A landmark study has shown that transplanting stem-cell derived dopamine progenitor cells into the brain is feasible and safe. Eight patients received the transplanted cell product, with no serious side effects observed during the first year of follow-up.
Study identifies binding pocket on sodium ion channels where anesthetics like sevoflurane stabilize in inactive state, reducing neuronal activity. The findings may enable the design of safer, more selective anesthetics with fewer side effects.
Macrophages are critical drivers of chronic allograft failure, with emerging strategies targeting key macrophage signaling pathways providing an important conceptual shift. Targeted therapies, such as inhibiting the purinergic pathway and mTOR/NF-κB pathway, show promise in preventing chronic rejection.
A new study reveals that lung tumors can cause cachexia by hacking into the nervous system and altering eating behavior. Researchers found that tumors missing a gene called LKB1 produced prostaglandin E2, a signaling molecule that amplifies inflammation and causes weight loss.
Researchers demonstrate reversible switching of helimagnetic order by manipulating the polarity of an electric current under an applied magnetic field. The study provides a principle for controlling complex magnetic order using electric currents, advancing fundamental understanding of helimagnets.
Researchers at Tokyo University of Science found that revealing visual elements sequentially and matching each element with the speaker's narration improves attention and learning. Participants in a cumulative presentation format showed higher test scores compared to whole-slide presentations.
A study by scientists at CNIC and UCLA reveals that mitochondrial calcium controls interaction between mitochondria and cellular fat stores. This regulation opens potential avenues for treating obesity and metabolic diseases.
Researchers found basking shark denticles are massive and arranged in 'paver blocks,' allowing for stretching during filter feeding. This unique arrangement may promote flexibility and repel parasites.
A new study reveals that household members who work together and have a champion for solar adoption are more likely to install rooftop panels. The research found that greater support from all household members predicted eventual adoption, while disagreement was linked to a higher likelihood of installing solar.
Research reveals multifloral honey's protective effects on human skin cells from UV radiation, promoting cell recovery and preventing aging. The study found that honey increased stemness-related markers and reduced aging-associated genes in skin stem cells and fibroblasts.
Researchers discovered that ancient organism Spriggina floundersi preferred to bend to the right, showing the oldest known example of lateralized behavior. This finding provides new insights into the origins of left-right asymmetry in animals and suggests that behavioral preferences emerged earlier in evolutionary history than previous...
Researchers found that tiny, invisible swirls in the deep ocean shape significant climate forces like sea level rise and fisheries collapse. Climate models require significant improvements to accurately predict these effects.
The study uses the upgraded GRAVITY+ instrument to measure the carbon isotope ratio in Beta Pic B's atmosphere, but finds inconsistent results that challenge its interpretation. The findings suggest that the planet may have formed outside the snowline, where CO was present as ice, rather than gas.
A team of 23 researchers from 14 nations identifies three research priorities: winter aerosols, clouds, and feedback; winter storms and sea ice interactions; and polar-global teleconnections. These processes are highly under-observed due to their high variability and logistical challenges.
A EU research project has found that reducing average living space per person can lead to significant CO2 emission reductions in the European building sector. By minimizing living spaces, emissions can be reduced by up to 90%, meeting the EU's 2.0-degree climate target by 2050.
A recent study by the Keck School of Medicine found a decline in ADHD medication misuse among US adults, particularly among young adults. The misuse was largely driven by a shortage of ADHD medications, leading to an estimated 71.5% of patients facing difficulty filling their prescriptions.
Researchers developed gallium-doped zinc oxide nanosheets that can detect red, green, and blue light while remaining nearly transparent. These nanosheets enabled the detection of full-color images with half the error of conventional cameras, making them suitable for demanding environments like space hardware and automotive systems.
Researchers found that smelling dark chocolate odors increased training volume and suppressed hunger, while milk chocolate had no effect. The study suggests that food scents can trigger changes in body and mind similar to actual consumption.
Korea Institute of Materials Science (KIMS) has developed a plasmonic-based liquid biopsy platform capable of ultrasensitive detection of KRAS mutations in the blood and urine of patients with Stage 0 and Stage I colorectal cancer. The platform demonstrates over 90% concordance in KRAS mutation status across matched tumor tissue, plasm...
Researchers discovered a novel spiroquinoxaline compound that inhibits Cryptococcus neoformans virulence and triggers lethal oxidative stress, offering a promising new lead for treating cryptococcal meningitis. The compound, B1, shows potent antifungal activity and induces cellular damage through oxidative stress-mediated mechanisms.
Researchers used numerical simulations and isotopic data to connect hot spring magmatic water to the subducting Pacific Plate. The study found that magmatic water from Kawayu Onsen in Japan closely matched isotopic values released from the Pacific Plate at a depth of 125 km.
A new UAB trial demonstrates promising results for a novel immunotherapy in treating glioblastoma. The treatment, DeltEx DRI, has been shown to more than double progression-free survival, with median overall survival reaching up to 19.5 months.
Researchers found that clouds in sub-Neptune atmospheres actively shape their interior conditions, driving temperatures higher and potentially creating magma oceans. This discovery challenges the interpretation of James Webb Space Telescope data, suggesting clouds may be distorting our view of these planets' true bulk composition.
A team of scientists developed a dual-band hydrochromic optical modulator for multimodal anticounterfeiting and encryption. The device changes its appearance in the visible and mid-infrared regions through three modes: water-triggered visible switching, infrared emissivity modulation, and chemical signature authentication.
A team from Singapore University of Technology and Design has developed an AI agent that uses artificial intelligence to help patients make life-or-death decisions. The system, called ACPAgent, was tested with 15 participants who agreed with its recommendations in 86.7% of cases, but also showed limitations in handling high-subjectivit...
Pregnant women who engage with child protection services often experience fear, mistrust, and stigma, leading some to avoid health and support services. The study identified missed opportunities for early intervention and support during pregnancy, which could improve outcomes for mothers and babies.
A second PSMA PET scan changed treatment plans for nearly half of patients whose first scan was negative, detecting evidence of disease in 56% of cases. The study found that repeat imaging was most likely to detect disease in patients with higher PSA levels and a PSA doubling time of less than twelve months.
The partnership aims to bridge the gap between university learning and real-world practice, equipping students with in-demand digital skills. Through the Octave NextGen Builders Program, students will gain practical experience using professional tools used across industry projects.
A new multimodal fluorescence-phase microscopy (MFPM) system combines fluorescence excitation with label-free imaging, achieving precise spatial co-registration and maximizing data acquisition efficiency. This unified platform enables comprehensive biological investigations with enhanced imaging throughput.
Researchers have developed a federated learning algorithm that solves the long-standing conflict between robustness and efficiency in AI development. The new approach anonymizes data and reduces single-point failure risks while maintaining speed. By remembering past client interactions, servers can protect against malicious input.
A new study from Edith Cowan University found that a midwife-led birth debrief can significantly strengthen women's emotional wellbeing after childbirth. The structured conversation provides an emotionally safe space for women to reflect on their birth experience and find meaning, leading to high satisfaction rates.
A culturally tailored midwifery model of care has been shown to improve perinatal outcomes for First Nations babies, including a 45% increase in healthy births and higher breastfeeding rates. The study found that continuity of care with a known midwife reduces disparities in birth outcomes.
Researchers at Saitama University have developed a sequential annulation strategy to construct regioisomeric ladder-type oligothiophenes with precise control over thiophene ring orientation. This allows for the systematic synthesis of complex molecular structures, paving the way for the design of next-generation organic semiconductors.
Insilico Medicine achieved a significant revenue increase of 272.7% to 287.3% for the First Half of 2026, with net profit expected in the range of USD33.5 million to USD39.5 million. Global collaborations and strategic partnerships drove business growth, with major deals secured with top pharmaceutical companies.
Researchers at QUT and AusHSI found two widely downloaded health datasets to have unknown origins, raising questions about their authenticity and suitability for clinical research. The study assessed the datasets using the internationally recognized TRIPOD+AI reporting framework and scored 0 out of 9 on essential data-provenance criteria.
A new UNM-led study combines ancient sand grains and fish DNA to reveal the Colorado River's gradual formation between 8-4.8 million years ago through Grand Canyon. The research team found that the river emerged as a series of smaller proto-rivers linked together over approximately 3 million years.
Researchers at Gladstone Institutes found that hypoxia therapy can extend lifespan and improve brain function in mice with motor neuron degeneration. The therapy works by reducing the amount of oxygen available to cells, which can help counteract the effects of defective mitochondrial quality control machinery.
The brief connects 16 movements, from the Institute for Colored Youth to today's Student Action on Curricular Restrictions, and pairs each with evidence-grounded policy recommendations. Key patterns across generations of youth organizing include mass mobilization, coalition-building, and legal pressure.
The American Heart Association brought Hands-Only CPR training to FIFA Fan events in the US, with over 8,000 attendees participating. This effort aims to double survival rates from cardiac arrest by 2030 and educate more people on lifesaving skills.
A large clinical trial found that commonly used antihistamines and an anti-inflammatory drug, colchicine, had a small but significant benefit in reducing long Covid fatigue. However, the benefits were not sustained after stopping treatment.
New analysis reveals that most obesity medications do not meaningfully improve quality of life, cardiovascular health, or reduce mortality risk. However, some emerging drugs like tirzepatide and subcutaneous semaglutide show potential benefits in weight loss and reduced heart failure risk.
A study of over 3 million NHS births found that one-size-fits-all charts often misclassify babies, leading to missed cases and unnecessary interventions. Customized GROW charts provide more accurate data, improving safety for mothers and babies.
The European Association for the Study of Obesity, dietitian societies, and other organizations have issued a consensus statement on the use of incretin drugs in obesity therapy. Key findings include the importance of medical nutrition therapy delivered by registered dietitians to complement incretin-based therapies. The statement also...
Researchers at KAIST developed technology to automatically identify and fabricate two-dimensional semiconductors, revealing the relationship between thickness and performance. The technology enables data-driven research and accelerates the commercialization of AI semiconductors and ultra-low-power semiconductors.
Studies found that people with anorexia nervosa have high levels of LEAP2, a hormone linked to impulse control and blood sugar regulation. Higher levels of LEAP2 are associated with increased impulsivity and risk of relapse after treatment.
Two ECNP-affiliated journals, European Neuropsychopharmacology and Neuroscience Applied, have seen significant increases in citation rates. The rise reflects growing interest in the biological underpinnings of mental health, as reflected in the journal's focus on precision psychiatry.
A clinical trial has shown that setmelanotide, a new drug, can achieve significant weight loss in people whose weight has become dysregulated following treatment for a brain tumor. The treatment resulted in a 20% reduction in BMI, with participants experiencing substantial health benefits.
Researchers found that guided home-based exercise programs can be safely integrated into long-term recovery for aortic dissection survivors. The study showed no deaths, recurrent dissections, or aortic operations in either group, and improved some aspects of cardiovascular health.
Hong Wang, a senior R&D scientist at ORNL, recognized by the European Academy of Sciences and Arts for outstanding achievements. He conducts research on connected mobility systems and intelligent transportation technologies.
A new study reveals that melanoidins, dark-colored compounds formed during hydrothermal treatment, can severely damage the microbial system responsible for methane production in anaerobic digestion. High doses of melanoidins can cause methane generation to nearly stop, leading to system collapse and energy loss.
A Wisconsin lab advance has developed a way to remove liquid chromatography from peptide mapping, an essential test for determining a candidate drug's stability. This technique accelerates the process by 100-fold, allowing companies to analyze massive data influx instantly and reducing costs.
Oak Ridge National Laboratory researchers received five awards for their work on commercial vehicle operations, freight corridors, and integrated energy systems. ORNL's research also focuses on fuel economy guides, high-performance steel alloys, and computational tools for welding and manufacturing.
A new UGA study found that AI chatbots often provide recommendations that are inconsistent across generative AI platforms and may vary by sociodemographic groups. The researchers created three hypothetical scenarios of people who needed advice on emergency funds, investment portfolios, and retirement savings, which were entered into se...
A new study finds that chronic kidney disease rates in the US have remained consistent over the past decade, despite advancements in kidney-protective therapies. The proportion of Americans with kidney disease driven by diabetes has increased, while kidney disease not linked to diabetes has held steady.
Researchers developed a sawdust-based adsorbent that can remove methylene blue dye and real potato processing wastewater. The material achieved high adsorption capacities and was effective in both batch and continuous column tests.
A new Nigerian study has found widespread microplastic contamination in borehole water near the Sokoto Cement Factory, contaminating communities that rely on groundwater. The research identified common plastic polymers and health risks associated with microplastic exposure.
Researchers at KAUST have developed a system that uses tiny laser devices to generate unique digital fingerprints, verifying device identity without traditional passwords or security keys. The technology combines with AI to authenticate fingerprints instantly, offering a faster and more secure alternative for large-scale digital networks.
The International Society for Stem Cell Research convenes its 2026 Annual Meeting in Montréal, showcasing groundbreaking discoveries and emerging clinical advances. The meeting features nearly 1,300 scientific posters and presentations spanning every area of stem cell research.
A study found people with early-onset dementia experienced reduced work productivity up to 15 years before diagnosis, with average losses of $86,000 per person. The study also revealed varying productivity losses depending on the type of dementia, highlighting a need for interventions to prevent or delay decline.
A new clinical trial has reported improved survival rates for babies born with a life-threatening fetal disorder called anhydramnios. The treatment involved repeated injections of amniotic fluid into the womb, followed by kidney replacement therapy after birth. Results show that some infants have survived and thrived into toddlerhood.