Researchers found that estrogen therapy can suppress adrenal androgen production, with marked reductions in DHEA-S, A4, and testosterone levels. The study suggests a potential mechanism for how estrogen affects androgen hormones, and has implications for postmenopausal women.
New research suggests two distinct brain areas, the hippocampus and subiculum, work together to process and store information for short-term memory. This finding broadens understanding of how memory works and could lead to more sensitive tests and treatments for conditions like Alzheimer's disease.
A study found that less educated individuals face higher daily stress levels, which have more significant negative impacts on their health. The researchers discovered that daily stressors vary by socio-economic status, with those in disadvantaged positions experiencing greater health downturns.
Researchers found that surgery to remove fatty deposits from narrowed vessels can significantly reduce stroke risk, with a 50% reduction in strokes among those who underwent the procedure. The study's results confirm previous findings and highlight the need for more adults to be screened for narrowed carotid arteries.
A study by Wake Forest Baptist found that eszopiclone significantly improved sleep measures in older adults with insomnia, including reduced napping and enhanced quality of life. The treatment increased total sleep time and reduced the tendency to wake up repeatedly during sleep.
Researchers from Wake Forest University Baptist Medical Center and Wake Forest Health found a 24% improvement in physical function among participants who combined weight loss with moderate exercise. Participants reported significant improvements in knee pain, with a decrease of over 30%.
A four-year study assesses pediatricians' ability to change parents' behaviors and prevent violence. The study measures media exposure, gun storage, and communication between parents and healthcare providers.
Researchers at Wake Forest University Baptist have developed a non-surgical treatment for cerebral palsy patients using Botox injections. The treatment has shown significant improvement in functional ability and muscle relaxation, allowing patients to perform daily activities with greater ease.
Anemia is associated with increased disability, poorer physical function, and low muscle strength in older adults. Researchers found that participants with anemia reported an average of 1.7 disabilities compared to 1.0 for non-anemic subjects.
Researchers found that long-term consumption of high amounts of isoflavones can alter patterns of agonistic and social behavior in primates, including increased aggressive and submissive behavior. The study suggests careful attention must be taken to balance beneficial and potentially adverse effects of soy consumption.
Prudent-layperson laws have reduced emergency department denials based on symptoms, rather than diagnoses. Insurers are now more likely to cover treatments, and fines for non-compliance have increased industry-wide changes in ED claims management.
A study found that only 25% of internal medicine residency programs in the US have formal instruction on interacting with drug company sales representatives. A six-hour curriculum was developed to teach residents about the ethics of these interactions and how they can be influenced by marketing tactics.
A recent study found that environmental factors such as temperature and humidity can significantly impact LASIK surgery results. The study of 191 patients revealed that indoor humidity had the largest impact on whether enhancement surgery was required, while outdoor temperature and humidity in the weeks before surgery also played a role.
A study found that 45% of families reported giving their child herbal products, with many caregivers unaware of potential side effects. Parents should seek expert guidance and inform their child's pediatrician about any supplements taken to ensure safe use.
A new study will compare patients who receive dialysis six times a week to those on the standard three-times-a-week plan. The researchers aim to determine if more frequent dialysis can prevent urea buildup, improve blood pressure, and enhance quality of life.
A study found that nearly half of rural North Carolina adults use home remedies for various health conditions. The most common remedies used were honey-lemon-vinegar-whiskey for respiratory issues, herbs for cardiovascular conditions, and teas for general well-being.
Researchers have made significant breakthroughs in understanding a natural mechanism cells use to protect themselves from stress, with potential applications for preventing motor nerve cell death. Up to 50% of nerve cell death could be prevented in mice with sciatic nerve injury using this approach.
Researchers found that high S-phase fraction and diploid status were key predictors of early and late recurrence rates. Patients with poor prognostic indicators, including older age at diagnosis and larger tumor size, had poorer outcomes.
A $3.3 million NIH grant-funded study will compare six-times-per-week overnight home hemodialysis to standard three-times-a-week hemodialysis at dialysis centers. The research aims to determine if the higher dose of dialysis improves patient outcomes, including hospitalization rates and quality of life.
A study published in the Proceedings of the National Academy of Sciences found that monkeys' brains sort computer clip art pictures into categories for recall, such as people, buildings, flowers, and animals. This process could lead to ways to improve memory in humans by reducing detail and categorizing information.
Researchers mapped rat brain activity, finding that cells in sensory borders share information from multiple senses. The discovery may explain how individuals adapt to sensory loss and improve their remaining senses.
Researchers found that a combination of surgery and intraperitoneal hyperthermic chemotherapy (IPHC) can increase survival rates for patients with peritoneal carcinomatosis. The procedure, which delivers heated chemotherapy directly to the tumor site, has shown promise in improving quality of life and extending survival.
A recent study found that high-dose vitamin therapy had no effect on preventing recurrent strokes and heart attacks. The VISP study involved 3,680 adults who received either a low or high dose of folic acid, B6, and B12 vitamins.
A 10-year study by Wake Forest researchers highlights the need for better safety measures to protect migrant farm workers and their families from pesticide exposure. Changes are needed in housing, hygiene procedures, and pesticide application to reduce health risks.
Late-life anemia significantly increases the risk of death and hospitalization in older adults, regardless of underlying conditions. Anemia affects about 13% of people over age 70, with approximately 30% cases remaining unexplained.
A study found pesticide residues on floors, toys, and hands of children living in farm worker households, posing a significant health risk. The research team detected six agricultural chemicals and 11 residential pesticides in the homes, highlighting the need for further study on this population's exposure to pesticides.
Researchers have identified multiple families with a genetic mutation causing gout and kidney failure, developing in teenage years and progressing to end-stage kidney disease by the 40s or 50s. The team hopes to find family members who may be unaware of their condition and develop improved treatment for this rare disease.
Research finds that heavy use of analgesics for at least nine years prior to irreversible kidney failure is associated with anatomic changes of SICK. Over 7% of dialysis patients had SICK, with 33% having overused analgesics preceding dialysis start.
Researchers have linked genetic factors to severe kidney disease in blacks, with evidence pointing to genes on chromosome 18 and another unidentified region. The study involved a large African-American cohort and could pave the way for targeted therapies.
A team of researchers has identified an enzyme, protein kinase C, that may play a crucial role in turning fleeting experiences into lasting memories. The study found that this enzyme helps to activate genes that express proteins involved in forming long-term memories.
Researchers found that people with dyslexia integrate visual and auditory information differently than good readers, suggesting a sensory integration deficit underlying reading difficulties. This discovery could lead to a simple test for early diagnosis and more effective teaching approaches.
Research by Wake Forest University Baptist Medical Center reveals that hearing can significantly improve the ability of individuals with mildly impaired eyesight to locate objects in space. The study found that when sound was added, participants with nearsightedness were able to perform as well as those with normal vision.
Researchers discovered a genetic link between prostate cancer and a specific gene variant, CYPIBI. The study found that tiny variations in the gene may increase or decrease its cancer-causing effects, leading to a higher risk of developing prostate cancer.
A three-year study found that low-dose methotrexate had no effect on maintaining restored hearing in patients with autoimmune inner ear disease (AIED). Researchers are now focusing on alternative treatments for this rare condition.
Researchers have isolated stem cells from parthenogenic monkey eggs that can differentiate into various cell types, including neurons and tissues. These findings hold promise for developing an unlimited number of neurons for treating Parkinson's disease.
The Enforcing Underage Drinking Laws program has led to increased state agency involvement and enforcement efforts, including retail outlet crackdowns and public education campaigns. However, results show no significant reductions in alcohol use among youth, highlighting the need for continued intervention and analysis.
Scientists at Wake Forest are studying the genetic defects that allow cancer cells to resist cell death, in hopes of developing new treatments. They will use normal cells converted into cancer cells through controlled mutations to understand how resistance occurs.
Seed Stage Associates LLC will provide education, assistance, training and advice to establish tech transfer offices, while aiding established offices in evaluation, marketing and licensing of new technologies. The company will leverage resources of western North Carolina schools for collaboration.
Researchers at Wake Forest University Baptist Medical Center found that Zemplar, a drug mimicking vitamin D hormone, sensitizes cancer cells to radiation therapy without harming normal cells. The combination reduced radiation dose by 2.4 times while maintaining treatment efficacy.
Researchers found that anemia is an independent risk factor for physical decline in older adults, leading to increased risk of nursing home admission, disability, and death. The study suggests that treating anemia may help preserve physical function.
A new study identified three genetic variants associated with a 30% increase in prostate-specific antigen (PSA) levels. The discovery could lead to more accurate testing and fewer unnecessary biopsies, particularly for black men who are at higher risk of developing prostate cancer.
Atrium Health Wake Forest Baptist has received a five-year federal grant to develop a model tobacco intervention curriculum, covering smoking and smokeless tobacco use. The program aims to integrate the curriculum into all four years of medical school curricula and will incorporate culturally sensitive strategies.
Researchers at Wake Forest University Baptist Medical Center have found that oxaliplatin can effectively treat human cancers resistant to other platinum-based therapies. The drug works differently than cisplatin and shows promise in combination with radiation therapy for patients with earlier stages of rectal cancer.
Researchers found that signals from the basal ganglia may be preventing intact visual areas from functioning properly. Disrupting basal ganglia activity could restore balance and treat visual neglect, a condition where patients perceive only half of their surroundings.
The Wake Forest Problem-Based Learning Center has received a $539,352 grant from the Howard Hughes Medical Institute to support teacher professional development. The center's program, which uses problem-based learning to engage students in real-world science and math projects, has shown remarkable success, with 97% of tracked students ...
Researchers used MRI to assess brain function while participants experienced heat stimuli. People who reported higher pain levels showed increased activation in key brain areas, such as the primary somatosensory cortex and anterior cingulate cortex. This confirms the importance of self-reports in guiding pain treatment.
A large collection of cases reveals that IVIG treatment can cause strokes in some patients, particularly those with hypertension, diabetes, and a history of cerebrovascular disease. The study found a 0.6% risk of stroke among inpatient IVIG recipients over a four-year period.
A recent study by Wake Forest University Baptist Medical Center found that combination hormone therapy increases the risk of probable dementia in women aged 65 and older, with approximately 23 additional cases per year. The study's results highlight the importance of considering alternative approaches to preventing cognitive decline.
Researchers at Brenner Children's Hospital have developed a new gene therapy technology that uses highly efficient protein delivery to correct mitochondrial defects. This approach has the potential to prevent or treat genetic diseases like SIDS and TFP deficiency in infants, as well as heart and brain diseases later in life.
A Wake Forest researcher has identified a syndrome that causes brain malformations, leading to death in premature infants. The malformations were found using ultrasound and MRI scans during autopsies of premature infants who died soon after birth.