The Buck Institute is pioneering a cloud-based platform to simulate the dynamic behavior of microbial cells, overcoming current whole-cell models' limitations. The SIMBA project aims to advance our understanding of bacterial behavior and address critical challenges in biomanufacturing and national security.
Researchers developed novel PbWO4 filler-reinforced B4C/HDPE composites with tunable microstructures, achieving enhanced synergistic radiation shielding performance. The optimized composite achieved a 97.32% shielding rate against ²⁵²Cf neutrons and 76.43% against ¹³⁷Cs gamma photons.
Australian scientists used AI to generate a protein that can kill antibiotic-resistant bacteria like E. coli, a major step forward in combating superbugs. The new approach enables efficient de novo design of proteins with specific characteristics and functions.
A new study found commercially available body-cooling garments provide significant protection against extreme heat for laborers. Participants wearing cooling garments had lower internal temperatures and improved performance in tasks compared to those without, making these garments a valuable resource in hot environments.
A new study found that older people with diabetes who do not control their blood sugar levels are three times more likely to develop eye disease than those with controlled blood sugar levels. High glucose levels were also linked to an increased risk of glaucoma and macular degeneration.
A recent study has shown that large language models (LLMs) can accurately predict liver cancer treatment responses, offering a new path towards AI-powered precision medicine. The LLMs demonstrated predictive accuracy on par with senior doctors, while outperforming junior and mid-level clinicians in speed and accuracy.
Researchers at Rice University found that electrode materials' thermodynamic properties impact energy flow and performance differently. They showed that even with similar structures, some materials degrade faster under identical cycling conditions due to uneven lithium flow.
Despite falling birth rates and hospital delivery volumes, neonatal mortality has decreased significantly in Finland, particularly among preterm infants, according to recent studies. The findings support centralizing high-risk deliveries to university hospitals, while small delivery units continue to have low overall mortality rates.
A Northwestern University study finds disparities in peanut allergy prevention guidance, with low-income and minority parents less likely to receive accurate advice. Early peanut introduction cuts allergy risk by over 80%, but guidance is often inadequate for these families.
Testosterone therapy has been shown to safely restore physiological hormone levels in neutered dogs, offering a promising avenue to counteract the adverse health effects of neutering. The study provides crucial data for veterinarians to treat spay-neuter syndrome and improve long-term canine health.
A large study of Danish children found that COVID-19 mitigation policies affected BMI across all weight categories, not just those with obesity. The findings suggest that age and BMI class differences were present, warranting policies targeting all BMI groups in children.
Researchers discovered over 15,000 kilometers of ancient riverbeds on Mars, suggesting that the planet may have experienced warm and wet conditions for a geologically relevant period. The presence of fluvial sinuous ridges indicates that flowing water was once widespread in Noachis Terra.
Life expectancy in California remained lower in 2024 than in 2019, with COVID-19 accounting for a deficit of 12.8%. The gap between racial groups narrowed, but life expectancy in the Black population was still significantly lower than others.
Researchers have engineered high-affinity antibodies against malaria by incorporating domains from inhibitory receptors, allowing them to block the interaction between parasite proteins and host immune cells. This new strategy offers a promising approach for treating malaria and could lead to innovative antimalarial drug discovery.
M-MATISSE aims to unravel Mars' magnetosphere, ionosphere, and thermosphere using two identical spacecraft. The mission could provide crucial insights into the planet's habitability and evolution.
A compact all-solid-state CW SLM laser with high frequency stability was developed using iodine-based frequency locking, advancing its application in atmospheric remote sensing and environmental monitoring. The laser achieves long-term frequency stability with a drift of 4 MHz over a continuous 7-hour period.
The American Society for Nutrition (ASN) has announced that NUTRITION 2026 will be held in National Harbor, Maryland, near Washington, DC. The meeting will showcase the latest developments in nutrition science and feature top experts in the field. Abstract submissions open this fall, and award nominations will also be accepted.
The collaboration aims to develop a predictive, high-fidelity AI model that identifies disease mechanisms and predicts patient outcomes. This initiative will focus on cancer but may expand to other complex medical challenges, such as transplant rejection and immunology.
Located in the western Mediterranean Sea, the Caprera Canyon is home to a high concentration of cetacean species. The canyon's unique geography supports a diverse array of marine life, including whales and dolphins.
Researchers used a laser measurement system to capture airflow near ocean surface, identifying two coupling mechanisms that occur simultaneously. This breakthrough sheds light on air-sea exchange processes and could advance atmospheric and oceanic models.
Researchers developed a single-layer metasystem for 3D inspection of fine structural features, integrating transmission and reception functionalities into a compact architecture. The system achieves high accuracy, with lateral resolution errors under 10 µm and depth variations as fine as 20 µm.
Researchers developed an AI model that screens for cardiac amyloidosis with high accuracy, outperforming existing methods. The tool analyzes routine heart ultrasound images to quickly detect the condition and differentiate it from other heart issues.
Researchers investigate cannabis-based treatment to improve quality of care for hospice-eligible patients with dementia. A clinical trial will test T2:C100, a drug containing THC and CBD, to determine its effectiveness in reducing agitation.
Researchers used Playmobil kits to facilitate discussions about women's experiences of menopause at work. Participants shared their symptoms and ideas for making work easier during menopausal times, highlighting the importance of social support and flexi time. The workshop provided a safe space for powerful and meaningful conversations.
Mary Beckerle is stepping down as Huntsman Cancer Institute's CEO after 20 years of service. Brad Cairns will take over leadership, continuing the institute's mission to eradicate cancer.
A UK-backed mission, VERVE, is set to search and map gases rich in hydrogen that shouldn't be present on Venus. The probe will investigate potential biomarkers phosphine and ammonia, which could indicate the presence of microbial lifeforms.
Researchers found that disabling mERα signaling in osteoblast lineage cells reduced cortical bone mass and density, leading to weaker bones. This pathway is essential for maintaining bone strength and density, especially in females.
Liquid biopsy-based multi-cancer early detection (MCED) offers broad population and cancer-type coverage, minimal invasiveness, and high patient compliance. However, significant challenges persist, including balancing surrogate endpoints with public health benefits, detecting early-stage cancers, and minimizing false positives.
A recent study reveals that lactate-induced mitochondrial calcium uptake 3 aggravates myocardial ischemia–reperfusion injury by promoting neutrophil extracellular trap (NET) formation. The study found that MICU3-mediated mitochondrial calcium uptake leads to mitophagy and NET activation.
Researchers at Cold Spring Harbor Laboratory have discovered that cryptic mutations in tomato genes can increase or decrease the number of reproductive branches on plants. This finding has implications for agriculture and medicine, potentially leading to better crops and more effective medicines.
Clinical trials show that sutezolid and delpazolid are safer alternatives to linezolid, with strong antimicrobial activity and fewer side effects. These novel antibiotics have the potential to replace linezolid in TB treatment regimens, particularly for long-term use.
Researchers at Emory University have discovered that psilocybin can delay cellular aging by over 50% and extend the lifespan of human skin and lung cells. In a study involving aged mice, psilocybin was shown to increase survival by 30% and improve physical features, suggesting potential for anti-aging therapies.
Researchers found that after accounting for known differences, implicit bias in physician and hospital levels persists among Black, Hispanic, and Native American people with vascular disease. The AI model helps identify unconscious biases in clinical decisions.
Researchers discovered that psychological stress activates the NR3C1/NUPR1 axis, accelerating ovarian tumor metastasis through epithelial-mesenchymal transition. Elevated NR3C1 positively correlates with NUPR1 expression and poorer prognosis in ovarian cancer patients.
A team of researchers from The University of Osaka has made a breakthrough in weight loss treatment by developing a one-time genome editing approach that introduces a GLP-1 receptor agonist gene. This innovative method enables the body to produce its own weight-loss medication, reducing the need for regular injections.
New research claims adding lime to agricultural soils can remove CO2 from the atmosphere, rather than cause emissions. The study, based on over 100 years of data, shows that the addition of acidity is the main driver for CO2 emissions from soils.
This study reveals that SRSF7 promotes pulmonary fibrosis by modulating the alternative splicing of pyruvate kinase (PKM), leading to metabolic dysregulation and fibroblast activation. Lomitapide was identified as a novel modulator of SRSF7, effectively mitigating experimental pulmonary fibrosis.
The Chang'e-6 mission has returned samples from the Moon's farside, providing new insights into the lunar geology and thermal evolution. The samples revealed prolonged volcanic activity, a fluctuating magnetic field, asymmetric water distribution, and ultra-depleted mantle signatures.
A research team led by Virginia Tech's Fralin Biomedical Research Institute is working on a technique that uses focused ultrasound to deliver creatine directly to the brain. This method aims to restore normal brain mass in models of creatine deficiency, which can impair brain development and lead to severe cognitive challenges.
A clinical trial found that women experience stronger subjective effects of acute alcohol intake, such as drunkenness and sedation, compared to men. The study adjusted doses to achieve identical blood alcohol concentrations for both sexes, revealing that women's effects were more intense.
The journal publishes original research articles, reviews, and rapid communications on pharmaceutical sciences. Recent studies focus on nanomedicine-driven tumor glucose metabolic reprogramming for enhanced cancer immunotherapy and the linkage of circadian rhythm disruptions with Alzheimer's disease and therapeutic interventions.
A new study reveals that koalas only spend around 10 minutes per day on the ground, which is linked to two-thirds of recorded koala deaths. The research used GPS loggers and accelerometers to analyze fine-scale movement patterns, finding that koalas move with little urgency and spend most of their time in trees.
Researchers have unveiled the petrogenetic history of a newly identified Martian meteorite, offering unprecedented insights into Mars' volcanic processes. The study's findings suggest episodic melt extraction from a long-lived, depleted mantle reservoir, which has significant implications for reconstructing Mars' magmatic evolution.
Researchers generated high-quality haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines. The studies identified numerous single nucleotide polymorphisms, indels, and structural variants surrounding HLA class I and II genes, providing valuable resources for cancer immunology research.
Researchers at Vanderbilt University Medical Center have developed a safe and effective fluorescent imaging agent that can assist surgeons in visualizing nerves during head and neck surgery. The agent, bevonescein, allows for intraoperative nerve-specific fluorescence visualization, reducing the risk of nerve injury.
Associate Professor Benjamin Mangrum's new book analyzes how comedy tackles technological advancements and their effects on human life. The book highlights the importance of humor in making technology seem ordinary and incorporating it into daily life.
Recent advancements in organic neuromorphic devices offer a promising solution for low-power, flexible computing. The review highlights the potential of these devices to overcome traditional computing limitations and contribute to next-generation systems.
A new study by Simon Fraser University warns that fish sounds and noise pollution are left out of critical conservation policies. This omission can have significant impacts on fish reproduction, population sizes, and ultimately, species survival.
A new study by researchers from Rice University has uncovered a mechanism by which the identity of nucleotides following a given nucleotide in DNA affects transcription accuracy. The discovery offers insight into hidden factors that influence transcription accuracy and may improve synthetic and therapeutic RNA.
A study published in Science Advances found that repurposing FDA-approved drugs can enhance the safety of nanomedicines by blocking complement activation and minimizing adverse effects. The research identified iptacopan, a drug approved for rare blood disorders, as a promising candidate for improving immune responses to nanoparticles.
A study published in Menopause journal found that four components of the Life's Essential 8 tool, including sleep quality, are key drivers of future cardiovascular risks. Healthy sleep, defined as 7-9 hours per night, may contribute to women's heart health and longevity.
MXene materials have been engineered to respond to light, enabling their use in soft robotics applications. This breakthrough could lead to the development of new types of robots that can change shape and function in response to external stimuli.
A University of Kansas professor's new book, 'On Bigotry', explores the concept of bigotry in a critical and nonpartisan manner. The book breaks down how bigotry functions, how it is taught, and its impact on individuals and society.
Researchers investigated differences between urban and natural soundscapes around the world, analyzing various descriptive indicators such as sound energy and variation in frequencies. The study found that green areas in urban settings often harbor a greater diversity of bird species than natural environments.
The study reveals that Hordeum bulbosum has a distinct genome expansion mainly at the chromosome ends. The team also decoded the Ryd4 resistance locus's structure in barley, providing a promising crop-wild introgression for resisting barley yellow dwarf virus.
A team of researchers has identified a molecular mechanism regulating the activity of NMTs, enzymes that modify proteins to regulate biological functions. The study reveals a potential new starting point for developing improved drugs targeting certain types of cancer and viral infections.
A UC study finds that murals are associated with higher foot traffic, denser housing, and increased cultural identity in Cincinnati's neighborhoods. The research also highlights the potential for murals to contribute to urban policy decisions, guiding investments in public art to achieve broader community development goals.
Compound heat-humidity extremes in eastern China are lasting longer than ever before, significantly increasing health risks for the elderly and young children. The study found that the active season has expanded, especially in South China, leading to a major public health crisis as China's population ages.
The Uncertainty-Aware Fourier Ptychography (UA-FP) framework offers a highly robust and flexible solution for computational imaging, overcoming traditional calibration constraints. It can maintain reliable performance even when confronted with substantial physical imperfections, setting a new standard for the field.
Researchers detected nanoplastic particles smaller than 1 µm in all depths analysed across the 12 measurement sites, with PET, PS, and PVC being the most common types. The study estimates around 27 million tonnes of nanoplastic are stored in the uppermost water layer of the North Atlantic.