A new natural history study of Amish nemaline myopathy provides a platform for exploring gene replacement therapy. The study's findings show promise for treating the lethal disorder, which is linked to a mutation of the TNNT1 gene.
Researchers found that in people living with HIV, a type of antibody called immunoglobulin G3 (IgG3) stops B cells from doing their normal job of fighting pathogens. This phenomenon appears to be one way the body tries to reduce immune-system hyperactivity caused by HIV.
Research found a strong correlation between blood omega-3s and executive function in children from Northern Ghana. Children with higher omega-3 levels were more likely to perform better on cognitive tests, suggesting potential benefits for brain development.
A new mathematical model explains the formation of zebrafish stripes by highlighting the crucial role of a single pigment cell type. The model shows that iridophores lead the process, providing redundancies to ensure reliable stripe formation even when cellular processes go wrong.
A new study finds that brief motivational interviewing interventions during routine HIV care can significantly reduce heavy drinking and improve condomless sex behavior among MSM living with HIV. Over a year, participants who received the intervention reported fewer drinks per week and days of heavy drinking.
Researchers found that groups that interacted only intermittently preserved the best of both worlds, having an average quality of solution nearly identical to those that interacted constantly. However, this intermittent interaction allowed high performers to learn from low performers and achieve even better solutions.
A recent study published in the Journal of Neurochemistry reveals that long-term use of cannabis or cannabis-based drugs impairs memory in mice, with significant effects on brain function and communication between learning and memory regions. The research highlights the potential negative side effects of long-term cannabinoid exposure.
Tropical Storm Leepi is weakening as it moves northwest, with maximum sustained winds near 63.2 mph. The storm's interaction with nearby System 98W is contributing to its decline.
Scientists have created specialized delivery methods using nucleic acid-based nanostructures to target cancer cells while leaving normal cells intact. The new approach utilizes aptamers to bind to specific receptors on cancer cells, allowing for the targeted delivery of chemotherapeutic drugs.
Researchers found altered nitrogen metabolism in many cancers, producing detectable changes in body fluids and contributing to new mutations. This dysregulation may facilitate early detection of cancer and predict immunotherapy success.
A team of researchers has discovered a protein called LEDGF/p75 that contributes to the regulation of gene expression in mixed lineage leukemia. The study found that this interaction is strongly modulated by phosphorylation from an enzyme called casein kinase 2, providing a new therapeutic route against the cancer.
A long-term study of eastern massasauga rattlesnakes in Illinois reveals they have retained a surprising amount of genetic diversity. However, the snakes' populations are likely to become locally extinct without significant intervention due to habitat loss and fragmentation.
A KAIST research team has developed a flexible drug delivery device with controlled release, blurring the path toward theragnosis. The device boasts fewer side effects and uniform therapeutic results compared to oral ingestion, making it suitable for smart contact lenses and brain disease treatments.
A KAUST study investigated the ignition of methanol-based fuel formulations and found that blending dimethyl ether (DME) with methanol improves combustion efficiency. The researchers also discovered that DME dominates reaction pathways during initial phase of ignition, but can be less effective at high temperatures.
Researchers have identified a potential new treatment for aggressive breast cancer by targeting the communication channel between non-cancerous cells and tumour cells. The study, published in Nature Communications, shows that disrupting this connection can slow tumour growth, increase sensitivity to chemotherapy and improve survival.
Scientists at KAUST developed a controlled method to create triple-layered hollow nanostructures with electrocatalytic activity, suitable for renewable fuel production and water desalination. The hybrid materials outperform single substances in terms of properties.
Researchers at NUS have developed an AI technology platform that can quickly determine the most effective drug combination for a patient. The Quadratic Phenotypic Optimisation Platform (QPOP) uses small experimental data sets to identify effective drug combinations and personalized treatment options.
Mentorship plays a crucial role in helping female athletes overcome sexism, bullying, and discrimination in sports. The study found that mentors provide emotional support, reduce delinquency, and instill positive work ethics. However, the researchers also identified mixed results, including gendered aspects of sport socialization.
A University of Kansas study suggests that food prices in ethnic enclaves impact assimilation rates and consumer spending patterns among Mexican and East Asian immigrants. The researchers found that Mexican immigrants spend less on food, while East Asian immigrants spend more, which could explain the difference in assimilation rates.
Researchers at KAUST have combined computer analysis with laser-based measurements to understand NOx production pathways in different fuel types, finding that alcohol fuels produce up to 50% less nonthermal NOx than conventional fossil fuels.
A study by University of Kansas researcher Erin Adamson finds that lifestyle migrants in Costa Rica's Caribbean coastal town create unintended consequences, including gentrification and racial segregation. Locals see benefits from the influx of migrants, but many are pushed out due to economic changes.
A major new study shows that rotavirus vaccination reduces infant diarrhoea deaths by 34% in rural Malawi, adding weight to the World Health Organisation's recommendation for its inclusion in national immunisation programmes. The study also found a direct link between vaccine coverage and mortality reduction.
A study by Northwestern University found that when a teenager's depression improved through treatment, their parent's depression also decreased. The research suggests that clinicians should assess a parent's level of depression when treating their child and provide appropriate referrals.
Research found that women who experience workplace incivility are more likely to engage in strict, controlling parenting practices, which can have a negative impact on their children. The study also suggests that this type of parenting is associated with various negative child outcomes.
A study by University of Kansas researcher Lukas Szrot found that younger religious Americans are more likely to harbor environmental concerns due to the emphasis on stewardship in religious groups. This shift is attributed to the growing discussion on creation care, which has led to a greater focus on environmental issues within churc...
A recent survey found that nearly a third of college students knew someone who overdosed on painkillers or heroin, while 20.5% said they know someone addicted to pain medication. The study highlights the collateral damage of the opioid epidemic on those closely tied to users.
Strathclyde will benefit from a UK-wide £1 billion funding boost to create the technologies of tomorrow through three Catapult Centres. The Advanced Forming Research Centre (AFRC) is set to receive £96 million, while FutureForge will establish a major advanced engineering facility.
New study finds that 40% of plant material is removed by insects and fungi each year, supporting diverse communities of organisms. Contrary to expectations, plants don't face trade-offs in defending themselves against different consumers, with some species protected against everything and others devoured.
Researchers found that autophagy efficiency declines with age, leading to accumulation of damaged biological structures in the kidneys. They discovered that nutrition restrictions and pharmacological drugs like rapamycin may help tackle this issue.
Dr Ariana Strandburg-Peshkin has established the first Gips-Schüle Junior Research Group at the University of Konstanz, researching animal social networks and collective behaviour. With €875,000 funding over five years, her team aims to characterize and understand these complex systems.
A study by the University of Melbourne and Harvard Medical School found that international aid spent on youth health projects is drastically underinvested in the developing world. Despite making up 12-13% of disease burden, adolescents receive only a tiny share of global investments.
A study published in Clinical Infectious Diseases identified nine clusters of respiratory infections in Uganda, including one potentially linked to UK tourism. The researchers used a genetic sequencing method called VirCapSeq-VERT to analyze nasal and throat swabs, providing detailed information on viral pathogens.
Scientists at Tohoku University successfully developed a method to create virus-like polymer particles with various nanostructures, which can be selectively functionalized. This technology has potential applications in immunoassay systems, drug delivery, and enzymatic reactions.
MIT researchers develop a machine-learning model that reduces toxic chemotherapy and radiotherapy dosing for glioblastoma patients, maintaining tumor-shrinking potential while minimizing side effects. The model uses reinforced learning to favor lower doses and schedules, improving patient quality of life.
A team led by W. Christopher Risher discovered that the α2δ-1 receptor is necessary for synapse structure and brain connectivity, implicating astrocyte-to-neuron signaling in psychiatric disorders such as autism and addiction.
Adolescents with conduct and substance use problems are five times more likely to die prematurely than their peers. Conduct disorder is a powerful predictor of early mortality, beyond substance use problems.
Researchers at IST Austria developed a method that can reproduce complex interactions with the environment and tiny details over huge areas in real time. The new simulation method simplifies artistic effects and allows graphics designers to create realistic water wave simulations with detailed interactions.
Researchers at ETH Zurich explore the coupling between heat and particle currents in a gas of strongly interacting fermionic atoms. They found an order of magnitude below predictions of the Wiedemann-Franz law, indicating separation of mechanisms responsible for particle and heat currents.
A new study published in the Journals of Gerontology, Series B, found that men respond to their spouse's illness just as much as women do and are better caregivers in later life. The research reveals similar levels of care given by male and female caregivers when a spouse is severely ill.
The research examines prison conditions, incarceration rates, and penal policy processes since the USSR's demise. It investigates social attitudes towards punishment, shaping cultural perceptions of history and political power.
A recent study demonstrates the feasibility of producing high-quality DNA sequence data at a laboratory in Indonesia. The research shows that molecular techniques like DNA extraction and PCR can be done using relatively simple methods and inexpensive reagents.
The research found that Homo erectus used 'least-effort strategies' for tool making and resource collection. This lack of innovation led to the species' demise, as they failed to adapt to a changing climate and technological advancements.
A study by Simon Fraser University aquatic ecologists reveals that young salmon may leap out of water to remove sea lice, which can reduce growth and competitive ability. The researchers found that on average, leaping salmon had 22% fewer sea lice than non-leaping fish.
Researchers at Massachusetts General Hospital have developed a novel approach to deep supercooling, allowing water-based solutions to remain liquid at temperatures below 0°C. This technique, dubbed 'deep supercooling,' may enable safe preservation of blood cells, tissues, and organs for extended periods.
Researchers have discovered synergy between colistin and other antibiotics, offering hope for treating multidrug-resistant Gram-negative bacterial infections. Combination therapy may allow clinicians to use lower effective doses of antibiotics, reducing toxicities and slowing antibiotic resistance development.
Despite making up 26% of the population, adolescents receive only 1.6% of global development assistance, with funding primarily focused on HIV/AIDS and other leading causes of illness, leaving underfunded areas such as mental health and injury prevention unaddressed.
Tropical Storm Kristy has a strong core with cloud top temperatures as cold as minus 70 degrees Fahrenheit, indicating powerful storms capable of heavy rain. The storm is moving north-northeast at 9 mph, with a turn expected later today and gradual weakening by Saturday.
Researchers say childhood thoughts and beliefs make people vulnerable to fake news. To defend against it, psychologists recommend reducing anxiety through humor, sublimation, and cultivating an open mind. Critical thinking skills also play a key role in questioning information and diminishing confirmation bias.
A new type of bed net showed a 12% reduction in clinical malaria cases compared to conventional nets, and children sleeping under it were 52% less likely to be anaemic. The study also found a 51% reduction in risk of malaria-infective mosquito bites.
A recent study using eDNA sequencing identified aquatic plant diversity in ponds, offering a new approach to ecological surveys. The study found that pondweed diversity had been underestimated at a reserve in Ontario, detecting three previously unknown species.
A new study reveals that chimpanzees in the savannah consume tougher and less digestible food than those in the rainforest. The researchers found that the outer casing of certain fruits had higher toughness values, suggesting that the chimps' teeth evolved to handle these more challenging foods.
Studies find that even minor phone use during meals can make diners feel distracted, reducing enjoyment. Compassionate people spend less time on social media than those with narcissistic tendencies. Digital distractions undermine face-to-face interactions, causing decreased bonding and emotional intelligence.
Researchers discovered a novel quasi-one-dimensional superconductor K2Mo3As3 with a critical temperature exceeding 10K. This breakthrough indicates that Cr and Mo-based Q1D superconductors share common underlying origins, paving the way for further exploration of exotic superconducting mechanisms.
The Icahn Institute is partnering with the National Institutes of Health to establish a center for reproducible biomedical modeling, aiming to accelerate development of predictive models for precision medicine and bioengineering. The center will provide much-needed model building resources to the research community.
A study found that nearly 40% of women with asthma may develop COPD, but certain factors such as smoking, obesity, and socioeconomic status may lower this risk. The researchers identified individual risk factors playing a more significant role in the development of COPD overlap syndrome than exposure to air pollution.
A recent study suggests that glaucoma is not just a pressure-related disease, but also an autoimmune disorder caused by the immune system attacking retinal cells. The researchers found that T cells, which normally target foreign substances, are responsible for progressive retinal degeneration in glaucoma.
The UT-ORNL team conducted the first full characterization measurement of an accelerator beam in six dimensions using a replica of the Spallation Neutron Source's linear accelerator. This achievement advances our understanding of particle accelerator beams and has significant implications for future accelerators.
A new LSU Pennington Biomedical study reveals a novel biomarker that may help diagnose hypoglycemia-associated autonomic failure (HAAF) in diabetics. The biomarker measures how well the brain uses acetate, which could indicate if someone is at risk for developing HAAF or has already suffered from it.
A quality-improvement project standardized feeding practices for micro preemies, leading to a significant increase in weight gain and improvements in nutritional status. The project also increased the frequency of lactation consultations by nearly fourfold.
Researchers at TU Wien have successfully synthesized high-tech dyes using plain water under high temperatures, breaking the need for toxic solvents. The new method utilizes water's properties to dissolve organic substances and crystallize the dyes, enabling their use in organic electronics and demanding applications.