Researchers at Mass General Brigham found that targeted radiation was successful in treating patients with brain metastases, resulting in a lower neurological death rate and reduced need for subsequent whole brain radiation. This study supports personalized treatment approaches to maintain quality of life while managing brain metastases.
This study proposes a comprehensive framework for typhoon disaster knowledge services, utilizing large language models to construct structured knowledge graphs and develop intelligent question-answering systems. The proposed system achieves high accuracy in concept, entity, attribute, and relation extraction, providing seamless convers...
A longitudinal cohort study found that recreational cannabis legalization was associated with increased cannabis and electronic nicotine delivery systems use, but not a significant increase in cigarette use. The study suggests that commercialization policy should be closely monitored as retail cannabis expands.
A study by autistic researchers reveals the challenges of navigating nonverbal cues, including body language, facial expressions, and tone of voice. Autistic adults often struggle to process these signals in real-time, leading to misunderstandings and social anxiety.
Researchers developed a novel DPG suspension with enhanced thermal stability and plugging efficiency, outperforming traditional CO2-responsive gels. The modified particles demonstrated significant irreversible swelling and improved thermal stability, achieving high plugging efficiencies even at 100°C.
Researchers demonstrated R-STDP synaptic plasticity in a single ferroelectric floating-gate device, enabling SNN to simulate robotic capture tasks with excellent performance. The network achieved a success rate up to 85.5% in dynamic capturing tasks.
Researchers employed SU(3) flavor symmetry theory and final-state re-scattering to predict larger CP violation effects in charmed baryon decays. The study suggests a matter-antimatter asymmetry of one-thousandth, exceeding prior estimates.
Recent studies reveal disparities in access to hepatitis C treatment for children and recently pregnant women, with significant racial and geographic disparities. The studies highlight the need for targeted resources to reach these vulnerable populations.
A team of researchers are studying the reproductive traits of Japanese tree frogs living in Fukushima Prefecture, Japan, to understand how radiation affects their survival. Their findings suggest that radiation can disrupt genetic pathways associated with sperm motility, potentially altering reproductive success.
Chronic health issues may emerge from long-term obesity in young adults, leading to epigenetic alterations, telomere attrition, and impaired nutrient sensing. The study found a significant association between long-term obesity and accelerated biological aging, highlighting the importance of addressing obesity early on.
Dr. Erin M. Schuman's groundbreaking research reveals that proteins critical for neuron communication are produced locally at synapses, overturning previous beliefs about protein synthesis. Her discovery is influencing the field of neuroscience, focusing on individual synapses rather than whole neurons.
A novel dual-enzyme-driven cascade reaction system significantly enhances catalytic therapy in tumors. Researchers developed this approach to refine single-atom catalytic kinetics, leading to improved cancer treatment outcomes.
A Johns Hopkins study identifies over 200 types of misfolded proteins associated with age-related cognitive decline in rats. The findings suggest that these proteins may contribute to Alzheimer's and dementia beyond just the previously known A-beta and tau amyloids.
Researchers solved a long-standing climate mystery by combining geological evidence with climate model simulations. They found that speleothem δ18O records reflect precipitation signals from multiple seasons, not just summer monsoon season.
Researchers at Duke University Medical Center discovered stress-induced regenerative capabilities in human ankle cartilage, which shares similarities with salamander's ability to regenerate severed limbs. This finding provides a new potential framework for joint repair and may lead to optimizing innate restorative function.
The researchers developed a new imaging technology that enables the creation of high-resolution 3D images of an entire mouse body, including its peripheral nervous system. The technology allows for the mapping of nerve routes at the subcellular level, providing insights into neural regulation and disease mechanisms.
This review explores the roles of orphan nuclear receptors (ONRs) in metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis. ONRs modulate key pathways involved in lipid metabolism, inflammation, and fibrosis, offering novel therapeutic avenues.
A new Ontario study reveals socioeconomic disparities in concussion-related emergency department visits among children and youth. The study found that children from higher socioeconomic status groups had significantly more concussions requiring ED visits compared to those from lower socioeconomic status groups.
A potent and selective RIPK2 inhibitor has been identified through the CMD-OPT model as a potential therapeutic agent for acute liver injury. The compound, RP20, demonstrates excellent kinase specificity and superior therapeutic effects in an APAP-induced ALI model.
A new study published in PLOS One suggests that a parasitic worm can serve as a valuable biomarker for managing blue crab populations in the Chesapeake Bay. The worms, which infest and live on the egg clutches of female blue crabs, have been found to have a wide salinity tolerance and can survive at lower salinities than previously tho...
A new study reveals that global ocean analysis products can achieve centimeter-level accuracy in seafloor positioning, comparable to traditional methods. This innovation could significantly reduce costs and logistical challenges in marine geodetic surveys.
A cross-sectional study found that stronger gun laws were associated with lower overall firearm mortality, particularly for suicide. Policies addressing root causes of violence through economic mobility and social services may also reduce homicides.
Researchers have engineered a monoclonal antibody that blocks allergic reactions against common pollen when applied inside the nose of mice, providing new hope for hay fever sufferers. The treatment, known as a 'molecular shield,' acts immediately and locally at the lining of the nose to prevent IgE antibodies from being activated.
Researchers have developed laser-treated hydrogels with enhanced conductivity, improving interfacial adhesion and nerve-conduction block capabilities. The material exhibits a maximum conductivity of 955 S/cm, meeting essential requirements for next-generation bioelectronic platforms.
A Rutgers-led study reveals that the brain protein cypin helps maintain strong connections between brain cells essential for learning and memory. The discovery has profound implications for treating traumatic brain injuries and diseases like Parkinson's and Alzheimer's.
The EU-wide requirement emphasizes five key steps for successful nature restoration: clear communication, agreed targets, coordinated measures, supportive frameworks, and attractive incentives. Effective implementation is crucial to achieving long-term biodiversity goals and mitigating climate change.
A novel metal-assisted van der Waals epitaxy technique successfully fabricates wafer-scale monolayer MoS2 films and achieves precise substitutional doping with transition metals. The research team demonstrates exceptional electrical properties, including high electron mobility and ultra-low power consumption.
Researchers found that small group professional coaching reduced physician burnout rates by nearly 30%, with participants experiencing significant improvements in work-life balance, self-efficacy, and social support. In contrast, one-on-one coaching resulted in a 13.5% reduction in burnout rates.
Researchers found that adults with autism perceive visual body information similarly to neurotypical adults, challenging long-standing assumptions about social difficulties in ASD. The study used fMRI to compare brain activity patterns in adults with autism and typically developing adults while viewing images of body parts.
Researchers at Scripps Research Institute have developed a new microchip that can reveal how antibodies interact with viruses, allowing for faster and clearer insights into vaccine development. The technology offers a quicker-than-ever method to analyze antibody interactions, enabling scientists to design more effective vaccines.
Polyphenols are multifunctional agents with anti-inflammatory, antioxidant, microbiota-modulating, and neuroprotective properties. The Polyphenols Applications 2025 congress explores novel applications of polyphenols in various fields.
Researchers identify Egr-1 as a key regulator of Treg cell development and function, suggesting it as a promising therapeutic target for autoimmune diseases. The study's findings indicate that activating the Egr-1 gene can help alleviate autoimmune inflammation via Foxp3 expression.
Researchers at Seoul National University have developed a fully biodegradable, high-performance conductive fiber that can be seamlessly integrated into wearable electronics. The fiber system maintains performance during use but vanishes in enzyme-rich or soil environments, leaving no harmful residues behind.
Researchers developed a novel fluorescent probe to visualize AMPA receptors on living brain cells, revealing that new receptors are inserted from inside the cell during long-term potentiation. This breakthrough allows for rapid study of synapse strength and plasticity, shedding light on memory formation and learning.
A new tool helps understand original landscape functioning and supports current land use strategies by generating realistic drone footage of past landscapes. The study uses AI to create photorealistic depictions of the Great Hungarian Plain before water regulations.
Researchers developed a co-crosslinked hydrogel combining the rapid filling properties of hyaluronic acid (HA) with the collagen-stimulating abilities of silk fibroin. The HA-SF hydrogel promotes tissue adhesion, stimulates collagen regeneration, and achieves combined volume restoration and anti-aging via fibroblast activation.
Researchers developed a ternary composite electrolyte additive system PAFE to address lithium metal battery stability issues. The system enables stable cycling at 4.7V, reducing activation energy and suppressing dendrite growth.
Heterometallic nanosheets with defined structures can be synthesized in a single-phase reaction, enabling their use as coatings, electronic devices, and catalysts. The discovery paves the way for mass-producing these nanomaterials using printing technology.
Researchers from Université Laval designed an ultra-fast and greener optical chip that can transfer massive amounts of data at speeds of 1,000 gigabits per second while reducing energy consumption. This innovation uses the phase of light to add a new dimension to the signal, reaching unprecedented performance levels.
Researchers developed an AI system that enables a four-legged robot to adapt its gait to different terrain, just like animals. The robot learned to switch gaits on the fly and navigate uneven surfaces without any alterations to the system itself, overcoming previous limitations around adaptability.
A recent Northwestern University study analyzed brain tissue from 174 donated brains, including some from former amateur football players. The researchers found no elevated levels of phosphorylated tau (p-tau) protein in the CA2 region of the hippocampus, which is often associated with CTE and normal aging.
A new Europe-focused study finds that polyethylene (PE) packaging has lower life cycle global warming potential (GWP) than paper, metals, and glass in most applications. The research highlights the benefits of PE-based packaging in reducing greenhouse gas emissions and packaging weight.
The study highlights CCUS-EOR as a critical pathway for global carbon emission reduction, with cumulative CO2 sequestration of over 400 million tons. The proposed two-stage process optimizes dual objectives of enhanced oil production and carbon reduction.
The European Centre for Disease Prevention and Control warns of an increased risk of Vibrio infections throughout the summer season due to rising sea surface temperatures. Several northern countries bordering the Baltic Sea have reported increases in recent years, with serious infections possible through foodborne or skin contact.
Researchers unveiled a graphene-based chip that films reactions with nanosecond resolution, capturing elusive intermediates in the Morita-Baylis-Hillman reaction. The electric field applied accelerated the reaction, achieving a turnover frequency of 5,000 reactions per second.
Researchers discovered how the genome uses competition between proteins to prevent rogue retrotransposon LINE1 from causing damage. The team found that a modified protein NRBP2 marks and disposes of another protein NRBP1, which is no longer functional due to mutations.
Researchers at Hokkaido University developed a new recipe for muscle-like gel polymers, which exhibit rapid self-strengthening due to mechanophores with weak bonds. The innovative design enables the creation of thermostable materials with improved stability and potential applications in biological fields.
Researchers developed a non-invasive questionnaire to identify children at risk of maltreatment, highlighting seven behavioral problem areas linked to maltreatment. The study found critical timing patterns and type of abuse matters, offering a more comprehensive approach to support maltreated children.
The new agreement provides unlimited opportunities for open access publishing in JMIR's journals, eliminating article processing charges and streamlining the publication process. This partnership underscores TU/e's commitment to advancing open science and increasing research impact.
Researchers have found extensive, previously unmapped flat surfaces beneath a 3,500 km stretch of the East Antarctic coastline, which were formed by large rivers after East Antarctica and Australia broke apart. These surfaces may currently be regulating the rate of ice loss from the East Antarctic Ice Sheet.
A new study reveals how variations in the stratospheric polar vortex affect where and when extreme cold hits, with a focus on the northwestern US. The research finds two distinct patterns that steer Arctic air into different areas, leading to colder winters in regions like Montana and Texas.
Researchers design polymer blends to accelerate battery development and identify key temperature thresholds for stability. The study validates a model predicting behavior at different temperatures, enabling more efficient materials design.
Researchers found that cultural heritage forms the foundation of community identity, nurturing a sense of place and continuity. Trust, emotional attachment, and social ties are also crucial for building resilient communities that can unite in times of crisis.
Researchers have identified RG7388 as exhibiting promising antiviral activity against Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), a tick-borne pathogen with a high mortality rate. The study found that RG7388 can inhibit virus replication by enhancing cells' sensitivity to apoptotic stimulation signals.
A recent study by Tarang Parekh reveals that 80% of US adults show signs of CKM syndrome, which increases the risk for cardiovascular disease. The condition progresses in stages, with stage 4 being the most dire, characterized by clinical CVD diagnoses such as heart failure and kidney failure.
A new analytical method reveals overlooked species at risk of extinction, providing a valuable layer of insight for conservationists. The dual-role approach captures both predator and prey interactions, identifying keystone species and vulnerabilities.
A sweeping national study by ICAMH at Hebrew University found substantial increases in substance use, behavioral addictions, and mental health disorders in Israel since the October 7, 2023 attacks. Younger, secular populations were most at risk, with sociodemographic disparities evident across repeated samples.
UVA engineer Nick Vecchiarello is using a $600,000 grant to develop customized molecularly engineered surfaces for purifying protein-based drugs. The technology has the potential to reduce waste and failed batches, saving manufacturers millions of dollars while making treatments more affordable.
Researchers at KIT have developed a new AI method that generates high-resolution precipitation maps from low-resolution data, offering improved assessments of regional climate risks and disaster control. The model provides physically plausible precipitation maps with statistical uncertainty, applicable to diverse climatic conditions.
A new breast scan system combines photoacoustic and ultrasound imaging to produce clear 3D images of common breast cancer subtypes. The system, called OneTouch-PAT, takes less than a minute to complete and excels at detecting suspicious lesions in women with dense breast tissue.