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California Institute of Technology


Developing our sense of smell

Researchers at Caltech have found that neural-crest stem cells differentiate into microvillous neurons, which sense pheromones, and are distinct from ciliated neurons that detect volatile scents. The discovery sheds light on how olfactory neurons form and may lead to new treatments for conditions like anosmia.

Creating indestructible self-healing circuits

Researchers developed a system with on-chip sensors and a central processor to detect and respond to faults, achieving significant power reduction and improved performance. The self-healing capability was demonstrated in high-frequency integrated circuits, opening up possibilities for next-generation electronics.

SourceCalifornia Institute of Technology·JournalIEEE Transactions on Microwave Theory and Techniques·DateMar 11, 2013

Visualizing biological networks in 4-D

Scientists at Caltech have developed a unique microscope that captures the motion of DNA structures in both space and time, allowing them to directly measure stiffness and map its variation. This breakthrough technique has far-reaching implications for understanding biological nanomaterials and their properties.

SourceCalifornia Institute of Technology·JournalProceedings of the National Academy of Sciences·DateFeb 11, 2013

Sorting out stroking sensations

Researchers at California Institute of Technology have identified a specific class of skin sensory neurons that react to massage-like stroking, paving the way for further study of pleasurable sensations. The discovery uses genetically modified mice and novel recording techniques to pinpoint individual neurons activated by touch.

A cloudy mystery

The G0.253+0.016 cloud defies conventional wisdom on star formation, with a dense gas content 25 times higher than the Orion Nebula but only producing small stars. The cloud's high velocities and presence of silicon monoxide suggest it may be two colliding clouds, preventing star formation due to its dynamic nature.

SourceCalifornia Institute of Technology·JournalThe Astrophysical Journal Letters·DateJan 10, 2013

Faulty behavior

Researchers at Caltech and JAMSTEC developed a new fault model that shows stable segments can behave differently during earthquakes, leading to larger events. This challenges current assumptions about seismic hazard in areas like the San Andreas Fault.

Planets abound

A Caltech-led team estimated that there are at least 100 billion planets in the galaxy, with one planet per star, based on their analysis of the Kepler-32 system. The planets in this system are typical of those found around M-dwarf stars and may represent the majority of planets in the galaxy.

Unlocking new talents in nature

Researchers have created new biocatalysts using the power of protein engineering and evolution, allowing nature's premier oxidation catalyst to drive synthetically useful reactions. This breakthrough enables the production of pharmaceutical drugs and natural products in a more efficient and environmentally friendly manner.

Social synchronicity

Researchers found that body-movement synchronization increases after short cooperative training, indicating a measurable indicator of social interaction. This study may provide a powerful tool for identifying neural underpinnings of social interactions and impaired interactions like autism.

SourceCalifornia Institute of Technology·JournalScientific Reports·DateDec 12, 2012

Point of light

Researchers at Caltech developed a new waveguide that channels light and focuses surface plasmon polaritons to achieve nanoscale precision. The device has the potential to revolutionize biological imaging and computer storage by allowing for high-resolution maps of molecules and increased memory capacity.

SourceCalifornia Institute of Technology·JournalNature Photonics·DateDec 7, 2012

Developmental bait and switch

A recent study led by Caltech researchers provides new insights into the process of neural crest cell development. The team discovered that DNA-methyltransferase (DNMT) enzyme acts as a switch to determine which cells will remain part of the central nervous system and which will become neural crest cells.

SourceCalifornia Institute of Technology·JournalGenes & Development·DateNov 1, 2012

Making the healthy choice

Scientists at Caltech identified competing brain systems that guide decisions on healthy options. The dorsolateral prefrontal cortex and ventromedial prefrontal cortex play different roles in self-regulation, with the former taking control when trying to suppress cravings and the latter taking over when encouraging desires.

Ready for your close-up?

A new Caltech study found that facial photos taken at close range influence perception, making subjects appear less trustworthy, competent, and attractive. Researchers used digital warping to manipulate images, confirming the effect. The findings may have implications for computer vision and social judgments.

Moving targets

Researchers at Caltech used Caenorhabditis elegans to study cell migration, identifying genes that are active during this process. These findings may lead to the development of new drugs that block cell migration, which is linked to tumor formation and metastatic cancer.

SourceCalifornia Institute of Technology·JournalProceedings of the National Academy of Sciences·DateSep 20, 2012

A model for development

Biologists at Caltech created a computational model of gene networks that control the development of sea-urchin embryos. The model accurately reproduces experiments and allows for virtual experiments, revealing unprecedented detail about gene regulatory networks.

SourceCalifornia Institute of Technology·JournalProceedings of the National Academy of Sciences·DateAug 30, 2012

Weighing molecules 1 at a time

A team of researchers has developed a nanomechanical device that can weigh individual molecules, enabling biologists to study viruses and probe molecular machinery. The device uses vibrational modes to determine particle mass and position, opening doors for biomedical applications such as disease diagnosis and immune system monitoring.

SourceCalifornia Institute of Technology·JournalNature Nanotechnology·DateAug 26, 2012

Learning 1 of cancer's tricks

Researchers at Caltech have identified a specific sugar, GlcNAc, that plays a key role in keeping cancerous tumors fed. By altering the addition of carbohydrates to proteins, tumor cells can survive under harsh conditions and thrive. This finding offers new potential targets for therapeutic intervention.

Thinking and choosing in the brain

A study published in PNAS found that different regions of the frontal lobes are responsible for behavioral control and decision making. The researchers mapped brain lesions in over 300 patients and showed that damage to specific areas can impair reasoning and decision-making abilities.

SourceCalifornia Institute of Technology·JournalProceedings of the National Academy of Sciences·DateAug 21, 2012

An earthquake in a maze

A Caltech-led team reports on the first high-resolution observations of the 2012 Sumatra earthquake, which ruptured along multiple faults at nearly right angles. The study provides fresh insights into the possibility of complex earthquakes occurring elsewhere, including California's San Andreas fault.

The physics of going viral

Researchers at Caltech have developed a method to measure the rate of DNA transfer from viruses to bacteria. They found that the amount of genetic material within the bacterial cells determines how quickly the bacteriophage's DNA is transferred, not the pressure in the virus itself.

SourceCalifornia Institute of Technology·JournalCurrent Biology·DateJun 27, 2012

Seeing inside tissue

Caltech engineers enable focusing of light deep into biological tissue, opening up possibilities for non-invasive diagnoses and treatments. The technique uses ultrasound waves to shift the frequency of light, allowing for image creation without scattering effects.

SourceCalifornia Institute of Technology·JournalNature Communications·DateJun 26, 2012

Hands-on research

Neuroscientists at Caltech found that the primary somatosensory cortex processes both physical and emotional aspects of touch, with brain activity reflecting emotional significance even before actual contact. This finding has implications for understanding autism, sexual abuse, and physical trauma.

SourceCalifornia Institute of Technology·JournalProceedings of the National Academy of Sciences·DateJun 4, 2012

Decoding worm lingo

Researchers found that many nematodes communicate using the same types of small-molecule pheromones, revealing a universal nematode language. This discovery could lead to strategies to prevent unwanted nematode species and improve agricultural and healthcare industries.

SourceCalifornia Institute of Technology·JournalCurrent Biology·DateApr 12, 2012

What triggers a mass extinction?

A Caltech-led team used a framework to analyze fossil occurrences and sedimentary rock records to determine that habitat loss due to falling sea levels and cooling of tropical oceans were the primary causes of the Late Ordovician mass extinction. The study largely ruled out a hypothesis suggesting a record bias as an explanation for th...

SourceCalifornia Institute of Technology·JournalProceedings of the National Academy of Sciences·DateApr 10, 2012