A randomized clinical trial shows cognitive behavioral therapy for prolonged grief outperforms present-centered therapy in treating comorbid symptoms, while both treatments demonstrate effectiveness and acceptability. The findings suggest potential for dissemination and increased patient choice.
A cross-sectional study found substantial burden of RSV-related hospitalizations, ICU admissions, and deaths in US adults. Increasing RSV vaccination among older adults has the potential to reduce these outcomes.
Researchers found semaglutide and liraglutide substantially decrease AUD hospitalization risk compared to approved medications. Clinical trials are needed to confirm these findings and explore their efficacy in treating AUD.
A large cohort study found that young adults with type 2 diabetes ages 20-39 who had low incomes were more likely to die prematurely. The study highlights the need for socioeconomic support to address income-related health disparities among younger individuals.
A cross-sectional study found a low frequency of physician disciplinary actions for spreading misinformation, despite increased salience and warnings since the COVID-19 pandemic. The findings suggest a disconnect between regulatory guidance and enforcement, questioning the suitability of licensure regulation in combating misinformation.
This study reveals prevalent adverse childhood experiences among children, including abuse and neglect, with notable disparities across demographics. Early identification and community interventions can reduce ACEs and mitigate future health consequences.
A cohort study found asthma to be associated with memory difficulties in children, which may impact executive function abilities. Earlier asthma onset is likely to exacerbate these effects.
A time-series study found heat waves associated with increased adverse health events among 65-year-olds, highlighting the need for heat adaptation strategies. Dually eligible individuals face vulnerable outcomes without such measures.
A cross-sectional study found that barriers to divorce were associated with higher pregnancy-associated homicide rates and better access to reproductive health care was linked to lower rates. The study highlights the importance of considering state legislation when addressing pregnancy-related violence.
The study reveals that many individuals and households incur significant financial burdens for abortion care, with those traveling from out of state facing the most extreme costs. To address this issue, expansion of insurance coverage to ensure equitable access to abortion care is needed, regardless of a person's state of residence.
A longitudinal cohort study found no significant associations between prenatal SARS-CoV-2 infection and child neurodevelopment outcomes in the first two years of life. Follow-up research is needed to determine if these effects persist into later childhood.
A study reveals racial disparities in genetic detection rates for inherited retinal diseases, with lower rates observed in Black patients compared to white patients. The findings highlight the need for improved genetic testing and therapeutic development to address these disparities.
A randomized clinical trial found that simultaneous administration of mRNA COVID-19 and inactivated influenza vaccines had comparable reactogenicity to sequential administration. This suggests a safe option for co-administration of these vaccines.
A retrospective cohort study found associations between COVID-19 and the long-term risk of various autoimmune and autoinflammatory connective tissue disorders. Long-term monitoring and care are crucial to mitigate these risks, taking into account demographic factors, disease severity, and vaccination status.
A systematic review and meta-analysis found nurse burnout to be associated with lower health care quality and safety, as well as lower patient satisfaction. The association was consistent across various nurse and study characteristics.
The study highlights widening cancer disparities across Human Development Index regions, age, and sex. Strengthening healthcare access and quality is crucial for evidence-based cancer prevention, diagnostics, and care.
JAMA launches a new series, Translational Science Reviews, providing concise summaries of important basic science discoveries transforming disease diagnosis and treatment. These reviews aim to keep clinicians informed about ongoing scientific advancements.
A cohort study found that hospital COVID-19 burden was associated with an increased risk of in-hospital adverse effects among patients with and without COVID-19. The results highlight the importance of hospitals having greater resilience and surge capacity to prevent declines in patient safety during surges in demand.
A digital health behavior intervention improved child weight-for-length trajectory and reduced childhood obesity at 24 months. The intervention was effective in a racially and ethnically diverse population, including groups at elevated risk for childhood obesity.
A recent revision of Alzheimer Association criteria focuses solely on AD core biomarkers, sparking uncertainty about patient outcomes. The new definition may limit diagnostic flexibility and impact treatment planning.
Recreational cannabis legalization in California is associated with higher rates of cannabis use during early pregnancy, driven by jurisdictions allowing adult-use retailers. The study found that individuals living in these areas were more likely to use cannabis during early pregnancy.
Light ex-smokers experience a CVD risk reduction similar to never-smokers within years of smoking cessation. Heavy ex-smokers require longer periods, up to 25 years, for their residual CVD risk to align with that of never-smokers.
This prospective cohort study found that evidence-based smoking cessation treatment within 6 months of a cancer diagnosis significantly improves survival outcomes. Smoking cessation is an essential early clinical intervention for patients with cancer, supporting the maximization of survival benefits.
A study published in JAMA found that drug-related reports of supply chain issues were 40% less likely to result in meaningful drug shortages in Canada compared to the US. This highlights the importance of global cooperation to curb the effects of drug shortages and strengthen pharmaceutical supply chains.
State policies allow law enforcement unfettered access to sensitive medical information without warrants or subpoenas in over half the country, sparking concerns about patient privacy and civil liberties. The lack of regulation puts gender-affirming care patients at risk, amid growing bans on such treatments.
Diagnosis prevalence for autism spectrum disorder increased substantially in the US between 2011 and 2022. The study highlights growing needs for medical services among this complex population.
A study published in JAMA Psychiatry found that targeting the prefrontal cortex with cognitive remediation and transcranial direct current stimulation can effectively slow cognitive decline in older adults at risk of cognitive decline. The treatment was particularly beneficial for those with remitted major depressive disorder and mild ...
The Kansas City Cardiomyopathy Questionnaire (KCCQ) demonstrated strong psychometric properties in patients with severe tricuspid regurgitation. The KCCQ can effectively measure symptoms, function, and quality of life, making it a valuable tool for assessing patient outcomes.
The PROTECTED trial found no significant impact of cerebral embolic protection on periprocedural stroke risk, but suggests a trend towards greater stroke reduction in US cohorts compared to outside the US
Elevated body mass index (BMI) was associated with a significantly increased post-acute sequelae of SARS-CoV-2 infection risk. The study highlights the need for targeted care to prevent chronic conditions in at-risk children and young adults.
A recent study found that early aortic valve intervention had no impact on all-cause death or unplanned hospitalization related to aortic stenosis in asymptomatic severe aortic stenosis and myocardial fibrosis patients. The results suggest further research is needed to confirm these findings.
A US cohort study found that prenatal cannabis exposure was associated with differences in executive function and aggressive behavior in children at age 5. The study's results may inform clinical recommendations on cannabis use during pregnancy.
A network meta-analysis of patients with asthma found that inhaled corticosteroid combinations with formoterol and short-acting β agonists significantly reduced asthma exacerbations. These therapies also improved asthma control compared to short-acting β agonist monotherapy.
A cross-sectional study found a significant increase in GLP-1 receptor agonist (RA) use as anti-obesity medications from 2022 to 2023. Meanwhile, the rate of metabolic bariatric surgery decreased by 25.6% during the same period. These findings suggest a potential shift in treatment strategies for obesity management
A cohort study found that postacute infection syndrome is not exclusive to COVID-19, but it can also occur in people with other severe lower respiratory tract infections. COVID-19 appears to exacerbate neurological, cognitive, and fatigue symptoms compared to other LRTIs.
A study published in JAMA found that personalized recommendations for hospitalized patients with acute kidney injury did not improve outcomes. Despite higher implementation rates in the intervention group, worsening acute kidney injury stage, dialysis, or mortality remained unchanged.
Research highlights social media's impact on youth mental health, including associations between excessive social media use and suicidal thoughts. The study emphasizes the need for targeted interventions and policy changes to address this growing concern among young people.
A cross-sectional study found increasing concentrations of fentanyl, cocaine, and methamphetamine in urine specimens from 2013 to 2023, highlighting a shift in illicit substance use patterns. Heroin concentration decreased during this period, emphasizing the need for updated surveillance initiatives and treatment strategies.
Researchers have successfully integrated genome sequencing into newborn screening to identify hundreds of rare genetic disorders. This approach allows for earlier diagnosis and treatment, promoting health equity and reducing time to diagnosis.
A cohort study of children with vesicoureteral reflux found that glomerular filtration rate changes after urinary tract infections. The study used data from the Children With Vesicoureteral Reflux trial to assess estimated glomerular filtration rate changes in participants with vs without recurrent UTIs.
Non-Hispanic Black patients are more likely to receive inadequate care and experience poor survival outcomes due to delays in treatment initiation. Guideline-concordant care is crucial in improving survival rates among these patients.
The use of GLP-1 receptor agonists (GLP-1RAs) and SGLT2 inhibitors in people with type 1 diabetes has significantly increased between 2010 and 2023. This trend is driven by their benefits in weight management and cardiorenal protection, but caution is advised due to concerns about euglycemic diabetic ketoacidosis.
A cross-sectional study of 14,000 insured adults found that individual-level social determinants of health are strongly linked to healthcare spending by Medicare, Medicaid, and private insurers. This association can inform health insurers and policymakers to incorporate social determinants into decision-making practices.
A cohort study examines how traumatic and adverse childhood experiences influence developmental changes in psychiatric risk and cognitive ability. The findings suggest targeted early prevention and intervention strategies for at-risk youth.
A large cohort study found that mothers with eating disorders were more likely to have children with psychiatric disorders, while those with pre-pregnancy BMI outside the normal range also showed an increased risk. The findings suggest that clinicians should consider these factors when preventing offspring mental illness.
The article highlights patchwork strategies for managing high prescription drug costs, but emphasizes the need for solutions that address root causes of high prices. Clinicians can use existing solutions to help patients access costly medications, but policy changes are necessary for sustainable affordable access.
Infant mortality rates in the US increased significantly following the Dobbs decision, with no post-Dobbs months showing lower-than-expected rates. The findings are consistent with previous reports of increased infant mortality in Texas following its abortion ban.
The World Medical Association's revised Declaration of Helsinki sets new standards for human participants in medical research, emphasizing informed consent and minimizing risk. The updated principles aim to protect vulnerable populations and promote transparent research practices.
This article provides practical recommendations for improving ethical oversight of clinical trials in the US. Key findings include enhanced regulatory mechanisms and training programs to ensure compliance with existing regulations.
A randomized clinical trial found that montelukast did not shorten the duration of COVID-19 symptoms among outpatients with mild to moderate illness. The study's findings suggest that montelukast is unlikely to be beneficial for treating mild to moderate COVID-19.