Research reveals how microRNA miR-21 helps cancer develop by blocking tumor-suppressor gene PTEN. High levels of miR-21 are found in many kinds of cancer cells, providing a potential marker for patient prognosis.
Researchers at Karolinska Institutet discovered that microRNA molecules, specifically miR-203, are significantly upregulated in psoriasis and may be involved in regulating keratinocytes. This study suggests that microRNA therapies could become more effective than traditional medicines targeting individual proteins.
Researchers at Virginia Tech and UC Berkeley developed irreversible electroporation (IRE) to target cancer cells, successfully abling tissue in rat livers. IRE preserves vessel architecture and kills cells with minimal damage to surrounding healthy tissue.
Researchers at Cold Spring Harbor Laboratory identified a family of micro RNAs (miRNAs) that enable the p53 pathway to fight cancer growth. By comparing levels of miRNAs in cells with various pre-cancerous genetic lesions, they found a connection between changes in the p53 pathway and the loss of specific miRNAs, such as miR-34.
Researchers found that the p53 gene activates microRNA miR-34a, which kills cells with damaged genes. This microRNA plays a crucial role in stopping tumor development and is often missing in pancreatic cancer cells.
Researchers at University of Wisconsin-Madison have devised a method to tackle antibiotic resistance, identifying four promising new compounds with preliminary antibacterial activity. The compounds show promise against MRSA and other Gram-positive bacteria, but further research is needed to understand their mechanism of action.
A microRNA in mouse immune cells is shown to balance the response of immune defenses, with its equivalent human gene playing a vital role. Knockout mice develop autoimmune symptoms and are less resistant to bacterial infections, highlighting the importance of this microRNA in the immune system.
Researchers at Gladstone Institute of Cardiovascular Disease identified a critical genetic factor, microRNA miR-1-2, that regulates heart form and function. The study found that deletion of this microRNA causes defects in heart growth, function, and electrical conduction, potentially leading to new treatments for cardiovascular diseases.
Researchers at UT Southwestern Medical Center have identified a small RNA molecule that regulates the contractility of the heart under stress. The study found that blocking this molecule might become a way to prevent or treat heart damage.
Researchers at Johns Hopkins Medicine have discovered a tiny piece of genetic code, miR-29b, that moves far away from the cell's protein-making machinery. This finding reveals that microRNAs contain hidden elements that control their behavior in cells, opening up new possibilities for gene regulation and cancer research.
Researchers discovered that microRNA miR-133 targets the alternative splicing factor nPTB during early myogenesis, promoting muscle cell differentiation. This regulation affects a larger temporal program of muscle cell gene expression by altering mRNA splicing.
Two microRNAs, miR-29 and miR-181, have been found to control the expression of the TCL1 oncogene responsible for aggressive forms of B-cell chronic lymphocytic leukemia. High levels of these miRNAs suppress TCL1 expression, while low levels correlate with more aggressive cancer.
Researchers at UT Southwestern Medical Center discovered that tiny RNA molecules, called microRNAs, play a significant role in causing heart enlargement and increasing the risk of heart failure. By manipulating these microRNAs, it may be possible to treat heart disease.
Researchers at Wake Forest University School of Medicine have identified micro-ribonucleic acids (micro-RNAs) as potential biomarkers for lupus. The study found significant differences in micro-RNA expression between lupus patients and healthy controls, with certain micro-RNAs linked to histone deacetylases and the development of lupus.
Researchers found that microRNA-9a regulates neural development in fruit flies, controlling the precise production of sensory organ precursor cells. mir-9a also represses transcription factor Senseless to regulate neuronal precursor cell numbers in Drosophila and potentially in mammalian neurogenesis.
Researchers found that epigenetic treatment can induce microRNA-127, which downregulates the proto-oncogene BCL6. This may have an anticancer effect. Further studies are necessary to understand the regulation of miRNA expression in cancer.
Stanford scientist Sarnow discusses new approach to treating hepatitis C virus using microRNA, a small fragment of RNA found in the liver that is necessary for viral growth and reproduction. The approach aims to lower microRNA levels in the liver without affecting liver function, potentially leading to improved treatment outcomes.
Researchers discovered a new therapeutic target for hepatitis C using microRNA-122. The study found that miR-122 binds to a specific region of the virus, suggesting a potential approach for inhibiting viral replication.
miR-278 plays a crucial role in regulating insulin sensitivity in flies, with reduced insulin sensitivity and elevated blood glucose levels observed in flies lacking this microRNA. The study highlights the importance of microRNAs in metabolic regulation.
A new mechanism for regulating brain function has been discovered using microRNAs, fine-tuning synaptic connections to enhance information storage and computational capacity. The research suggests a link between microRNA miR-134 and disorders such as mental retardation and autism.
Scientists have identified two microRNAs, miR-1 and miR-133, that play opposing roles in determining whether myoblasts proliferate or differentiate into mature muscle cells. Increasing miR-1 promotes differentiation, while increasing miR-133 enhances proliferation.
Researchers found that deleting or over-expressing the lin-4 microRNA in C. elegans worm resulted in a shorter or longer lifespan, respectively. This study suggests an intrinsic biological clock regulates both organ development and aging.
Researchers at Gladstone Institutes have made a breakthrough discovery about the role of miRNA-1 in the early stages of heart development. They found that miR-1 helps determine heart progenitor cells and maintain them until later embryonic stages, which could lead to new strategies for cardiac regenerative medicine.
Researchers have identified a specific microRNA - miR 196 - playing a protective role in hindlimb development, but not forelimb development, suggesting a fail-safe mechanism to regulate gene expression. This finding may be useful in understanding birth defects and has implications for the regulation of protein expression in limbs.
Dmir-1 is specifically expressed in muscle cells, regulating Twist and Mef2 transcription factors. Muscle integrity and identity are maintained by Dmir-1, ensuring non-muscle gene mRNAs remain inactive.
Chronic leukemia affects 9,700 Americans annually, with unusual microRNAs enabling damaged cells to survive. Researchers discovered that miR-15 and miR-16 play a crucial role in controlling Bcl-2 levels, leading to tumor growth.
Researchers at UT Southwestern discovered that microRNA miR-1 targets the mRNA of the gene Hand2, a key regulator of heart formation. This fine-tuning allows proper heart muscle development and may aid in understanding congenital heart disease.
Researchers found that mir-17-92 cluster microRNAs are overexpressed in most common cancers, including B-cell lymphoma and colorectal carcinomas. This overexpression may contribute to cancer development and progression.
A new high-resolution ultrasound imaging device, SCAD, can monitor and diagnose bone quantity, density and strength in space. The technology has the potential to aid diagnosis for a number of skeletal disorders and improve treatment outcomes for people suffering from osteoporosis.
A team of researchers has discovered that microRNA miR-375 regulates insulin secretion, opening up new avenues for understanding and treating diabetes. The study's findings define a biological function for a mammalian microRNA gene and highlight the importance of collaboration between computation and experiment in modern biology.
Researchers identified two genetic signatures in CLL samples, one associated with a good prognosis and the other with a mutation in the Ig gene. The study suggests that miRNA expression may be used to predict CLL behavior and provides new targets for future drug development.
The study found that astronauts lost bone at a rate of 0.8-0.9 percent per month, with trabecular bone loss being more significant than cortical bone loss. The researchers used three-dimensional x-ray computed tomography to quantify bone loss in the hip and estimate changes in hip bone strength.
A long-term study found that administering oral antivirals reduced the risk of blindness and other serious eye effects in patients with eye shingles. Untreated patients experienced 8.9% adverse outcomes, while treated patients had only 2.1%. Timing of treatment also affected long-term outcomes.
Researchers found that astronauts' endogenous circadian pacemaker (ECP) loses its influence after about 90 days in space, leading to reduced sleep quality and duration. This could jeopardize performance on longer missions like those to Mars.
Researchers will study 12 astronaut crew members before, during and after space missions to assess cardiac mass, compliance and relaxation. Findings may help prevent cardiac atrophy and arrhythmias in individuals confined to long-term bed rest or with conditions associated with cardiac stiffness.
Respiratory sounds can precisely determine the level of shortness of breath in asthma patients. A new computer program uses acoustic analysis to detect breathing problems, potentially setting off an alarm during sleep and enabling researchers to study conditions without inducing symptoms.
Researchers at the University of Idaho and INEEL are using a unique laser-based method to study airflow around turbine blades, which can lead to improved performance and reduced maintenance costs. The Matched Index of Refraction Flow System will enable detailed measurements of flow patterns and surface roughness.
Researchers found American astronauts and mission control personnel reported lower emotional health scores compared to their Russian counterparts. The study suggests steps NASA can take to boost morale, such as rotating leadership roles among three-person crews.
A new analysis by Futron estimates the risks faced by NASA's space station crew, including serious illness, deaths, and accidents inside the station. The consultancy predicts a 93% probability that a micrometeorite impact will cause disaster if it occurs.
Researchers found that the heart's fluctuations in beats are strongly correlated with sleep, showing a fractal pattern on both short and long timescales. This suggests a hitherto unsuspected role for sleep in regulating the heartbeat.
Researchers have successfully engineered cardiac tissue, a crucial step towards repairing damaged heart tissue and testing new drugs. The team characterized the tissues' structural and electrical properties, identifying key parameters for growth and development.
A team of scientists from Montana State University designed an experiment to study the role of gravity on infection-fighting white blood cells. The goal is to understand why astronauts are more vulnerable to infections in space and develop pharmaceuticals to boost immune responses.
Russian scientists are developing a bacterial mixture to break down organic waste from astronauts' underwear, reducing storage issues in space. The disposal unit will process plastic, cellulose, and other waste aboard spacecraft, addressing the acute problem of waste management in space.
The conference will bring together over 100 principal investigators to discuss recent microgravity materials science research, including results from the Microgravity Sciences Laboratory-1 (MSL-1) mission. Researchers will also preview plans for the International Space Station and its Materials Science Research Facility.
Researchers have developed a unique antenna design called the Orlan antenna to provide communications and vital signs for astronauts on the International Space Station. The antenna's special loop design couples sufficient energy to transmit radio-frequency signals while minimizing reflections.
The STS-89 mission will conduct experiments on granular materials, studying their behavior under conditions that cannot be simulated on Earth. The Mechanics of Granular Materials experiment will make twice as many test runs under an expanded range of conditions, potentially leading to great ramifications for down-to-Earth engineering. ...
Researchers grew viable cartilage tissue from bovine cells on polymer scaffolds, but found that tissues grown in space were smaller and mechanically weaker than those on Earth. This study demonstrates the feasibility of cultivating cells and tissues in space over long periods.
Scientists are using NASA's Michelson interferometer to study protein crystal growth in space, a method that may lead to new treatments for diseases. The device, which was originally used to test the existence of the luminiferous ether, is being repurposed to analyze how molecules assemble into crystals.
Researchers at Michigan Technological University have developed a method to measure dynamic indentation hardness in materials, which could render traditional tests obsolete. The new device can achieve results in under 200 microseconds, reducing the need for costly and time-consuming tests.
The two miniature water worlds, designed by former Biosphere 2 crew members, have been safely transferred to the American space shuttle Atlantis for comprehensive testing of their effects on plants and animals in space. The experiments aim to provide insights into long-term human spaceflight and pharmaceutical research.
The Penn State students will test off-the-shelf semiconductor chips to learn the effect of high energy particle radiation on standard semi-conductors. They will also measure how much micro debris hits the shuttle using a piezoelectric device, and map the Earth's magnetic field as it flies through it.