A clinical trial found that patients with mesothelioma who received combination immunotherapy drugs before surgery had successful surgeries and improved early outcomes. The study showed that tracking tumor DNA in the blood could help predict treatment benefit.
The new model simplifies trial openings and streamlines patient enrollment, enabling rapid expansion across multiple locations. City of Hope operates a single centralized hub with diverse research locations, reducing patient enrollment times and increasing access to leading-edge treatment options.
REDIMadrid is launching an end-to-end quantum secure data transport project with Ciena, enabling high-speed security for research and education in Madrid. The collaboration integrates Quantum Key Distribution technology with optical infrastructure, paving the way for widespread adoption of quantum-secure networks.
Researchers found that freeze-drying preserves sulfoethylated kraft lignin's functional integrity, maintaining charge density, solubility, and sulfonic acid groups. Oven drying compromised performance, triggering chemical changes that reduced solubility and increased glass transition temperature.
A cohort study shows bariatric surgery significantly lowers major metabolic comorbidity risk compared to medical weight management. The procedure is deemed a durable approach for obesity-related risk mitigation.
The University of Pittsburgh has received prestigious R&D World 100 Awards for two emerging technologies: VulcanAlloy and eMission Critical Sensor. These innovations can withstand high temperatures continuously approaching 500 degrees Celsius and identify rare earth elements in waste streams or feedstocks, respectively.
Experts weighed in on the current state of artificial intelligence (AI) in cancer care, noting both its potential for improving efficiency and its challenges. Many expressed excitement over AI's possibilities for helping support an overburdened oncology workforce and accelerating the pursuit of new cures.
A study by Empa researchers found that electric car sharing can reduce emissions by up to 82%, but achieving cost savings and low-emission charging simultaneously is rare. The optimal charging strategy would require real-time tariff models, automated systems, and incentives like CO₂ prices.
A study examined the interactive effects of meteorological factors and air pollution on influenza cases in Huaian, China. The main findings showed that increasing PM2.5 levels decreased risk at low concentrations but increased risk at high concentrations.
The International Osteoporosis Foundation identifies critical global barriers to osteoporosis care, including limited DXA scanning and outdated treatment criteria. The IOF advocates for a paradigm shift in bone health management worldwide, recognizing high fracture risk as a valid criterion for treatment and reimbursement.
A recent study published in the Journal of Bone and Mineral Research found that blood fatty acid composition can predict bone mineral density from childhood to adolescence. The study, which included 480 children, found that higher proportions of certain fatty acids were linked to higher bone density.
A nationwide biomonitoring study in China detected 25 primary aromatic amines with varying levels of exposure among residents. High concentrations were observed in smokers, non-adults, and industrialized cities, with correlations to oxidative DNA damage.
A team of Chinese researchers has developed an assembloid model that mimics the physiological structure of endometrium and adenomyotic lesions, recapitulating transcriptional features consistent with in vivo tissue. The novel system reveals abnormal composition of stromal cell subpopulations during the secretory-like phase may disrupt ...
Five new professors join Goethe University's C3S, focusing on biodiversity modeling, socioeconomic drivers of climate change, data surveillance, critical computational literacy, and the normative constitution of computation. Hagen, Linsenmeier, Akbari, Verständig, and Müller-Mall bring fresh momentum to the center.
A new study finds that food insecurity is a significant risk factor for long COVID in US adults. Strengthening access to Supplemental Nutrition Assistance Program (SNAP) and raising awareness about the issue may help mitigate the health impact of long COVID.
A 2012 paper by Max Bazerman claimed 'signing first' increased honesty, but two experiments were later found to be fraudulent. The book tells the story of how this scandal upended academic careers and faith in research.
Researchers at Fraunhofer IAF have developed high-efficiency GaN power amplifiers with record-breaking linearity, promising to revolutionize broadband satellite communication systems. The 70nm GaN transistors demonstrate exceptional performance, exceeding the requirements of the European Space Agency for satellite communications.
Zhijian 'James' Chen, PhD, is awarded the Elaine Redding Brinster Prize for his groundbreaking discovery of the DNA-sensing enzyme cGAS. This breakthrough sheds light on how the immune system spots harmful DNA from germs and starts fighting them.
Researchers developed a high-energy ultrasonic regeneration strategy to restore nano-phase change emulsion performance under low-temperature conditions. This innovation enhances the stability of phase change emulsions, unlocking their full potential for thermal energy storage and cold-chain logistics applications.
A study published in the journal Sleep analysed data from over 26,000 days and nights to find that bedroom temperature and daytime light are associated with objectively measured sleep. People living with dementia have disrupted sleep patterns when bedrooms are hotter or lighting is dimmer.
Researchers developed wearable microneedle patches that improve drug absorption while reducing pain in long-term delivery. The new technology, inspired by bee stings, enables continuous drug release and anchors securely into the skin.
The Leopoldina Annual Assembly will focus on the progress of artificial intelligence in various fields, including medicine, image creation, medical diagnoses, and decision-making processes. Experts from natural and social sciences will discuss the effects of AI on society, ethics, and democracy.
A University of Minnesota Medical School research team has launched a groundbreaking study on infants born with congenital cytomegalovirus (cCMV). The five-year, $3.3 million grant will track the development of 200 infants over three years to better understand the virus's impact on long-term health and inform medical providers' clinica...
FAU researchers propose a method to produce methanol from wet biomass without prior drying, reducing energy consumption and costs. The new process enables decentralized production of methanol from renewable energy sources like photovoltaics or local wind farms.
Adult fibrosarcoma is a rare and highly aggressive malignancy requiring precise diagnosis and multimodal treatment. The case report emphasizes the need for early detection, complete surgical removal, and tailored postoperative care to improve outcomes in patients with this type of tumor.
Emphysema detected on low-dose chest CT scans in asymptomatic adults increases mortality risk over a 25-year follow-up period. The study found that emphysema severity is associated with higher COPD and cardiovascular disease mortality rates, suggesting it as a distinct disease entity linked to poorer health outcomes.
DZ-002 is an innovative cancer treatment developed through a collaborative effort among Georgia State University, Emory University and Cedars-Sinai Medical Center. The technology harnesses targeted radiation to destroy tumors with precision, offering hope for improved patient outcomes.
A UIC researcher team led by Dr. Subhash C. Pandey will investigate how long-term alcohol use affects the structure and function of brain cells, aiming to improve targeted treatments for alcohol use disorder. The grant renewal aims to fuel cutting-edge research into cellular interaction in areas key to alcohol addiction.
High consumption of ultra-processed foods is associated with higher levels of systemic inflammation and a greater risk of cardiovascular disease. The study found that individuals who consumed the most ultra-processed foods had significantly higher levels of high-sensitivity C-reactive protein, a key marker of inflammation.
Researchers discovered a large set of previously unrecognized enzymatic domains, the Lipocone superfamily, with a shared lipid-modifying mechanism. This superfamily is linked to Wnt, playing a role in cell communication during human development and associated with various diseases.
A Kennesaw State University researcher is working on an electronic nose that can detect bacterial contamination in food using volatile organic compounds (VOCs). The system uses AI models trained from thousands of samples to identify pathogens like salmonella and E. coli, aiming to revolutionize food safety.
A novel Bocaparvovirus was identified in goat fecal samples using metagenomic techniques, with high sequence identity to a known strain. The discovery raises concerns about the potential for interspecies transmission and highlights the need for further research on its pathogenicity.
The global integration of traditional and modern medicine has been shown to improve patient outcomes by enhancing symptom management, quality of life, and treatment adherence. Effective integration relies on robust regulatory frameworks governing practitioner licensing, quality control, pharmacovigilance, and research.
A new study proposes a unified framework for understanding risk as a result of human cognition, connecting perception and analysis. The model highlights the disparity between target value expectations and realistic ones, emphasizing the role of self-aware stakeholders in transforming perception into rational response decisions.
Beaked whales are recorded in the Foz do Amazonas Basin using passive acoustic monitoring, demonstrating their first documentation in Brazilian waters. The study contributes to understanding cetacean biodiversity and showcases the effectiveness of acoustic monitoring for categorizing elusive sea creatures.
A recent study found that toddlers with a fluctuating gut microbiome showed poorer growth compared to those with a stable microbiome. The researchers created a public health database containing complete genetic profiles of microbes from fecal samples, which can be used for future studies to help predict and prevent malnutrition.
Researchers have developed a new technique to measure boron in individual cancer cells, enabling the study of how drugs interact with tumour cells. This breakthrough could lead to more effective treatments for head and neck cancers.
A randomized Phase II trial shows that resecting the primary thoracic tumor after EGFR TKI therapy may prolong disease control in patients with metastatic EGFR-mutated non-small cell lung cancer. The study aims to extend the benefits of EGFR TKI beyond standard monotherapy by targeting residual disease through surgery.
Five well-publicized polar geoengineering ideas are highly unlikely to benefit the polar regions and could harm ecosystems, communities, and international relations. Researchers found that these proposals would likely cost billions in setup and maintenance while introducing ecological, environmental, legal, and political challenges.
A phase 2a clinical trial investigated an experimental viral immunotherapy, CAN-2409, in patients with unresectable stage III/IV NSCLC who previously failed to respond adequately to ICI. Patients showed longer overall survival and increased cytotoxic effector T cells after treatment.
A new study from Columbia University found that racial stereotypes can temporarily distort the brain's visual system, prompting people to see harmless objects as weapons. The study used functional magnetic resonance imaging (fMRI) and neural decoding techniques to investigate this phenomenon.
A new study at WCLC demonstrates that monitoring circulating tumor DNA can refine and personalize the use of consolidation immunotherapy in patients with limited-stage small cell lung cancer. Early ctDNA detection after induction chemotherapy identifies patients more likely to benefit from consolidation immunotherapy.
Graz researchers investigate homocysteine's impact on the aorta, finding elevated levels lead to stiffer and less elastic vessels. This discovery contributes to understanding of cardiovascular diseases like atherosclerosis.
Researchers create nanoparticles shaped like bottlebrushes with antibodies guiding them to tumor sites, delivering a large range of chemotherapy drugs directly to cancer cells. This approach reduces the need for potent drugs and enhances customizability of treatment options.
Virginia Tech researchers create method combining MRI, fluid dynamics, and algorithm to identify hidden glioblastoma cells. The technique uses fluid flow patterns to predict tumor re-growth, allowing for more aggressive surgical approaches. This technology has potential to improve cancer treatment outcomes
Researchers at Harvard Medical School have designed an AI model that identifies treatments for diseases by pinpointing genes and drug combinations. The new tool, PDGrapher, shows superior accuracy and efficiency compared to other similar tools.
Researchers used advanced X-ray imaging to track how tiny defects in stainless steel respond to hydrogen exposure. The study revealed three key changes once hydrogen was introduced, allowing internal defects to move more easily and leading to unexpected failure in metals.
The PALOMA-2 study found that subcutaneous amivantamab every 4 weeks, combined with daily oral lazertinib, yields a high objective response rate in patients with previously untreated EGFR-mutated advanced non-small cell lung cancer. This dosing regimen offers fewer administration-related reactions and improved convenience for patients.
A new study suggests that low-dose CT screening may be effective for detecting lung cancer in Asian women who have never smoked. The Female Asian Nonsmoker Screening Study found a lung cancer detection rate of 1.3% among the screened population.
A large-scale survey by Lung Cancer Europe identified critical communication barriers affecting information access and understanding among lung cancer patients and caregivers. The study found that complex medical language was a major obstacle to shared decision-making, with only 56% of respondents feeling their opinion was considered i...
A study of 40,000 users over 15 years found that musical taste becomes more refined and personal with age, with younger listeners exploring a wide range of contemporary music and older listeners returning to their youth favorites. Nostalgia is a strong driving force in middle age and beyond.
A new study suggests that the high prevalence of Autism Spectrum Disorder in humans is linked to the rapid evolution of specific brain cell types and genes. The research found that human brains contain a unique array of neuronal cell types that evolved rapidly compared to other primates.
Dr. Gerhard Andersson's pioneering work in internet-delivered cognitive behavioral therapy has produced over 200 controlled trials and transformed mental healthcare accessibility across continents.
Dr Oliver Pain develops GenoPred platform advancing personalized mental healthcare worldwide through accessible genetic tools, democratizing access to cutting-edge genomic methodologies. His work aims to reduce global health inequities by developing inclusive polygenic scoring methods that perform accurately across all ancestry groups.
A new technique uses ground-based observations and DART data to calculate safe asteroid deflection spots. The method takes into account asteroid shape, surface topology, rotation, and mass to minimize the risk of pushing the asteroid through a 'gravitational keyhole'.
Researchers successfully etched hafnium oxide films at atomic-level precision and smoothness without halogen gases. The new method uses nitrogen and oxygen plasmas to form volatile byproducts, resulting in reduced surface roughness and improved device performance.
A study by Dr. Esther Sternberg highlights the importance of social engagement, intellectual stimulation, purposeful activity, humor, and spiritual exploration in achieving exceptional cognitive and social functioning in advanced age. Dr. Reichlin's example challenges conventional assumptions about aging trajectories.
New research questions the origin of organic molecules in Enceladus's plumes, suggesting they could be formed by radiation on Saturn's surface rather than originating from the sub-surface ocean. This challenges astrobiologists' assumptions about the moon's habitability.
A new survey across seven large countries in the Global South reveals both depth of climate knowledge and trade-offs citizens face when weighing climate policies against other urgent needs. Strong support is found for earmarking revenues from carbon taxes for health and education programs.
A new review warns that strobilurin fungicides, widely used in farming, are contaminating staple foods, water, and human bodies. Small amounts can cause harm, interfering with cell energy production and potentially disrupting hormones.