The quality of fathers' involvement is the most important factor in early family environment related to daughters' puberty timing.
The BioSimMER VR application simulates a 3D computer-simulated setting where emergency personnel practice responding to biological warfare agent attacks. By engaging rescuers' senses and decision-making abilities, the tool helps them make better decisions in real-life emergencies.
Researchers from HHMI at Children's Hospital and Harvard Medical School discovered that stem cells can deliver therapeutic genes to diseased organs, potentially remodeling genetically defective tissues. The study suggests that adult stem cells may be manipulated to heal genetic defects in various organs and tissues.
A leading forensic toxicologist suggests that cocaine abuse may be behind some deaths in custody, rather than police brutality. The expert's neurochemical test detects a unique brain signature associated with excited delirium (ED), which can cause sudden death due to cardiac arrest.
Researchers found that interventions with peers grouped together often worsen adolescent problem behavior, leading to increased delinquency and substance abuse. Training adolescents to give up destructive behaviors seems ineffective when several group members have a tendency toward these behaviors.
Historically black colleges and universities are partnering with high-tech research-intensive universities for $1 million environmental health grants. The program, called ARCH, aims to strengthen research capabilities at minority-serving institutions, enabling them to conduct competitive research in environmental health sciences.
A report on a June 15 earthquake in Mexico highlights the need for enforcing special seismic design standards for critical buildings like schools, hospitals, and fire stations. The study found that these buildings are often constructed with heavier materials than recommended, increasing the risk of damage during earthquakes.
Researchers found that treating small, asymptomatic, unruptured cerebral aneurysms may increase health risks and death. The study's complex analysis suggested that in some cases, aneurysm treatment is unnecessary, highlighting the need for personalized care.
Richard M. Amasino, a plant molecular biologist at the University of Wisconsin-Madison, has been awarded the 1999 Alexander von Humboldt Award for his groundbreaking research on flowering time and senescence in plants. His discoveries have significant implications for agriculture, with potential to improve crop yields and resistance.
Astronomers believe that megaflares produced by tangled magnetic fields on a star and its planet might help identify distant Sun-like stars with planetary systems. This phenomenon could provide energy for the development of life on rocky planets, making it a promising area to search for extraterrestrial life.
Research indicates the Indian Ocean has its own El Niño-like phenomenon characterized by an east-to-west oscillation of warm waters affecting other parts of the world. The study found significant warming of the western portion of the Indian Ocean in 16 out of 48 years between 1950 and 1998, but only three were active El Niño years.
Scientists have found a possible way to induce new blood vessels without gene therapy, by lowering an individual's heart rate, according to a University of Iowa Health Care study.
A new study forecasts movie performance for domestic and international markets using a Bayesian model that examines information like star quality, past film performance, and screen numbers. The model provides accurate updates as sales figures come in to help plan better marketing activities.
A UK study found that breast-feeding significantly boosts cognitive development in babies, with benefits seen as early as 6 months and sustained through 15 years of age. The study analyzed data from 20 published reports and found that breast milk provides essential nutrients required for rapid brain development.
A simple cooling system can significantly reduce fuel vapour formation in aircraft tanks, minimizing the risk of explosion. The Polarjet system cools fuel to -1°C or below, reducing hydrocarbon vapours and oxygen levels, making planes safer without expensive modifications.
A recent study highlights the dangers of communications towers for migrating birds, which mistake tower lights for the moon and collide with structures. The Cornell University meeting brought together experts to discuss solutions, including co-location rules and reduced lighting in tall buildings.