By adopting a 'Just-in-Time' training and inventory process, researchers reduced patient wait times by 175 minutes and improved resident preparation, leading to better on-time performance and reduced pressure on clinic faculty.
A study in mice implanted with breast and melanoma cancers found that combining radiation therapy with a checkpoint inhibitor increases antitumor responses from the immune system. The combination also enhances memory T-cells, which retain memory of the tumor and can attack it long after treatment.
Researchers at Johns Hopkins have identified a highly sensitive means of analyzing tiny amounts of DNA. The new analytical method compares favorably with existing techniques, enabling the detection of small amounts of DNA in samples.
Researchers found that a combination of delayed walking and cognitive delays in boys can be an early warning sign for Duchenne muscular dystrophy. This combination may prompt pediatricians to conduct further testing, potentially leading to earlier diagnosis and treatment.
A team of researchers has identified a new target for treatment of common eye diseases, including wet macular degeneration and diabetic macular edema. Activating a biochemical pathway that suppresses VEGF's effects may offer a safer alternative to current treatments.
A blood test detecting the 'nicked' protein AR-V7 in prostate cancer patients can predict resistance to commonly used treatments enzalutamide and abiraterone. This biomarker may help tailor treatment strategies for men with detectable levels of AR-V7.
Researchers at Johns Hopkins Medicine discover that tumor cells can spread through lymphatic vessels by releasing signaling molecules, which attract and facilitate the growth of new blood vessels. The HIV drug maraviroc blocks these signals, preventing breast cancer metastasis when combined with a VEGF-blocking drug.
A new study from Johns Hopkins Medicine suggests that nearly half of African-Americans may not receive effective doses of the HIV drug maraviroc due to their genetic makeup. Researchers developed a simple genetic test to determine individual dosage needs, which could help improve treatment outcomes.
Researchers have found that cancers exhibit distinct patterns of methylation on the DNA genome, enabling tumor cells to turn genes on or off as needed. These epigenetic changes allow cancer cells to adapt and spread, making them a key factor in tumor development.
Researchers discovered that commonly used NSAIDs alter the activity of enzymes within cell membranes, which can lead to unwanted side effects. This finding provides a basis for a test to predict and avoid these side effects in new medicines.
Researchers have developed a new method to create patient-specific neural crest cells from skin cells, which can help study and potentially treat rare disorders. The technique accelerates the creation of these cells, allowing for more accurate predictions of disease progression and treatment efficacy.
Monthly blood transfusions significantly lower the risk of recurrent strokes in children with sickle cell disease who have already suffered a silent stroke. Children receiving regular transfusions had a 58% lower risk of suffering repeat silent or overt strokes compared to those without treatment.
Johns Hopkins scientists develop a new material that binds slippery molecules, potentially delivering long-lasting lubrication and easing painful joints. The material, inspired by natural functions lost in synthetic materials, has shown promise in animal tests.
A recent study using stem cells found that a rare genetic variation, known as DISC1, reduces synapse growth in young brain cells, contributing to schizophrenia and depression. The researchers also discovered that the variation regulates the activity of over 100 genes related to synapses.
A new study by Johns Hopkins Medicine found that nearly one in ten inner-city children has a food allergy, with breastfed kids and high exposure to endotoxin being potential risk factors. The study also highlighted a subgroup of children with higher-than-average allergy risk.
A study led by Johns Hopkins Medicine found that at least one in 10 inner-city children has a food allergy, with peanuts being the most common allergen. The study also suggests that early-life exposure to certain microbes may play a protective role against food allergies.
Scientists discovered that people learn new motor tasks faster when they recall the errors made during the first attempt. The brain uses this information to fine-tune its performance and adapt to future similar tasks. This study sheds light on how our brains learn from mistakes.
A modified version of Clostridium novyi bacterium has been shown to produce a strong anti-tumor response in rats, dogs and now humans. The treatment involves direct injection of spores into tumors, targeting oxygen-starved cells while sparing healthy tissue.
A new triple therapy combining two immunotherapies and targeted radiation has prolonged the survival of mice with glioblastoma brain cancer by up to 67 days. The treatment induces an immune response against tumors, creating long-term immunity.
Physicians at Johns Hopkins have developed blood and saliva tests that accurately predict the recurrence of HPV-linked oral cancers. The tests screen for DNA fragments of the human papillomavirus shed from cancer cells, with accuracy rates of up to 70% in some patients.
Researchers have developed a novel imaging technique that allows for real-time visualization of brain sound processing in mice. This breakthrough enables the study of complex neural interactions and may lead to better treatments for hearing loss.
Researchers at Johns Hopkins Medicine have discovered a genetic alteration linked to stress reactions that could lead to suicidal thoughts and behaviors. The study suggests that a blood test based on this finding may be able to identify individuals at increased risk of suicide attempts, allowing for early intervention and prevention.
Cancer cells can divide even without sufficient oxygen by manipulating the protein HIF-1alpha. Lysosomes play a crucial role in regulating this process by marking or degrading HIF-1alpha. The study suggests that inhibiting Cdk2 may be an effective treatment strategy for certain types of cancer.
A phase III clinical trial shows that a combination drug therapy cures chronic hepatitis C in the majority of patients co-infected with both HIV and hepatitis C. The new all-oral regimen sofosbuvir and ribavirin has cure rates of up to 92% for treatment-experienced patients, offering a transformative step in treating this population.
A new study by Johns Hopkins researchers found that healthy living kidney donors often face pointless insurance hurdles after donation. Despite being heavily screened before approval, these donors are frequently denied or charged higher premiums for life insurance, highlighting the need for better support systems.
Researchers found that blood clots are rare in children undergoing spine operations, and most patients can be safely monitored without anti-clotting medication. High-risk groups include children with congenital scoliosis or spinal curvatures part of a syndrome, as well as older children.
A team of researchers has created a way to induce normally mild-mannered cells to gobble up their undesirable neighbors by exploiting a molecular signal. This breakthrough could lead to therapies that enlist patients' own cells to better fend off infection and even cancer.
Researchers used game theory to study tumor cell cooperation and found that within certain ranges of mutation rates, critical transitions occur in energy metabolic strategies. This switch in tactics may make tumors vulnerable to disruption, potentially ideal for clinicians to test new therapies.
Researchers at Johns Hopkins Medicine have discovered a biological tactic to protect crops from insect plagues using specific spider toxins. The study found that naturally occurring insect toxins can be lethal for one species and harmless for a closely related one, suggesting the development of more species-specific insecticides.
A new study finds that minimally invasive surgery is underutilized in many US hospitals, with significant variability in procedure types and complication rates. The study suggests that differences in physician training and hospital practices contribute to this disparity.
A Johns Hopkins study finds that a gene deletion linked to schizophrenia alters brain cell skeletons, disrupting layer formation. Researchers also identify a crucial protein involved in building cellular skeletons, which may contribute to the condition.
A study published by Johns Hopkins Medicine found that children undergoing simple emergency surgeries on weekends are more likely to suffer complications and die than those treated during the week. The researchers analyzed 22 years' worth of surgical records involving nearly 440,000 pediatric admissions nationwide.
Researchers at Johns Hopkins Bayview Medical Center introduced guidelines and changes to the computerized provider order entry system to reduce redundant biomarker testing. This led to a 66% decrease in tests ordered and saved an estimated $1.25 million in laboratory charges.
Scientists found a shared mechanism regulating ion intake in sodium and calcium channels, enabling unified understanding of conditions affecting these channels. The discovery may lead to the development of next-generation pharmaceuticals targeting this common control element.
A Johns Hopkins-led research team found that motivational interviewing significantly reduced secondhand smoke exposure among children living in households with smokers. The study showed a 17% increase in prevalence of home smoking bans and a 13% decrease in smokers in the intervention group.
Researchers at Johns Hopkins University deciphered the inner workings of YiiP, a protein that prevents zinc toxicity in bacteria. The study reveals how protons drive the transport of zinc ions across cell membranes, shedding light on potential targets for modulating ZnT proteins and treating type 2 diabetes.
Researchers discover that retinal ganglion cells pass on worn-out mitochondria to astrocytes for disposal at the optic nerve head. This process challenges the common understanding of cellular trash management and has implications for diseases like glaucoma, Parkinson's, and Alzheimer's.
A new study reveals that astrocytes can monitor and respond to nearby neural activity, but only when primed by the fight-or-flight chemical norepinephrine. This ability suggests that astrocytes may help control the brain's ability to focus.
Researchers developed a vaccine that triggered the growth of immune cell nodules within pancreatic tumors, reprogramming these intractable cancers. The vaccine, GVAX, consists of irradiated tumor cells modified to recruit immune cells, and boosted activity of molecular mechanisms that inhibit cancer-fighting immune cells.
The AMEN protocol provides a script to help doctors and nurses talk to dying patients and families about their hopes for a miracle. This approach aims to respect patients' beliefs and values while maintaining trust and open communication, even when discussing futile treatments.
Scientists at Johns Hopkins Medicine have successfully created a three-dimensional complement of human retinal tissue in the laboratory, including functioning photoreceptor cells that can respond to light. The achievement offers new opportunities for vision-saving research and may ultimately lead to technologies that restore vision in ...
Researchers at Johns Hopkins Medicine have plotted the complex paths of cholinergic neurons, which degenerate first in people with Alzheimer's. The study reveals that these neurons face significant challenges due to their thin pipeline and numerous branch points.
A new study confirms that children who live in homes with high levels of roach and mouse allergens and pollutants have higher overall allergy and asthma rates. However, those who encounter such substances before their first birthdays seem to benefit rather than suffer from them.
A study by Johns Hopkins Medicine found that saliva enzymes, blood proteins, and muscle proteins can protect against DNA damage caused by pyrogallol-like polyphenols (PLPs) in teas, coffees, and liquid smoke flavorings. The presence of these defenses may explain why PLPs are not causing widespread illness despite their toxic effects.
A study by Johns Hopkins Medicine found that older black trauma patients are 20% less likely to die from their injuries compared to white patients. This counterintuitive finding suggests that factors such as better access to healthcare and lower rates of penetrating trauma may contribute to the difference in survival rates.
A commercial epigenetic diagnostic test has been found to be accurate enough to exclude the need for repeat prostate biopsies in many men. The test analyzes DNA hypermethylation levels in specific genes and shows an 88% likelihood of no cancer when all three biomarkers are absent.
Researchers at Johns Hopkins Medicine have cataloged over 17,000 human proteins from 30 different tissues, identifying 193 novel proteins not previously known to exist. This comprehensive dataset provides a solid foundation for speeding up biological research and diagnostic development.
Critically ill patients receiving steroids in the ICU are significantly more likely to develop delirium, with up to 80% of ventilated patients at risk. Minimizing steroid use may reduce delirium and its long-term impact on functional recovery and cognitive function.
Researchers found a genetic variant in noncoding DNA that leads to protein overproduction in heart cells, increasing the risk of sudden cardiac death by 40%. The discovery could lead to new drug treatments and improve understanding of cardiac repolarization.
Researchers have found chemical signals that enable breast cancer metastasis by recruiting normal cells from the host animal, providing a promising new direction for cancer treatment. Blocking these signals in mice with breast tumors significantly reduced their ability to spread.