A new urine test using nanoparticles that detect early enzyme activity of immune cells attacking cancer has received a major funding boost from the National Institutes of Health. The test can identify immunotherapy effectiveness very early, helping doctors adjust treatment and combat resistance.
Researchers applied two competing stock market return models, Heston and multiplicative, to US historical data. The Heston model excels in predicting long-time accumulations of stock returns, while the multiplicative model is better suited for short-term predictions.
Researchers at the University of Minnesota have developed a 3D-printed transparent skull implant that allows for real-time brain activity monitoring. The device, called See-Shell, provides unprecedented control and precision in studying brain function, enabling new insights into human brain conditions.
A new study reveals dopamine generates sustained activity in ensemble of cells in the prefrontal cortex, lasting up to 20 minutes. This coordinated activity supports complex functions such as motivation and attention to complete a task.
Researchers at ICFO have developed an infrared detector using Bismuth Sulphide flakes with sulphur vacancies, creating extended in-gap states for sub-bandgap absorption. The resulting device has high gain, low noise, and sensitivity, enabling fast response times and broad spectral coverage.
A study analyzing air samples from the Amazon rainforest and polluted areas found that human activity increases the production of climate-changing particles by 60-200% compared to natural forest carbon. The researchers developed an advanced computer model to simulate chemical reactions, improving predictive abilities.
A Henry Ford Health System study suggests recognizing four fundamental quality factors in the safety of care category and assigning equal weights to eight measures would produce more accurate results. This alternative approach could make hospital star ratings more meaningful and unbiased.
Researchers tracked platinum and tin atom movement during iNPs synthesis, discovering intermediate phases with unique catalytic properties. This discovery enables control over material synthesis and potential applications in energy-efficient fuel conversion and biofuel production.
A study by Newcastle University reveals that the NHS dental budget is not being spent efficiently, with too much focus on orthodontics and specialist oral surgery. The team recommends investing in prevention measures and making services more accessible, such as opening new high street practices.
Astronomers have made the first direct image of a dusty, doughnut-shaped feature surrounding a supermassive black hole in Cygnus A, a galaxy 760 million light-years from Earth. The feature, known as a torus, helps explain why objects with similar properties appear differently when viewed from different angles.
Researchers argue that eliminating the entire tsetse fly family is not ethically justified due to its intrinsic value. Targeted elimination campaigns are proposed as a compromise to minimize harm while promoting human and animal well-being.
A new Tel Aviv University study demonstrates improved radar detection using low-bandwidth technology, with applications in the automotive industry and beyond. The research, published in Nature Communications, uses a partially coherent approach to achieve high-range resolution without broadband signals.
Researchers from University of Copenhagen and EMBL found consistent changes in gut bacteria across seven countries, providing a universal signature for colorectal cancer. These microbiome changes may play a role in developing the cancer and could be used as biomarkers for diagnosis and therapeutic targets.
A UTA researcher is studying the relationship between cardiovascular disease and depression, with potential breakthroughs in prevention and therapy. Adults with depression are at an accelerated risk of developing cardiovascular disease, which can happen at an earlier age than expected.
Researchers uncover six distinct genera and over 60 species of wood-boring clams, revealing their unique diet and importance in the ocean's carbon cycle. The discovery sheds new light on these tiny creatures' role in shaping the deep-sea ecosystem.
A recent UBC study found that a 'reduced workload' program is the best option for men recovering from a radical prostatectomy, reducing the risk of burnout and promoting full recovery. The researchers recommend that patients have an open conversation with their employer before surgery to come up with a plan for a gradual return to work.
Dr. Carl June receives the 2019 Harrington Prize for his contributions to CAR T therapy, a revolutionary cancer treatment. The prize honors his development of new strategies and culture systems that have enabled CAR T clinical trials.
A new University of Colorado Boulder study found that the 18 most highly-studied candidate genes for depression are no more associated with it than randomly chosen genes. The research suggests that depression is influenced by many variants, each having a miniscule effect, and challenges previous 'candidate gene hypotheses',
A Russian scientist has received funding to analyze the tumor microenvironment and develop new cancer therapies. The project aims to create targeted treatments with minimal side effects, building on gene and cell technologies.
A recent study found that caregivers of older patients with advanced cancer are a vulnerable group, experiencing poorer physical and mental health. Strategies such as talking to healthcare providers about stress related to caregiving can help improve caregiver well-being.
Scientists have identified genes involved in sugarcane root cell separation, a process that can be applied to other parts of the plant. The development of transgenic varieties with soft cell walls similar to papaya could increase sucrose extraction and reduce enzyme cocktails for ethanol production.
A study of messaging patterns on an online dating platform reveals geographic distance as the strongest driver of reciprocal interactions. Researchers found 19 distinct communities that closely mirrored geographic regions across the US, with age and race also influencing dating markets.
Researchers developed a system to automatically identify and classify violin bow gestures, providing real-time feedback for students. The system achieved 94% accuracy in identifying bowing techniques, enabling practical learning scenarios for music education.
A team of NJIT researchers has created a novel electrochemical biosensing device that can identify tiny signals of biomarkers emitted by diseases, such as cancer and malaria. The device uses gold nanoparticles to enhance signal response and separates plasma from blood to achieve high accuracy.
Researchers found that chronic morphine treatment decreased survival in control mice, but not in sickle mice with sickle cell disease. Chronic opioid therapy also caused hyperalgesia, a condition of increased pain sensitivity, in sickle mice. The study suggests that opioids may still be effective for managing pain in SCD patients despi...
New study reveals extreme scale of sea-ice melting in Arctic, with only 20% of young ice reaching Transpolar Drift. This reduction affects nutrient and sediment transport, potentially impacting ecological processes and biogeochemical cycles.
Researchers developed a new model predicting proton beam effects on tumour and normal tissue more precisely, allowing for effective treatment plans. The study replaced traditional radiobiological models with complex ones, showing improved results for low-energy beams.
A team of researchers developed a computer model called NarcoLogic to assess cocaine interception scenarios and predict how drug smugglers react. The model demonstrated that narcotics trafficking is widespread and difficult to eradicate due to law enforcement intervention.
Researchers discovered sea snakes can dive as deep as 250 meters in the mesopelagic zone, challenging previous assumptions about their habitat. The ability to cope with diving sickness allows them to access previously unexplored ecosystems.
Salk scientists discovered a new mechanism of action for the CDK12 protein, revealing its role in regulating gene expression and cell division. This finding suggests that targeting CDK12 could be an effective way to kill cancer cells and improve treatment outcomes.
Researchers developed a new machine learning model to describe the dynamics of cell development, estimating selection pressure and formation of new cells. The tool simplifies the interpretation of single-cell time series observations, shedding light on vital questions in biology.
A new study from the University of Virginia identifies a compound that can recruit oligodendrocytes, a type of glial cell, to repair damage in the peripheral nervous system. This finding has implications for treating debilitating neurological disorders such as muscular dystrophy and Charcot-Marie-Tooth disease.
A study found a high rate of metabolic syndrome among elderly individuals aged 60-100 years. Three simple measures - waist diameter, waist circumference, and neck circumference - were predictive of metabolic syndrome in both men and women.
Researchers tracked the spread of K. pneumoniae bacteria in a Beijing hospital and found they were highly transmissible and adaptable to antibiotics. The study highlights the importance of genomic data in understanding multi-drug resistant infections, which are predicted to rise to 10 million per year by 2050.
A study published in The Lancet Child & Adolescent Health found that children with obesity experience a range of health issues, including anxiety, dyslipidemia, and non-alcoholic fatty liver disease. The research suggests that using a clinical staging system is more useful than BMI alone to identify these health concerns.
A research team led by Prof. HUANG Xuhui discovered the mechanism of RNA polymerase II correcting errors in RNA synthesis, which relies on the RNA itself rather than amino acid residues. This finding offers insights into how transcription may go wrong in ageing and diseased cells, potentially leading to various human diseases.
A plant pathologist at UC Riverside has secured a $4 million grant from the USDA to develop a cure for citrus-destroying disease. The research focuses on a novel class of peptides that can directly kill the bacteria and protect healthy trees from infection, offering hope for California's multibillion-dollar citrus industry.
Researchers have discovered a causal link between the gut microbiome and anti-tumor immunity, identifying key bacterial strains that activate the immune system to slow melanoma growth. The study also reveals the role of unfolded protein response (UPR) in this process, providing potential markers for patient stratification.
An international team of researchers used the Subaru telescope to detect primordial black holes using gravitational lensing effects. The study found that these black holes can contribute no more than 0.1% to all dark matter mass, ruling out their theory as a primary composition.
The UC Davis program aims to close the gender gap in STEM learning by providing mentors and hands-on STEM education tools to 11-year-old girls. The one-year pilot program will recruit 15,000 girls and pair them with mentors for up to 20 hours of guidance.
Researchers aim to boost efficiency and avoid grid extension measures by increasing automation of grid operations. They are developing expert systems for real-time fault detection and co-simulation.
A subgroup of patients with advanced BRCA- or PALB2-mutated pancreatic cancer showed sustained clinical responses to rucaparib, a PARP inhibitor. The treatment provided complete or partial responses and reduced tumor size in some instances.
A team of researchers has developed MyRoot, an AI-powered software that uses machine learning to analyze root growth of Arabidopsis thaliana seedlings. The software has been shown to reduce the time required for manual measurements by approximately half and provide more precise root length measurements.
A recent study found that adults at high risk of HIV infection have significantly lower rates of HPV vaccination, with only 3.39% fully vaccinated among those with high-risk behaviors. The lowest vaccination rates were seen in non-Hispanic black respondents and LGBTQ+ individuals.
Researchers are developing a system to test multiple biomarkers at once and a smartphone-based analysis and reporting system for disease monitoring and home care. They aim to identify predictive biomarkers to empower patients to monitor their own disease and prevent serious complications.
A new study found that delayed-release, extended-release methylphenidate can be taken in the evening without affecting its efficacy for at least 10 hours. This formulation may provide a more flexible treatment option for adults with attention deficit hyperactivity disorder (ADHD).
A new analysis of 40 years of bird collision data reveals that nocturnal flight calls increase building collisions among migrating birds, especially in areas with artificial light. The study suggests that the faint chirps may lure other nearby birds to their death.
A study by Massachusetts General Hospital found that none of the US commercial laboratories offering noninvasive prenatal screening (NIPS) fully meet the American College of Medical Genetics and Genomics recommendations for genetic disorder detection and reporting. The report highlights inconsistencies and inadequacies in NIPS test res...
A Mayo Clinic study found that extended chemotherapy, a normal CA 19-9 tumor marker, and a dead tumor after surgery can significantly increase survival time for patients with advanced pancreatic cancer. The study achieved an average survival time of 58.8 months, or nearly five years.
A recent study has identified the Greek wild crocus species C. cartwrightianus as the sole progenitor of modern saffron, revealing its origins in Attica. This breakthrough could enable plant breeders to create new saffron genotypes with increased genetic diversity.
Professor Jonas Bergh is recognized for his work on breast cancer biology, including tailored treatments and the impact of chemotherapy. He has made significant contributions to primary breast cancer treatment through his involvement in clinical trials and research collaborations.
A new study by economists at UC Berkeley found that soda sales dropped an average of 10-20% in the three months after the election, even before prices went up. The results suggest that education and social norms played a significant role in changing drinking habits.
Researchers create 'megasupramolecules' that can significantly reduce misting of fuel during high-speed impacts, reducing the risk of fire or explosion. The additives also enhance lubrication and flow through pipelines and hoses, and reduce soot formation in diesel engines.
Researchers at Arizona State University have developed a method to assemble protein and DNA building blocks into three-dimensional cages. The technique allows for precise control over cage structure and size, opening up new possibilities for targeted delivery, structural biology, biomedicine, and catalytic materials.
Scientists have discovered that white blood cells enter the spleen primarily via vessels in the red pulp and migrate to other structures. The Clever-1 molecule controls this process, also regulating antibody-producing white blood cell expression.
A common genetic variant on the 5p15.33 locus is associated with a high risk of stroke in childhood cancer survivors who received cranial radiation therapy (CRT). The study found that survivors who carried this variant had nearly three times the risk of developing stroke compared to those without it.
Researchers at Cima, Clínica Universidad de Navarra have identified three biomarkers associated with atrial fibrillation risk, including CITP, MMP-1, and PICP. These biomarkers can help optimize treatment and follow-up for patients with this cardiac ailment.
Researchers found that transplanting human bone marrow-derived endothelial progenitor cells into mice with ALS-like symptoms improved motor function and slowed disease progression. The treatment repaired damage to the blood-spinal cord barrier, leading to increased motor neuron survival and reduced capillary leakage.
Research from Rice University links digital device overload to obesity risk, finding media multitasking associated with increased susceptibility to food temptations and lack of self-control. The study suggests a possible link between media multitasking, higher body mass index, and greater percentage of body fat.
German scientists discovered two new species of rare giant stick insects in Madagascar's dry forests, with males exhibiting dazzling blue or multicolored armor. Genetic tests confirm the existence of two new species, challenging previous theories on stick insect evolution and raising questions about their reproductive strategies.