Researchers demonstrate that a single transplantation of iPSC-derived macrophages into the lungs of mice with herPAP can effectively treat this life-threatening disease. The transplanted macrophages adapt and differentiate to function efficiently, providing long-term therapeutic benefits.
Dr. Silvana Costa receives a National MS Society grant to investigate the effect of visual, cognitive, and motor deficits on information processing speed in individuals with multiple sclerosis. The four-year study will utilize neuropsychological evaluations and eye-tracking technology.
Kenneth Tyler's review article in the New England Journal of Medicine highlights the need for improved diagnosis and treatment of acute viral encephalitis. The condition, which affects about seven patients per 100,000 population annually, imposes a heavy economic burden on healthcare systems.
Researchers at Syracuse University use nitrogen isotopic composition of sediments to understand changes in marine conditions during the Paleocene-Eocene Thermal Maximum, a brief period of rapid global warming approximately 56 million years ago. The study provides a benchmark for present and future climate and ocean models.
A material called graphene nano-ribbons has different electronic properties depending on its shape and width, allowing for the creation of tailor-made semiconductors, metals or insulators. The ribbons form a chain of interlinked quantum states with adjustable electronic structure.
Increasing control and physical activity may be the secret to staying young for older adults. Research suggests that a younger subjective age is associated with better memory performance, health, and longevity. A study found that participants who reported feeling more in control on days with higher step counts felt younger.
A large-scale patient population study reveals that palliative care is associated with a significantly reduced risk of suicide in veterans diagnosed with advanced stage lung cancer. The findings show that patients who received at least one palliative care visit had an 81% lower rate of suicidal death.
Researchers at University of Illinois Chicago discovered that a mutation in the NPM1 gene helps improve sensitivity to chemotherapy in patients. The study found that patients with this mutation tend to respond better to chemotherapy and have higher rates of remission.
Scientists at the University of Washington discovered ferroelectric switching in the 2-D form of tungsten ditelluride, a metal that can be applied to memory storage and capacitors. The discovery reveals a spontaneous electrical polarization that can be flipped by an applied electric field.
The project aims to improve patient safety by increasing the specificity of warnings about dangerous drug combinations and identifying shared experiences to refine algorithms. It will be implemented in over 50 health-care facilities across the US.
Researchers have identified two changes to a single gene that can make yeast tolerate pretreatment chemicals used in biofuel production. The modified yeast can survive and ferment alongside amounts of toxic ionic liquids, increasing efficiency by up to 70%. This breakthrough could revolutionize the biofuel industry.
Research team proposes that ultrahot Jupiters have normal compositions, with atmospheres resembling stars due to high temperatures and radiation. Water molecules are torn apart on the dayside, but may recombine into clouds in the nightside hemispheres.
The authors propose increasing incentives and modifying regulations to improve competition, redirecting overinvestment in new drug development to the generic market, and pivoting from short-term survival mode to long-term organized responses. These solutions aim to enhance competition, provide patients with reliable access to vital dru...
Researchers developed a novel approach to identify microbial genes specifically present in the gut, accounting for ancestral relationships between bacteria. The analysis uncovered thousands of genes associated with bacteria prevalent in the gut and those linked to Crohn's disease.
A prospective study of over 3700 US juveniles found an independent association between conduct disorder and mortality hazard. Conduct disorder was linked to a 4.99 times higher risk of mortality compared to community controls.
Researchers tracked drivers' eye movements at busy Toronto intersections and found that more than half failed to scan for pedestrians or cyclists during right turns. The study highlights the need for road infrastructure changes, such as consistent bike lane implementation, to improve traffic safety.
Researchers at Hokkaido University have developed a hybrid catalyst that combines simple rhodium and organic catalysts to selectively produce molecules with high enantiomer selectivity. This technology is expected to assist in rapid and low-cost drug synthesis, particularly for nucleotide medicine.
A large international study found that individuals consuming average amounts of sodium (3-5g/day) do not face increased health risks. However, those exceeding five grams a day may experience cardiovascular events, and improving dietary quality with potassium-rich foods can mitigate this risk.
RCSI and Bayer are working together to create new, tailored treatments for people with severe haemophilia. The goal is to promote blood clotting with increased precision, improving the quality of life for those affected by this condition.
Researchers discovered a high infection rate of Purkinje neurons with HHV-6 in patients with bipolar disorder and/or severe depression. The study suggests viruses can cause cognitive disturbances leading to mood disorders, contradicting the belief that dormant viruses never cause disease.
New research reveals that coral-algal partnerships date back to the Jurassic Period, approximately 160 million years ago. This finding challenges previous assumptions and provides evidence for a more diverse range of algal species worldwide.
NASA's Aqua satellite captured Hurricane Hector's large eye after it passed the Hawaiian Islands. The storm's cloud top temperatures were as cold as minus 70 degrees Fahrenheit, indicating strong storms capable of heavy rain. A tropical storm watch is in effect for Johnston Island, with swells expected to produce dangerous waves.
Parker Solar Probe will make its journey to the Sun's atmosphere, closer than any spacecraft in history, with a highly elliptical orbit and speeds of up to 430,000 miles per hour. The spacecraft will observe the acceleration of the solar wind and study extreme events on the Sun, such as solar flares and coronal mass ejections.
Researchers at Penn Medicine discovered PARP inhibitors could prevent toxic TDP-43 accumulations in brain cells. The treatment shows promise for neurodegenerative disorders like ALS and FTD.
Researchers at the University of Minnesota have developed a groundbreaking 3D-printed device that uses regenerative cells to connect living nerve cells above and below spinal cord injury sites. The device has shown promise in improving bladder control, stopping uncontrollable movements, and alleviating pain.
A genome-wide scan reveals the shared loss of Paraoxonase 1 (PON1) gene function across marine mammal lineages, leaving them vulnerable to neurotoxic chemicals. This loss may be related to PON1's role in fatty acid oxidation and poses a significant health risk for marine mammals living near agricultural runoff.
A $2.5 million federal grant will help diagnose speech sound disorders in bilingual Latino children in Arizona and other states with large Hispanic populations. Researchers aim to develop evidence-based diagnostic criteria for clinicians to accurately identify bilingual children with speech disorders.
A proposed four-pillar strategy aims to drastically change consumption patterns, ensuring agricultural production and supply chains play a greater role in sustainable development. The transformation hinges on renewing food system governance, prioritizing human development, food security, and rational resource management.
Researchers have identified a genetic mutation and faulty development process that causes a debilitating brain-based disorder in children. The mutation, in the alpha-N-catenin gene (CTNNA2), leads to abnormal cell adhesion and impaired neuronal migration, resulting in severe intellectual impairment and limited life expectancy.
A new review suggests that mitochondrial dysfunction may be the root cause of depression, providing a potential breakthrough for novel antidepressant medication. The researchers found that depression is associated with decreased energy production and increased metabolic demand in brain cells.
A study led by Adam Wende found an underlying mechanism that reprograms the hearts of patients with ischemic cardiomyopathy, altering cellular remodeling and metabolism. The researchers identified epigenetic changes that encode a 'metabolic plasticity' in failing hearts, which may repair the ischemic and failing heart.
Researchers found that marine mammals lost the functional Paraoxonase 1 (PON1) gene, which protects land-dwelling mammals from pesticides. This loss may have allowed marine mammals to adapt to a marine environment, but also makes them vulnerable to organophosphate poisoning.
A USC study found that when clinicians are given information about a patient's fatal overdose, they prescribe fewer powerful painkillers. Clinicians who received a letter from the county medical examiner were 9.7% less likely to prescribe opioids in the following three months.
Researchers discovered a security hole in popular encryption software that could have allowed hackers to steal encryption keys from smartphones by intercepting electromagnetic signals. A fix for the vulnerability was adopted in software versions made available in May.
Scientists discovered a link between polysialic acid and aggressive behavior in mice with psychiatric disorders. The absence of the enzyme ST8SIA2 reduced fear processing and anxiety, leading to abnormal aggression.
A team of scientists found that coral-algal partnerships are older and more diverse than previously thought, with a history dating back to the 'age of dinosaurs.' This relationship has enabled corals to adapt to environmental changes over millions of years.
Researchers have discovered a genetic marker, MUC16 mutation, associated with higher tumor mutation load and improved responsiveness to immunotherapy in gastric cancer. This finding could help identify eligible patients for immunotherapy treatment, which currently responds positively in only 20-30% of cases.
A new RNA sequencing platform has been developed to match thousands of drugs with late-stage and drug-resistant multiple myeloma patients, providing a more accurate treatment approach. The platform's results showed that a majority of patients benefited from personalized treatment plans based on their cancer's RNA profile.
A new study reveals that women Veterans with fibromyalgia have high rates of childhood abuse history, which is linked to military sexual trauma and post-traumatic stress disorder. Screening for childhood abuse may enhance treatment for these patients.
A proof-of-concept study found that antibiotic treatment prior to vaccination increased viral shedding in healthy adult men, while narrow-spectrum antibiotics showed a slight increase in early vaccine boosting. The results suggest a potential correlation between the microbiome and vaccine performance.
Researchers found that viruses like norovirus and rotavirus are transmitted through membrane-cloaked 'virus clusters' that increase disease severity. These clusters, previously unknown to cause human-to-human transmission, may lead to more effective treatments targeting these clusters.
A study by University of California, Berkeley economists found that air pollution emissions from US manufacturing fell by 60% between 1990 and 2008 due to stricter environmental regulations. The researchers analyzed data on over 1,400 products and found that changes in production technologies were the primary driver of these decreases.
A study found that inducing labor at 39 weeks in healthy women reduces the need for cesarean sections and is as safe as waiting for spontaneous labor. The procedure may also lower the risk of preeclampsia and respiratory issues in newborns.
Researchers discovered that cancer cells release exosomes carrying PD-L1 to suppress the immune system, enabling a new approach to predict treatment response and track therapy effectiveness through blood tests. This finding has significant implications for precision medicine and personalized cancer care.
Researchers have created a new drug that stimulates GPR88 receptor, reducing rats' tendency to drink alcohol. The molecule, RTI-13951-33, is potent and selective for the receptor, crossing the blood-brain barrier more effectively than its predecessor.
The Hemingway Letters Project has received a three-year NEH grant to publish nearly 6,000 surviving letters written by Ernest Hemingway, including previously unpublished work. The project will cover volumes five through seven, spanning 1932-1941.
Researchers from four international universities analyzed cichlid fish DNA to understand the formation of new species. They found that hybridization between species led to rapid evolution and adaptation, boosting innovation and species development.
A study by ETH Zurich researchers has discovered new cancer-specific molecular changes in RNA molecules, which could inform the development of cancer treatments. The analysis found that alternative splicing occurs more frequently in tumor tissues than healthy tissues, particularly in pulmonary adenocarcinomas.
A global study using camera trap data found that large-bodied mammalian carnivores exclude other carnivore species, shaping local communities. This leads to a chain reaction affecting prey species, plant communities, and even insect populations.
Most online daters aim for partners who are 25% more desirable, using strategic messaging to reach higher tiers. Despite low response rates, persistence can lead to replies from a mate beyond one's league.
A new analysis by University of California, Berkeley researchers concludes that injecting particles into the atmosphere to cool the planet would have no effect on reducing crop damage from rising temperatures. The study found that lower productivity due to reduced sunlight would negate any benefits of cooler temperatures.
Researchers at Lawrence Berkeley National Laboratory have discovered a way to transform a liquid-like state into a solid-like state and back again by introducing a chemical compound. The study has implications for developing all-liquid electronics and interacting with cells, and could lead to new ways of controlling nanoscale elements.
Researchers found that compounds in Sakurajima Daikon radish promote nitric oxide production, which can improve coronary blood vessel function. The study identifies trigonelline as the active component behind this effect.
The workshop discussed how AI can help victims of disasters, including using unmanned aerial vehicles to find survivors and robots to communicate with trapped victims. The goal is to leverage AI to better deliver resources and people to those in urgent need.
A new study analyzing online dating website interactions in four major US cities found that both men and women pursued partners about 25% more desirable than themselves. The authors discovered a consistent hierarchy of desirability based on age, education, gender, and race/ethnicity.
Researchers found distinct genetic mutations in appendix cancer that predict survival rates and may impact therapy choices. The study identified specific genes, such as TP53 and GNAS, as biomarkers for high-risk patients.
Hurricane Hector maintains its major hurricane status as it moves south of Hawaii, with cloud top temperatures indicating strong storms capable of creating heavy rain. The National Weather Service predicts tropical storm conditions and large surf along the Big Island and Maui, prompting monitoring from interests in Johnston Island.
Scientists at the Helmholtz-Zentrum Berlin have developed an ultra-stable turntable to capture fast 3D tomographic images at a rate of approximately 2000 projections per second. This breakthrough enables detailed analysis of material processing, such as pore formation in metallic foams.
A study using online citizen scientist observations and museum specimens predicts updated distribution ranges for the Northern black widow and Black purse-web spider. The models suggest that the purse-web spider's range may have shifted, while the black widow's range may have increased over time.
A new study by Harvard Medical School and Tufts University finds that immigrants use significantly less health care than US-born individuals, with lower rates of utilization and expenditures. Immigrants also pay more out-of-pocket health care payments, effectively subsidizing private insurance and some public programs like Medicare.