A new review leverages cutting-edge spatial transcriptomics and single-cell omics to identify robust predictive biomarkers for tumor immunotherapy. Representative case studies highlight the potential of spatially resolved markers to guide immunotherapy decisions and predict irAE risk.
Researchers analyzed over 1,400 gut microbiome samples from 292 mammalian species to find distinct gut microbiomes corresponding to different gut morphology types. These microbiomes were grouped into three enterotypes: Fusobacterium in simple-gut species, UCG-005 in foregut fermenters, and Prevotella in hindgut fermenters.
The University of South Florida's Trafficking in Persons Lab estimates that more than 700,000 Floridians were trafficked last year. The lab's annual report highlights coordinated prevention, prosecution, and policy measures to combat human trafficking, with prosecutions rising and penalties exceeding the national average.
Researchers uncover significant tectonic transition from subduction-related magmatism to extensional back-arc basin magmatism in Wutai Complex. The study suggests plate tectonics began operating by the latest Neoarchean, challenging traditional views of stagnant-lid tectonics.
A study by Indiana University researchers suggests that intentional abusive behavior can provide short-term benefits to supervisors, but harms subordinates. This challenges the idea that abusive supervision is always impulsive or emotionally driven.
A new study found that chemical reactions in newly uncovered glacial sediments initially suppress greenhouse gas emissions, but as soil matures, it produces more methane, contributing to warming. The research provides insights into the role of soil and water in the climate change cycle.
A study published in Science Bulletin discovered that histone demethylase LSD1 maintains dormant primordial follicles, which are essential for long-term ovarian function. Loss of LSD1 triggers ovarian reserve depletion and premature failure.
Researchers discovered that rivers develop multiple channels if erosion outpaces deposition on their banks, leading to a widening and division of the channel over time. This understanding could revolutionize flood planning and restoration efforts for over 3 billion people worldwide.
A new study from the University of Illinois examines how green spaces and outdoor structures influence executive functioning in early childhood. Having trees or a sandbox before age 2 is associated with better cold EF, while having an outdoor sitting area or living on a farm improves hot EF.
A new study by the University of Arizona Health Sciences found a potential link between growth problems among infants and high levels of toxic metals and other elements in the breast milk of Mayan women in Guatemala's Lake Atitlán watershed region. High concentrations of arsenic, barium, beryllium, and lead were associated with impaire...
Researchers develop fiber-based O-TWTFT system, offering unparalleled stability across vast distances. Fiber optics enables applications such as redefining the second and precise geodesy.
The wristband sensor continuously monitors glucose, lactate, and alcohol levels in real-time, while also tracking blood pressure, heart rate, and arterial stiffness. This wearable device provides a comprehensive physiological snapshot, enabling early action to reduce diabetes risk.
Researchers developed a new diagnostic method using Doppler ultrasound waveform to estimate toe brachial index (TBI), providing faster and more accurate results for early detection of peripheral artery disease (PAD). The study found eTBI to be consistent with standard TBI, detecting effectiveness of treatments in improving blood flow.
Researchers have discovered that ascidians measure time to adulthood by accumulating cyclic adenosine monophosphate (cAMP), ensuring a reliable timing of metamorphosis. The study's findings provide insights into time-measurement mechanisms in other organisms and may aid in aquaculture and marine biofouling control.
A Phase II study found that 87% of patients with stage III melanoma remained alive and disease-free four years after treatment with nivolumab and relatlimab. Researchers identified unique biomarkers associated with better outcomes, including high TIGIT levels and low B7-H3 levels.
Researchers found that azuki bean beetles infected with Wolbachia bacteria produce larger eggs yielding exclusively male offspring when exposed to elevated temperature and carbon dioxide. This adaptive reproduction strategy enhances the survivability of their offspring.
A third of women who died during or in the year after pregnancy were known to Children's Social Care, with most deaths due to suicide, psychiatric causes, and homicide. The study highlights the need for coordinated care and support for mothers with social care involvement.
Women and ethnic minority groups continue to be underrepresented in astronomy and geophysics, with 97% of permanent staff being white. Despite efforts to increase representation, the fields still struggle with low numbers of female professors and senior lecturers, but show some improvement among postdoctoral researchers.
Researchers developed a microglia replacement strategy using bone marrow transplantation, effectively improving ALSP symptoms in mouse models. In an eight-patient clinical cohort, tBMT successfully corrected CSF1R mutations and halted disease progression over two years.
A research team developed a novel artificial membrane with ultra-high ion selectivity between monovalent and bivalent metal ions. The membrane combines graphene oxide and polyacrylic acid to create nanoscale channels with 'smart gates', enabling adaptive ion permeation.
Researchers studied underwater shaped charge explosions, revealing key findings on metal jet velocities, wave propagation, and bubble behavior. The study provided insights into shaping charge applications and impacts in underwater environments.
A new AI tool called Ark+ has demonstrated exceptional capability in diagnosis of lung diseases and rare conditions like COVID-19. The tool outperformed proprietary software developed by Google and Microsoft, making it a potential game-changer for healthcare.
A team of physicists has developed a tiny device that can detect and control antiferromagnetic resonance, enabling ultrafast and energy-efficient electronics. The breakthrough allows for a compact, electrically tunable platform to manipulate electron spins.
Scientists discover natural compounds from turmeric and rhubarb can combat antibiotic-resistant bacteria in wastewater, which could pose risks to public health if not treated. The study found emodin and curcumin to be effective at inhibiting bacterial growth and biofilm formation.
A recent study from the University of Colorado Anschutz Medical Campus has challenged decades-old neuroscience dogma by revealing that dopamine acts with extraordinary precision in the brain. This discovery offers fresh hope for millions living with dopamine-related disorders, highlighting the importance of targeted treatments.
Research suggests that nine commonly used pesticides in viticulture have significantly underestimated environmental impact, with half-lives exceeding two days and potential for long-range transport.
The proposed helical microswimmer system achieves real-time obstacle evasion using radar-based navigation fused with a neural-fuzzy motion controller. The integrated control scheme minimizes computational load while ensuring collision-free navigation, enabling a 2.6 Hz update frequency for motion direction.
A new Princeton analysis suggests that enhanced geothermal systems (EGS) could become the third most significant clean energy technology in the US by 2050. EGS has the potential to deploy up to 250 gigawatts of electricity, which is comparable to the current grid capacity of 1,200 gigawatts.
A new study finds that US universities rely heavily on international students to offset the country's trade deficit, but new tariff and visa policies may reverse this trend. The researchers estimate that a 25% drop in Chinese students from 2017-18 to 2018-19 resulted in $1.1 billion in revenue loss for US universities.
Research found that premature babies who had early skin-to-skin contact with their mother were more likely to be breastfed at discharge and for up to one year. Early contact also promotes bonding, reduces stress, and supports long-term development.
BioEmu, a generative AI model, rapidly and accurately predicts protein structural ensembles, enabling high-speed molecular simulation. The model samples thousands of realistic conformations in one GPU-hour, making it orders of magnitude faster than traditional approaches.
A new treatment method using microglia replacement has shown promising results in halting the progression of genetic neurological disease ALSP in both mice and human individuals. The treatment, developed at Fudan University, successfully replaced mutated microglia with healthy ones, improving neurological function and extending life ex...
The robot features a soft electrohydraulic actuator that allows it to adapt to different environments, including land crawling, underwater crawling, and swimming. It achieves high speeds of up to 5.9 cm/s in water and demonstrates excellent temperature adaptability.
A new genomic study reveals that population structure in the Himalayas began over 10,000 years ago, shaping human survival in one of Earth's most challenging environments. The research identifies novel genetic variants linked to adaptation in hypoxia, metabolism, immunity, and physical activity.
A new study in Annals of the Entomological Society of America reveals the reproductive biology of Ormia ochracea, a parasitic fly that gives live birth and nourishes its developing embryos internally. The research also sheds light on partial parthenogenesis and technical challenges for genetic manipulation.
A new tissue-integrated prosthetic knee restores natural leg function in above-knee amputees, enabling fluid and adaptive movement. The osseointegrated mechanoneural prosthesis (OMP) system combines direct neuromuscular control, bone-anchored implant, and agonist-antagonist myoneural interfaces to replicate natural muscle interactions.
A new Leicester study found that women with type 2 diabetes are nearly twice as likely as men to have hidden heart damage, according to researchers. The study used advanced MRI scans and data from four studies conducted at the NIHR Leicester Biomedical Research Centre.
A new study from Edith Cowan University found that learning music plays a critical role in enhancing the wellbeing of children and adolescents. The review identified significant social, emotional, and educational benefits, including improved self-confidence, social connections, and engagement in education.
Researchers discovered that ApoE3 Christchurch interacts with tau and supports Wnt signaling, two key mechanisms that help prevent Alzheimer's-related damage. This finding opens the door to new treatment strategies, including therapies inspired by the variant's protective effects.
Researchers have developed a novel fluorinated polyimide with improved mechanical properties and reduced dielectric constant, making it suitable for advanced microelectronic packaging. The material achieves low dielectric properties, excellent mechanical toughness, and synergistic optimization of comprehensive properties.
A study in the Malheur National Forest shows a rapid tree die-off in Eastern Oregon, with a quarter of trees over 300 years old dying within 10 years. The decline is attributed to a triple whammy of drought, bug infestations, and competition with younger trees.
A new report by Digital Science reveals China is outstripping the rest of the world in AI research, with a nationwide innovation ecosystem and a young, growing workforce. The UK remains small but globally impactful, while the EU risks falling behind due to weaker international collaboration.
Researchers found that spermidine supplementation improves memory and preserves physical activity, while reducing protein intake boosts mitochondrial activity and extends lifespan. Combining the two interventions offers additive benefits, suggesting potential for synergistic effects.
Ancient sled dogs in Greenland have a rich history of Inuit migration and Arctic adaptation, as revealed by genomic insights. The study found that the Qimmit breed form a distinct clade with other ancient Arctic dogs, supporting a rapid Inuit migration theory.
Researchers at Rice University developed a new glass coating that forms a thin, tough layer that reflects heat and resists scratches and moisture. The coating improves energy savings by 2.9% compared to existing alternatives, making it a promising solution for cities with cold winters.
The study reveals three new subsets of follicular T cells that increase in follicular lymphoma, each with distinct gene expression and spatial distribution patterns. These T-cell subsets serve as a strong predictor of patient prognosis, enhancing treatment approaches for the disease.
A new study by King's College London and University of Sussex found that content moderators engage in five main practices to manage distressing material, including emotion management and empathy. The research calls for regulators and platform providers to reduce the toll of this highly skilled emotional work.
A recent study analyzed 95 commercial probiotic products from China, revealing low labeling accuracy and high prevalence of antibiotic resistance genes in Enterococcus strains. The findings suggest that low-quality probiotics can disrupt intestinal homeostasis and serve as a reservoir for ARGs. Researchers emphasize the need for carefu...
The study reveals substantial variations in obesity rates across disaggregated Asian American, Native Hawaiian, and Pacific Islander subgroups. Rapid temporal increases in high BMI were seen among Filipino and other Southeast Asian populations, with nearly half of females and two-thirds of males having a BMI greater than or equal to 27.5.
Researchers found that hypothermia in mice elevated fasting glucose and insulin levels, mimicking insulin resistance. Reversing the hypothermia restored normal glucose metabolism through warming the animals.
Researchers found Galectin-1, a sugar-binding protein, plays a critical role in helping hepatocellular carcinoma cells resist thermal ablation and thrive after being treated with high heat. Blocking Gal-1 can make thermal ablation more effective and reduce the risk of recurrence.
A large international study found that additional ultrasound measurements to assess placental function can help determine the best course of action for pregnant women experiencing reduced fetal movement. The study showed that this approach leads to fewer complications during delivery and improves fetal outcomes.
Researchers at Memorial Sloan Kettering Cancer Center have gained new insights into how cancer spreads, revealing that metastatic cells can endlessly divide and produce diverse cell types. This flexibility allows them to adapt to various environments and develop resistance to treatments.
The study found that global surface SOC content is increasing, driven by temperature and precipitation, with vegetation cover playing a crucial local role. Natural carbon sinks alone are insufficient to meet the Paris Agreement's targets, emphasizing the need for human-induced strategies to achieve global carbon neutrality.
Researchers have discovered a simple way to protect atoms from losing information by shining a single laser beam on them, reducing spin relaxation rates. The technique uses light to subtly shift atomic energy levels, aligning spins and keeping them in sync even as they collide with each other or surroundings.
Researchers explore the biological mechanisms of myopenia in RA, finding it affects individuals of all ages, with notable muscle mass loss without concurrent fat loss. The review highlights the diagnostic and therapeutic relevance of myopenia in RA, emphasizing the importance of early detection and tailored management strategies.
Researchers are investigating whether boobies create a protective 'bubbly barrier' to reduce the impact of their high-speed dives. Preliminary findings suggest that supercavitation may indeed help mitigate the forces of impact, and further experiments are planned to confirm this effect.
Researchers at Caltech have created a new method to sum up large numbers of Feynman diagrams, enabling the prediction of electron-phonon interactions in materials. This breakthrough has solved the polaron problem, allowing scientists to predict how electrons flow in certain materials, both conventional and quantum.
Researchers evaluated the safety profiles of ethylhexyl triazone (EHT) and diethylhexyl butamido triazone (HEB) using integrated genotoxicity and phototoxicity assessments. The studies found no significant increases in mutagenic or chromosomal damage, and only minor micronucleus increases at high concentrations.
Research review finds handgrip strength is a reliable predictor of cirrhosis complications and outcomes, including malnutrition, muscle loss, cognitive impairment, hepatic encephalopathy, and mortality. Regular HGS assessments can inform timely personalized interventions to enhance patient quality of life.