Researchers have developed a gel that improves the formation of arteriovenous fistulas, a vital connection site for kidney failure patients undergoing dialysis. The gel helps reduce intimal hyperplasia and vein narrowing, leading to better blood flow and increased success rates.
The international consensus statement provides critical recommendations for the cardiovascular management and follow-up of patients undergoing radiation therapy. The paper highlights the need to identify and address cardiovascular risk factors to prevent cardiotoxicity, emphasizing the importance of regular screening and treatment for ...
Researchers from UNIGE found that a single missing genetic switch can lead to clubfoot and other malformations by disrupting cellular activation. The study highlights the crucial role of genetic switches in developmental disorders, suggesting that flaws in these mechanisms may be responsible for numerous malformations.
Researchers at HHU reconstructed LUCA's metabolism and found almost all chemical steps used by primordial life are energy-releasing reactions. The team identified the long-sought source of energy as hydrogen gas, which releases energy from within metabolism itself.
A study by Leibniz Institute for Zoo and Wildlife Research found that juvenile Nathusius' pipistrelle bats are killed more frequently than adults at wind turbines, with females also being disproportionately affected. This highlights the need to implement schemes to mitigate wind turbine mortality and protect migratory bat populations.
Researchers from Rice University and the University of Wyoming discovered self-organization into circular aggregates in Myxococcus xanthus, a model system for social cooperation. The circular behavior is linked to TraAB protein overexpression, which creates a sticky bond between cells, preventing reversals.
Researchers at Chalmers University of Technology have developed an algorithm that learns optimal energy usage for electric delivery-vehicles. By focusing on overall energy usage instead of just distance travelled, the vehicles can reduce their energy consumption by up to 20% and minimize battery usage.
Researchers used CT scanning to study the cranium of Cladarosymblema narrienense, a 330-million-year-old fish that may have evolved into first four-limbed vertebrates. The analysis suggests a significant brain role in regulating endocrine glands and supports the monophyletic group of megalichthyid fish.
Researchers identified a new crystal structure of hydrogen compounds that shows promise for high-temperature superconductivity. The discovery uses theoretical simulations to find potential candidates among ternary hydrides, which could lead to low-cost superconductive technology.
Researchers developed an RNA-based breath test called the Bubbler that can detect SARS-CoV-2 in exhaled breath, revealing a more direct indicator of current infection. The test also provides additional information on viral load and strain identity.
Researchers at the Monell Chemical Senses Center found that COVID-19 patients experience distinct smell distortions, with parosmia affecting younger females more often and phantosmia common in middle-aged individuals. The study suggests that understanding these differences may help physicians treat patients better.
Researchers at NTU Singapore have developed a new use for e-waste plastics by repurposing them as an alternative to laboratory cell culture containers. The team found that over 95% of human stem cells seeded on e-waste plastics remained healthy after a week, comparable to cells grown on conventional plates.
Researchers found that our concept of self becomes increasingly indistinct as we think about ourselves farther in the past or future, affecting decision-making and memory recall. The 'temporal self-compression' effect challenges traditional notions of identity and time perception.
Researchers at Tohoku University successfully fabricated n-type conductive SnS thin films without toxic elements, paving the way for higher-conversion-efficiency solar cells. The achievement could lead to more environmentally friendly solar cell panels with improved performance.
A recent UCLA-led study provided indirect evidence that PSMA PET/CT improves risk-stratification and prognostic capabilities for high-risk prostate cancer patients. The study found that PSMA nomogram outperformed existing tools in predicting clinical outcomes, suggesting its significance in disease course prediction.
A study by Arizona State University found that stress alone can lead to excessive drinking in women, while men only drink more when they've already consumed alcohol. The research highlights the importance of studying sex differences in alcohol consumption and challenges existing models developed primarily for men.
Patients with multiple myeloma receive limited COVID-19 vaccine effectiveness compared to cancer survivors not on treatment. The disease and its treatment can weaken immune systems, reducing vaccine efficacy.
Researchers have described a dynamic genomic landscape of tumour heterogeneity in hepatocellular carcinoma, highlighting the need for novel strategies targeting heterogeneous tumors. The study, published in National Science Review, used multi-omic data to reveal variations in genetic and transcriptomic profiles across patients.
Researchers at Tohoku University have successfully created capsule-like DNA structures using two different types of nanostructures that can stick together. These structures can form water-in-oil droplets with patch-like patterns depending on the concentration of each type, and can be used to carry substances to specific target organs o...
Researchers at Technion and Sheba Medical Center have developed a new technology for fabricating custom-made ear implants for microtia patients. The biodegradable auricle scaffold is 3D-printed using the patient's own cells, reducing the risk of complications and discomfort associated with traditional methods.
A combination of five existing drugs, including bortezomib and lenalidomide, kept patients with ultra-high risk multiple myeloma alive longer than those who received standard care. The trial found that patients receiving the new five-drug cocktail had stable disease at 18 months compared to those in a previous study.
Researchers have standardized black carbon measurements in the Arctic, improving our understanding of climate change. By correlating absorption coefficients with COSMOS measurements, they derived reliable conversion factors for various instruments, enabling more accurate climate modeling and air quality assessments.
A team of researchers proposes that endothermy in mammals and birds has a common ancestry and is much older than previously accepted. They found evidence of endothermy in early ancestors of modern birds and mammals, including Pelycosaurs and Pareiasaurs.
Researchers found that indigenous people in Gabon possess an astonishing 732 plant and fruit-eating animal interactions, exceeding academic literature. Local knowledge is invaluable for understanding ecological processes, particularly in remote areas.
Researchers at Lund University have successfully detected insect DNA in the air, offering a novel approach to monitoring terrestrial biodiversity. This method, known as airborne DNA metabarcoding, allows for the detection of multiple species from single samples and could accelerate biodiversity surveys.
Scientists from OIST and University of Cambridge discovered distinct types of defects in state-of-the-art perovskite thin films, which may hinder solar cell efficiency. The most detrimental defects were grain boundaries and polytypes, while lead iodide defects had a benign impact on performance.
A University of Otago study finds caries in wild primates occur at low frequencies but vary among groups, with distinct tooth patterns compared to fossil humans. The research provides a new perspective on human evolution and living primate behaviour.
A new cell line from human adult bone marrow can grow infinitely and differentiate into red blood cells, making it a potential source for generating endless amounts of RBCs. This breakthrough could simplify methods for establishing immortalized cell lines and select clones with maximum RBC production potential.
Researchers have discovered the Apterous protein's crucial role in retaining memories through its interaction with the Chi cofactor and regulation of neurotransmitters. In fruit flies, Ap plays a double role in long-term memory consolidation, highlighting potential new treatment approaches for memory-related disorders.
A new study found that Omicron's immune-evading capabilities are significant, but some vaccinated and previously infected individuals have 'stronger' protection. However, the protection from Omicron may be compromised over time.
A team developed statistical models to predict the risk of early death in patients with non-intensive AML therapy. The models incorporated various health measures and quality-of-life scores, showing modest success in predicting outcomes.
A new study published in the New England Journal of Medicine found that using CAR T therapy as a second-line treatment provided better outcomes compared to standard care in patients with diffuse large B-cell lymphoma. The two-year follow-up data showed a median event-free survival of 8.3 months in the CAR T arm versus 2 months in the s...
Scientists have discovered a way to extract monthly and weekly ocean temperature records from the shells of tiny surf clams, revealing clues to Earth's past climate. The study uses a species of short-lived clam that has not been used before, allowing researchers to reconstruct sea surface temperatures and past climates with precision.
Researchers at the University of Texas MD Anderson Cancer Center demonstrated axi-cel's efficacy in treating high-risk lymphoma patients with enhanced responses and prolonged survival benefits. The study showed improved outcomes for patients with indolent non-Hodgkin lymphoma, with an estimated 81% overall survival rate at 24 months.
Researchers found a novel therapy called AVID200 safe and well-tolerated, with modest improvements in symptom burden, anemia, and spleen enlargement. The therapy needs to be combined with other drugs to optimize impact in patients.
A new study found elevated rates of a myeloma precursor condition, MGUS, in older Black adults and those with a family history of blood cancer. Individuals at high risk were twice as likely to have MGUS, an asymptomatic condition that can progress to myeloma.
The coating protects bacteria during the freeze-drying and manufacturing process, allowing them to be used therapeutically. The researchers tested the coating on a strain of E. coli and another species that aids in digestion of plant starches.
A new study found that intranasal vaccination provides broad-based protection against respiratory viruses in mice, while systemic immunization did not. The nasal vaccine triggers a localized immune response through IgA antibodies, which can be used to add reinforcements at the source of infection.
Researchers identified epimutations in cheek cells that can predict rheumatoid arthritis susceptibility. The discovery could lead to a non-invasive diagnostic test for the disease. Biomarkers were found in both Caucasian and African-American women with rheumatoid arthritis, suggesting a strong signal for the disease.
Researchers at Indiana University have developed a silicon device that can change skin tissue into blood vessels and nerve cells. The technology, called tissue nanotransfection, is being explored for use in treating conditions such as stroke and diabetes-related nerve damage.
Researchers discovered that forest mammals eavesdrop on monkey meals to access fruit dropped by messy eaters. This eavesdropping strategy is crucial for these animals' survival, particularly during periods when almond trees produce abundant food.
Researchers discovered peptide bonds can form in liquid sulphur dioxide, a breakthrough for understanding the origin of life. The findings suggest a volcanic environment could have supported peptide formation on early Earth.
Researchers at Eindhoven University of Technology developed a robot that can learn to move through a labyrinth using a human-like brain. The robot, based on the Mindstorms EV3 kit, uses synapses to 'tune' its resistance and navigate the maze in 16 runs. Its ability to generalize its learning makes it suitable for various applications.
Researchers analyzed 140 neuroblastoma samples to understand the genetic changes associated with the disease. They found that mutations can disappear and reappear, occurring in distinct sections or individual cells, making targeted therapy less effective.
A recent study published in PNAS reveals that humans can instantly estimate slipperiness of a surface by detecting radial strain in the fingertip skin during initial contact. This innovation has significant implications for robotics and prosthetics design.
Researchers observed diverse aquatic biota in post-flood communities, with changes in flow dynamics and water chemistry supporting biological adaptation. The study highlights the role of floods in shaping floodplain ecosystems.
A study found that arterial stiffness increases with age, but hormonal fluctuations also play a role. Women's hormone levels, particularly estradiol and follicle-stimulating hormone, were associated with stiffer arteries, while older women had stiffer vessels regardless of hormone status.
A new AI algorithm, APOLLO, accurately predicts microprocessor power consumption by analyzing just 100 signals out of millions, offering potential to improve efficiency and develop new processors. The technique has been validated on high-performance microprocessors and could help designers inform future chip design.
Researchers at UCLA have identified rare T cells capable of targeting a protein found in SARS-CoV-2 and other coronaviruses. By adding a fragment of this protein to vaccines, they hope to create a longer-lasting immune response and increase protection against new variants. This breakthrough could lead to more effective COVID-19 vaccines.
A case study published in Nature Medicine reports a patient experiencing progressive neurological features resembling Parkinson's disease after CAR-T cell therapy, suggesting potential neurotoxicity. The study highlights the importance of monitoring for neurotoxicity in patients receiving BCMA-targeted CAR-T therapies.
The article highlights the importance of access and equity in sharing biodiversity data, with scientists warning that unequal distribution of genetic data and benefits is hindering innovation and conservation efforts. The CBD and Plant Treaty need reform to address this issue.
A team of researchers from NIMS and JEOL have developed a lanthanum hexaboride (LaB6) nanowire-based field emission gun for high-resolution transmission electron microscopy. The gun achieves an energy resolution of 0.2 eV, enabling atomic-level observation.
Three young stars have been discovered at the center of our galaxy, contradicting initial assumptions about a gas and dust cloud called G2. The unusual temperature of G2 has sparked debate among astronomers, but new observations reveal it is actually composed of three evolving young stars.
Researchers have discovered microRNAs that can detect ovulation and egg quality in fish, and also identify growth signatures. These findings could lead to the development of non-invasive biomarkers for monitoring animal physiological states, enabling cost-effective and accessible information on health.
Researchers used NMR analysis to determine lipid content in organic waste, achieving higher accuracy and speed than Soxhlet method. The new technique is faster, more accurate, and environmentally friendly, paving the way for improved anaerobic digestion processes.
Researchers at UT Southwestern Medical Center have discovered a potential cure for strongyloidiasis, a deadly tropical disease caused by Strongyloides stercoralis. Combining dafachronic acid and ivermectin increased survival rates to 85% in animal models, offering a new therapeutic target for parasitic nematode diseases.
A new study reveals that balancing iron and phosphorus levels is crucial to prevent chlorosis, a condition associated with yellowing leaves. The research team found that removing phosphorus can help restore photosynthesis, highlighting the need for more environmentally friendly agricultural practices.
Research finds lockdowns led to significant reductions in non-COVID mortality, with a decrease of 12.5% after loosening measures, resulting in the prevention of 293,000 deaths. Improved air quality and increased sanitizing surfaces also contributed to fewer deaths from infectious diseases.
Researchers created anti-COVID-19 stainless steel with alloying elements, inactivating viruses on its surface. The material can replace frequently touched public products to reduce COVID-19 transmission risk.
Researchers will test four interventions to determine which combinations are most effective at helping people who inject drugs and who are HIV positive to suppress their viral load. Strategies include patient navigators, psychological therapy, methadone treatment, and educational sessions.