Researchers identify Sanguinarine as a potent agent that synchronously induces apoptosis and ferroptosis in lung squamous cell carcinoma by hijacking the ER chaperone protein BiP. This 'switch' triggers Endoplasmic Reticulum Stress, leading to catastrophic cell death.
A new study by researchers at the University of Toronto identified a specific brain pathway through which cholecystokinin (CCK) acts to amplify pain in response to negative expectations. This pathway, traveling from the anterior cingulate cortex to the lateral periaqueductal gray, increases pain sensitivity and worsens symptoms.
A large-scale study reveals that obesity rates have slowed and even reversed in many high-income countries, while continuing to rise in developing nations. The analysis, involving over 1,900 researchers and 232 million people across 200 countries, suggests that previous claims of a global obesity epidemic may be an oversimplification.
Advincula received the Frank Tiller Award for his pioneering work on new materials, 3D printed membranes and smart separation surfaces. His research at ORNL focuses on polymer design, synthesis and characterization.
Research explores the impact of donor-acceptor ratio on buried interface optimization in perovskite solar cells. The study reveals that an EDG-rich modification leads to efficient defect passivation and high-quality film growth, resulting in improved stability and performance.
A novel biogel solves hair-related issues with EEG systems, maintaining stable performance across different hair types for multiple days. The biogel enables objective measurements of brain responses to touch, potentially revolutionizing virtual reality and human-computer interfaces.
Researchers argue that reflective practice has lost its ancient meaning under neoliberal governance, advocating for a return to phronesis as virtue. They propose teacher flourishing as the core of pedagogical tact, emphasizing the importance of habituation of virtue in daily practice.
Researchers at Memorial Sloan Kettering Cancer Center have uncovered promising combination therapies for a rare childhood brain tumor by analyzing patient samples, cell models, and laboratory data. The study found that cancer cells can develop workarounds to evade targeted RAS therapies, highlighting the need for new treatment strategies.
The Bulgarian Society of Endocrinology's open-access journal, Endocrinologia, has moved to the ARPHA publishing platform developed by Pensoft. The platform provides a fast-track system for authors, reviewers, and editors, improving management and increasing international integration.
The study shows that Finnish support for NATO is linked to current perceived threats, increasing rapidly after Russia's invasion of Ukraine in 2022. Material factors like assets and emotional attachment to Europe also influence people's willingness to defend the nation.
Researchers identify MARK2 as a unique upregulator of mutant p53 in triple-negative breast cancer, linked to poor survival. Disrupting the MARK2-mutp53 interaction through dominant-negative mutants may restore mutp53 degradation and inhibit TNBC growth.
A new study reveals that worker bumble bees play a crucial role in determining the sex of baby bees, with juvenile hormone being the key trigger. The researchers found that when workers were treated with the hormone, they passed it to larvae through food, making them more likely to become queens.
Researchers at Lund University developed a blood test that can detect early signs of breast cancer recurrence, providing information on how the disease responds to chemotherapy. The method, called Pathlight, measures small fragments of tumor DNA in blood samples and detected recurrence up to four years before current methods.
A daily glass of 100% fruit juice could help people reach the UK's 5-a-day fruit and vegetable targets, potentially supporting mental wellbeing. The study found that participants who consumed fruit juice in addition to whole fruit had lower depression scores compared to those who only ate whole fruit.
The University of North Carolina at Chapel Hill has been ranked 18th among US universities in the inaugural Cure Innovation Index. The Index evaluates institutions nationwide based on research output, entrepreneurial readiness, and market translation.
Researchers identified chipericumin D as a potent inhibitor of human aortic valve interstitial cell calcification, halting the disease progression by silencing the EGFR/PI3K/AKT signaling pathway. This natural compound offers a new therapeutic strategy for calcific aortic valve disease.
Researchers found that after five exposures, users' impressions stabilize and shape their response to future information. The study challenges the common assumption that people evaluate information accuracy before forming opinions.
Research identifies HMGB3 as a critical driver of malignancy in ESCC, enhancing cell proliferation, migration, and invasion. TGIF2-mediated HMGB3 overexpression drives the oncogenic cascade through the TLR3/TGF-β axis, promoting tumor progression and metastasis.
A new study by UC3M researchers reveals how extracellular acidosis destabilizes microtubules, the 'avenues' that organize internal cellular traffic, leading to disruptions in cellular function. This finding holds significant implications for understanding pathologies like cancer, diabetes, and certain infectious processes.
Researchers investigate MDK's role in bone remodeling and inflammation, finding its inhibition enhances osteogenesis while suppressing inflammatory response. Inhibition also restores PI3K/Akt pathway activity, promoting osteogenic gene expression and enhancing bone formation.
A mobile app is being developed to identify disease-carrying insects from their wing patterns using machine learning, aiming to reduce the risk of disease transmission in low-income communities. The technology will enable rapid and accurate identification of vectors, tracing disease clusters and responding effectively to outbreaks.
A hybrid Ti3C2Tx/Bi2Se3 material exhibits high-efficiency photothermal conversion and gradually conceals targets in environmental simulations. This work constructs a thermal protection strategy via enhanced photothermal conversion, providing a promising approach for developing advanced stealth technologies.
West Virginia University is launching the WVU Rare Earth Elements Initiative to explore U.S. feedstocks and commercialize AMDREE technology for extracting rare earths from acid mine drainage. The initiative aims to enhance national security interests and economic innovation by securing a domestic supply of critical materials.
A new study identifies distinct gut microbiome 'cluster types' associated with disease severity and progression risk in IBD. These clusters reflect higher-order microbial community organization, suggesting a more integrated view of host-microbe interactions in IBD.
Researchers at KAIST have developed an AI system that supports the initial psychiatric interview process, helping patients organize their symptoms and condition in advance. The system effectively obtained key clinical information within 30 minutes of conversation.
The LIGO-Virgo-KAGRA Collaboration has released a new catalog of gravitational-wave detections, revealing distinct sub-populations of merging black holes. These sub-populations are thought to arise from different formation pathways, including the collapse of gas clouds and hierarchical mergers between black holes.
Researchers at UCF–UF develop a gram-scale mechanical resonator suspended entirely by diamagnetic levitation, eliminating mechanical supports and energy losses. The device achieves exceptional stability and low dissipation, outperforming high-end MEMS sensors.
A team of scientists at Ohio State University identified a four-step process by which the managing protein converts precursor complex into a mature RISC. This discovery provides insight into RNA interference and could advance therapeutic siRNA development to silence problematic genes linked to diseases.
Researchers have developed a new procedure to speed up elaborate computer simulations analyzing matter under extreme conditions. The method, which uses mathematical transformation into imaginary time, enables faster evaluation of X-ray scattering experiments, improving fields like fusion research and laboratory astrophysics.
A research team at CityUHK has designed a capillary structure that triggers the Leidenfrost effect, offering a practical solution for temperature-regulated heat transfer. The study reveals an ultra-low Leidenfrost point of 110°C, significantly reducing energy input and enabling frictionless motion applications.
The role of teachers is becoming increasingly complex and demanding as AI reshapes education. Human capacities, such as emotional competence and professional judgment, remain essential in areas where technology has clear limitations.
A new study led by UMass Amherst researchers found that large-scale solar energy projects in the US encounter relatively little public conflict. The study analyzed 686 projects and found that 56% fell into 'no' or 'low' conflict categories.
The Lancet Commission, led by Professor Paul Franks, aims to design health systems that work for everyone, not just the average model. The commission will explore how stratified approaches can improve cost-effectiveness in low- and middle-income countries.
Scientists at the University of Stuttgart have developed a synthetic membrane platform that mimics cellular interactions, allowing for coordinated molecular transport and programmable biochemical reactions. This breakthrough enables the creation of artificial compartments with dynamic regulation of membrane permeability, opening up opp...
The GWTC-5.0 catalog includes 161 new gravitational wave events detected between April 10, 2024 and January 28, 2025, bringing the total number of confirmed events to 390.
Researchers from University of Galway developed an AI accelerated computational model to investigate the theory behind why physical forces slow cancer growth. The study suggests that harnessing pressure on a tumor could open new roles for treatments known as mechanotherapies.
Researchers discovered that DNA uses multiple ultrafast relaxation pathways involving moving electrons and protons to dissipate energy within femtoseconds, making it remarkably photostable. This complex network of competing processes enhances DNA's ability to safely drain away harmful UV energy before damage can spread.
A new multimodal controller for myoelectric prosthetic hands uses tactile, kinesthetic, and EMG signals to improve tool handling and reduce tool drops. The system significantly reduced the number of tool drops and shortened completion times in both able-bodied participants and amputees.
Researchers developed a deep learning framework to classify and profile subcortical vascular cognitive impairment using DTI volumes. The model achieved high accuracy and correlated with neuropsychological scores, enabling stratification of patients by predicted risk of impairment in specific cognitive functions.
A new AI system has dramatically reduced the time spent on complex experiments to test and find new gallium-based semiconductor materials. The AI uses Bayesian optimization to predict entirely new material compositions with desired electronic properties.
Researchers at Nagoya Institute of Technology have developed new guidelines for mixing dense suspensions, reducing impeller speed and energy requirements. The study's findings suggest that placing the impeller near the solid-liquid interface improves energy efficiency in baffled conditions.
The International Scientific Association for Probiotics and Prebiotics (ISAPP) is hosting a scientific symposium in Tokyo to foster global collaboration and knowledge-sharing. Key findings from leading experts will be presented on innovative biotics research and microbiome science.
New Flinders University research reveals that autistic Australians are three times more likely to be homeless, with poor communication and sensory sensitivities major contributors. Strong family support is the most powerful protective factor, while targeted training and autism-informed services can significantly reduce homelessness risk.
Researchers have developed a chemical upcycling method that converts existing plastics into new materials with rapidly degrading properties. This process has the potential to tackle global plastic pollution issues by replacing non-biodegradable plastics.
The transient electro-thermal (TET) technique offers a powerful method for measuring thermal diffusivity and conductivity in emerging low-dimensional materials. With high precision and simplicity, TET is reshaping heat transport characterization.
A recent study reveals that nearly half of every T-shirt goes to waste before it's even produced, highlighting the need for a more circular approach to fashion. The research found that only 17% of original fibers in a new T-shirt can be recycled globally.
3D printed anatomical models are being used to improve surgical outcomes in complex and delicate structures. Medical 3D printing technologies also create highly personalized implants and prostheses, supporting better surgical outcomes and post-operative results.
A new study published in JAMA Neurology finds ecopipam to be effective in suppressing tics in patients with Tourette syndrome. The medication was well-tolerated and showed no significant adverse effects over a period of up to 24 weeks.
A nationally representative study found a nearly 4-fold increase in type 2 diabetes prevalence among US children and adolescents between 10 to 17 years old. The substantial rise is concerning due to the disease's lifetime risk of severe complications and premature deaths.
Researchers developed an experimental gene therapy that protects brain cells from toxic protein damage caused by TDP-43, which is linked to neurodegenerative diseases such as frontotemporal dementia and Alzheimer's disease. The approach strengthens the neuron's resilience and helps preserve brain function.
The LVK network has announced the release of its updated Gravitational Wave Transient Catalogue-5.0, containing 161 new events detected between April 2024 and January 2025. This update includes exceptional detections, such as the best sky localization ever achieved and evidence for second-generation black holes.
Researchers developed a wearable ultrasound patch to monitor high-risk pregnancies, providing continuous, real-time information about blood flow in the fetus and umbilical cord. The device holds promise for helping doctors detect conditions like intrauterine growth restriction, which affects 10% of all pregnancies.
A plasma-based staging model using eMTBR-tau243 and %p-tau217 demonstrated strong concordance with positron emission tomography-based staging and clinical severity of Alzheimer disease. This approach may provide a scalable, minimally invasive method for biological stratification and treatment selection.
Researchers discovered layered guanine platelets in deep-sea fish that scatter light in complex ways, unlike traditional mirrors. These findings offer insights into creating highly efficient biomimetic designs for biomedical devices.
A new AI model, MutationProjector, analyzes tumor DNA to predict immunotherapy and chemotherapy outcomes in various cancers. The model identifies biomarkers associated with treatment responses and provides insights into why predictions are made.
The Journal of Medical Internet Research publishes a theme issue on digital inclusion in the Global South, examining access, agency, and impact. The focus areas include measuring digital access, gendered digital realities, and digital innovations across health and livelihoods.
Researchers at TIFRH introduce IRAA, a rapid, additive-free doping strategy that generates self-regenerating active species during the process. This approach eliminates the need for stabilizing additives or prolonged incubation, transforming the field of electronic doping in soft semiconductors.
A new study found that drinking tomato-soy juice lowered pro-inflammatory proteins in healthy adults with obesity after four weeks. The findings hint at the juice's promise as a functional food that may help curb chronic inflammation and improve health outcomes for patients with pancreatitis.
A recent study using satellite data measures the economic cost of war in Gaza, revealing that three-quarters of the economy has been destroyed since October 2023. The analysis found a 68.5% drop in night-time light intensity, indicating significant decline in human and economic activities.
Researchers found that over half of projects in the popular OpenStack ecosystem are affected by shared instability from “flaky tests”, resulting in a cumulative loss of 1,156 days of developer time. The study identifies environmental and system-level factors as major causes of test instability.