A novel formulation and delivery approach for the NeoVax personalized cancer vaccine improved immune responses in patients with melanoma. The updated vaccine demonstrated strong vaccine-specific immune responses and cytotoxic responses by special T cells called CD-8+ T cells.
Japan is set to host a global summit on microbiome medicine and fermentation science, featuring pioneering research and collaboration among industry leaders. The event aims to promote personalized nutrition, microbial diagnostics, and next-generation therapeutics.
Researchers at Tohoku University developed a new framework for simulating nonlinear quantum dynamics, making it easier to understand and study complex quantum systems. The method uses time-evolution data to extract nonlinear response functions without requiring explicit multipoint correlations.
Scientists studying ant plants in Fiji have discovered a way for the plant to keep the peace among conflicting ants by providing separate chambers. The new research reveals that compartmentalization is an effective evolutionary strategy to mitigate conflicts, allowing the host plant to benefit from multiple symbiotic relationships.
Researchers have discovered an anomalous low-field quantum oscillation at ultraclean LaAlO₃/SrTiO₃ (LAO/STO) oxide interfaces, revealing evidence of time-reversal symmetry-protected transport. The findings provide a new platform for designing and engineering novel quantum states.
A University of Portsmouth student has discovered a new species of prehistoric mammal, Novaculadon mirabilis, dating back 145 million years. The fossilized jaw features distinctive teeth and provides insights into early mammals that lived alongside dinosaurs.
Researchers developed a wireless implantable drug delivery system that enables anticancer drugs to penetrate deep into solid tumors without harming surrounding healthy tissue. The Dual-Phoretic Wireless Drug Delivery System achieved over four times greater drug delivery efficiency than standard injection methods and reduced tumor volum...
The discovery sheds light on the complex connections between ancient Maya and central Mexican civilizations. Archaeologists found artifacts indicating early contact between the two regions around AD 350.
A research team led by Associate Professor Michinao Hashimoto from SUTD developed a novel 3D printing method that turns biodegradable materials into electrically conductive structures. The breakthrough enables the formation of sharp, well-defined 3D structures with high filler content, suitable for applications such as flexible circuit...
An international team has uncovered a new mechanism by which mitochondria and peroxisomes work together to defend against oxidative stress, maintaining cellular health. This discovery challenges the long-standing idea that cellular defense is confined within individual compartments.
Yen-Ling Kuo, a UVA computer scientist, has been awarded the NSF CAREER Award to help robots understand and respond to human behavior. Her research focuses on building AI systems that can reason, communicate, and collaborate like humans, enabling robots to support people in various settings.
A research team from the University of Münster has developed a new way to produce spin waveguides, allowing for large networks capable of processing information efficiently. The team created the largest spin waveguide network to date, with precise control over properties such as wavelength and reflection.
John Ohab joins ITV's Executive Board bringing scientific expertise and strategic insight from his roles at the National Human Genome Research Institute and U.S. Naval Research Laboratory. His appointment strengthens the region's innovation voice and amplifies connections to the national research ecosystem.
Higher anticholinergic exposure accelerates decline in gait speed and grip strength in older adults, affecting healthy aging. The study suggests minimizing anticholinergic medications is crucial for maintaining physical function.
Researchers from KIMS have developed a biosensor capable of detecting trace amounts of cancer cell DNA in the bloodstream with high sensitivity. The biosensor uses light signals and AI-based analysis to diagnose cancer early without complex testing procedures.
Researchers discovered that short-term physical activity decreases liver disease severity by breaking down branched-chain amino acids in skeletal muscle. This process enhances redox balance and inhibits lipid accumulation in hepatocytes.
Reuben Saunders has developed a method to track the precise effects of thousands of genetic changes across millions of individual cells, using CRISPRi technology and sequencing and imaging techniques. His work provides new insights into gene function in living tissues and could transform how scientists link genes to disease.
A UNIGE team has shown that memories are more strongly triggered by the deeper meaning of a situation than its surface-level cues. This finding highlights the importance of structuring knowledge transfer in schools, where students often struggle to connect different examples of an unfamiliar concept.
Researchers found that low levels of serine trigger a process that turns hair follicle stem cells into skin repair specialists, potentially accelerating wound healing. By manipulating serine levels through diet or medications, it may be possible to speed up the healing process.
A study assessing twelve DNA methylation signatures of aging found that GrimAge2 is robustly and independently associated with all-cause mortality, surpassing other DNAm signatures and chronological age. The findings suggest GrimAge2 as a promising tool for assessing mortality risk and evaluating healthy aging interventions.
In a small clinical study, users of this prosthesis navigated more easily and said the limb felt more like part of their body. The new system is directly integrated with the user’s muscle and bone tissue, enabling greater stability and control.
Researchers found that ring-tailed and sifaka lemurs show differences in life pacing and lifespan, making them useful comparisons to human evolution. The study suggests that lemurs avoid the phenomenon of inflammaging widely observed in humans, pointing to potential differences in aging mechanisms.
A recent study published in Nature reveals that over 16,000 chemicals are present in plastics, with at least 4,200 posing health and environmental hazards. The research outlines three key strategies for making plastics safer: removing hazardous chemicals, increasing transparency, and designing simpler chemically assessed plastics.
Scientists have developed a method to produce hundreds of different types of nerve cell types, varying in function and structure. This breakthrough enables more precise studies on diseases such as Alzheimer's, Parkinson's, and depression using cell culture experiments.
Researchers developed a novel framework combining worker self-reports and expert evaluations to predict worker performance. The proposed SOM-BN model demonstrated high accuracy and specificity, outperforming traditional methods.
A new study by Waseda University researchers suggests that learners need to automatize word meanings in context to achieve fluent speech. By assessing automatized vocabulary knowledge (AVK) and declarative vocabulary knowledge (DVK), the team found AVK to be a stronger predictor of L2 speaking fluency.
Researchers found that LLMs are better at representing non-sensorimotor concepts but struggle with sensory and motor concepts. Incorporating sensory input improves LLM performance and leads to more human-like representation, consistent with previous human studies on multimodal learning.
A study using AI language models analyzed sentiments and emotions expressed by almost 400 pediatric patients on social media, finding that 94% of comments were negative, with sadness and fear prevalent. The study highlights the need for integrated care approaches to support vulnerable young patients managing complex medical conditions.
Researchers have developed a new approach using nickel phthalocyanine-based covalent organic frameworks for electrochemical CO2 reduction. The study, led by Professor Zheng Meng, presents highly efficient CO2 conversion and innovative design mechanisms.
The NASA Roman Space Telescope team has completed installing solar panels on the observatory, a crucial step towards launch. The Solar Array Sun Shield will provide power and shade, keeping instruments cool for infrared observations.
Researchers have charted how plant metabolism responds to genetic changes that increase oil production, finding simultaneous increases in both oil and protein content. The study's findings will provide scientists with clues for optimizing biofuel production in plants such as camelina and pennycress.
A study by University of Miami professors establishes a strong correlation between distressed births and experiencing mental and physical problems later in life. The research found that individuals born with distress were more susceptible to chronic health conditions like diabetes, hypertension, and heart disease.
A head-to-head comparison of five scRNA-seq CNV inference methods identified CaSpER and CopyKAT as top performers, excelling in tumor subpopulation identification and rare cell detection. The study provides a roadmap for researchers to select accurate CNV tools tailored to specific platforms and research goals.
Research finds nearly a third of UK maternal deaths between 2014 and 2022 were linked to children's social care services. Women with such involvement were at higher risk of dying from psychiatric causes, murder, and mental health-related issues.
The ESA2025 Annual Meeting in Baltimore will feature four 20-minute talks on various ecological themes. The event provides media access to scientific sessions and a press room with refreshments and internet.
Researchers have developed a novel approach to create reversible and tunable color filtering across the visible spectrum, enabling applications in next-generation displays and optical devices. The technology leverages phase change properties of Sb2S3 to achieve distinct color changes by inducing phase transitions.
A pooled data analysis of 85 studies found that consistently physically active adults had a 30–40% lower risk of death from any cause. Increasing physical activity levels also resulted in a 20–25% lower risk of death, with switching to an active lifestyle at any point extending lifespan.
A recent study of 1,543 males aged 15 to 35 found that those who used prescription weight loss medications reported significantly higher levels of disordered eating behaviors and attitudes. The study suggests that boys and men may face unique pressures or vulnerabilities related to body image and weight control, highlighting the need f...
A recent study published by Fujita Health University found that poor oral health can increase the risk of lifestyle-related diseases such as diabetes and heart disease. The researchers examined 118 individuals aged 50 or above and found significant links between oral function test results and blood test results.
Researchers developed nanosheets of layered manganese dioxide for efficient heat storage below 100°C through dual-mode mechanism of intercalation and surface adsorption. The material can store heat even at temperatures as low as 60°C, enhancing energy density by approximately 30% compared to bulk MnO2.
Researchers identified TMEM9B-AS1, a long non-coding RNA that regulates cellular functions, as significantly reduced in skeletal muscles of people with type 2 diabetes. Its absence disrupts protein production, leading to muscle weakness and loss.
Recent advances in molecular clock models and paleontological discoveries suggest many bird lineages originated during Late Cretaceous period. This early diversification coincided with the Cretaceous Angiosperm Terrestrial Revolution, a pivotal phase of terrestrial ecosystem restructuring.
Researchers have developed a predictive model that uses electrochemical data from initial LMB cycles to forecast potential failures. The model identifies early indicators that correlate with different types of anode failure, providing key insights into the failure mechanisms.
A new study predicts up to 34,027 yearly UK heat-related deaths in the 2070s, a 50-fold increase from recent baseline rates. Climate change mitigation and adaptation strategies could significantly limit this rise, but even under best-case scenarios, heat-related mortality is projected to rise six-fold by 2070.
The BA.2.86 Omicron strain was found to have emerged with a high number of genetic mutations in its spike protein, but failed to become a dominant strain. Its sporadic global detection has raised questions about the possibility of laboratory involvement in its emergence.
A 70-billion-parameter large language model called ChemELLM has been developed for chemical engineering applications. It was trained on a specialized dataset and demonstrated superior performance in various tasks compared to mainstream models.
A study of 62,839 people diagnosed with non-metastatic prostate cancer in Sweden found that those treated according to NCCN Guidelines were likely to survive their cancer for their remaining life-expectancy. Those with low- and intermediate-risk cancer were six times more likely to die of other causes than prostate cancer.
Researchers develop flexible/stretchable displays using ECLDs, which offer lightweight and intelligent wearable devices. The study explores material selection principles, preparation processes, and applications for ECLDs, highlighting the potential for multi-color displays and wearables.
New research predicts a significant rise in heat-related deaths in England and Wales due to climate change, with projections of sixfold to fiftyfold increases by the 2050s and 2070s. The study suggests that careful planning and adaptation strategies can mitigate these impacts.
An international study has shown that BrECADD preserves fertility significantly better than eBEACOPP without worsening recovery chances. After treatment, 95% of women and 86% of men had normal hormone levels, enabling more pregnancies and births.
Researchers develop a groundbreaking, non-destructive method to monitor oyster health by analyzing heartbeat patterns using high-resolution image processing. The technique tracks vitality loss through cardiac activity and biochemical markers, providing a sensitive and real-time tool for seafood quality assurance.
Public universities in Spain dominate scientific research, producing over 95% of total publications and receiving the majority of competitive funding. They also attract top talent and drive innovation, with nearly all prestigious postdoctoral fellowships going to public university researchers.
A study reveals that ganoderic acids predominantly accumulate in the shell of Ganoderma lingzhi, suggesting an environmental stress response role. The research also identifies a novel cytochrome P450 enzyme involved in GA biosynthesis.
A 26-year study found that removing feral animals like cats and foxes from a reserve sparked an ecological transformation, favoring the growth of smaller rodents like Bolam's mouse and spinifex hopping mouse. Larger species like plains mouse and stripe-faced dunnart also surged in population after five to nine years.
A Danish study finds that HPV vaccination has reduced prevalence of high-risk HPV types among vaccinated women, suggesting population immunity. However, non-vaccine types remain common and new infections occur more frequently in vaccinated women than unvaccinated women.
Researchers have developed a new way to precisely tune magnetism using ultra-thin CrPS₄ material. This breakthrough could solve long-standing scientific problems and pave the way for smarter magnetic technologies.
Researchers developed misaligned bilayer metagratings to overcome intrinsic dispersion locking, enabling precise angular and wavelength control. This breakthrough offers new opportunities for compact optical imaging and computing technologies.
Research shows how tropical plants like Squamellaria manage rival ant colonies by physically separating them within the plant's domatia. The compartments act as individual flats, preventing physical contact and allowing multiple ant species to coexist peacefully.
Research from the University of Sydney reveals that children aged 10-16 years sweat at the same rate as adults in extreme heat, contradicting previous advice on dehydration and hyperthermia risk. The study's findings emphasize the importance of proper hydration for children during physical activity.
New research predicts the existence of 80-100 additional satellite galaxies surrounding the Milky Way, orbiting at close distances. These 'orphan' galaxies are lost in most simulations but should have survived in the real Universe.