Researchers identified specific metabolic vulnerabilities in leukemia cell lines, including sensitivity to PI3K and fatty acid synthase inhibitors. The study highlights the potential for targeted cancer therapy by exploiting these dependencies.
Researchers at UC3M have created an open laboratory for the population to participate in digitizing and analyzing archaeological heritage. Volunteers will receive training in archaeology, digital humanities, and software skills.
Physicists from the Technische Universität Dresden have confirmed an unusual movement of light-emitting particles in atomically-thin semiconductors. Excitons seem to move in opposite directions at the same time, a behavior previously known only for individual electrons.
A new NIH-funded study aims to test a program using a pharmacist-community health worker team to help patients with high blood pressure stay on track with their medication. The intervention addresses barriers to adherence, such as low health literacy and limited transportation access, through culturally relevant education and support.
Researchers at the University of Basel traced the neuronal fingerprint of sound processing in mouse brains, finding ten distinct activity patterns that depend on factors like attention, arousal, and reward. These findings suggest that even simple sound detection is a cognitive process that profoundly shapes brain activity.
Researchers have found evidence of joint ruptures, or shared earthquakes, between the San Andreas and san Jacinto faults in California. The Lytle Creek Ridge Fault, a small fault between the two major faults, acted as a passive marker during these events, with 20% to 23% of earthquakes on these faults being shared.
A group of Croatian students used photographs from iNaturalist to describe a new species of pygmy grasshopper, challenging traditional methods. The study highlights the potential of citizen science and encourages people to engage with nature to raise awareness about conservation.
A new poll of people over 50 finds most are finding joy and staying resilient amid the pandemic, but a sizable minority feel significant stress, particularly about COVID-19 risk. The poll highlights the importance of focusing on those in poor health and finding safe ways to enjoy favorite activities.
Researchers discover novel compound AD732 with anti-inflammatory and analgesic properties, outperforming standard NSAIDs while causing minimal harm. The compound may be a safer alternative for treating pain and inflammation in difficult diseases like ulcerative colitis and Crohn's disease.
A new study reveals that modern top-down climate-related factors combined with traditional bottom-up tectonic models can help uncover the history of the Andes Mountains. The research suggests that a submerged volcanic hotspot chain, known as the Juan Fernandez Ridge, plays a crucial role in shaping the Andes' unique tectonic setting.
A new study found that Galápagos Islands Darwin's finch females who spend longer inside the nest can ward off deadly larvae of the introduced avian vampire fly, improving offspring survival. The maternal buffer is a life-saver, especially during the first days after hatching.
A recent review article by Duke University Medical Center suggests that antibiotics can be an effective first-line therapy for uncomplicated appendicitis cases, treating up to 70% of cases. However, the definitive treatment option remains surgery, usually done laparoscopically, for severely inflamed appendices or high-risk patients.
This special issue explores how new technologies impact marketing, including improved firm-consumer interactions, new data forms, and enhanced decision-making capabilities. Researchers develop frameworks for understanding the role of new technologies in driving marketing innovations.
A citizen science project found urban growers in Brighton and Hove harvested 1kg of insect-pollinated fruit and vegetables per metre squared, comparable to conventional farming. Urban farming benefits biodiversity and human health while offering sustainable and productive alternatives.
A Clemson-led study aims to accelerate crop breeding by editing the cotton genome in microgravity. The research seeks to understand gene function and develop new methods for precision genetics, which could lead to improved crop yields and disease resistance.
Researchers from Pusan National University have developed an algorithm to restore missing data in event logs, improving restoration accuracy by 10-30% compared to existing algorithms. The high accuracy of the new algorithm ensures its widespread application in industries and potential improvements in AI technologies.
A new study by Nathan Grant Smith and colleagues found that straight men use anti-gay slurs not due to their sexual orientation but to protect traditional masculine norms. The study suggests that threatening straight men's status can trigger the use of such slurs, highlighting a significant problem in our culture.
A new study projects that farmed seafood supply will drop by 16% globally by 2090 if no action is taken to mitigate climate change. The industry is vulnerable to the effects of climate change, and some regions could see a decline in mariculture production by up to 90%.
A study published in Allergy reveals the importance of PU.1 transcription factor in regulating CCL17 gene expression, which contributes to allergic diseases. The research found that suppressing PU.1 can reduce inflammation in asthmatic mice, paving the way for novel treatments.
Seagrass wasting disease, caused by warming waters, compromises roots and storage sugars, setting up plants for a harder winter. The disease affects eelgrass meadows, vital nutrient stores, and supports herring, salmon, and other marine life.
The new technology measures ammonium levels in soil using machine learning and combines it with weather data to predict optimal fertilisation timing. This could lead to reduced overfertilisation, lower expenses for growers, and improved crop yields, particularly for nutrient-thirsty crops like wheat.
Researchers have found that individuals with extremely treatment-resistant schizophrenia carry a higher burden of rare, damaging genetic variants than those with typical schizophrenia. This study suggests that focusing on patients with severe forms of the illness could improve the detection of disease-associated genetic variants.
A team of researchers has uncovered a previously unrecognised process contributing to the disappearance of ancient megafauna communities across south-eastern Australia. Changing food supply driven by climatic changes or human land use in the Late Pleistocene era might have facilitated the extinction of the biggest herbivores.
Researchers have successfully cooled a pair of highly charged ions to an unprecedentedly low temperature of 200 µK using quantum algorithms. This achievement brings the team closer to building an optical atomic clock with highly charged ions, which could potentially be more accurate than existing clocks.
Researchers found that up to one in five patients experience increased troponin levels after major surgery, indicating potential heart damage. These patients were also more likely to be anaemic before the operation.
Surgeons at Henry Ford Health performed the world's first precision prostatectomy through the bladder using a single port robotic surgical system. The procedure preserves a portion of the prostate capsule, improving functional outcomes such as erectile function and urinary control.
Researchers found that adapted D-dimer thresholds are safe and efficient for ruling out acute pulmonary embolism, even in high-risk patient subgroups. Strategies with adapted thresholds have up to 3-fold increased efficiency, but also higher predicted failure rates.
Researchers found that flavanols activate brown adipose tissue, causing it to burn calories and produce heat. Long-term consumption of flavanols increased the levels of heat-related proteins in mice, suggesting a potential therapeutic effect against obesity-related diseases.
Researchers have developed Find Cut-and-Transfer (FiCAT) technology, a tool capable of accurately writing small and large genes. FiCAT allows precise insertion of large fragments into the genome, enabling development of therapeutic solutions for diseases like Duchenne muscular dystrophy and hereditary blindness.
Scientists have created a new material using nanometer-scale ceramic particles decorated with polymer strands that exhibit enhanced toughness. The material's unique property allows it to dissipate energy from impacts rapidly, making it suitable for applications such as body armor and bulletproof glass.
A new treatment combination of dasatinib, blinatumomab, and prednisone has shown promise in treating older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia. The trial achieved a three-year DFS rate of 80 percent and an overall survival rate of 85 percent for enrolled patients.
Researchers at UC Berkeley propose creating a market for small diameter trees and woody biomass to reduce wildfire risk while limiting carbon emissions. By investing in innovative wood products, the state can achieve both net carbon benefits and wildfire mitigation benefits.
Researchers developed an algorithm to differentiate life-threatening gunshot events from non-life-threatening plastic bag explosion events. The study found that 75% of plastic bag pop sounds were misclassified as gunshot sounds, highlighting the need for a diverse dataset of similar sounds.
Researchers at NYU Langone Health have successfully performed their second xenotransplantation procedure using a genetically engineered pig kidney. The procedure, part of an ongoing study, demonstrates continued promise for these genetically engineered organs as a renewable source of life-saving gifts.
A landmark study found that convalescent plasma was safe and effective in treating early COVID-19 patients, particularly those with weakened immune systems. The trial showed improved outcomes in patients given high-titer plasma during the first quarter of the pandemic.
A study by UC Riverside researchers shows that reactivating the Fmr1 gene in young transgenic mice with Fragile X syndrome eliminates symptoms. This breakthrough treatment offers hope for young children living with FXS and suggests targeting early brain development may be effective.
The Marathon experiment has provided new insights into the distribution of quarks, particularly the down quark, as a function of momentum. The study suggests that nuclei may be built using quasi-particles with changed internal quark structures, a paradigm shift in atomic physics.
Researchers discovered a compact object in supernova AT2018cow, which was a product of a dying star. The team found X-ray pulses indicating an object measuring no more than 1,000 kilometers wide and with a mass smaller than 800 suns.
A new study suggests that melting glaciers in the Pacific mountains could produce over 6,000 kilometers of new salmon habitat by 2100. Researchers modeled glacial retreat under different climate change scenarios and found that 315 glaciers could create habitats with conditions suitable for salmon.
Researchers create new route for producing PCTA monomer using plant-based acrylate and acetaldehyde, achieving overall yield of 61%. The method also produces UNOXOL diol in high yield, reducing carbon footprint.
University of Adelaide scientists developed a new simple and inexpensive method to detect low concentrations of agricultural lime in soils. The Mid Infrared spectroscopy technique allows for accurate detection of very small amounts of lime, enabling farmers to manage their soils more effectively.
A Penn State study found that live-streaming ads for alcohol, energy drinks, and junk food significantly increased during the pandemic, targeting young viewers. The researchers discovered that energy drinks made up nearly 80% of marketing, while ads for restaurants and soda were also prevalent.
Researchers at Vanderbilt University Medical Center have identified a nanoparticle called a supermere, which carries enzymes, proteins, and RNA associated with multiple diseases. The discovery provides new insights into the role of extracellular vesicles and nanoparticles in disease transmission.
Researchers analyzed Marvel movies to understand aging trajectories and outcomes among superheroes. They found that physical activity, social cohesion, and a positive mindset are essential for healthy aging, while negative behaviors such as loud noises and smoking increase the risk of dementia and disability.
A meta-analysis of 83 studies found that digital interventions improved depression symptoms over control conditions, but the effect was not as strong as face-to-face psychotherapy. Digital treatments with human components were most effective in reducing symptoms, particularly when accompanied by human guidance.
Researchers have demonstrated a novel topology arising from losses in hybrid light-matter particles, introducing a new avenue to induce topological effects. The study found that the mere presence of loss in an exciton-polariton system causes it to exhibit nontrivial topology.
Researchers found alarmingly high attendance rates at hospital emergency departments for children, teens, and adult victims of child abuse and neglect. Children exposed to child maltreatment have substantially increased risk of attending emergency departments during childhood and early adulthood.
Researchers have discovered that NOR-1 protein can provide broad protection against heart damage following cancer treatment. Administering the protein directly may reduce heart risk, at least in laboratory tests.
The Research Corporation for Science Advancement and USDA have awarded $1.25 million to early-career scientists to detect and mitigate emerging zoonotic diseases. Crystal Hepp and Jason Ladner of Northern Arizona University will receive funding for projects on serological approaches and genomic epidemiology.
A Geisinger study found that adults with rare genetic causes of mental health disorders are more likely to have chronic illnesses like diabetes and dementia. The research also discovered that these individuals had twice as many annual emergency room visits compared to a control group without the genetic conditions.
A new study by Dana-Farber Cancer Institute researchers found that a 2.5-year regimen involving ibrutinib and chemoimmunotherapy can provide deep and lasting remissions of chronic lymphocytic leukemia in young patients. The therapy was effective even for patients with higher-risk CLL, and showed minimal side effects.
A new study by researchers at the University of Arkansas found that personality traits, such as conscientiousness and extraversion, have varying effects on job performance across different occupational groups. The study's findings suggest that jobs with moderate complexity are ideal for relying on personality traits to predict performa...
Research at University of Basel discovered that certain areas in tissue allow bacteria to survive despite antibiotic therapy. Immune system plays a critical role in eradicating bacteria, and boosting defenses with immune therapy can lead to more effective clearance.
Vanderbilt researchers discover how a protein may treat schizophrenia, including reversing working memory deficits. Enhancing the activity of mGlu1 selectively increases the activity of specific inhibitory interneurons, restoring their ability to inhibit neuronal circuits.
Researchers at Georgia Institute of Technology have identified a key class of genetic changes associated with cancer, which may be missed by current gene expression analyses. These 'hub genes' play a central role in shaping the network structure of cancer cells and could serve as new targets for targeted gene therapy.
A study found that nearly a quarter of pregnant and postpartum women in the US reported unmet healthcare need due to cost. Women with private insurance and lower incomes were more likely to experience unaffordable healthcare, while those with public insurance and higher incomes had better access.
A study published in the European Respiratory Journal found that people with both insomnia and obstructive sleep apnoea are at a higher risk of heart problems and mortality. Participants with co-morbid insomnia and sleep apnoea were two times more likely to have high blood pressure and 70% more likely to have cardiovascular disease.
A study identified three major areas for organizations to reduce burnout and increase work engagement: balancing job demands and resources. Clinicians cited policies that hinder care delivery as a key factor, emphasizing the need for systemic change.
Black soldier fly larvae thrive in dense groups when given the right amount of airflow, reducing the risk of overheating. The research, published in Frontiers in Physics, aims to make these protein-rich insects more readily available as recyclers of food waste, which totals 1.3 billion tons per year.
Researchers developed an AI system to detect inflammation in ulcerative colitis patients using live colonoscopy videos. The system accurately predicted remission cases with high accuracy, reducing the need for invasive biopsies.