Studies in Drosophila complement mammalian systems to uncover EV biogenesis and function, revealing conserved molecular pathways. The review highlights diverse physiological functions of EVs across species, including development, metabolism, immunity, and cancer progression.
Epithelial tissues behave like solids while retaining the disordered structure of liquids. The team developed an active vertex model that incorporated mechanochemical feedback to reproduce experimental signatures of glass dynamics, revealing a link between cellular mechanics, actin organisation, and collective tissue behaviour.
A study published in Cancer Cell identified a six-gene signature in microscopic colorectal cancer liver metastases that may help predict recurrence after treatment. The findings suggest these tiny tumor deposits could serve as a tissue-based marker of residual cancer cells, recurrence risk and chemotherapy resistance.
Living labs in agricultural, food and nutrition research facilitate stakeholder collaboration to identify problems and develop solutions. Long-term funding perspectives are essential for efficient and successful research.
A collaborative project between Alqem AI and the Max Planck Institute for Chemical Physics of Solids aims to identify new magnetic materials without rare earth elements. The company's AI platform combines extensive databases with high-quality training data to turn digital predictions into real materials.
Researchers from BST and IGTP are developing therapies based on extracellular vesicles, which can perform tissue regeneration and modulate inflammation. These nanoparticles could revolutionize medicine by delivering medicines directly to damaged tissues.
Haemophilia patients are at risk of life-threatening bleeding during dental procedures due to clotting factor deficiencies or inhibitor antibodies. Dentists must assess patients carefully before invasive procedures and use evidence-based treatments such as clotting factor replacement and local haemostatic measures.
Scientists used a new method to measure Earth's temperature over the Phanerozoic period, finding past temperatures were around 10 degrees Celsius above pre-industrial levels. The study suggests that natural processes have regulated the planet's climate for millions of years, and humans must take action to maintain a habitable range.
A recent study analyzed over 9,000 size changes in marine animals and found that body size decrease is a general response to environmental crises. The research suggests that warmer temperatures can lead to stronger and more variable changes in species size, posing far-reaching consequences for food chains and fisheries.
The iron cycle complements hydrogen-based power generation by providing a long-term energy storage solution. Iron powder can be transported globally with less infrastructure investment, making renewable energy usable worldwide.
A recent study reveals that astrocyte subtype dynamics play a crucial role in regulating mental health, particularly in mood disorders such as depression and anxiety. The review highlights how inflammatory signaling, metabolic imbalance, and ion channel dysfunction contribute to disease progression.
This study demonstrates the efficacy of Fufang Huangbo Formula in alleviating myeloproliferative neoplasms by inducing cell senescence, inhibiting proliferation, and reducing inflammation. Key components like forsythiaside A and chlorogenic acid are identified as active molecules targeting STAT3 and NF-κB pathways.
A systematic review found that babies born by caesarean section or exposed to antibiotics around the time of birth tend to have differences in their gut bacteria composition, with less diversity and beneficial bacterial groups less abundant. Exclusively breastfed infants appear to show a partial restoration of microbial balance.
Scientists at Institut Laue-Langevin create novel combination of neutron and light scattering to elucidate molecular structure of therapeutic nanoparticles. The technique enables precise determination of particle dimensions, internal structure homogeneity, and potential drug location.
A mechanical soft force sensor eliminates electronic components, allowing soft robots to sense and respond without power or signal processing. The sensor detects multi-axis forces and converts them directly into fluidic actuation.
A new study found that prophylactic naldemedine is a cost-effective intervention for opioid-induced constipation in cancer patients. The analysis revealed an incremental cost-effectiveness ratio of 1,445,276 Japanese yen per QALY gained, which is below the official willingness-to-pay threshold of 5 million yen.
A novel gene promoter called cmGAD67 shows promise for treating drug-resistant epilepsy by selectively stimulating inhibitory neurons. The study found that the promoter drove strong and highly selective gene expression in specific brain regions, reducing abnormal electrical activity and seizures.
The SNU Engineering team has developed an eco-friendly artificial spiderweb pressure sensor that achieves high sensitivity, fast response time, and excellent mechanical stability. The sensor is capable of real-time detection of human pulse, respiration, vocalization, and finger movements, making it suitable for Parkinson’s disease reha...
Researchers discovered that random sounds played during sleep can disrupt the consolidation of new memories by altering the composition of sleep stages. Participants who heard randomly played sounds spent less time in deep sleep and experienced poorer memory performance.
A new study identifies a rare genetic mutation in the CDK12 gene as a cause of aggressive prostate cancer at a young age. Genetic testing for this mutation could help identify families at risk and support early cancer detection, potentially saving lives.
Researchers developed a novel film by incorporating tannic acid into deacidified chitin nanofibers, achieving remarkable tensile strength, UV shielding, and antioxidant properties. The film demonstrated exceptional performance in preserving fruits, such as strawberries, for extended periods.
After Medicare expanded coverage for Wegovy to prevent heart complications in obese patients with heart disease, prescription fills jumped sharply. However, a significant fraction of eligible beneficiaries still did not receive the treatment.
A preclinical study reveals that different muscles remodel on different timelines after hemorrhagic stroke, with specific adaptations occurring between 2-12 weeks. Rehabilitation programs may need to be timed to these post-stroke windows to effectively leverage muscle plasticity for functional recovery.
A recent study found that frequent formulary rejections of single-source branded drugs in the US lead to delayed or absent treatment, highlighting trade-offs between cost and access to medicines. The study highlights the need for more affordable medication options, particularly for patients with chronic conditions.
Researchers have developed a new AI-based approach to automatically detect and classify e-cigarettes with digital screens. The tool has been trained on over 7,000 images and achieved accuracy rates of over 90%, enabling the detection of thousands of devices sold online.
Researchers at JAIST and NIMS have developed a high-throughput screening strategy that simultaneously explores catalysts and reactions. The approach resulted in the discovery of promising materials and revealed minor products, including 1-butene and benzene, indicating early signs of unknown reaction pathways.
A recent hantavirus outbreak on a nature cruise has sparked concerns about the potential for a global pandemic. Experts warn that Ebola-like viruses pose significant threats to public health.
Subjective olfactory impairment consistently associated with depression, while objective impairment linked to aging and anosmia. The study suggests partly distinct underlying mechanisms for subjective and objective impairments.
A study published in Global Change Biology found that falling water levels increase methane emissions from Mediterranean reservoirs. The research, conducted at the Cubillas reservoir in Spain, used a floating platform with eddy covariance technology to continuously measure greenhouse gas emissions.
A cohort study of California public high schools found that dedicated health courses were associated with modestly lower prevalence in several common forms of adolescent substance use. The study suggests that sustained, dedicated health coursework may be a scalable component of school-based substance use prevention.
A new study found that seagrass meadows are a vital source of nutritionally rich fish for coastal communities, with an average seagrass fish providing up to 21% of a child's daily zinc needs. Seagrass meadows are essential habitats for supporting the health and well-being of millions of people in tropical coastal regions.
A new genus of giant salamander, Limnospondylus ajimuensis, has been identified from fossilized vertebrae found in the Ajimu region of Japan. The discovery sheds light on Japan's evolutionary history and highlights the importance of preserving extant species for the future.
A study published in Psychology of Violence found that school administrators experienced verbal and threatening aggression from parents, with nearly 3.5 times the rate reported by teachers. The researchers recommend implementing tiered systems of support for all school personnel to foster a healthier climate.
Recent studies validate AI-based chatbots as effective alternatives to human fitness professionals for generating personalized training programs. However, limitations in nuance and continuous monitoring require hybrid models combining AI tools with human expertise.
The Center for BrainHealth has partnered with Dr. Krystal Sexton to expand its workplace-focused strategy, providing science-based tools to optimize workforce performance and resilience. The partnership aims to equip organizations with scalable solutions to enhance adaptability, innovation, and long-term performance.
A new study by University of Technology Sydney researchers suggests that honesty can be more efficient than incentive contracts in organisations. By modeling principal-agent relations, the authors show that trust and professional integrity may outperform performance-based pay, potentially eroding trust over time.
Researchers at HZB developed a novel perovskite triple-junction solar cell with a GO/SAM bilayer, achieving an efficiency of 27.3% and retaining over 90% of its original efficiency after 770 hours. This study demonstrates the potential of all-perovskite multi-junction solar cells for high power conversion efficiencies.
Acute myeloid leukemia (AML) is classified into 16 subgroups based on its epigenomic features, each with unique clinical prognosis and drug sensitivity. Epigenomic analysis reveals an additional dimension of AML diversity beyond gene mutations alone.
A new study found that over 50 million Americans live in counties without a radiation oncology clinic, highlighting vulnerabilities in the nation's cancer care infrastructure. Radiation oncology practices have closed disproportionately in rural areas and freestanding settings, raising concerns about patients' access to cancer care.
This cohort study found that TCM syndrome differentiation-based treatment improved clinical outcomes and reduced TCM symptom scores in patients with post-COVID-19 syndrome. The study showed favorable efficacy across subgroups, with a higher effective rate in the treatment group compared to the control group.
Researchers have discovered stellar cocoons rich in complex organic molecules within a supernova remnant, indicating that newborn stars can remain protected and preserve their molecular composition. The study suggests that the environment of our Solar System's formation may be more diverse than previously recognized.
An international team led by Juan Diego Soler has produced the sharpest maps ever made of neutral hydrogen in the Orion Nebula, revealing giant expanding shells and mysterious elongated structures. The findings suggest that the Orion Nebula has been shaped by multiple episodes of stellar feedback rather than a single expanding bubble.
This ecological study identified hemolysis-associated disorders as major drivers of the escalating global PAH burden. Hemoglobinopathies and hemolytic anemias correlated positively with PAH incidence, with G6PD trait, other hemoglobinopathies/hemolytic anemias, and vitamin A deficiency identified as top predictors.
Dr. Joe Northup, a renowned metabolic and bariatric surgeon, has been elected the 40th president of ASMBS. He aims to ensure patients understand the role of surgery in comprehensive obesity care.
The STEM-PD trial demonstrated the safety and feasibility of stem cell-derived dopaminergic cell transplantation in patients with moderate to advanced Parkinson's disease. The findings mark an important step in evaluating this approach as a potential treatment strategy for neurodegenerative diseases.
Early signs of clinical improvement have been observed in patients with treatment-resistant systemic sclerosis treated with investigational stem cell-derived CAR T-cell therapy, known as FT819. The therapy has demonstrated a reassuring safety profile and has the potential to expand access to patients who might otherwise face barriers t...
A genetic study has identified a link between irritable bowel syndrome and lipid metabolism, specifically triglyceride regulation. The research found that variations in the GCKR gene play a key role in this connection, highlighting a new approach to treating IBS
A Phase 1/2a clinical study demonstrates long-term survival of transplanted human neural progenitor cells in patients with retinitis pigmentosa, maintaining a favorable safety profile. Visual acuity remained stable, and imaging showed cells remaining present in the subretinal space for at least one year.
Researchers have found that GLP-1 agonists can normalize genetic pathways involved in pulmonary fibrosis, a lung disease associated with Long COVID. The treatment has shown promise in reducing the risk of fibrous buildup, suggesting potential benefits for people with type 2 diabetes and severe COVID-19 symptoms.
Research suggests that infrasound is registered in the inner ear through different sensory hair cells and electrical potentials, leading to varying perceptions among individuals. This discovery may help explain why some people are bothered by low-frequency noise while others are not.
Researchers at ISSCR 2026 present interim clinical findings from the first Phase 1/2a trial of autologous iPSC-derived dopamine neuron precursor cells for Parkinson's disease. The approach uses each patient's own cells, and new genomic quality control methods ensure the manufactured cells are suitable for transplantation.
The REGEN4HD study marks a significant milestone in the development of regenerative medicine approaches for Huntington's disease. The Phase 1b/2a trial enrolls early-stage symptomatic patients to evaluate safety and tolerability.
Researchers present new insights into an iPSC-derived neural progenitor cell therapy for chronic ischemic stroke, demonstrating safety and biological activity over extended follow-up. The findings have the potential to expand treatment options for patients living with chronic stroke disability.
A new study published in the Annals of the American Thoracic Society found that nearly one-third of COPD patients demonstrate unacceptable inhaler technique, leading to smaller lung function improvements. Instructing patients to hold their breath for 5-10 seconds improves acute bronchodilation.
The center aims to address the structural gap in care delivery by offering advanced functional diagnostics, individualized treatment planning, surgical intervention, and long-term management. Led by Professor Sungsoo Park, it provides objective, precision-based diagnosis and tailored treatment strategies for patients with refractory GERD.
Researchers at the University of Pennsylvania and Chinese University of Hong Kong created TD3B, an AI framework guiding peptide generation toward candidates predicted to have a desired effect. The tool predicts binding likelihood and determines activation or deactivation of associated cellular machinery.
Researchers developed antifungal nanoparticles from human immune cells that target Candida albicans, reducing fungal growth and improving survival rates in mice. The nanodiscs physically damage fungal cells and boost the body's natural immune defenses.
A recent study finds that individuals experiencing food insecurity prefer telehealth abortion services due to cost savings and avoidance of secondary expenses. The study reveals that nearly 50% of those in food-secure households opted for telehealth abortion primarily due to its lower cost.
The partnership aims to streamline prior authorizations, appeals, and financial assistance, addressing delays or denials in accessing prescribed therapies. By combining AGA's clinical leadership with Forus's medication access platform, the collaboration seeks to enhance patient advocacy and access to effective treatments.
Esprit's frameless mask-based system reduces patient discomfort and psychological stress through submillimeter accuracy and real-time motion management. The AI-powered Lightning treatment planning software streamlines workflow, reducing planning time by up to 80% and enhancing protection of critical normal structures.